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Results for YLR278C

Z-value: 1.69

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Transcription factors associated with YLR278C

Gene Symbol Gene ID Gene Info
S000004268 Zinc-cluster protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
YLR278C0.783.0e-06Click!

Activity profile of YLR278C motif

Sorted Z-values of YLR278C motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YLR174W 23.05
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YJR095W 21.37
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YPL223C 21.10
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YJL045W 20.00 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YOR343C 19.77 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YNR002C 18.44
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YLR377C 18.34
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YER065C 15.39
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YJL116C 15.38
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YFR053C 15.28
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YMR107W 15.26
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YKR097W 14.94
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YDR277C 14.39
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YMR017W 13.67
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YBR072W 13.51
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YAL062W 13.33
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YIL057C 11.95 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YHR096C 11.25
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YGR032W 10.83
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YJR048W 10.70
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YOR100C 10.48
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YPL171C 10.48
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YMR206W 10.37 Putative protein of unknown function; YMR206W is not an essential gene
YAR053W 9.73 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR139C 9.61
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YFL030W 9.60
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YML042W 9.25
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YOR348C 9.25
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YBL015W 9.09
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YPL222W 9.02
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL109W 8.96
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YGR067C 8.40 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YGR110W 8.37 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YBR116C 8.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YLL041C 8.17
SDH2
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YJL161W 7.52
FMP33
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR211W 7.30
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YAR060C 7.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR007C 7.09 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YBL064C 6.99
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YPR023C 6.98
EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YFL052W 6.96 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YML089C 6.91 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YDR036C 6.74
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YPR001W 6.74
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YEL008W 6.69 Hypothetical protein predicted to be involved in metabolism
YEL009C 6.59
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YPR151C 6.44
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YDL244W 6.20
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YLR004C 6.06
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YDR536W 5.92
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YCR005C 5.88
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YPR030W 5.87
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YKR009C 5.76
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YGL258W-A 5.61 Putative protein of unknown function
YDR070C 5.57
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR087C 5.54
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YMR244W 5.51 Putative protein of unknown function
YHL024W 5.49
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YPL201C 5.46
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YOL084W 5.38
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YLR149C 5.34 Putative protein of unknown function; YLR149C is not an essential gene
YOR139C 5.32 Hypothetical protein
YGL045W 5.27
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YKL148C 5.27
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YPL250C 5.25
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YPL186C 5.18
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YDL214C 5.14
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YOR140W 5.13
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YLR296W 5.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER158C 5.07 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YOR049C 4.90
RSB1
Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
YHR212C 4.87 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL017C 4.87
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YOR120W 4.80
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YPR013C 4.75 Putative zinc finger protein; YPR013C is not an essential gene
YGR045C 4.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL163C 4.74
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YOL060C 4.70
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YDR216W 4.68
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YBR203W 4.65
COS111
Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR006C 4.65
ICL2
2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YPL185W 4.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YLR366W 4.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YKR102W 4.53
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YLR122C 4.50 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YPL024W 4.45
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YHR212W-A 4.45 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YPL181W 4.36
CTI6
Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
YDR406W 4.35
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YML090W 4.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YAL039C 4.33
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YGR144W 4.32
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YIR039C 4.31
YPS6
Putative GPI-anchored aspartic protease
YDL215C 4.29
GDH2
NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YDR343C 4.23
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YLR295C 4.21
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YNL055C 4.19
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YER098W 4.18
UBP9
Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YPR196W 4.15 Putative maltose activator
YAR069C 4.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL182C 4.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
YGR028W 4.06
MSP1
Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase
YNR034W-A 4.06 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YEL012W 3.98
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YPL015C 3.98
HST2
Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
YLL053C 3.96 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YAR070C 3.94 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML081C-A 3.94
ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YDL210W 3.92
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YEL070W 3.86
DSF1
Deletion suppressor of mpt5 mutation
YDR171W 3.85
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YPL026C 3.83
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YER066W 3.81 Putative protein of unknown function; YER066W is not an essential gene
YAL018C 3.80 Putative protein of unknown function
YEL049W 3.79
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YGR243W 3.78
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR123C 3.76 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YAL054C 3.76
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YAL063C 3.75
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YKR040C 3.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
YGL053W 3.65
PRM8
Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
YDL246C 3.65
SOR2
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YGR288W 3.63
MAL13
MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C
YOR393W 3.63
ERR1
Protein of unknown function, has similarity to enolases
YLR334C 3.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
YDR441C 3.59
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YLR356W 3.59 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YGL205W 3.56
POX1
Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YFL024C 3.55
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YNL180C 3.53
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YLL052C 3.53
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YDR043C 3.52
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YDL138W 3.44
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YPL058C 3.43
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YJL127C-B 3.42 Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii
YLL019C 3.41
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YPL135W 3.40
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YDL245C 3.39
HXT15
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YPL200W 3.37
CSM4
Protein required for accurate chromosome segregation during meiosis
YNL277W-A 3.36 Putative protein of unknown function
YHR080C 3.35 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YML091C 3.35
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YGR088W 3.35
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YPL222C-A 3.32 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YJR151C 3.31
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YOR138C 3.31
RUP1
Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; required for binding of Rsp5p to Ubp2p; contains an UBA domain
YDL194W 3.30
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YNL179C 3.29 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YJL112W 3.28
MDV1
Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats
YOR381W 3.27
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YDL130W-A 3.25
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YOR388C 3.24
FDH1
NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate
YCL001W-B 3.21 Putative protein of unknown function; identified by homology
YPR015C 3.21 Putative protein of unknown function
YOR378W 3.18 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YIR029W 3.18
DAL2
Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YER097W 3.16 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR052C-A 3.16 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR530C 3.12
APA2
Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
YHR210C 3.10 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YLR365W 3.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
YFL054C 3.02 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YOR223W 3.01 Putative protein of unknown function
YBR179C 3.00
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YMR250W 2.98
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YAR068W 2.97 Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YJR159W 2.96
SOR1
Sorbitol dehydrogenase; expression is induced in the presence of sorbitol
YIR027C 2.94
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YFL051C 2.94 Putative protein of unknown function; YFL051C is not an essential gene
YMR081C 2.94
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YLR124W 2.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR019C 2.90
GAL10
UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
YGR174C 2.88
CBP4
Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp3p and function is partially redundant with that of Cbp3p
YDR102C 2.87 Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YGL134W 2.85
PCL10
Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
YDR030C 2.84
RAD28
Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair
YMR182C 2.80
RGM1
Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth
YKL171W 2.79 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YEL065W 2.79
SIT1
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
YNL274C 2.77
GOR1
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER091C-A 2.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR154W 2.74 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YLR312C 2.74
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YPL271W 2.70
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YOL157C 2.69 Putative protein of unknown function
YOL051W 2.69
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YGR239C 2.68
PEX21
Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p
YPR024W 2.67
YME1
Subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover
YLL018C-A 2.66
COX19
Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase
YJL166W 2.65
QCR8
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YDR148C 2.65
KGD2
Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
YMR181C 2.64 Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YMR018W 2.64 Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene
YEL007W 2.63 Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YDR287W 2.63
INM2
Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
YER004W 2.63
FMP52
Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDR538W 2.63
PAD1
Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiX
YDR058C 2.62
TGL2
Protein with lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; role in yeast lipid degradation is unclear
YOL055C 2.57
THI20
Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities; involved in thiamine biosynthesis and also in thiamine degradation; member of a gene family with THI21 and THI22; functionally redundant with Thi21p

Network of associatons between targets according to the STRING database.

First level regulatory network of YLR278C

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 21.4 GO:0015740 C4-dicarboxylate transport(GO:0015740)
6.2 18.6 GO:0015755 fructose transport(GO:0015755)
4.8 43.4 GO:0006097 glyoxylate cycle(GO:0006097)
4.7 4.7 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
4.3 12.9 GO:0019676 ammonia assimilation cycle(GO:0019676)
3.8 11.4 GO:0019541 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
3.2 9.6 GO:0006545 glycine biosynthetic process(GO:0006545)
3.2 15.8 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
3.1 9.3 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
3.0 17.8 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
2.9 8.6 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
2.8 2.8 GO:0046487 glyoxylate metabolic process(GO:0046487)
2.7 10.8 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
2.4 7.3 GO:0006538 glutamate catabolic process(GO:0006538)
2.1 8.4 GO:0015804 neutral amino acid transport(GO:0015804)
2.0 6.1 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
1.9 13.2 GO:0006083 acetate metabolic process(GO:0006083)
1.8 14.0 GO:0015758 glucose transport(GO:0015758)
1.7 7.0 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
1.7 17.4 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.7 5.0 GO:0042843 D-xylose catabolic process(GO:0042843)
1.6 6.6 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
1.6 4.9 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
1.6 4.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
1.5 6.2 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
1.5 4.6 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
1.5 4.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
1.4 4.3 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.4 7.1 GO:0051099 positive regulation of binding(GO:0051099)
1.4 8.5 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
1.4 14.0 GO:0006635 fatty acid beta-oxidation(GO:0006635)
1.4 20.3 GO:0015696 ammonium transport(GO:0015696)
1.4 5.4 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
1.4 18.9 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
1.3 2.6 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
1.3 5.1 GO:0006848 pyruvate transport(GO:0006848)
1.3 11.6 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
1.2 1.2 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
1.2 4.8 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
1.2 4.7 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
1.2 1.2 GO:0032071 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
1.1 2.2 GO:0061413 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
1.0 14.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
1.0 6.2 GO:0006279 premeiotic DNA replication(GO:0006279)
1.0 7.3 GO:0016239 positive regulation of macroautophagy(GO:0016239)
1.0 6.1 GO:0043457 regulation of cellular respiration(GO:0043457)
1.0 2.9 GO:0015888 thiamine transport(GO:0015888)
1.0 4.8 GO:0015793 glycerol transport(GO:0015793)
0.9 0.9 GO:0006108 malate metabolic process(GO:0006108)
0.9 0.9 GO:0019627 urea metabolic process(GO:0019627)
0.9 4.5 GO:0044070 regulation of anion transport(GO:0044070)
0.9 1.8 GO:2000219 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.9 4.4 GO:0044746 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.9 6.9 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.8 3.4 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.8 12.5 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.8 4.1 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.8 8.2 GO:0046686 response to cadmium ion(GO:0046686)
0.8 5.7 GO:0000023 maltose metabolic process(GO:0000023)
0.8 3.2 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.8 20.4 GO:0006094 gluconeogenesis(GO:0006094)
0.8 6.1 GO:0045332 phospholipid translocation(GO:0045332)
0.8 13.0 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.7 0.7 GO:0019395 fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
0.7 1.3 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.7 3.3 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.6 1.9 GO:0005993 trehalose catabolic process(GO:0005993)
0.6 4.4 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.6 4.9 GO:0015891 siderophore transport(GO:0015891)
0.6 3.0 GO:0008053 mitochondrial fusion(GO:0008053)
0.6 1.2 GO:0043335 protein unfolding(GO:0043335)
0.6 2.9 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.6 0.6 GO:0006559 L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.6 2.9 GO:0046464 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.6 2.3 GO:0034764 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.6 2.8 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.6 1.7 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.5 2.7 GO:0071333 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.5 2.7 GO:0043112 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.5 6.9 GO:0045144 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.5 4.7 GO:0046777 protein autophosphorylation(GO:0046777)
0.5 1.6 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.5 4.6 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.5 2.5 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.5 1.5 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.5 0.5 GO:0006740 NADPH regeneration(GO:0006740)
0.5 1.4 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.5 1.9 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.4 3.1 GO:0000266 mitochondrial fission(GO:0000266)
0.4 0.4 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
0.4 2.2 GO:0000730 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.4 8.8 GO:0016579 protein deubiquitination(GO:0016579)
0.4 1.3 GO:0036257 multivesicular body organization(GO:0036257)
0.4 0.9 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.4 10.0 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.4 4.1 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.4 0.4 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.4 3.2 GO:0072348 sulfur compound transport(GO:0072348)
0.4 2.8 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.4 1.2 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.4 1.2 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.4 3.8 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.4 1.5 GO:0006598 polyamine catabolic process(GO:0006598)
0.4 1.1 GO:0090630 activation of GTPase activity(GO:0090630)
0.4 0.4 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.3 13.2 GO:0071940 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.3 0.7 GO:0008216 spermidine metabolic process(GO:0008216)
0.3 1.0 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.3 1.3 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.3 0.6 GO:0042819 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.3 0.3 GO:0072337 modified amino acid transport(GO:0072337)
0.3 0.3 GO:0015846 polyamine transport(GO:0015846)
0.3 0.8 GO:0031297 replication fork processing(GO:0031297)
0.3 1.6 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.3 1.5 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.3 3.3 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.3 0.8 GO:0009107 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.2 1.0 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.2 0.7 GO:0071281 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.2 3.0 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.2 0.7 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.2 0.2 GO:0070726 cell wall assembly(GO:0070726)
0.2 2.5 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.2 0.6 GO:0042407 cristae formation(GO:0042407)
0.2 1.7 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.2 0.6 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.2 2.5 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.2 0.8 GO:0016241 regulation of macroautophagy(GO:0016241)
0.2 0.6 GO:0072530 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.2 0.6 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.2 0.9 GO:0005980 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.2 0.5 GO:0036294 cellular response to decreased oxygen levels(GO:0036294) cellular response to oxygen levels(GO:0071453) cellular response to hypoxia(GO:0071456)
0.2 0.5 GO:0070199 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.2 0.5 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.2 1.6 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.2 0.7 GO:0010969 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0010969) regulation of signal transduction involved in conjugation with cellular fusion(GO:0060238)
0.2 3.4 GO:0007266 Rho protein signal transduction(GO:0007266)
0.2 5.7 GO:0009060 aerobic respiration(GO:0009060)
0.2 0.9 GO:0070058 tRNA gene clustering(GO:0070058)
0.1 0.4 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.1 0.9 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.3 GO:1902533 positive regulation of intracellular signal transduction(GO:1902533)
0.1 1.0 GO:0000103 sulfate assimilation(GO:0000103)
0.1 1.3 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.5 GO:0051403 stress-activated protein kinase signaling cascade(GO:0031098) regulation of stress-activated MAPK cascade(GO:0032872) stress-activated MAPK cascade(GO:0051403) regulation of stress-activated protein kinase signaling cascade(GO:0070302)
0.1 1.9 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.1 2.4 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 1.0 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.3 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 0.9 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.5 GO:0043200 response to amino acid(GO:0043200)
0.1 0.3 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.1 2.7 GO:0008361 regulation of cell size(GO:0008361)
0.1 0.7 GO:0051274 beta-glucan biosynthetic process(GO:0051274)
0.1 0.4 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.1 0.8 GO:0010821 regulation of mitochondrion organization(GO:0010821)
0.1 3.7 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.1 0.3 GO:0072476 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.1 0.4 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 0.9 GO:0008360 regulation of cell shape(GO:0008360)
0.1 2.0 GO:0006915 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.1 0.6 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.1 0.9 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1 1.2 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.6 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.1 0.3 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.1 0.8 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.5 GO:0051181 cofactor transport(GO:0051181)
0.1 0.4 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 1.3 GO:0005977 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.1 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.1 GO:0031564 transcriptional attenuation(GO:0031555) transcription antitermination(GO:0031564)
0.1 0.5 GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled(GO:0030846)
0.1 2.4 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.1 0.5 GO:0006826 iron ion transport(GO:0006826)
0.1 0.9 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.6 GO:0007129 synapsis(GO:0007129)
0.1 0.5 GO:0015802 basic amino acid transport(GO:0015802)
0.1 0.2 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.1 0.2 GO:0019935 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.0 0.4 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.3 GO:0033313 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.0 0.1 GO:0019243 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.1 GO:0033523 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178) negative regulation of histone modification(GO:0031057) histone H2B ubiquitination(GO:0033523) histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647) histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.0 3.2 GO:0006457 protein folding(GO:0006457)
0.0 0.0 GO:0042148 strand invasion(GO:0042148)
0.0 0.5 GO:0015918 sterol transport(GO:0015918)
0.0 0.3 GO:0055074 cellular calcium ion homeostasis(GO:0006874) calcium ion homeostasis(GO:0055074)
0.0 0.2 GO:0046020 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.1 GO:0030007 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.0 0.1 GO:0015851 nucleobase transport(GO:0015851)
0.0 0.0 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.4 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.2 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 0.2 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.5 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 0.2 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 0.1 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.0 0.2 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.4 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.3 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.0 0.4 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.3 GO:0030474 spindle pole body duplication(GO:0030474)
0.0 0.3 GO:0000902 cell morphogenesis(GO:0000902)
0.0 0.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.6 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 2.7 GO:0007005 mitochondrion organization(GO:0007005)
0.0 0.0 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.0 0.1 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.0 0.1 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.4 GO:0006893 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0 0.0 GO:2001040 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.0 0.1 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.1 GO:0019932 calcium-mediated signaling(GO:0019722) second-messenger-mediated signaling(GO:0019932)
0.0 0.4 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.0 GO:0000722 telomere maintenance via recombination(GO:0000722)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 15.8 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
2.7 10.8 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
2.3 9.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
2.1 16.9 GO:0042597 periplasmic space(GO:0042597)
1.5 4.4 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
1.4 7.1 GO:0032221 Rpd3S complex(GO:0032221)
1.4 4.2 GO:0046930 pore complex(GO:0046930)
1.3 3.8 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
1.2 14.1 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
1.0 2.9 GO:0045252 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.9 11.8 GO:0005619 ascospore wall(GO:0005619)
0.9 18.9 GO:0070469 respiratory chain(GO:0070469)
0.8 2.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.7 2.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.7 0.7 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.6 15.9 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.6 3.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.5 1.6 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.5 3.4 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.4 6.5 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.4 0.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.4 2.3 GO:0032126 eisosome(GO:0032126)
0.4 2.7 GO:0034657 GID complex(GO:0034657)
0.4 1.2 GO:0030870 Mre11 complex(GO:0030870)
0.4 25.6 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 1.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.4 4.8 GO:0098798 mitochondrial protein complex(GO:0098798)
0.3 3.8 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.3 1.0 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.3 1.1 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.3 1.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.3 42.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 1.4 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.2 31.9 GO:0005740 mitochondrial envelope(GO:0005740)
0.2 2.7 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.2 1.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 0.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 104.8 GO:0005739 mitochondrion(GO:0005739)
0.2 1.9 GO:0033698 Rpd3L complex(GO:0033698)
0.2 0.8 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.2 0.3 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.2 0.6 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 0.6 GO:0070209 ASTRA complex(GO:0070209)
0.1 5.5 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.8 GO:0033101 cellular bud membrane(GO:0033101)
0.1 0.5 GO:0032116 SMC loading complex(GO:0032116)
0.1 2.9 GO:0016592 mediator complex(GO:0016592)
0.1 0.5 GO:0031932 TORC2 complex(GO:0031932) TOR complex(GO:0038201)
0.1 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.4 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 1.1 GO:0005769 early endosome(GO:0005769)
0.1 0.3 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.4 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.1 0.3 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.5 GO:0019867 outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.1 2.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 0.5 GO:0033263 CORVET complex(GO:0033263)
0.1 0.3 GO:0033309 SBF transcription complex(GO:0033309)
0.1 0.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.2 GO:0032301 MutSalpha complex(GO:0032301)
0.1 0.2 GO:0030666 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.4 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.4 GO:0031211 palmitoyltransferase complex(GO:0002178) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) nucleoplasmic THO complex(GO:0000446)
0.0 0.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 1.7 GO:0044440 endosomal part(GO:0044440)
0.0 3.8 GO:0000329 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.0 0.5 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.0 0.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 2.4 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 23.0 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
5.9 23.6 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
5.3 15.8 GO:0016289 CoA hydrolase activity(GO:0016289)
4.7 14.1 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
4.5 17.8 GO:0005537 mannose binding(GO:0005537)
4.3 17.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
3.8 15.3 GO:0004396 hexokinase activity(GO:0004396)
3.7 18.3 GO:0050308 sugar-phosphatase activity(GO:0050308)
3.6 10.8 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
3.2 15.8 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
3.1 9.3 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
2.9 20.0 GO:0016833 oxo-acid-lyase activity(GO:0016833)
2.6 10.4 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
2.2 6.7 GO:0005536 glucose binding(GO:0005536)
2.0 8.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
2.0 10.0 GO:0015295 solute:proton symporter activity(GO:0015295)
1.6 4.8 GO:0016208 AMP binding(GO:0016208)
1.5 6.2 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
1.5 7.5 GO:0008198 ferrous iron binding(GO:0008198)
1.4 4.2 GO:0015288 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
1.4 4.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
1.3 14.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.3 3.8 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.2 4.7 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
1.2 4.6 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
1.1 16.7 GO:0016831 carboxy-lyase activity(GO:0016831)
1.1 4.4 GO:0016417 S-acyltransferase activity(GO:0016417)
1.1 4.4 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
1.1 15.8 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.9 6.4 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.9 12.2 GO:0015297 antiporter activity(GO:0015297)
0.8 6.6 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.8 2.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.8 2.5 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.8 4.0 GO:0070403 NAD+ binding(GO:0070403)
0.8 2.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.8 6.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.8 4.6 GO:0000400 four-way junction DNA binding(GO:0000400)
0.7 3.7 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.7 1.4 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.7 2.8 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.7 2.0 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.7 2.0 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.7 10.8 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.7 1.3 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.7 2.7 GO:0016531 copper chaperone activity(GO:0016531)
0.7 1.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.6 1.9 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.6 13.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.6 4.5 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.6 3.4 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.6 7.2 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.6 5.0 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.5 6.0 GO:0035064 methylated histone binding(GO:0035064)
0.5 1.6 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.5 1.6 GO:0015658 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.5 11.4 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.5 1.9 GO:0016854 racemase and epimerase activity(GO:0016854)
0.5 1.4 GO:0070569 uridylyltransferase activity(GO:0070569)
0.5 1.9 GO:0051183 vitamin transporter activity(GO:0051183)
0.5 4.5 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.4 12.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.4 3.9 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.4 3.3 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.4 2.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.4 1.2 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.4 6.6 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.4 4.0 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.4 1.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.4 1.4 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.3 1.0 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.3 5.8 GO:0004843 obsolete ubiquitin thiolesterase activity(GO:0004221) thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.3 1.2 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.3 2.0 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.3 1.7 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 0.8 GO:0032183 SUMO binding(GO:0032183)
0.3 2.8 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.3 2.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 1.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 0.8 GO:0004457 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.2 1.5 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 4.3 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.2 2.4 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.2 2.1 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.2 2.7 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.2 1.5 GO:0010181 FMN binding(GO:0010181)
0.2 0.6 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.2 1.0 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.2 4.5 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.2 0.9 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.2 0.5 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.2 2.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 0.5 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.2 1.0 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.2 3.2 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 11.6 GO:0051082 unfolded protein binding(GO:0051082)
0.2 0.9 GO:0015293 symporter activity(GO:0015293)
0.2 0.6 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.1 0.4 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 5.9 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 0.3 GO:0005102 receptor binding(GO:0005102)
0.1 2.1 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 1.6 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.1 0.8 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 1.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.1 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.1 1.6 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.1 0.5 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 0.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 0.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 0.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.5 GO:0008374 O-acyltransferase activity(GO:0008374)
0.1 0.2 GO:0043812 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 0.4 GO:0097372 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H3-K9 specific)(GO:0032129) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.1 0.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 1.5 GO:0031491 nucleosome binding(GO:0031491)
0.1 1.0 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.3 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.8 GO:0043495 protein anchor(GO:0043495)
0.1 0.8 GO:0016298 lipase activity(GO:0016298)
0.1 0.5 GO:0005507 copper ion binding(GO:0005507)
0.1 1.4 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 0.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.2 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 2.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.3 GO:0008143 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
0.1 0.2 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.3 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.0 1.0 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.0 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 4.5 GO:0004672 protein kinase activity(GO:0004672)
0.0 0.6 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.4 GO:0050661 NADP binding(GO:0050661)
0.0 0.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 1.0 GO:0032182 ubiquitin-like protein binding(GO:0032182)
0.0 0.3 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.0 0.1 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.0 1.1 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.1 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.0 GO:0000150 recombinase activity(GO:0000150)
0.0 0.0 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.0 0.2 GO:0070566 adenylyltransferase activity(GO:0070566)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 14.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.0 3.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.7 5.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.5 1.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 0.8 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.4 1.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.3 0.8 PID FOXO PATHWAY FoxO family signaling
0.2 0.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 0.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 138.9 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 0.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 0.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.1 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.1 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.0 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 32.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
3.6 10.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
1.2 3.5 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.7 2.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.5 1.9 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.2 0.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 0.1 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.1 0.5 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.1 138.9 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.2 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.0 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.0 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing