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Results for UPC2

Z-value: 0.99

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Transcription factors associated with UPC2

Gene Symbol Gene ID Gene Info
UPC2
S000002621 Sterol regulatory element binding protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
UPC2YDR213W-0.518.0e-03Click!

Activity profile of UPC2 motif

Sorted Z-values of UPC2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YIL162W 5.22
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YDR541C 2.54 Putative dihydrokaempferol 4-reductase
YOR382W 2.47
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YOL154W 2.42
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YLR295C 2.40
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YLR056W 2.30
ERG3
C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
YIL012W 2.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR279C 2.27
SCW4
Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YFL051C 2.04 Putative protein of unknown function; YFL051C is not an essential gene
YMR316C-B 1.87 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCR005C 1.82
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YMR271C 1.81
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YGR234W 1.75
YHB1
Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YEL065W 1.72
SIT1
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
YHL046W-A 1.67 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL136C 1.65
PFK27
6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YMR317W 1.64 Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YOR010C 1.59
TIR2
Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
YLR297W 1.56 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDR516C 1.52
EMI2
Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p
YER158C 1.49 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YHR143W 1.49
DSE2
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YHL047C 1.48
ARN2
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YPL017C 1.47
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YPR146C 1.47 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNR016C 1.44
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YBL082C 1.43
ALG3
Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
YPL271W 1.43
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YML083C 1.38 Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
YOL128C 1.37
YGK3
Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
YMR082C 1.37 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL134C 1.36 Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
YNL327W 1.33
EGT2
Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YMR297W 1.33
PRC1
Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
YLR350W 1.33
ORM2
Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YML081C-A 1.32
ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YIR020C 1.30 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL044W 1.28 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR032C 1.28
PST2
Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL012W 1.26
ERG4
C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YPR145C-A 1.24 Putative protein of unknown function
YGR191W 1.20
HIP1
High-affinity histidine permease, also involved in the transport of manganese ions
YMR081C 1.20
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YOL075C 1.17 Putative ABC transporter
YMR319C 1.13
FET4
Low-affinity Fe(II) transporter of the plasma membrane
YML131W 1.11 Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YPR157W 1.08 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YLR178C 1.08
TFS1
Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase; phosphatidylethanolamine-binding protein involved in protein kinase A signaling pathway
YKL103C 1.07
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YOL082W 1.06
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YMR092C 1.06
AIP1
Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats
YLR327C 1.05
TMA10
Protein of unknown function that associates with ribosomes
YPR196W 1.04 Putative maltose activator
YBR182C 1.04
SMP1
Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors
YEL008W 1.03 Hypothetical protein predicted to be involved in metabolism
YNL160W 1.02
YGP1
Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YOL119C 1.01
MCH4
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YGR190C 1.01 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YLR296W 1.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR256W 1.00
HAP1
Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
YPR160W 1.00
GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YNL077W 0.99
APJ1
Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR542W 0.97
PAU10
Hypothetical protein
YHL026C 0.96 Putative protein of unknown function; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
YGL255W 0.96
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YPL240C 0.96
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YCL048W-A 0.95 Putative protein of unknown function
YHR092C 0.95
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YDR476C 0.94 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YBL049W 0.94
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YDR453C 0.94
TSA2
Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YPR184W 0.93
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YIL108W 0.93 Putative metalloprotease
YOR343C 0.92 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YBR145W 0.92
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YFL031W 0.92
HAC1
bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis
YKL043W 0.92
PHD1
Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YPL171C 0.91
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YOR317W 0.90
FAA1
Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase
YDR033W 0.90
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YEL028W 0.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL045C 0.86
COR1
Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
YDR264C 0.86
AKR1
Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats
YEL027W 0.85
CUP5
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YNR050C 0.84
LYS9
Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway
YER010C 0.84 Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction
YER141W 0.83
COX15
Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
YNL190W 0.83 Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
YHR177W 0.82 Putative protein of unknown function
YIR020W-A 0.81 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YDR010C 0.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLL053C 0.79 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YHL044W 0.79 Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern
YHL040C 0.79
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YER066W 0.79 Putative protein of unknown function; YER066W is not an essential gene
YOR152C 0.78 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YLR438W 0.78
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YIL033C 0.78
BCY1
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YPL092W 0.77
SSU1
Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YBR177C 0.77
EHT1
Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YFR053C 0.76
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YIR039C 0.76
YPS6
Putative GPI-anchored aspartic protease
YJL172W 0.75
CPS1
Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
YJR116W 0.73 Putative protein of unknown function
YMR210W 0.73 Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
YDL204W 0.73
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YBR183W 0.73
YPC1
Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance
YGR204W 0.73
ADE3
Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine
YDR345C 0.72
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YLR328W 0.72
NMA1
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YMR316C-A 0.72 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene DIA1/YMR316W
YJR146W 0.72 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YBR162C 0.72
TOS1
Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
YOR100C 0.71
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YFR047C 0.71
BNA6
Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YGR144W 0.71
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YGL053W 0.70
PRM8
Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
YGL258W-A 0.70 Putative protein of unknown function
YEL009C 0.68
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YBR214W 0.68
SDS24
One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis
YLL052C 0.68
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YLR259C 0.68
HSP60
Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YER091C-A 0.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL336W 0.67
COS1
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YOL081W 0.67
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YKL051W 0.67
SFK1
Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YLR437C-A 0.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YAL061W 0.66
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YML126C 0.65
ERG13
3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
YER044C 0.65
ERG28
Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p
YHL025W 0.64
SNF6
Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p
YPR010C-A 0.64 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YHR199C 0.64
AIM46
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YCL035C 0.63
GRX1
Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage
YLR122C 0.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YML132W 0.63
COS3
Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YGR284C 0.63
ERV29
Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo
YLR023C 0.63
IZH3
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YGR023W 0.62
MTL1
Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YMR206W 0.62 Putative protein of unknown function; YMR206W is not an essential gene
YNR014W 0.62 Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
YMR007W 0.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL307C 0.62
MCK1
Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family
YMR170C 0.62
ALD2
Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YDL129W 0.62 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene
YML058W 0.62
SML1
Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
YJL213W 0.61 Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YAL042W 0.61
ERV46
Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
YOR204W 0.61
DED1
ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility
YNR034W 0.61
SOL1
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p
YJR153W 0.61
PGU1
Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
YOR378W 0.61 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YLR356W 0.60 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YAL034C 0.60
FUN19
Non-essential protein of unknown function
YNL195C 0.60 Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR130C 0.60
ZRT2
Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YNL117W 0.59
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YPL257W 0.59 Putative protein of unknown function;; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene
YNR058W 0.59
BIO3
7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
YBR101C 0.59
FES1
Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum
YNR057C 0.59
BIO4
Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels
YOR247W 0.59
SRL1
Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YNL305C 0.58 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YPL244C 0.58
HUT1
Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
YIL121W 0.58
QDR2
Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake
YER124C 0.57
DSE1
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YPL179W 0.57
PPQ1
Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors
YJR085C 0.57 Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER065C 0.57
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YJR048W 0.57
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YGR038W 0.57
ORM1
Evolutionarily conserved protein with similarity to Orm2p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YGL055W 0.56
OLE1
Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YGL040C 0.56
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YER060W 0.56
FCY21
Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
YLR121C 0.56
YPS3
Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YOL047C 0.56 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YPR156C 0.56
TPO3
Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YHR212C 0.55 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR065C 0.55
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YPL250C 0.55
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YDL160C 0.55
DHH1
Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation
YGL187C 0.55
COX4
Subunit IV of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; N-terminal 25 residues of precursor are cleaved during mitochondrial import; phosphorylated
YDR533C 0.54
HSP31
Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YDR492W 0.54
IZH1
Membrane protein involved in zinc metabolism, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
YDL124W 0.54 NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family
YIL109C 0.53
SEC24
Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p
YGR022C 0.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YDL244W 0.53
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YGR032W 0.53
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YBL099W 0.53
ATP1
Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YJL152W 0.52 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL272C 0.52 Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene
YOR099W 0.52
KTR1
Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family
YJL158C 0.52
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YGL256W 0.52
ADH4
Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
YBL081W 0.51 Non-essential protein of unknown function
YFL054C 0.50 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YBR139W 0.50 Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
YPL014W 0.50 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YDL125C 0.50
HNT1
Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint

Network of associatons between targets according to the STRING database.

First level regulatory network of UPC2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 7.3 GO:0015891 siderophore transport(GO:0015891)
0.7 5.5 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.6 1.9 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.5 1.6 GO:0019748 secondary metabolic process(GO:0019748)
0.5 2.0 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.5 1.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.5 0.5 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.4 0.9 GO:0006000 fructose metabolic process(GO:0006000)
0.4 6.0 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.4 2.1 GO:0005980 glycogen catabolic process(GO:0005980)
0.4 1.6 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.4 1.2 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.4 3.4 GO:0006097 glyoxylate cycle(GO:0006097)
0.4 1.1 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.4 2.2 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.3 1.0 GO:0046160 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.3 1.0 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.3 0.3 GO:0006119 oxidative phosphorylation(GO:0006119)
0.3 1.7 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.3 0.6 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.3 0.8 GO:1900371 regulation of cyclic nucleotide metabolic process(GO:0030799) regulation of cyclic nucleotide biosynthetic process(GO:0030802) regulation of nucleotide biosynthetic process(GO:0030808) regulation of cAMP metabolic process(GO:0030814) regulation of cAMP biosynthetic process(GO:0030817) regulation of purine nucleotide biosynthetic process(GO:1900371)
0.3 0.3 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.2 2.0 GO:0006828 manganese ion transport(GO:0006828)
0.2 2.0 GO:0006829 zinc II ion transport(GO:0006829)
0.2 1.5 GO:0010969 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0010969) regulation of signal transduction involved in conjugation with cellular fusion(GO:0060238)
0.2 0.7 GO:0090110 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.2 0.4 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.2 0.9 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.2 0.6 GO:0015856 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.2 0.6 GO:0015786 pyrimidine nucleotide-sugar transport(GO:0015781) UDP-glucose transport(GO:0015786)
0.2 0.8 GO:0006598 polyamine catabolic process(GO:0006598)
0.2 0.8 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.2 0.8 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.2 1.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 3.6 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.2 1.1 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.2 0.9 GO:0048209 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.2 0.5 GO:0006624 vacuolar protein processing(GO:0006624)
0.2 0.5 GO:0043335 protein unfolding(GO:0043335)
0.2 0.8 GO:0000023 maltose metabolic process(GO:0000023)
0.2 0.5 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.2 0.5 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.2 0.2 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.2 0.9 GO:0030042 actin filament depolymerization(GO:0030042)
0.2 0.8 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.2 0.6 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.2 0.3 GO:0015847 putrescine transport(GO:0015847)
0.2 0.9 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.2 0.3 GO:0008216 spermidine metabolic process(GO:0008216)
0.1 0.7 GO:0043954 cellular component maintenance(GO:0043954)
0.1 0.9 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 1.8 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.1 0.7 GO:0034487 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.1 0.3 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 4.0 GO:0044108 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.1 0.3 GO:0006754 ATP biosynthetic process(GO:0006754)
0.1 0.3 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.1 0.5 GO:0015976 carbon utilization(GO:0015976)
0.1 0.1 GO:0046688 response to copper ion(GO:0046688)
0.1 0.4 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 1.3 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 2.1 GO:0072348 sulfur compound transport(GO:0072348)
0.1 0.1 GO:1902653 secondary alcohol biosynthetic process(GO:1902653)
0.1 0.4 GO:0050685 positive regulation of mRNA processing(GO:0050685)
0.1 0.5 GO:0015886 heme transport(GO:0015886)
0.1 0.7 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 0.4 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.1 0.8 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.2 GO:0034764 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.1 0.6 GO:0008299 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.1 0.6 GO:0032105 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.1 0.3 GO:0032365 intracellular lipid transport(GO:0032365)
0.1 0.4 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.1 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.1 1.4 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.1 0.4 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.1 0.8 GO:0009435 NAD biosynthetic process(GO:0009435)
0.1 0.6 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.3 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.1 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.3 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 0.1 GO:0019365 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.1 0.4 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.1 0.7 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.3 GO:0030837 negative regulation of actin filament polymerization(GO:0030837)
0.1 0.5 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.1 0.5 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.1 0.4 GO:0044070 regulation of anion transport(GO:0044070)
0.1 0.5 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.2 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 0.5 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.1 GO:0010672 regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010672)
0.1 0.4 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.1 2.6 GO:0022900 electron transport chain(GO:0022900)
0.1 0.3 GO:0000296 spermine transport(GO:0000296)
0.1 0.3 GO:1903513 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.1 0.2 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.2 GO:0060988 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.1 0.4 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.1 0.1 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.1 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.2 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 1.2 GO:0006772 thiamine metabolic process(GO:0006772)
0.1 0.3 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993)
0.1 0.1 GO:0061414 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
0.1 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.1 0.1 GO:0046323 glucose import(GO:0046323)
0.1 0.8 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 0.5 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.1 0.5 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.2 GO:0006848 pyruvate transport(GO:0006848)
0.1 0.2 GO:0005993 trehalose catabolic process(GO:0005993)
0.1 0.9 GO:0009062 fatty acid catabolic process(GO:0009062)
0.1 0.3 GO:1901070 guanosine-containing compound biosynthetic process(GO:1901070)
0.1 1.3 GO:0019319 hexose biosynthetic process(GO:0019319)
0.1 0.3 GO:0071616 thioester biosynthetic process(GO:0035384) acyl-CoA biosynthetic process(GO:0071616)
0.1 0.1 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 0.4 GO:0015893 drug transport(GO:0015893)
0.0 0.0 GO:0015695 organic cation transport(GO:0015695)
0.0 1.0 GO:0031503 protein complex localization(GO:0031503)
0.0 0.4 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.0 0.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.8 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.0 GO:0042743 hydrogen peroxide metabolic process(GO:0042743)
0.0 0.1 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.3 GO:0016241 regulation of macroautophagy(GO:0016241)
0.0 0.1 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.0 0.3 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.2 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.0 0.3 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.0 0.1 GO:0006567 threonine catabolic process(GO:0006567)
0.0 0.3 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.0 0.3 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.0 0.1 GO:0042407 cristae formation(GO:0042407)
0.0 0.0 GO:0052652 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.0 0.3 GO:0009262 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.0 GO:0001315 age-dependent response to reactive oxygen species(GO:0001315) cellular age-dependent response to reactive oxygen species(GO:0072353)
0.0 0.8 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.1 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.4 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.1 GO:0043649 glutamate catabolic process(GO:0006538) dicarboxylic acid catabolic process(GO:0043649)
0.0 0.7 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.0 0.1 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.0 0.2 GO:0042732 D-xylose metabolic process(GO:0042732)
0.0 0.2 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 0.1 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.2 GO:1901661 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.3 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 0.1 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.2 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.2 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.1 GO:0032186 cellular bud neck septin ring organization(GO:0032186)
0.0 0.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.0 0.1 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.0 0.3 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0098630 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) aggregation of unicellular organisms(GO:0098630) cell aggregation(GO:0098743)
0.0 0.1 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.0 0.3 GO:0007155 cell adhesion(GO:0007155) biological adhesion(GO:0022610)
0.0 0.1 GO:0044107 ergosterol metabolic process(GO:0008204) phytosteroid metabolic process(GO:0016128) cellular alcohol metabolic process(GO:0044107)
0.0 0.1 GO:0001881 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.0 0.1 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.0 0.4 GO:0042326 negative regulation of phosphorylation(GO:0042326)
0.0 0.1 GO:0019388 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.1 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.1 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.0 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.0 0.2 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.0 2.7 GO:0045229 external encapsulating structure organization(GO:0045229) cell wall organization(GO:0071555)
0.0 0.1 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.4 GO:0072662 protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0 0.2 GO:0090529 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.0 0.0 GO:0034227 tRNA thio-modification(GO:0034227)
0.0 0.1 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.1 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.1 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 0.4 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.0 0.0 GO:0031333 negative regulation of protein complex assembly(GO:0031333)
0.0 0.1 GO:0000730 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.0 0.1 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:0000435 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.0 0.1 GO:0018342 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0 0.1 GO:0006639 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.0 0.1 GO:0015939 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.0 0.1 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 0.0 GO:0007063 regulation of sister chromatid cohesion(GO:0007063) maintenance of sister chromatid cohesion(GO:0034086) regulation of maintenance of sister chromatid cohesion(GO:0034091)
0.0 0.2 GO:0007120 axial cellular bud site selection(GO:0007120)
0.0 0.1 GO:0032447 protein urmylation(GO:0032447)
0.0 0.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) peptidyl-histidine modification(GO:0018202)
0.0 0.0 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.1 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.0 0.1 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.1 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0006167 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.0 0.0 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.0 0.1 GO:0034620 endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.0 0.0 GO:0045744 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032) negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.0 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 0.0 GO:0070199 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.0 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.0 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.0 0.0 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.0 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.0 GO:0006465 signal peptide processing(GO:0006465)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.4 1.3 GO:0030428 cell septum(GO:0030428)
0.4 3.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.4 3.7 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.3 0.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 0.5 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 0.5 GO:0005775 vacuolar lumen(GO:0005775)
0.2 0.9 GO:0031901 early endosome membrane(GO:0031901)
0.2 15.9 GO:0005576 extracellular region(GO:0005576)
0.2 0.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 0.6 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.2 0.7 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.2 1.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 4.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 1.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 1.0 GO:0035339 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.2 0.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 2.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.4 GO:0046930 pore complex(GO:0046930)
0.1 3.5 GO:0070469 respiratory chain(GO:0070469)
0.1 0.7 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 0.8 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.3 GO:0030478 actin cap(GO:0030478)
0.1 1.8 GO:0009277 fungal-type cell wall(GO:0009277)
0.1 0.3 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.4 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 0.3 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.1 0.4 GO:0000837 Doa10p ubiquitin ligase complex(GO:0000837)
0.1 0.2 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.1 0.2 GO:0005784 Sec61 translocon complex(GO:0005784)
0.1 0.2 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.1 GO:0031310 intrinsic component of vacuolar membrane(GO:0031310)
0.1 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.7 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.1 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.2 GO:0001400 mating projection base(GO:0001400)
0.1 0.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 2.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 2.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.7 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0032126 eisosome(GO:0032126)
0.0 0.1 GO:0071256 translocon complex(GO:0071256)
0.0 0.5 GO:0098797 plasma membrane protein complex(GO:0098797)
0.0 0.2 GO:0034044 exomer complex(GO:0034044)
0.0 3.0 GO:0010008 endosome membrane(GO:0010008)
0.0 2.3 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.3 GO:0005811 lipid particle(GO:0005811)
0.0 25.5 GO:0016021 integral component of membrane(GO:0016021)
0.0 0.2 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)
0.0 0.2 GO:0044440 endosomal part(GO:0044440)
0.0 0.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.1 GO:0032301 MutSalpha complex(GO:0032301)
0.0 0.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.1 GO:0070209 ASTRA complex(GO:0070209)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
1.0 3.9 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.7 3.0 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.6 1.9 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.6 1.9 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.6 2.4 GO:0004396 hexokinase activity(GO:0004396)
0.5 6.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.5 2.2 GO:0004180 carboxypeptidase activity(GO:0004180)
0.5 1.4 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.4 1.2 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.4 1.6 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.4 1.2 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.4 1.9 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.3 1.0 GO:0016872 intramolecular lyase activity(GO:0016872)
0.3 0.9 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.3 0.9 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.3 1.7 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.3 4.6 GO:0015926 glucosidase activity(GO:0015926)
0.3 1.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.3 1.8 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.3 0.8 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.2 2.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 0.7 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.2 0.7 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.2 1.6 GO:0010181 FMN binding(GO:0010181)
0.2 0.6 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.2 2.4 GO:0022838 substrate-specific channel activity(GO:0022838)
0.2 1.6 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 0.6 GO:0016880 AMP binding(GO:0016208) acid-ammonia (or amide) ligase activity(GO:0016880)
0.2 1.7 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.2 0.9 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.2 1.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 1.7 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.2 0.8 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.2 1.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 0.5 GO:0016882 cyclo-ligase activity(GO:0016882)
0.2 0.8 GO:0008198 ferrous iron binding(GO:0008198)
0.2 1.1 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.2 0.6 GO:0015295 solute:proton symporter activity(GO:0015295)
0.2 0.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 1.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 0.5 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.2 0.6 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 1.7 GO:0015293 symporter activity(GO:0015293)
0.1 2.5 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1 0.4 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 1.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.4 GO:0016408 C-acyltransferase activity(GO:0016408)
0.1 0.4 GO:0008242 omega peptidase activity(GO:0008242)
0.1 2.2 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 1.1 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.4 GO:0004629 phospholipase C activity(GO:0004629)
0.1 2.4 GO:0015297 antiporter activity(GO:0015297)
0.1 0.4 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.1 0.7 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 0.7 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.3 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 0.3 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 0.9 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.6 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.1 0.5 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.1 0.7 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.4 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 1.7 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.3 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 0.3 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.4 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.4 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.1 0.3 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.4 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 1.1 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.9 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.1 0.2 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.1 2.1 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 0.1 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 0.7 GO:0004601 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.1 0.1 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.1 0.2 GO:0015216 purine nucleotide transmembrane transporter activity(GO:0015216)
0.1 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.7 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.1 0.3 GO:0005537 mannose binding(GO:0005537)
0.1 0.5 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.1 0.8 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.1 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.1 0.4 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.2 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 0.7 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.1 0.2 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 0.3 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.1 0.4 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 0.1 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 0.2 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 0.1 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 0.2 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.2 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.0 0.1 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 1.0 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.0 0.2 GO:0001168 transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.0 0.9 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0009922 fatty acid elongase activity(GO:0009922)
0.0 0.2 GO:0019212 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.0 0.1 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.7 GO:0051087 chaperone binding(GO:0051087)
0.0 0.1 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.0 0.2 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.0 0.2 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.6 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442)
0.0 0.8 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.1 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.3 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.4 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.0 0.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.2 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.4 GO:0008320 protein transmembrane transporter activity(GO:0008320) macromolecule transmembrane transporter activity(GO:0022884)
0.0 0.4 GO:0038023 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.0 0.4 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.1 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 0.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.0 0.1 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 0.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 0.2 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 0.2 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.2 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.0 0.0 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782) sulfurtransferase activity(GO:0016783)
0.0 0.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.2 GO:0005507 copper ion binding(GO:0005507)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.1 GO:0016898 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.0 0.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.2 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.0 0.2 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0000149 SNARE binding(GO:0000149)
0.0 0.1 GO:0008144 drug binding(GO:0008144)
0.0 0.1 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.9 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.0 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.8 GO:0016757 transferase activity, transferring glycosyl groups(GO:0016757)
0.0 0.0 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.2 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.0 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 0.1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.2 GO:0000049 tRNA binding(GO:0000049)
0.0 0.2 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.1 GO:0030246 carbohydrate binding(GO:0030246)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.3 0.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 1.2 PID PLK1 PATHWAY PLK1 signaling events
0.2 0.2 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 0.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 0.1 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 0.2 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.1 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.0 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 36.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.0 PID FOXO PATHWAY FoxO family signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.2 0.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 0.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.3 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.1 1.6 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 0.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 0.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 0.4 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.1 0.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.0 REACTOME BIOLOGICAL OXIDATIONS Genes involved in Biological oxidations
0.0 36.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.0 0.0 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation