Results for XBP1
Z-value: 4.11
Motif logo
Transcription factors associated with XBP1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
XBP1
|
S000001363 | Transcriptional repressor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 37.95 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
||
| YFR056C Show fit | 33.38 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
||
| YDR033W Show fit | 24.13 |
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p |
||
| YGR108W Show fit | 22.26 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
||
| YML052W Show fit | 20.50 |
Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants |
||
| YDR044W Show fit | 20.23 |
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) |
||
| YPR119W Show fit | 19.83 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
||
| YJL158C Show fit | 18.55 |
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family |
||
| YCR018C Show fit | 18.52 |
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation |
||
| YMR032W Show fit | 17.46 |
Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p |
Network of associatons between targets according to the STRING database.
First level regulatory network of XBP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 141.6 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 2.0 | 68.5 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 0.3 | 55.5 | GO:0006364 | rRNA processing(GO:0006364) |
| 6.0 | 42.3 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 12.7 | 38.0 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 8.6 | 34.5 | GO:0046500 | S-adenosylmethionine metabolic process(GO:0046500) |
| 4.9 | 34.3 | GO:0046501 | protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501) |
| 1.7 | 30.1 | GO:0006407 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 2.5 | 29.5 | GO:0000917 | barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529) |
| 0.8 | 24.3 | GO:0006879 | cellular iron ion homeostasis(GO:0006879) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 110.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.0 | 61.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.3 | 60.2 | GO:0005829 | cytosol(GO:0005829) |
| 0.8 | 54.9 | GO:0005576 | extracellular region(GO:0005576) |
| 0.2 | 50.6 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 42.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 41.7 | GO:0005730 | nucleolus(GO:0005730) |
| 4.4 | 39.9 | GO:0000144 | cellular bud neck septin ring(GO:0000144) |
| 3.4 | 20.3 | GO:0032126 | eisosome(GO:0032126) |
| 0.3 | 20.3 | GO:0005815 | microtubule organizing center(GO:0005815) spindle pole body(GO:0005816) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 169.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.0 | 68.5 | GO:0016875 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 2.0 | 53.1 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.7 | 42.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 7.0 | 42.1 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 3.2 | 31.8 | GO:0005216 | ion channel activity(GO:0005216) |
| 0.7 | 27.5 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 2.4 | 23.9 | GO:0032934 | steroid binding(GO:0005496) sterol binding(GO:0032934) |
| 5.1 | 20.5 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 1.4 | 20.3 | GO:0015926 | glucosidase activity(GO:0015926) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 12.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 2.8 | 8.4 | PID CDC42 PATHWAY | CDC42 signaling events |
| 1.5 | 3.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.5 | 2.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.0 | 2.0 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.5 | 1.8 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 1.7 | PID ATR PATHWAY | ATR signaling pathway |
| 0.5 | 1.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 0.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 0.7 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.2 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 1.2 | 8.6 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 2.1 | 8.5 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 2.5 | 7.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.9 | 7.2 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 2.1 | 6.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 1.4 | 5.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 1.3 | 4.0 | REACTOME ACTIVATED TLR4 SIGNALLING | Genes involved in Activated TLR4 signalling |
| 1.2 | 3.6 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.7 | 3.6 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |