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Results for YDR026c

Z-value: 2.57

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Transcription factors associated with YDR026c

Gene Symbol Gene ID Gene Info
NSI1
S000002433 RNA polymerase I termination factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
YDR026C0.009.8e-01Click!

Activity profile of YDR026c motif

Sorted Z-values of YDR026c motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YLR154C 29.73
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YLR154W-A 24.93 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-B 24.74 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGR242W 23.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YFR055W 22.64
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YCR031C 22.09
RPS14A
Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YGR241C 20.32
YAP1802
Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YFR056C 19.80 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YHR094C 17.94
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YIL118W 17.34
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YDR098C 17.04
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YML043C 17.02
RRN11
Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YGR264C 16.90
MES1
Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YGR265W 16.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YLR154W-C 15.90
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YER131W 15.85
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YMR001C-A 14.60 Putative protein of unknown function
YOL124C 14.60
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YMR183C 14.34
SSO2
Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
YDR033W 12.66
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YMR290W-A 12.58 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YMR290C 12.53
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YPR102C 12.49
RPL11A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YOL005C 12.25
RPB11
RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
YDL047W 12.20
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YJL107C 11.61 Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YDL085C-A 11.49 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YER146W 10.88
LSM5
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YLR249W 10.68
YEF3
Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YJR094W-A 10.60
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YPR119W 10.51
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YPR074C 10.48
TKL1
Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YLR212C 10.47
TUB4
Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
YGL179C 10.38
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YMR123W 10.37
PKR1
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YOL086C 10.20
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YPR157W 10.12 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YGR060W 10.06
ERG25
C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YOL123W 10.01
HRP1
Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YKL218C 10.00
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YDR060W 9.86
MAK21
Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
YOR063W 9.75
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YHR216W 9.55
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YDR041W 9.52
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YPR029C 9.50
APL4
Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
YGL034C 9.33 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR369C 9.18
RPS12
Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YBL077W 9.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YFL022C 9.00
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YDR146C 8.97
SWI5
Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
YFL015W-A 8.97 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL079C 8.83
TPM1
Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
YFL015C 8.67 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YGL035C 8.59
MIG1
Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YPL075W 8.49
GCR1
Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YJL106W 8.49
IME2
Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YHR021C 8.48
RPS27B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YDL007W 8.47
RPT2
One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
YOR226C 8.33
ISU2
Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YDR040C 8.20
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YDR144C 8.14
MKC7
GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p
YKR038C 8.13
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YNL078W 8.11
NIS1
Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
YGR266W 8.09 Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane
YDR279W 8.06
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YKL182W 8.05
FAS1
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YJR009C 8.04
TDH2
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YNL111C 7.95
CYB5
Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YML123C 7.95
PHO84
High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YML121W 7.94
GTR1
Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
YER019C-A 7.91
SBH2
Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
YLL050C 7.88
COF1
Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
YMR184W 7.86
ADD37
Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene
YCR004C 7.82
YCP4
Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL113W 7.80
RPC19
RNA polymerase subunit, common to RNA polymerases I and III
YPL037C 7.77
EGD1
Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YKL063C 7.76 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YNR016C 7.67
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YIL148W 7.64
RPL40A
Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YPR043W 7.64
RPL43A
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype
YPL250W-A 7.63 Identified by fungal homology and RT-PCR
YGL148W 7.63
ARO2
Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YGL097W 7.61
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YEL053W-A 7.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YML052W 7.40
SUR7
Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
YKL009W 7.22
MRT4
Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YNL090W 7.12
RHO2
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
YML103C 7.07
NUP188
Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
YJL158C 7.06
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YDR023W 7.03
SES1
Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YHL015W 6.99
RPS20
Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YOR101W 6.94
RAS1
GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YML124C 6.79
TUB3
Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p
YLR150W 6.75
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YGR052W 6.68
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YBR096W 6.58 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER
YKR013W 6.58
PRY2
Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YER001W 6.55
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YDL048C 6.45
STP4
Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YBL085W 6.41
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YOR153W 6.36
PDR5
Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YIL009W 6.23
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YNL066W 6.21
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YKR092C 6.20
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YMR177W 6.14
MMT1
Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YHR144C 6.13
DCD1
Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YGL039W 5.93 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YPL062W 5.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YHL028W 5.90
WSC4
ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YLR355C 5.85
ILV5
Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YER156C 5.85 Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YOR272W 5.84
YTM1
Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YHR181W 5.82
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YDL208W 5.81
NHP2
Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
YPL256C 5.81
CLN2
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YGL120C 5.81
PRP43
RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YPL160W 5.80
CDC60
Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
YOR276W 5.79
CAF20
Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
YBR143C 5.77
SUP45
Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YDL191W 5.70
RPL35A
Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
YGR050C 5.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR015C 5.64
ERG5
C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YOL139C 5.61
CDC33
Cytoplasmic mRNA cap binding protein; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p)
YBL032W 5.61
HEK2
RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
YEL001C 5.61
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YOR047C 5.60
STD1
Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YMR083W 5.58
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YPL231W 5.47
FAS2
Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains beta-ketoacyl reductase and beta-ketoacyl synthase activities; phosphorylated
YIL053W 5.41
RHR2
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YGR280C 5.37
PXR1
Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YKR012C 5.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YGR195W 5.35
SKI6
3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs
YGR145W 5.32
ENP2
Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
YBR257W 5.31
POP4
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P
YLR196W 5.31
PWP1
Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
YLR413W 5.24 Putative protein of unknown function; YLR413W is not an essential gene
YDL075W 5.23
RPL31A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YPL178W 5.19
CBC2
Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YER130C 5.17 Hypothetical protein
YDR072C 5.17
IPT1
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YLR132C 5.16 Protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to mitochondria and nucleus; YLR132C is an essential gene
YNL065W 5.15
AQR1
Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YDR382W 5.11
RPP2B
Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YGL209W 5.10
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YPL141C 5.02 Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
YDR257C 4.99
SET7
Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins
YLL008W 4.98
DRS1
Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles
YPR074W-A 4.97 Hypothetical protein identified by homology
YKR075C 4.94 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YPR163C 4.93
TIF3
Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
YMR121C 4.93
RPL15B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YJL090C 4.91
DPB11
Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis, also required for S/M checkpoint control
YDR101C 4.88
ARX1
Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
YFR054C 4.87 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL009C-A 4.85
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YBR164C 4.84
ARL1
Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
YOR025W 4.84
HST3
Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YLR197W 4.81
SIK1
Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YHR203C 4.80
RPS4B
Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
YJR010W 4.79
MET3
ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
YOR271C 4.77
FSF1
Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YDR147W 4.75
EKI1
Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway
YOL031C 4.72
SIL1
Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
YBL044W 4.71 Putative protein of unknown function; YBL044W is not an essential protein
YDR095C 4.70 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR130C 4.68
SHE3
Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
YGR037C 4.62
ACB1
Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes
YDR094W 4.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YDR037W 4.61
KRS1
Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YLR328W 4.59
NMA1
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YML119W 4.59 Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YOR157C 4.58
PUP1
Endopeptidase with trypsin-like activity that cleaves after basic residues; beta 2 subunit of 20S proteasome, synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
YML024W 4.58
RPS17A
Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein
YJR003C 4.57 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL023C 4.56 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YPR148C 4.55 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YGL009C 4.54
LEU1
Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YGR251W 4.53 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YGR285C 4.53
ZUO1
Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
YFL016C 4.50
MDJ1
Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YFL037W 4.48
TUB2
Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules
YGL202W 4.47
ARO8
Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YGR051C 4.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YOL101C 4.38
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YMR281W 4.30
GPI12
ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
YPL266W 4.28
DIM1
Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
YNL075W 4.23
IMP4
Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
YKL110C 4.23
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YDL226C 4.23
GCS1
ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
YOR046C 4.22
DBP5
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination
YER009W 4.21
NTF2
Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
YJR076C 4.21
CDC11
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YOR243C 4.20
PUS7
Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); Asp(256) mutation abolishes activity; conserved in archaea, some bacteria, and vertebrates
YBR256C 4.20
RIB5
Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YBL063W 4.16
KIP1
Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YML001W 4.14
YPT7
GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7
YOR299W 4.13
BUD7
Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
YOL085C 4.11 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YHR127W 4.10 Protein of unknown function; localizes to the nucleus
YEL051W 4.10
VMA8
Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis

Network of associatons between targets according to the STRING database.

First level regulatory network of YDR026c

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.5 22.6 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
5.6 39.4 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
4.6 18.5 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
4.6 18.2 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
3.2 9.5 GO:0046039 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
3.0 12.0 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
3.0 9.0 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
2.8 8.5 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
2.8 8.5 GO:0043171 peptide catabolic process(GO:0043171)
2.8 14.0 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
2.7 8.0 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
2.6 10.4 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
2.5 40.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
2.5 10.0 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
2.5 14.8 GO:0045896 regulation of transcription during mitosis(GO:0045896)
2.3 4.6 GO:0015909 long-chain fatty acid transport(GO:0015909)
2.3 6.8 GO:0032006 regulation of TOR signaling(GO:0032006)
2.3 6.8 GO:0043069 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
2.2 8.9 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
2.2 6.7 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
2.1 8.3 GO:0009423 chorismate biosynthetic process(GO:0009423)
2.0 2.0 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
1.9 7.8 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
1.9 31.1 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
1.9 5.7 GO:0019419 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
1.9 5.6 GO:0046495 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
1.8 29.5 GO:0006415 translational termination(GO:0006415)
1.8 12.6 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
1.7 18.4 GO:0006817 phosphate ion transport(GO:0006817)
1.7 10.0 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
1.7 53.3 GO:0000027 ribosomal large subunit assembly(GO:0000027)
1.6 11.3 GO:0043457 regulation of cellular respiration(GO:0043457)
1.6 17.6 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
1.6 6.3 GO:0000296 spermine transport(GO:0000296)
1.6 11.0 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
1.5 10.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
1.5 4.5 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
1.5 6.0 GO:0000092 mitotic anaphase B(GO:0000092)
1.5 4.5 GO:1902223 tyrosine biosynthetic process(GO:0006571) L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
1.4 23.1 GO:0006450 regulation of translational fidelity(GO:0006450)
1.4 7.2 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
1.4 5.6 GO:0030497 fatty acid elongation(GO:0030497)
1.4 6.9 GO:0045947 negative regulation of translational initiation(GO:0045947)
1.3 4.0 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
1.3 5.4 GO:1904357 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
1.3 5.3 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
1.3 7.8 GO:0009099 valine biosynthetic process(GO:0009099)
1.3 33.6 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
1.3 3.9 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
1.3 1.3 GO:0045901 positive regulation of translational elongation(GO:0045901)
1.3 3.8 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
1.3 5.1 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
1.2 1.2 GO:0035955 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
1.2 6.0 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
1.2 3.6 GO:0018216 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
1.2 4.7 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
1.2 2.3 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
1.2 10.5 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
1.2 10.5 GO:0061572 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
1.2 21.9 GO:0030488 tRNA methylation(GO:0030488)
1.1 10.3 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
1.1 3.4 GO:0042992 negative regulation of transcription factor import into nucleus(GO:0042992)
1.1 1.1 GO:1902750 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) negative regulation of cell cycle G2/M phase transition(GO:1902750)
1.1 5.6 GO:0048255 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
1.1 4.5 GO:0048313 Golgi inheritance(GO:0048313)
1.1 5.5 GO:0009098 leucine biosynthetic process(GO:0009098)
1.1 10.0 GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947)
1.1 3.2 GO:0001015 snoRNA transcription from an RNA polymerase II promoter(GO:0001015)
1.1 7.5 GO:0006855 drug transmembrane transport(GO:0006855)
1.1 3.2 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
1.1 3.2 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
1.1 28.8 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
1.1 3.2 GO:0002188 translation reinitiation(GO:0002188)
1.0 6.3 GO:0006491 N-glycan processing(GO:0006491)
1.0 4.1 GO:0006448 regulation of translational elongation(GO:0006448)
1.0 20.2 GO:0006633 fatty acid biosynthetic process(GO:0006633)
1.0 6.8 GO:0071474 cellular hyperosmotic response(GO:0071474)
1.0 1.0 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
1.0 1.9 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.9 0.9 GO:0097271 protein localization to bud neck(GO:0097271)
0.9 4.6 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.9 3.7 GO:0033865 coenzyme A metabolic process(GO:0015936) nucleoside bisphosphate metabolic process(GO:0033865) ribonucleoside bisphosphate metabolic process(GO:0033875) purine nucleoside bisphosphate metabolic process(GO:0034032)
0.9 4.6 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.9 4.5 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.9 97.8 GO:0002181 cytoplasmic translation(GO:0002181)
0.9 20.6 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.9 18.6 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.9 3.5 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.9 8.7 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.9 0.9 GO:0090342 regulation of cell aging(GO:0090342) regulation of replicative cell aging(GO:1900062)
0.9 6.0 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.9 20.7 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.9 14.5 GO:0006999 nuclear pore organization(GO:0006999)
0.8 5.9 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.8 15.3 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.8 1.7 GO:0016578 histone deubiquitination(GO:0016578)
0.8 1.7 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.8 2.5 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.8 4.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.8 0.8 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.8 4.8 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.8 1.6 GO:0006657 CDP-choline pathway(GO:0006657)
0.8 3.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.8 3.0 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.7 2.2 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.7 4.5 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.7 14.1 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.7 2.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.7 6.4 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.7 21.7 GO:0016126 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.7 0.7 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.7 14.5 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.7 2.8 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.7 9.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.7 4.1 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.7 3.4 GO:0007009 plasma membrane organization(GO:0007009)
0.7 2.6 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.7 9.1 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.6 6.3 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.6 0.6 GO:0048211 SNARE complex disassembly(GO:0035494) Golgi vesicle docking(GO:0048211)
0.6 1.2 GO:0051693 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.6 4.8 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.6 17.8 GO:0045047 protein targeting to ER(GO:0045047)
0.6 2.3 GO:0071267 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.6 8.0 GO:0010833 telomere maintenance via telomerase(GO:0007004) telomere maintenance via telomere lengthening(GO:0010833)
0.6 4.5 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.6 2.3 GO:0032262 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.6 0.6 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.6 2.8 GO:0009262 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.6 3.9 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.6 3.3 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.6 1.1 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.5 6.0 GO:0045860 positive regulation of protein kinase activity(GO:0045860)
0.5 2.7 GO:0042991 transcription factor import into nucleus(GO:0042991)
0.5 8.1 GO:0006334 nucleosome assembly(GO:0006334)
0.5 2.7 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.5 3.1 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.5 15.0 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.5 6.1 GO:0000011 vacuole inheritance(GO:0000011)
0.5 4.1 GO:0032042 mitochondrial DNA metabolic process(GO:0032042)
0.5 8.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.5 2.0 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.5 7.4 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.5 5.3 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.5 67.6 GO:0006364 rRNA processing(GO:0006364)
0.5 1.9 GO:0018279 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.5 11.3 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.4 4.7 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.4 1.7 GO:0006750 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.4 1.2 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.4 0.8 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.4 1.2 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.4 4.0 GO:0006446 regulation of translational initiation(GO:0006446)
0.4 1.6 GO:0046656 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.4 2.0 GO:0034661 rRNA catabolic process(GO:0016075) ncRNA catabolic process(GO:0034661)
0.4 6.2 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.4 2.7 GO:0031134 sister chromatid biorientation(GO:0031134)
0.4 1.1 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.4 4.6 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.4 4.2 GO:0009435 NAD biosynthetic process(GO:0009435)
0.4 5.3 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.4 1.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.4 3.0 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.4 1.4 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.4 5.7 GO:0015918 sterol transport(GO:0015918)
0.4 0.7 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.4 9.9 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.4 2.5 GO:0046513 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.3 1.0 GO:0065005 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.3 4.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.3 2.7 GO:0072384 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
0.3 2.0 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.3 3.3 GO:0006547 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.3 1.3 GO:0015883 FAD transport(GO:0015883)
0.3 4.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.3 3.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.3 1.5 GO:0006998 nuclear envelope organization(GO:0006998)
0.3 2.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.3 3.1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.3 0.6 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.3 1.4 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.3 1.7 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.3 1.7 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.3 1.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.3 9.8 GO:0007088 regulation of mitotic nuclear division(GO:0007088)
0.3 2.5 GO:0000084 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.3 2.7 GO:0006284 base-excision repair(GO:0006284)
0.3 2.2 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.3 0.5 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.3 0.8 GO:2001021 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.3 2.1 GO:0007130 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.3 1.0 GO:0016574 histone ubiquitination(GO:0016574)
0.3 0.8 GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.3 6.3 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.2 2.2 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.2 2.4 GO:0023058 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion(GO:0000754) adaptation of signaling pathway(GO:0023058)
0.2 4.1 GO:0006400 tRNA modification(GO:0006400)
0.2 1.0 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.2 1.4 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.2 1.4 GO:0051664 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.2 4.1 GO:0051170 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) nuclear import(GO:0051170) single-organism nuclear import(GO:1902593)
0.2 0.4 GO:0061395 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061395) cellular response to arsenic-containing substance(GO:0071243)
0.2 1.5 GO:0042176 regulation of protein catabolic process(GO:0042176)
0.2 1.6 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.2 2.4 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.2 0.4 GO:0034059 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.2 0.8 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.2 0.9 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.2 0.8 GO:0015809 arginine transport(GO:0015809)
0.2 1.1 GO:0006037 cell wall chitin metabolic process(GO:0006037) cell wall polysaccharide metabolic process(GO:0010383)
0.2 1.6 GO:0006862 nucleotide transport(GO:0006862)
0.2 4.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.2 1.1 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.2 1.8 GO:0007015 actin filament organization(GO:0007015)
0.2 0.5 GO:0009097 isoleucine biosynthetic process(GO:0009097)
0.2 2.7 GO:0006541 glutamine metabolic process(GO:0006541)
0.2 3.7 GO:0051169 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.2 0.5 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 0.7 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.1 0.4 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 1.4 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 0.7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 0.5 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.1 0.4 GO:0009113 purine nucleobase biosynthetic process(GO:0009113)
0.1 0.7 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 1.3 GO:0006887 exocytosis(GO:0006887)
0.1 0.5 GO:0000162 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.1 0.3 GO:0044038 cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.1 0.1 GO:2001020 regulation of response to DNA damage stimulus(GO:2001020)
0.1 1.7 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 0.8 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.7 GO:0045996 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.1 0.7 GO:0015846 polyamine transport(GO:0015846)
0.1 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.7 GO:0051666 actin cortical patch localization(GO:0051666)
0.1 2.0 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.2 GO:0031382 mating projection assembly(GO:0031382)
0.1 1.0 GO:0051668 localization within membrane(GO:0051668)
0.1 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.3 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.1 0.1 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.1 0.3 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 1.7 GO:0006873 cellular ion homeostasis(GO:0006873)
0.1 0.2 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.1 0.3 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 1.0 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.2 GO:0000173 inactivation of MAPK activity involved in osmosensory signaling pathway(GO:0000173)
0.1 0.4 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0007050 cell cycle arrest(GO:0007050)
0.0 2.1 GO:0006897 endocytosis(GO:0006897)
0.0 0.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.0 0.3 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.3 GO:0015939 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.0 0.3 GO:0007120 axial cellular bud site selection(GO:0007120)
0.0 0.1 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.3 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.0 1.3 GO:0006457 protein folding(GO:0006457)
0.0 0.1 GO:0006906 vesicle fusion(GO:0006906)
0.0 0.2 GO:0030261 chromosome condensation(GO:0030261)
0.0 0.1 GO:0010526 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.0 0.0 GO:0006110 regulation of glycolytic process(GO:0006110)
0.0 0.5 GO:0070897 DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.0 0.0 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
12.6 37.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
6.2 18.7 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
4.6 18.2 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
4.2 12.6 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
3.6 10.9 GO:0008275 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
3.1 9.2 GO:0071261 Ssh1 translocon complex(GO:0071261)
2.8 14.0 GO:0034518 RNA cap binding complex(GO:0034518)
2.6 7.9 GO:0016363 nuclear matrix(GO:0016363)
2.6 7.8 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
2.5 7.6 GO:0070545 PeBoW complex(GO:0070545)
2.5 14.8 GO:0043527 tRNA methyltransferase complex(GO:0043527)
2.3 11.5 GO:0030689 Noc complex(GO:0030689)
2.2 2.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
2.0 8.2 GO:0044611 nuclear pore inner ring(GO:0044611)
2.0 13.8 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
1.9 5.8 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
1.9 9.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
1.8 5.5 GO:0031415 NatA complex(GO:0031415)
1.8 5.4 GO:0031417 NatC complex(GO:0031417)
1.8 9.0 GO:0005641 nuclear envelope lumen(GO:0005641)
1.8 35.5 GO:0030118 clathrin coat(GO:0030118)
1.7 103.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.7 8.5 GO:0000408 EKC/KEOPS complex(GO:0000408)
1.5 10.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
1.5 10.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
1.4 10.0 GO:0032432 actin filament bundle(GO:0032432)
1.4 11.4 GO:0005688 U6 snRNP(GO:0005688)
1.4 4.2 GO:0034457 Mpp10 complex(GO:0034457)
1.4 4.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
1.4 4.2 GO:0072687 meiotic spindle(GO:0072687)
1.4 5.5 GO:0017053 transcriptional repressor complex(GO:0017053)
1.4 5.5 GO:0097255 R2TP complex(GO:0097255)
1.2 2.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
1.2 16.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
1.2 8.2 GO:0030126 COPI vesicle coat(GO:0030126)
1.2 98.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.2 3.5 GO:0000229 cytoplasmic chromosome(GO:0000229) mitochondrial chromosome(GO:0000262)
1.2 18.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
1.1 8.0 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
1.1 3.3 GO:0033186 CAF-1 complex(GO:0033186)
1.1 7.5 GO:0072686 mitotic spindle(GO:0072686)
1.1 14.9 GO:0022626 cytosolic ribosome(GO:0022626)
1.0 4.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
1.0 6.0 GO:0035327 transcriptionally active chromatin(GO:0035327)
1.0 6.0 GO:0005871 kinesin complex(GO:0005871)
1.0 4.9 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.9 2.8 GO:0070985 TFIIK complex(GO:0070985)
0.9 4.7 GO:0034448 EGO complex(GO:0034448)
0.9 2.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.9 3.5 GO:0044697 HICS complex(GO:0044697)
0.9 6.0 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.8 3.3 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.8 6.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.8 4.1 GO:0034044 exomer complex(GO:0034044)
0.8 2.4 GO:0005955 calcineurin complex(GO:0005955)
0.8 4.0 GO:0030478 actin cap(GO:0030478)
0.8 40.7 GO:0030686 90S preribosome(GO:0030686)
0.8 3.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.7 4.4 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.7 2.2 GO:0051286 cell tip(GO:0051286)
0.7 4.3 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.7 29.4 GO:0044445 cytosolic part(GO:0044445)
0.7 8.4 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.7 2.8 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.7 4.1 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.7 8.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.7 4.1 GO:0016272 prefoldin complex(GO:0016272)
0.7 7.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.7 4.0 GO:0016459 myosin complex(GO:0016459)
0.6 2.3 GO:0031105 septin complex(GO:0031105)
0.6 25.3 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.5 9.7 GO:0016586 RSC complex(GO:0016586)
0.5 3.6 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.5 2.0 GO:0005797 Golgi medial cisterna(GO:0005797)
0.5 1.5 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.5 1.5 GO:0000131 incipient cellular bud site(GO:0000131)
0.5 1.5 GO:0097344 Rix1 complex(GO:0097344)
0.5 1.9 GO:0031518 CBF3 complex(GO:0031518)
0.5 6.4 GO:0000786 nucleosome(GO:0000786)
0.5 10.9 GO:0005844 polysome(GO:0005844)
0.4 7.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.4 1.3 GO:0030869 RENT complex(GO:0030869)
0.4 4.3 GO:0034399 nuclear periphery(GO:0034399)
0.4 58.9 GO:0005730 nucleolus(GO:0005730)
0.4 2.5 GO:0042555 MCM complex(GO:0042555)
0.3 1.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.3 7.2 GO:0005802 trans-Golgi network(GO:0005802)
0.3 1.7 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.3 4.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 2.3 GO:0000346 transcription export complex(GO:0000346)
0.3 2.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.3 1.0 GO:0005884 actin filament(GO:0005884)
0.3 0.9 GO:0030867 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.3 2.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.3 1.5 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.3 3.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 43.8 GO:0005933 cellular bud(GO:0005933)
0.3 1.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.2 3.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 8.4 GO:0005811 lipid particle(GO:0005811)
0.2 5.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 1.8 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.2 0.8 GO:0005720 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.2 2.7 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.2 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 0.4 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.2 1.2 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.2 1.8 GO:0000137 Golgi cis cisterna(GO:0000137)
0.2 3.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.2 16.5 GO:0005635 nuclear envelope(GO:0005635)
0.2 0.8 GO:0045254 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.2 0.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.2 2.6 GO:0033698 Rpd3L complex(GO:0033698)
0.2 0.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 1.9 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.2 1.0 GO:0000798 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.2 1.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.5 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.1 1.1 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.6 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 2.8 GO:0061645 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.1 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.1 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.6 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.1 0.3 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.8 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.2 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 0.2 GO:0016587 Isw1 complex(GO:0016587)
0.1 0.3 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 1.2 GO:0005682 U5 snRNP(GO:0005682)
0.1 2.2 GO:0015935 small ribosomal subunit(GO:0015935)
0.1 0.5 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.2 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.1 12.5 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.0 1.6 GO:0005794 Golgi apparatus(GO:0005794)
0.0 0.2 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.4 37.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
6.1 18.2 GO:0001187 transcription factor activity, RNA polymerase I CORE element sequence-specific binding(GO:0001169) transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting(GO:0001187)
4.9 14.6 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
4.1 16.3 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
3.3 9.9 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
3.2 9.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
3.1 9.3 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
3.1 18.6 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
3.0 9.0 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
3.0 35.6 GO:0030276 clathrin binding(GO:0030276)
2.9 8.6 GO:0019003 GDP binding(GO:0019003)
2.7 8.2 GO:0000339 RNA cap binding(GO:0000339)
2.7 13.4 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
2.6 15.7 GO:0070300 phosphatidic acid binding(GO:0070300)
2.5 7.6 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
