Results for UME6
Z-value: 3.50
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Transcription factors associated with UME6
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
UME6
|
S000002615 | Key transcriptional regulator of early meiotic genes |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YJL089W Show fit | 52.88 |
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus |
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| YMR107W Show fit | 47.80 |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
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| YKL217W Show fit | 46.19 |
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose |
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| YML042W Show fit | 37.61 |
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes |
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| YAL054C Show fit | 31.21 |
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions |
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| YML089C Show fit | 28.21 |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage |
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| YDL210W Show fit | 23.19 |
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane |
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| YJR095W Show fit | 21.27 |
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization |
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| YOR100C Show fit | 20.80 |
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation |
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| YCL025C Show fit | 19.66 |
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) |
Network of associatons between targets according to the STRING database.
First level regulatory network of UME6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 20.4 | 61.2 | GO:0035947 | regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414) |
| 8.2 | 57.3 | GO:0006083 | acetate metabolic process(GO:0006083) |
| 18.5 | 55.5 | GO:0009437 | amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437) |
| 11.5 | 46.2 | GO:0006848 | pyruvate transport(GO:0006848) |
| 2.8 | 39.3 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 1.1 | 31.7 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 1.1 | 27.4 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 6.4 | 25.8 | GO:0046323 | glucose import(GO:0046323) |
| 6.0 | 23.9 | GO:0015847 | putrescine transport(GO:0015847) |
| 2.0 | 23.7 | GO:0046686 | response to cadmium ion(GO:0046686) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 93.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.5 | 82.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 1.1 | 76.8 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.5 | 39.4 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.6 | 26.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 22.3 | GO:0000322 | storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324) |
| 0.8 | 19.5 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 4.8 | 19.4 | GO:0033309 | SBF transcription complex(GO:0033309) |
| 0.7 | 18.9 | GO:0042764 | prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764) |
| 2.6 | 15.7 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 105.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 13.9 | 69.4 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 18.5 | 55.5 | GO:0016406 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
| 3.2 | 34.8 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 10.4 | 31.2 | GO:0016208 | AMP binding(GO:0016208) |
| 1.1 | 27.2 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 1.9 | 26.2 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 7.8 | 23.5 | GO:0036440 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
| 7.2 | 21.5 | GO:0016289 | CoA hydrolase activity(GO:0016289) |
| 5.3 | 21.2 | GO:0015556 | C4-dicarboxylate transmembrane transporter activity(GO:0015556) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 407.5 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 6.0 | 18.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.9 | 5.8 | PID ATM PATHWAY | ATM pathway |
| 0.9 | 5.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.5 | 2.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 1.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 0.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 0.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 0.3 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.0 | PID P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 407.5 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 3.0 | 26.9 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 1.5 | 10.4 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 2.8 | 8.3 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 2.2 | 6.6 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.6 | 1.9 | REACTOME PI3K EVENTS IN ERBB2 SIGNALING | Genes involved in PI3K events in ERBB2 signaling |
| 0.4 | 1.5 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.2 | 1.3 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 1.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 1.1 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |