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Results for YPR015C

Z-value: 0.29

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Transcription factors associated with YPR015C

Gene Symbol Gene ID Gene Info
S000006219 Putative protein of unknown function

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
YPR015C-0.357.7e-02Click!

Activity profile of YPR015C motif

Sorted Z-values of YPR015C motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YDR044W 0.62
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YLR154W-A 0.52 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-B 0.48 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YDR033W 0.48
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YNR001W-A 0.48 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YBR158W 0.44
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YOR107W 0.43
RGS2
Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YCL049C 0.40 Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene;
YIR021W 0.38
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YLR314C 0.36
CDC3
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YPR157W 0.36 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YMR083W 0.36
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YIL009W 0.32
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YKL164C 0.32
PIR1
O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YNL066W 0.31
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YLR413W 0.31 Putative protein of unknown function; YLR413W is not an essential gene
YLR312W-A 0.30
MRPL15
Mitochondrial ribosomal protein of the large subunit
YLR206W 0.29
ENT2
Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
YMR106C 0.29
YKU80
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YIL009C-A 0.28
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YGL097W 0.28
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YMR266W 0.25
RSN1
Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant
YJL048C 0.24
UBX6
UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline
YDL055C 0.24
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YBR177C 0.23
EHT1
Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YDR098C 0.22
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YGR086C 0.22
PIL1
Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YAL022C 0.22
FUN26
Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes
YNL234W 0.21 Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p
YER107C 0.21
GLE2
Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p
YIL118W 0.21
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YER107W-A 0.21 Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C
YCL024W 0.21
KCC4
Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YDR100W 0.21
TVP15
Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
YGL009C 0.20
LEU1
Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YGL012W 0.20
ERG4
C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YDR297W 0.20
SUR2
Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
YDR185C 0.20 Mitochondrial protein of unknown function; has similarity to Ups1p, which is involved in regulation of alternative topogenesis of the dynamin-related GTPase Mgm1p
YGL201C 0.20
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YOL124C 0.20
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YMR265C 0.19 Putative protein of unknown function
YER137C 0.19 Putative protein of unknown function
YLR400W 0.19 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR432W 0.19
IMD3
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YMR043W 0.19
MCM1
Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes
YMR202W 0.19
ERG2
C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
YCL023C 0.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YJL035C 0.19
TAD2
Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
YLR154C 0.19
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YLR154W-C 0.18
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YMR320W 0.18 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFR055W 0.18
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YKL051W 0.18
SFK1
Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YGR242W 0.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YKL052C 0.17
ASK1
Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases
YHR183W 0.17
GND1
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
YOR099W 0.17
KTR1
Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family
YNL087W 0.17
TCB2
Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud
YKL080W 0.17
VMA5
Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YPR156C 0.17
TPO3
Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YBR017C 0.16
KAP104
Transportin, cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm, binds rg-nuclear localization signals on Nab2p and Hrp1p, plays a role in cell-cycle progression
YER131W 0.16
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YKL096W-A 0.16
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YPR074C 0.16
TKL1
Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YHR181W 0.16
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YOR047C 0.16
STD1
Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YER133W-A 0.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YER134C.
YEL068C 0.16 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKR043C 0.16 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YML077W 0.16
BET5
Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi
YPL172C 0.15
COX10
Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders
YPL004C 0.15
LSP1
Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways
YER012W 0.15
PRE1
Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YGR241C 0.14
YAP1802
Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YPR126C 0.14 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL012C 0.14
HTZ1
Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YFR056C 0.14 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YDL120W 0.14
YFH1
Frataxin, regulates mitochondrial iron accumulation; interacts with Isu1p which promotes Fe-S cluster assembly; interacts with electron transport chain components and may influence respiration; human homolog involved in Friedrich's ataxia
YPL256C 0.14
CLN2
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YDR084C 0.14
TVP23
Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YMR173W 0.14
DDR48
DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS
YBR210W 0.14
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YFL015C 0.14 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YGR249W 0.14
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YPL003W 0.13
ULA1
Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation
YDL121C 0.13 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDL121C is not an essential protein
YLR229C 0.13
CDC42
Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
YGR259C 0.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YHR182C-A 0.13 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR173W-A 0.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W
YEL066W 0.13
HPA3
D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YLR029C 0.13
RPL15A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YKL097C 0.13 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YLR333C 0.13
RPS25B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YMR199W 0.13
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YGR036C 0.13
CAX4
Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
YER134C 0.12 Putative protein of unknown function; non-essential gene
YNL241C 0.12
ZWF1
Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia
YJL173C 0.12
RFA3
Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YLR328W 0.12
NMA1
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YER130C 0.12 Hypothetical protein
YFL015W-A 0.12 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR072C 0.12
IPT1
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YKL218C 0.12
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YFR042W 0.12
KEG1
Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
YPR017C 0.11
DSS4
Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol
YBR028C 0.11 Putative protein kinase, possible substrate of cAMP-dependent protein kinase (PKA)
YPR118W 0.11
MRI1
Methylthioribose-1-phosphate isomerase, catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway
YEL058W 0.11
PCM1
Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
YPL178W 0.11
CBC2
Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YOL011W 0.11
PLB3
Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
YGL022W 0.11
STT3
Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis
YLR230W 0.11 Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
YNR016C 0.11
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YOR273C 0.11
TPO4
Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YDR133C 0.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YDR348C 0.11 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck; potential Cdc28p substrate
YNR017W 0.11
TIM23
Essential protein of the mitochondrial inner membrane, component of the mitochondrial import system
YGR040W 0.10
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YML054C-A 0.10 Putative protein of unknown function
YDL171C 0.10
GLT1
NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
YDR152W 0.10
GIR2
Highly-acidic cytoplasmic RWD domain-containing protein of unknown function, sensitive to proteolysis, N-terminal region has high content of acidic amino acid residues, putative IUP (intrinsically unstructured protein)
YGL209W 0.10
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YOL101C 0.10
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YMR172C-A 0.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR080W 0.10
TEF1
Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YBR247C 0.10
ENP1
Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
YHR103W 0.10
SBE22
Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
YOR013W 0.10
IRC11
Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
YNL169C 0.09
PSD1
Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine
YGL020C 0.09
GET1
Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
YEL052W 0.09
AFG1
Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
YPL154C 0.09
PEP4
Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates
YDR023W 0.09
SES1
Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YBR048W 0.09
RPS11B
Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YJR123W 0.09
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YBR178W 0.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C
YNL178W 0.09
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YJR124C 0.09 Putative protein of unknown function; expression induced under calcium shortage
YGR027C 0.09
RPS25A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
YNR003C 0.09
RPC34
RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
YNL043C 0.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YMR082C 0.09 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL058W 0.09 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHL003C 0.09
LAG1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YOR155C 0.09
ISN1
Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
YNL104C 0.09
LEU4
Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YPR113W 0.08
PIS1
Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins
YDR073W 0.08
SNF11
Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
YDR002W 0.08
YRB1
Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YGL019W 0.08
CKB1
Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases
YEL059C-A 0.08
SOM1
Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates
YLR120C 0.08
YPS1
Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YLR353W 0.08
BUD8
Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
YDR531W 0.08 Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YEL053C 0.08
MAK10
Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
YOL056W 0.08
GPM3
Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
YLR177W 0.08 Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; YLR177W is not an essential gene
YJR001W 0.08
AVT1
Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YOR048C 0.08
RAT1
Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription termination
YKL122C 0.08
SRP21
Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YER147C-A 0.08 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL272C 0.08 Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene
YLR411W 0.08
CTR3
High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YNL289W 0.08
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YBR032W 0.08 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YDL084W 0.08
SUB2
Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56
YPL274W 0.08
SAM3
High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
YLR257W 0.08 Putative protein of unknown function
YKL110C 0.07
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YKR013W 0.07
PRY2
Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YDL211C 0.07 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YGR265W 0.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YFR041C 0.07
ERJ5
Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response
YDR237W 0.07
MRPL7
Mitochondrial ribosomal protein of the large subunit
YPR170W-B 0.07 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YMR009W 0.07
ADI1
Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YMR208W 0.07
ERG12
Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YCR028C-A 0.07
RIM1
Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
YDR375C 0.07
BCS1
Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone, required for the incorporation of the Rip1p and Qcr10p subunits into the cytochrome bc(1) complex; member of the CDC48/PAS1/SEC18 ATPase family
YMR011W 0.07
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YGR177C 0.07
ATF2
Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing
YHR180W-A 0.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YLL027W 0.06
ISA1
Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources
YML006C 0.06
GIS4
CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
YLR002C 0.06
NOC3
Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation
YAL007C 0.06
ERP2
Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YFR035C 0.06 Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein
YDR261C 0.06
EXG2
Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YOR043W 0.06
WHI2
Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
YNL173C 0.06
MDG1
Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations
YGR264C 0.06
MES1
Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YGR108W 0.06
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YER136W 0.06
GDI1
GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
YNR054C 0.06
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YOL086C 0.06
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YKL043W 0.06
PHD1
Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YHL017W 0.06 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles
YLR420W 0.06
URA4
Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
YJR010W 0.06
MET3
ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism

Network of associatons between targets according to the STRING database.

First level regulatory network of YPR015C

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0023021 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 0.3 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.1 0.6 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.1 0.4 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.1 0.2 GO:0070637 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.1 0.2 GO:2000197 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.1 0.3 GO:1903530 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
0.1 0.3 GO:0000296 spermine transport(GO:0000296)
0.1 0.2 GO:0045895 negative regulation of cellular amine metabolic process(GO:0033239) regulation of cellular amine catabolic process(GO:0033241) positive regulation of mating-type specific transcription, DNA-templated(GO:0045895)
0.1 0.2 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.1 0.3 GO:0007535 donor selection(GO:0007535)
0.1 0.2 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.1 0.1 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
0.1 0.2 GO:0046160 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.1 0.2 GO:0006183 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.0 0.2 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.4 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.0 0.4 GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947)
0.0 0.1 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.0 0.3 GO:0009098 leucine biosynthetic process(GO:0009098)
0.0 0.7 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.2 GO:0070941 eisosome assembly(GO:0070941)
0.0 0.5 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.6 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.0 0.3 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.0 0.1 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.0 0.1 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0009226 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048) nucleotide-sugar biosynthetic process(GO:0009226) glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.2 GO:0060304 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.1 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.1 GO:0033014 porphyrin-containing compound biosynthetic process(GO:0006779) heme biosynthetic process(GO:0006783) tetrapyrrole biosynthetic process(GO:0033014)
0.0 0.2 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.1 GO:1900434 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.0 0.1 GO:0045862 positive regulation of proteolysis(GO:0045862)
0.0 0.4 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.0 0.3 GO:0015858 nucleoside transport(GO:0015858)
0.0 0.1 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.0 0.1 GO:0045116 protein neddylation(GO:0045116)
0.0 0.2 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.0 0.1 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.0 0.2 GO:0042991 transcription factor import into nucleus(GO:0042991)
0.0 0.0 GO:0090342 regulation of cell aging(GO:0090342) regulation of replicative cell aging(GO:1900062)
0.0 0.0 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.1 GO:0019419 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.0 0.1 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.0 0.1 GO:0070893 DNA integration(GO:0015074) transposon integration(GO:0070893)
0.0 0.1 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.0 0.4 GO:0016129 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.0 0.2 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.1 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.0 0.1 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.1 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.3 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.2 GO:0090662 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.5 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 0.2 GO:0033673 negative regulation of protein kinase activity(GO:0006469) negative regulation of kinase activity(GO:0033673)
0.0 0.0 GO:0009162 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.0 0.1 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.0 0.2 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.1 GO:0015677 copper ion import(GO:0015677)
0.0 0.0 GO:0016094 polyprenol metabolic process(GO:0016093) polyprenol biosynthetic process(GO:0016094) dolichol metabolic process(GO:0019348) dolichol biosynthetic process(GO:0019408)
0.0 0.1 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.0 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.0 0.2 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.1 GO:0007120 axial cellular bud site selection(GO:0007120)
0.0 0.3 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.1 GO:0043102 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.0 0.1 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.0 0.1 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.1 GO:0046513 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.0 0.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.0 GO:1904666 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) regulation of ubiquitin protein ligase activity(GO:1904666) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.0 0.1 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.1 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 0.1 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.0 0.1 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.2 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.1 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.0 0.2 GO:0006885 regulation of pH(GO:0006885)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0032160 septin filament array(GO:0032160)
0.1 0.2 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.2 GO:0032126 eisosome(GO:0032126)
0.0 0.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.1 GO:0043529 GET complex(GO:0043529)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0034456 UTP-C complex(GO:0034456)
0.0 0.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.2 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.2 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0034518 RNA cap binding complex(GO:0034518)
0.0 0.5 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.1 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.1 GO:0030689 Noc complex(GO:0030689)
0.0 0.2 GO:0000399 cellular bud neck septin structure(GO:0000399) cleavage apparatus septin structure(GO:0032161)
0.0 0.1 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0005724 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0042597 periplasmic space(GO:0042597)
0.0 0.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.1 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0 0.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.1 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 0.0 GO:0070209 ASTRA complex(GO:0070209) R2TP complex(GO:0097255)
0.0 0.1 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.1 GO:0000346 transcription export complex(GO:0000346)
0.0 0.0 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1 0.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.3 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 0.2 GO:0070568 guanylyltransferase activity(GO:0070568)
0.1 0.4 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1 0.2 GO:0072341 modified amino acid binding(GO:0072341)
0.1 0.3 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.1 0.2 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.2 GO:0004000 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
0.1 0.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.3 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.1 0.2 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.1 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.1 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.5 GO:0005216 ion channel activity(GO:0005216)
0.0 0.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.2 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.1 GO:0019003 GDP binding(GO:0019003)
0.0 0.1 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.1 GO:0016841 ammonia-lyase activity(GO:0016841) racemase and epimerase activity(GO:0016854)
0.0 0.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.3 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.0 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.0 0.3 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.2 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.0 0.1 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.1 GO:0008252 nucleotidase activity(GO:0008252)
0.0 0.2 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.1 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.0 0.1 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0004100 chitin synthase activity(GO:0004100)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.1 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.0 0.1 GO:0001026 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.0 0.4 GO:0015926 glucosidase activity(GO:0015926)
0.0 0.3 GO:0050661 NADP binding(GO:0050661)
0.0 0.1 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.0 0.1 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.0 0.1 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.0 0.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.1 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.2 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.5 GO:0051536 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.0 0.0 GO:0015186 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.0 0.1 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.1 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 0.1 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.0 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0 0.1 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.0 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.0 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.0 GO:0030332 cyclin binding(GO:0030332) ubiquitin-protein transferase activator activity(GO:0097027)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.0 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.0 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME GPCR DOWNSTREAM SIGNALING Genes involved in GPCR downstream signaling
0.1 0.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.2 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.0 REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE Genes involved in NFkB and MAP kinases activation mediated by TLR4 signaling repertoire