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Results for YAP1

Z-value: 0.62

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Transcription factors associated with YAP1

Gene Symbol Gene ID Gene Info
YAP1
S000004466 Basic leucine zipper (bZIP) transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
YAP1YML007W-0.879.6e-09Click!

Activity profile of YAP1 motif

Sorted Z-values of YAP1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YDR033W 3.27
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YGR108W 2.99
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YDL055C 2.74
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YFR055W 2.54
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 2.44 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YIR021W 2.27
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YEL066W 2.12
HPA3
D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YEL068C 2.06 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR052W 2.00
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YJR105W 1.87
ADO1
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YDR509W 1.74 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR328W 1.71
NMA1
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YDR508C 1.66
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YHR181W 1.63
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YHR094C 1.62
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YHR180W-A 1.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YCR031C 1.57
RPS14A
Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YPR119W 1.52
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YDR345C 1.52
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YKR038C 1.50
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YDL241W 1.38 Putative protein of unknown function; YDL241W is not an essential gene
YJR094W-A 1.38
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YML026C 1.38
RPS18B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YKL153W 1.32 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
YLR029C 1.31
RPL15A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YGR050C 1.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR234W 1.27
YHB1
Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YKR075C 1.25 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YDR385W 1.25
EFT2
Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YEL067C 1.22 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL145W 1.20
SFH5
Putative phosphatidylinositol transfer protein (PITP), exhibits phosphatidylinositol- but not phosphatidylcholine-transfer activity, localized to cytosol and microsomes, similar to Sec14p; may be PITP regulator rather than actual PITP
YLR075W 1.16
RPL10
Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family
YJR001W 1.16
AVT1
Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YMR321C 1.16 Putative protein of unknown function
YMR318C 1.15
ADH6
NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YCR022C 1.14 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YLR212C 1.12
TUB4
Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
YJR123W 1.11
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YBR092C 1.08
PHO3
Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YOL124C 1.07
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YKL081W 1.06
TEF4
Translation elongation factor EF-1 gamma
YJL158C 1.04
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YOR385W 1.04 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene
YNL300W 1.00 Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YIL118W 1.00
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YLR154C 0.99
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YNL178W 0.98
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YAL003W 0.96
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YCR102W-A 0.93 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR016C 0.91
ILV3
Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
YOR169C 0.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W
YGL201C 0.84
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YMR183C 0.84
SSO2
Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
YOL031C 0.84
SIL1
Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
YPL014W 0.83 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YGR249W 0.81
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YOL155C 0.81
HPF1
Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YIL009W 0.81
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YDR276C 0.81
PMP3
Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YMR177W 0.80
MMT1
Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YNL301C 0.80
RPL18B
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YIL169C 0.80 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YNL327W 0.80
EGT2
Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YIL009C-A 0.78
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YGL097W 0.78
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YHR007C 0.75
ERG11
Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YPR157W 0.74 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YBL108W 0.73 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR074W 0.73
TPS2
Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YGR106C 0.72
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YBR104W 0.72
YMC2
Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
YIR020C 0.72 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR290C 0.72
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YGL077C 0.72
HNM1
Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
YHR013C 0.70
ARD1
Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YLR109W 0.70
AHP1
Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YHR182C-A 0.69 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCL024W 0.68
KCC4
Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YOL123W 0.68
HRP1
Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YOL030W 0.66
GAS5
1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YKL120W 0.66
OAC1
Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YMR290W-A 0.65 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YMR266W 0.64
RSN1
Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant
YLL024C 0.64
SSA2
ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall
YIL133C 0.64
RPL16A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YHR183W 0.64
GND1
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
YJR145C 0.64
RPS4A
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YPL227C 0.63
ALG5
UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
YER107W-A 0.63 Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C
YOR315W 0.63
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YOR212W 0.63
STE4
G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats
YEL051W 0.63
VMA8
Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
YMR102C 0.62 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YPR160W 0.61
GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YCR104W 0.59
PAU3
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YBR244W 0.58
GPX2
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YLR011W 0.58
LOT6
FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature
YGR055W 0.57
MUP1
High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
YCL023C 0.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YIL142W 0.56
CCT2
Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YLR154W-B 0.56 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YMR049C 0.56
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YDL037C 0.55
BSC1
Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YKL122C 0.55
SRP21
Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YDR032C 0.55
PST2
Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNR067C 0.55
DSE4
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
YGR107W 0.55 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR048W 0.54
RPS0B
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YMR319C 0.54
FET4
Low-affinity Fe(II) transporter of the plasma membrane
YHR089C 0.53
GAR1
Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YER107C 0.53
GLE2
Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p
YFL056C 0.53
AAD6
Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response
YJL011C 0.53
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YMR011W 0.53
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YIL142C-A 0.53 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR027C 0.53
RPS25A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
YMR215W 0.52
GAS3
Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YNL066W 0.52
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YDR535C 0.52 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YDR534C 0.51
FIT1
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YPL256C 0.51
CLN2
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YOL154W 0.51
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YDL132W 0.50
CDC53
Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
YMR082C 0.50 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL075W 0.50
GCR1
Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YFR054C 0.50 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR153W 0.49
PDR5
Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YKL218C 0.49
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YJR057W 0.49
CDC8
Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
YPL091W 0.49
GLR1
Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione
YPL143W 0.48
RPL33A
N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
YOR362C 0.48
PRE10
Alpha 7 subunit of the 20S proteasome
YGL157W 0.48 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YBR164C 0.47
ARL1
Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
YPR010C 0.47
RPA135
RNA polymerase I subunit A135
YGR287C 0.47 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to alpha-D-glucosidase (maltase); authentic, non-tagged protein detected in purified mitochondria in high-throughput studies
YLR258W 0.47
GSY2
Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YER012W 0.47
PRE1
Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YKR052C 0.46
MRS4
Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron
YPL170W 0.46
DAP1
Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
YKL060C 0.45
FBA1
Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
YGR155W 0.45
CYS4
Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YHR216W 0.45
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YNL043C 0.45 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YGR146C-A 0.45 Putative protein of unknown function
YHR144C 0.45
DCD1
Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YER074W 0.44
RPS24A
Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YHR143W 0.44
DSE2
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YER124C 0.44
DSE1
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YKL110C 0.44
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YDR072C 0.44
IPT1
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YJL173C 0.44
RFA3
Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YLR285W 0.44
NNT1
Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination
YLL044W 0.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
YCR012W 0.43
PGK1
3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YPL141C 0.43 Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
YPL235W 0.43
RVB2
Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
YLL064C 0.42
PAU18
Hypothetical protein
YHR092C 0.42
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YDR065W 0.42 Protein of unknown function, required for vacuolar acidification; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR061W 0.42
KTR2
Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YLR256W 0.42
HAP1
Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
YIL163C 0.42 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR010W 0.41
RPL27A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YNR054C 0.41
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YAL038W 0.40
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YDR510W 0.40
SMT3
Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
YIR020W-A 0.40 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YGR040W 0.40
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YMR261C 0.40
TPS3
Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YPL160W 0.40
CDC60
Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
YGL202W 0.39
ARO8
Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YMR029C 0.39
FAR8
Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
YHR179W 0.39
OYE2
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YGR051C 0.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YDR500C 0.39
RPL37B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein
YCR018C 0.39
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YJR003C 0.39 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR384C 0.39
ATO3
Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
YIL004C 0.38
BET1
Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins
YBR238C 0.38 Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
YKL219W 0.38
COS9
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YOL120C 0.37
RPL18A
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation
YCR006C 0.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR154W-A 0.37 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YIL011W 0.37
TIR3
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YCR102C 0.36 Putative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene
YDR267C 0.36
CIA1
Essential protein involved in assembly of cytosolic and nuclear iron-sulfur proteins
YDL171C 0.36
GLT1
NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
YGR118W 0.36
RPS23A
Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal
YPR170W-A 0.36 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YLR344W 0.36
RPL26A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YDL189W 0.36
RBS1
Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
YBL063W 0.36
KIP1
Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YBL076C 0.36
ILS1
Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A
YMR184W 0.36
ADD37
Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene
YMR320W 0.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL116C 0.35
PRR1
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YLR108C 0.35 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YER188W 0.35 Hypothetical protein

Network of associatons between targets according to the STRING database.

First level regulatory network of YAP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.8 2.5 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.8 2.3 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.6 1.9 GO:0044209 AMP salvage(GO:0044209)
0.6 4.1 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.4 2.2 GO:1903530 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
0.4 1.3 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.3 2.3 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.3 5.1 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.2 0.9 GO:0009394 pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221) 2'-deoxyribonucleotide biosynthetic process(GO:0009265) 2'-deoxyribonucleotide metabolic process(GO:0009394) deoxyribose phosphate biosynthetic process(GO:0046385)
0.2 0.2 GO:0097052 kynurenine metabolic process(GO:0070189) L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.2 0.6 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.2 0.6 GO:0072363 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
0.2 1.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.2 1.0 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.2 0.6 GO:0042992 negative regulation of transcription factor import into nucleus(GO:0042992)
0.2 0.6 GO:0008272 sulfate transport(GO:0008272)
0.2 0.6 GO:0000101 sulfur amino acid transport(GO:0000101)
0.2 0.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.2 1.1 GO:0009099 valine biosynthetic process(GO:0009099)
0.2 1.2 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.2 0.9 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.2 0.9 GO:0070813 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.2 0.5 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.2 1.5 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.2 2.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 0.6 GO:0015680 intracellular copper ion transport(GO:0015680)
0.2 2.0 GO:0009435 NAD biosynthetic process(GO:0009435)
0.2 0.5 GO:0046831 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.2 1.7 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.2 2.8 GO:0032508 DNA duplex unwinding(GO:0032508)
0.2 0.5 GO:0006183 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.1 1.2 GO:0043102 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.1 0.6 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.1 0.4 GO:0032006 regulation of TOR signaling(GO:0032006)
0.1 0.6 GO:0000296 spermine transport(GO:0000296)
0.1 0.7 GO:0006074 (1->3)-beta-D-glucan metabolic process(GO:0006074)
0.1 0.4 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.1 1.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 1.2 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.5 GO:0050810 regulation of steroid metabolic process(GO:0019218) regulation of ergosterol biosynthetic process(GO:0032443) regulation of steroid biosynthetic process(GO:0050810)
0.1 0.5 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.1 1.0 GO:0015758 glucose transport(GO:0015758)
0.1 1.6 GO:0009636 response to toxic substance(GO:0009636)
0.1 0.4 GO:0030541 plasmid partitioning(GO:0030541)
0.1 0.6 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 0.1 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.1 12.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 3.1 GO:0006414 translational elongation(GO:0006414)
0.1 0.3 GO:0071478 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.1 0.8 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 0.3 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.1 0.9 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.1 0.4 GO:0072337 modified amino acid transport(GO:0072337)
0.1 0.5 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 0.3 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.1 0.8 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.6 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.1 0.2 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.1 1.5 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.4 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.1 0.3 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.1 0.2 GO:0071825 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.1 0.6 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.1 0.3 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 0.2 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.1 0.2 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 0.3 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.1 0.1 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.4 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.1 1.0 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.3 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.1 0.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.1 1.7 GO:0006096 glycolytic process(GO:0006096) nucleoside diphosphate phosphorylation(GO:0006165) ATP generation from ADP(GO:0006757)
0.1 0.3 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 2.1 GO:0006893 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.1 0.3 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.1 0.1 GO:0006687 glycosphingolipid metabolic process(GO:0006687) glycosphingolipid biosynthetic process(GO:0006688)
0.1 0.2 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.1 2.1 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.2 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.3 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.1 0.3 GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.1 1.1 GO:0044108 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.1 0.1 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.1 0.3 GO:0060304 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.6 GO:0006734 NADH metabolic process(GO:0006734)
0.0 0.5 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.0 0.2 GO:0000162 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.0 0.1 GO:2001057 reactive nitrogen species metabolic process(GO:2001057)
0.0 1.3 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.5 GO:0006613 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 1.0 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.0 0.3 GO:0007009 plasma membrane organization(GO:0007009)
0.0 0.6 GO:0006826 iron ion transport(GO:0006826)
0.0 0.1 GO:0008216 spermidine metabolic process(GO:0008216)
0.0 0.1 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.0 1.0 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.0 0.4 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.2 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.0 0.9 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.0 0.2 GO:0015867 ATP transport(GO:0015867)
0.0 0.1 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0 0.2 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.0 0.2 GO:0045896 regulation of transcription during mitosis(GO:0045896)
0.0 0.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.1 GO:0006721 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.0 1.0 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.0 0.4 GO:0007120 axial cellular bud site selection(GO:0007120)
0.0 0.1 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.1 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.1 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.0 0.1 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.0 0.4 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.2 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0 0.2 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 0.1 GO:0048313 Golgi inheritance(GO:0048313)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.0 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 0.5 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.0 0.2 GO:0001009 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.0 0.1 GO:0000173 inactivation of MAPK activity involved in osmosensory signaling pathway(GO:0000173)
0.0 0.1 GO:0006038 cell wall chitin biosynthetic process(GO:0006038) fungal-type cell wall chitin biosynthetic process(GO:0034221) fungal-type cell wall polysaccharide biosynthetic process(GO:0051278) fungal-type cell wall polysaccharide metabolic process(GO:0071966)
0.0 0.4 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.1 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.0 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.4 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.1 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.2 GO:0090529 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.0 0.2 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.5 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.1 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0 0.3 GO:0006999 nuclear pore organization(GO:0006999)
0.0 1.3 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.1 GO:0015940 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.0 0.2 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.0 0.2 GO:1990267 response to transition metal nanoparticle(GO:1990267)
0.0 0.1 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.0 0.0 GO:0032365 intracellular lipid transport(GO:0032365)
0.0 0.3 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.2 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.0 GO:0071902 positive regulation of protein serine/threonine kinase activity(GO:0071902)
0.0 0.1 GO:0007535 donor selection(GO:0007535)
0.0 0.1 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.1 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.0 1.1 GO:0016311 dephosphorylation(GO:0016311)
0.0 0.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.3 GO:0009267 cellular response to starvation(GO:0009267)
0.0 0.9 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.1 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0 0.3 GO:0008064 regulation of actin polymerization or depolymerization(GO:0008064) actin filament polymerization(GO:0030041) regulation of actin filament length(GO:0030832) regulation of actin filament polymerization(GO:0030833)
0.0 0.1 GO:0006415 translational termination(GO:0006415)
0.0 1.0 GO:0006364 rRNA processing(GO:0006364)
0.0 0.1 GO:0045116 protein neddylation(GO:0045116)
0.0 0.0 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.0 0.1 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.0 GO:0045744 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032) negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.6 GO:0000910 cytokinesis(GO:0000910)
0.0 0.3 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.1 GO:0009187 cyclic nucleotide metabolic process(GO:0009187)
0.0 0.0 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.0 GO:0006750 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.0 0.1 GO:0006344 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392)
0.0 0.1 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0030428 cell septum(GO:0030428)
0.4 1.3 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.4 2.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 1.1 GO:0008275 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.3 0.9 GO:0031415 NatA complex(GO:0031415)
0.3 1.1 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.3 1.1 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.2 1.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.2 0.8 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 1.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 3.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 0.6 GO:0070545 PeBoW complex(GO:0070545)
0.2 1.1 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.2 1.0 GO:0042555 MCM complex(GO:0042555)
0.2 9.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.6 GO:0097255 ASTRA complex(GO:0070209) R2TP complex(GO:0097255)
0.1 0.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.8 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 8.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.3 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 1.6 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.3 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.1 0.6 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 1.0 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 2.1 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.1 1.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.3 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 1.2 GO:0005940 septin ring(GO:0005940)
0.1 1.0 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.3 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.1 0.2 GO:0031417 NatC complex(GO:0031417)
0.1 0.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.5 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.1 0.2 GO:0097344 Rix1 complex(GO:0097344)
0.1 0.2 GO:0030874 nucleolar chromatin(GO:0030874)
0.1 0.4 GO:0005871 kinesin complex(GO:0005871)
0.1 0.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.2 GO:0005827 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.1 0.5 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.1 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.3 GO:0034456 UTP-C complex(GO:0034456)
0.0 0.1 GO:0043529 GET complex(GO:0043529)
0.0 0.0 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.2 GO:0032221 Rpd3S complex(GO:0032221)
0.0 0.1 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.2 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.2 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.0 0.5 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.7 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.4 GO:0000243 commitment complex(GO:0000243)
0.0 5.8 GO:0005933 cellular bud(GO:0005933)
0.0 0.3 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0030867 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.1 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.0 0.1 GO:0098797 plasma membrane protein complex(GO:0098797)
0.0 0.1 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.1 GO:0070772 PAS complex(GO:0070772)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.4 GO:0031201 SNARE complex(GO:0031201)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.1 GO:0034044 exomer complex(GO:0034044)
0.0 0.1 GO:0000346 transcription export complex(GO:0000346)
0.0 0.4 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.0 0.1 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.3 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.6 GO:0030686 90S preribosome(GO:0030686)
0.0 0.0 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.0 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.4 GO:0012506 vesicle membrane(GO:0012506) cytoplasmic vesicle membrane(GO:0030659)
0.0 0.3 GO:0044445 cytosolic part(GO:0044445)
0.0 0.4 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0070568 guanylyltransferase activity(GO:0070568)
0.8 0.8 GO:0032451 demethylase activity(GO:0032451)
0.6 2.6 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.5 1.9 GO:0019206 nucleoside kinase activity(GO:0019206)
0.4 1.2 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.4 1.1 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.4 1.1 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.4 2.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.3 1.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3 1.5 GO:0070300 phosphatidic acid binding(GO:0070300)
0.2 1.0 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.2 1.2 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.2 2.2 GO:0005216 ion channel activity(GO:0005216)
0.2 3.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 0.8 GO:0009378 four-way junction helicase activity(GO:0009378)
0.2 1.2 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 1.2 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.2 0.6 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.2 0.6 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.2 0.6 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2 0.5 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.2 1.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.2 1.8 GO:0051213 dioxygenase activity(GO:0051213)
0.2 3.8 GO:0019901 protein kinase binding(GO:0019901)
0.2 1.0 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.2 0.5 GO:0016504 peptidase activator activity(GO:0016504)
0.2 0.5 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.2 1.1 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.2 0.5 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.2 0.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 0.8 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 0.6 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.1 0.8 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 0.5 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.5 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 1.8 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 1.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 2.2 GO:0015926 glucosidase activity(GO:0015926)
0.1 0.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.6 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 1.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 0.6 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.1 0.6 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 2.1 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 0.4 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 0.6 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 0.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.6 GO:0008312 7S RNA binding(GO:0008312)
0.1 1.0 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.8 GO:0019205 nucleobase-containing compound kinase activity(GO:0019205)
0.1 17.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.2 GO:0008310 3'-5'-exodeoxyribonuclease activity(GO:0008296) single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.2 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 1.3 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 1.0 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 0.3 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1 0.2 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.1 2.2 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.1 0.3 GO:0008443 phosphofructokinase activity(GO:0008443)
0.1 0.2 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 0.2 GO:0004100 chitin synthase activity(GO:0004100)
0.1 0.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.3 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 0.4 GO:0031386 protein tag(GO:0031386)
0.1 0.8 GO:0050661 NADP binding(GO:0050661)
0.1 0.3 GO:0030145 manganese ion binding(GO:0030145)
0.1 0.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 0.4 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 0.3 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.1 0.3 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 1.9 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.2 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.0 0.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.5 GO:0005199 structural constituent of cell wall(GO:0005199)
0.0 0.4 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.5 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.3 GO:0001016 RNA polymerase III regulatory region DNA binding(GO:0001016)
0.0 0.6 GO:0043022 ribosome binding(GO:0043022)
0.0 0.7 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.7 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 1.1 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.5 GO:0005048 signal sequence binding(GO:0005048)
0.0 1.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.1 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.3 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.4 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.1 GO:0009922 fatty acid elongase activity(GO:0009922)
0.0 0.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.2 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 1.2 GO:0016758 transferase activity, transferring hexosyl groups(GO:0016758)
0.0 0.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.1 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.0 0.2 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.3 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891) endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters(GO:0016893)
0.0 0.1 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.0 0.2 GO:0030276 clathrin binding(GO:0030276)
0.0 0.3 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.3 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 0.2 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.0 0.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.1 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.1 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.0 0.2 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.2 GO:0005507 copper ion binding(GO:0005507)
0.0 0.0 GO:0019003 GDP binding(GO:0019003)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379) peroxiredoxin activity(GO:0051920)
0.0 0.4 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.1 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.0 0.0 GO:0016410 N-acyltransferase activity(GO:0016410)
0.0 0.1 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 0.1 GO:0003774 motor activity(GO:0003774)
0.0 0.1 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.1 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.0 GO:0008143 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 0.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 0.2 PID LKB1 PATHWAY LKB1 signaling events
0.1 0.1 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.1 PID ATM PATHWAY ATM pathway
0.0 0.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.1 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.3 2.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 0.7 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 2.3 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 1.0 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 0.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.2 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 0.6 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 0.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.2 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 0.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.2 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.0 0.2 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.2 REACTOME GPCR LIGAND BINDING Genes involved in GPCR ligand binding
0.0 0.0 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.0 0.1 REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM Genes involved in Cytokine Signaling in Immune system
0.0 0.2 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.0 0.1 REACTOME MITOTIC M M G1 PHASES Genes involved in Mitotic M-M/G1 phases