2.5 10.1 GO:0016841 ammonia-lyase activity(GO:0016841)
2.5 14.9 GO:0016408 C-acyltransferase activity(GO:0016408)
2.1 4.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
2.1 6.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
2.1 2.1 GO:0015248 sterol transporter activity(GO:0015248)
2.0 7.9 GO:0001055 RNA polymerase II activity(GO:0001055)
2.0 7.9 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
2.0 11.9 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
1.9 9.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
1.9 5.6 GO:0009922 fatty acid elongase activity(GO:0009922)
1.8 5.4 GO:0010521 telomerase inhibitor activity(GO:0010521)
1.7 10.5 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
1.7 6.9 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
1.7 5.1 GO:0070568 guanylyltransferase activity(GO:0070568)
1.7 8.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.7 6.7 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
1.7 11.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.6 9.9 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
1.6 21.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
1.6 6.3 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
1.6 4.7 GO:0051219 phosphoprotein binding(GO:0051219)
1.5 4.6 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
1.5 20.1 GO:0051015 actin filament binding(GO:0051015)
1.4 4.3 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
1.4 5.5 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
1.3 4.0 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
1.3 33.6 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
1.2 12.4 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
1.2 6.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
1.2 86.5 GO:0003924 GTPase activity(GO:0003924)
1.2 6.0 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
1.2 3.6 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
1.2 16.5 GO:0001054 RNA polymerase I activity(GO:0001054)
1.1 10.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
1.1 32.9 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
1.1 3.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
1.1 49.2 GO:0019843 rRNA binding(GO:0019843)
1.1 4.4 GO:0008312 7S RNA binding(GO:0008312)
1.1 12.2 GO:0030295 protein kinase activator activity(GO:0030295)
1.1 3.2 GO:0016972 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) thiol oxidase activity(GO:0016972)
1.0 8.2 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
1.0 8.2 GO:0031072 heat shock protein binding(GO:0031072)
1.0 10.0 GO:0005216 ion channel activity(GO:0005216)
1.0 9.9 GO:0043178 alcohol binding(GO:0043178)
1.0 2.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.9 3.7 GO:0008172 S-methyltransferase activity(GO:0008172)
0.9 4.6 GO:0070403 NAD+ binding(GO:0070403)
0.9 163.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.9 11.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.9 3.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.9 3.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.9 7.7 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.8 4.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.8 2.4 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.8 4.0 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.8 2.4 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.8 4.0 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.8 2.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.8 2.4 GO:0000146 microfilament motor activity(GO:0000146)
0.8 7.6 GO:0019239 deaminase activity(GO:0019239)
0.7 3.0 GO:0004771 sterol esterase activity(GO:0004771)
0.7 7.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.7 2.8 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.7 9.6 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.7 4.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.7 16.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.7 2.7 GO:0005034 osmosensor activity(GO:0005034)
0.6 2.6 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.6 3.7 GO:0003993 acid phosphatase activity(GO:0003993)
0.6 1.2 GO:0003785 actin monomer binding(GO:0003785)
0.6 6.0 GO:0003777 microtubule motor activity(GO:0003777)
0.6 15.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.6 14.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.6 2.8 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.5 8.5 GO:0030515 snoRNA binding(GO:0030515)
0.5 8.4 GO:0015616 DNA translocase activity(GO:0015616)
0.5 4.6 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.5 2.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.5 2.0 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.5 6.9 GO:0070566 adenylyltransferase activity(GO:0070566)
0.5 5.4 GO:0042803 protein homodimerization activity(GO:0042803)
0.5 12.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.5 0.9 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.5 7.9 GO:0042162 telomeric DNA binding(GO:0042162)
0.4 1.8 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.4 1.7 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.4 2.1 GO:0017108 5'-flap endonuclease activity(GO:0017108) flap endonuclease activity(GO:0048256)
0.4 1.2 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.4 6.1 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.4 1.6 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.4 10.8 GO:0015631 tubulin binding(GO:0015631)
0.4 3.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.4 5.8 GO:0050661 NADP binding(GO:0050661)
0.4 1.1 GO:0016872 intramolecular lyase activity(GO:0016872)
0.4 2.3 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.4 10.0 GO:0046982 protein heterodimerization activity(GO:0046982)
0.4 18.6 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.3 5.6 GO:0031491 nucleosome binding(GO:0031491)
0.3 1.3 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.3 1.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.3 1.3 GO:0004622 lysophospholipase activity(GO:0004622)
0.3 7.1 GO:0003779 actin binding(GO:0003779)
0.3 2.4 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.3 5.8 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.3 1.8 GO:0003724 RNA helicase activity(GO:0003724)
0.3 10.7 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.3 0.9 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.3 1.1 GO:0008198 ferrous iron binding(GO:0008198)
0.3 1.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 1.4 GO:0003774 motor activity(GO:0003774)
0.3 0.8 GO:0019901 protein kinase binding(GO:0019901)
0.3 2.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.3 0.5 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.3 0.8 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.2 2.7 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.2 2.4 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 0.7 GO:0008144 drug binding(GO:0008144)
0.2 0.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 4.7 GO:0015926 glucosidase activity(GO:0015926)
0.2 6.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.2 4.0 GO:0005319 lipid transporter activity(GO:0005319)
0.2 0.6 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.2 2.6 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.2 5.8 GO:0042393 histone binding(GO:0042393)
0.2 1.8 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.2 0.8 GO:0008252 nucleotidase activity(GO:0008252)
0.2 1.0 GO:0019237 centromeric DNA binding(GO:0019237)
0.2 0.9 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.2 0.7 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.2 2.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 0.4 GO:0016783 sulfurtransferase activity(GO:0016783)
0.2 0.7 GO:0009378 four-way junction helicase activity(GO:0009378)
0.2 1.5 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.2 0.5 GO:0003680 AT DNA binding(GO:0003680)
0.2 0.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 0.6 GO:0019206 nucleoside kinase activity(GO:0019206)
0.2 0.6 GO:0017048 Rho GTPase binding(GO:0017048)
0.2 1.0 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.2 2.7 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 6.9 GO:0008565 protein transporter activity(GO:0008565)
0.1 1.1 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 2.2 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.7 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)
0.1 1.5 GO:0005048 signal sequence binding(GO:0005048)
0.1 1.2 GO:0043495 protein anchor(GO:0043495)
0.1 0.4 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.3 GO:0052744 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.1 1.6 GO:0005525 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.1 0.8 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.1 3.8 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.1 0.9 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 1.0 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 0.5 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.9 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.1 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.1 GO:0016896 exoribonuclease activity(GO:0004532) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.1 0.3 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1 0.4 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.1 0.1 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 9.1 GO:0003723 RNA binding(GO:0003723)
0.1 0.2 GO:0008242 omega peptidase activity(GO:0008242)
0.1 0.2 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.1 4.8 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.6 GO:0005199 structural constituent of cell wall(GO:0005199)
0.0 0.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467) fatty acid ligase activity(GO:0015645)
0.0 0.3 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.0 0.5 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.2 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.4 GO:0016791 phosphatase activity(GO:0016791)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.1 PID SHP2 PATHWAY SHP2 signaling
1.6 6.6 PID E2F PATHWAY E2F transcription factor network
1.6 4.8 PID LKB1 PATHWAY LKB1 signaling events
1.2 3.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
1.2 3.5 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.9 3.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.7 2.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.6 1.2 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.5 2.5 PID PLK1 PATHWAY PLK1 signaling events
0.5 2.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.4 0.4 PID ERBB4 PATHWAY ErbB4 signaling events
0.4 1.2 PID MYC PATHWAY C-MYC pathway
0.3 0.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 0.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 1.0 PID ATR PATHWAY ATR signaling pathway
0.1 0.1 PID FGF PATHWAY FGF signaling pathway
0.1 0.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.0 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
2.7 5.5 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
2.5 5.0 REACTOME G1 PHASE Genes involved in G1 Phase
2.4 7.1 REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT Genes involved in SLC-mediated transmembrane transport
2.2 17.9 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
2.0 13.8 REACTOME DEADENYLATION DEPENDENT MRNA DECAY Genes involved in Deadenylation-dependent mRNA decay
1.9 5.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
1.3 2.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
1.1 7.9 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
1.0 15.5 REACTOME METABOLISM OF MRNA Genes involved in Metabolism of mRNA
1.0 3.9 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.9 3.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.9 3.4 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.8 5.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.6 2.5 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.6 1.2 REACTOME GPCR DOWNSTREAM SIGNALING Genes involved in GPCR downstream signaling
0.6 1.9 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.6 1.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.6 1.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.6 1.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.6 1.7 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.4 2.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 2.5 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.3 2.8 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.2 0.4 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 2.0 REACTOME MITOTIC M M G1 PHASES Genes involved in Mitotic M-M/G1 phases
0.1 0.3 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.1 1.8 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.1 0.4 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane