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Results for YRR1

Z-value: 0.36

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Transcription factors associated with YRR1

Gene Symbol Gene ID Gene Info
YRR1
S000005688 Zn2-Cys6 zinc-finger transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
YRR1YOR162C-0.635.6e-04Click!

Activity profile of YRR1 motif

Sorted Z-values of YRR1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 4.57
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 4.06 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YJR094W-A 2.50
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YER131W 2.42
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YMR102C 1.97 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YHR094C 1.92
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YIL056W 1.90
VHR1
Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YDR345C 1.84
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YLR180W 1.81
SAM1
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YOR315W 1.80
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YKL096W-A 1.51
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YOL086C 1.48
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YJR063W 1.46
RPA12
RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
YLR328W 1.30
NMA1
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YDR033W 1.28
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YGR280C 1.28
PXR1
Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YPL137C 1.27
GIP3
Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments
YPR074C 1.24
TKL1
Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YGL157W 1.23 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YHR163W 1.18
SOL3
6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p
YGL158W 1.17
RCK1
Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YNR001W-A 1.16 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YDR002W 1.16
YRB1
Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YKR075C 1.14 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YHR092C 1.12
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YGR148C 1.09
RPL24B
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YDR044W 1.08
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YGR234W 1.08
YHB1
Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YKL051W 1.07
SFK1
Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YER130C 1.07 Hypothetical protein
YIL118W 1.06
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YLR154C 1.03
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YFR054C 1.01 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR154W-C 0.98
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YPL136W 0.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C
YLR154W-B 0.95 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YMR001C-A 0.94 Putative protein of unknown function
YDL075W 0.94
RPL31A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YKL218C 0.93
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YIR021W 0.92
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YGL055W 0.91
OLE1
Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YDR072C 0.91
IPT1
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YOR101W 0.91
RAS1
GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YJL011C 0.90
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YDR278C 0.89 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL101C 0.89
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YDR279W 0.88
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YKR038C 0.86
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YLR154W-A 0.85 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGL209W 0.85
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YIL169C 0.83 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YOR163W 0.83
DDP1
Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases
YLR179C 0.82 Protein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential
YJL153C 0.82
INO1
Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YEL027W 0.82
CUP5
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YOR314W 0.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML043C 0.81
RRN11
Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YML075C 0.81
HMG1
One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YML026C 0.76
RPS18B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YCR035C 0.76
RRP43
Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp4p and Dis3p; required for efficient maturation of 5.8S, 18S and 25S rRNA
YPL197C 0.75 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
YLR301W 0.75 Protein of unknown function that interacts with Sec72p
YMR122W-A 0.75 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum
YDR133C 0.74 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YIL121W 0.74
QDR2
Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake
YBL085W 0.72
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YBR137W 0.72 Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); YBR137W is not an essential gene
YMR121C 0.70
RPL15B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YLR110C 0.69
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YHR128W 0.69
FUR1
Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
YNL178W 0.68
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YMR318C 0.68
ADH6
NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YOL085C 0.68 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YPL250W-A 0.68 Identified by fungal homology and RT-PCR
YOR029W 0.68 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGR052W 0.67
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YER137C 0.66 Putative protein of unknown function
YDR346C 0.65
SVF1
Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis
YMR009W 0.65
ADI1
Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YIL076W 0.64
SEC28
Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
YOR313C 0.64
SPS4
Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YMR082C 0.63 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL327W 0.63
EGT2
Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YEL029C 0.63
BUD16
Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YDR344C 0.63 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR376W-A 0.63 Putative protein of unknown function; identified by fungal homology and RT-PCR
YMR205C 0.62
PFK2
Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YOL136C 0.61
PFK27
6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YGR037C 0.61
ACB1
Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes
YDR095C 0.60 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR217W 0.60
GUA1
GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YIL159W 0.60
BNR1
Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1
YMR015C 0.59
ERG5
C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YAL003W 0.58
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YGR050C 0.58 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR073W 0.58
SNF11
Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
YBR158W 0.57
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YJL216C 0.57 Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YLR129W 0.57
DIP2
Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
YKL154W 0.56
SRP102
Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane
YGR242W 0.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YKL081W 0.56
TEF4
Translation elongation factor EF-1 gamma
YLL044W 0.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
YBR038W 0.56
CHS2
Chitin synthase II, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for the synthesis of chitin in the primary septum during cytokinesis
YPL256C 0.56
CLN2
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YKL063C 0.55 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YNR072W 0.55
HXT17
Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
YHR149C 0.54
SKG6
Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YOR051C 0.53 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YHR047C 0.53
AAP1
Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation
YOR130C 0.53
ORT1
Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
YOR050C 0.51 Hypothetical protein
YLR257W 0.51 Putative protein of unknown function
YPL183C 0.51
RTT10
Cytoplasmic protein with a role in regulation of Ty1 transposition
YNL118C 0.51
DCP2
Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family
YLR453C 0.51
RIF2
Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YLR285W 0.51
NNT1
Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination
YGR108W 0.51
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YLL024C 0.51
SSA2
ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall
YEL040W 0.50
UTR2
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YLR100W 0.50
ERG27
3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs
YMR199W 0.49
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YKL164C 0.49
PIR1
O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YOL124C 0.49
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YGR287C 0.49 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to alpha-D-glucosidase (maltase); authentic, non-tagged protein detected in purified mitochondria in high-throughput studies
YOR273C 0.48
TPO4
Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YHL001W 0.48
RPL14B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein
YDR385W 0.48
EFT2
Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YGL031C 0.48
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YDR098C 0.48
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YKL068W-A 0.48 Putative protein of unknown function; identified by homology to Ashbya gossypii
YKR041W 0.47 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YJL107C 0.47 Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YJL105W 0.47
SET4
Protein of unknown function, contains a SET domain
YKL219W 0.47
COS9
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YNR016C 0.46
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YGR241C 0.46
YAP1802
Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YGR017W 0.46 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YDR454C 0.46
GUK1
Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
YLR355C 0.46
ILV5
Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YCL063W 0.45
VAC17
Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YLR262C-A 0.45
TMA7
Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin
YOR375C 0.45
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YGL039W 0.44 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YHL028W 0.43
WSC4
ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YGR214W 0.43
RPS0A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YPR157W 0.43 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YBR151W 0.43
APD1
Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
YHR148W 0.42
IMP3
Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
YPL062W 0.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YEL056W 0.42
HAT2
Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YMR131C 0.42
RRB1
Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
YMR033W 0.42
ARP9
Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YGL030W 0.41
RPL30
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YNL204C 0.41
SPS18
Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation
YIL009W 0.41
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YJL212C 0.41
OPT1
Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
YNR018W 0.40
AIM38
Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YHR141C 0.40
RPL42B
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YDL111C 0.40
RRP42
Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp4p, Rrp41p, Rrp43p and Dis3p
YBR087W 0.40
RFC5
Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YGR245C 0.40
SDA1
Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
YIR013C 0.40
GAT4
Protein containing GATA family zinc finger motifs
YEL051W 0.39
VMA8
Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
YOL123W 0.39
HRP1
Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YPL012W 0.39
RRP12
Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats
YDR502C 0.39
SAM2
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YDR382W 0.39
RPP2B
Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YER055C 0.39
HIS1
ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YMR315W 0.39 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR315W is not an essential gene
YOL121C 0.38
RPS19A
Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp
YGR035C 0.38 Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YGR249W 0.38
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YGR192C 0.38
TDH3
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YGR251W 0.38 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YMR011W 0.37
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YOR319W 0.37
HSH49
U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
YGR155W 0.37
CYS4
Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YKR039W 0.37
GAP1
General amino acid permease; localization to the plasma membrane is regulated by nitrogen source
YMR049C 0.37
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YOR137C 0.37
SIA1
Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose
YMR220W 0.37
ERG8
Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YCR002C 0.36
CDC10
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YER046W 0.36
SPO73
Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
YMR194C-A 0.36 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR170W-A 0.36 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YDL205C 0.36
HEM3
Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p
YDR094W 0.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YPR033C 0.36
HTS1
Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence
YHR007C 0.36
ERG11
Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YHR196W 0.35
UTP9
Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YGR229C 0.35
SMI1
Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
YER102W 0.35
RPS8B
Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YML088W 0.34
UFO1
F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YKL052C 0.34
ASK1
Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases
YER091C 0.34
MET6
Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
YMR083W 0.34
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YMR305C 0.34
SCW10
Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YBR149W 0.34
ARA1
NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
YER159C 0.34
BUR6
Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of YRR1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.5 2.2 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.3 1.0 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.3 0.6 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.3 1.9 GO:0046037 GMP metabolic process(GO:0046037)
0.3 0.9 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.3 1.2 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.3 1.2 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.3 2.0 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.3 1.4 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.3 1.7 GO:0070649 parallel actin filament bundle assembly(GO:0030046) formin-nucleated actin cable assembly(GO:0070649)
0.3 4.8 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.3 0.8 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.2 1.7 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.2 1.2 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.2 1.1 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.2 0.6 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.2 0.8 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.2 0.6 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 1.4 GO:0006007 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.2 0.8 GO:1900434 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.2 0.7 GO:0098742 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.2 1.3 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.2 0.7 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.2 0.7 GO:0010138 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.2 0.2 GO:0032233 regulation of actin filament bundle assembly(GO:0032231) positive regulation of actin filament bundle assembly(GO:0032233)
0.2 0.5 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.2 0.8 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.2 0.5 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.2 1.1 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.2 0.3 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
0.1 0.6 GO:0000296 spermine transport(GO:0000296)
0.1 0.6 GO:0036213 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.1 0.7 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.3 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.8 GO:0006021 inositol biosynthetic process(GO:0006021)
0.1 0.4 GO:0048024 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
0.1 1.2 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.1 0.5 GO:0030497 fatty acid elongation(GO:0030497)
0.1 0.7 GO:0043102 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.1 0.4 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.1 0.9 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.9 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 0.7 GO:0009099 valine biosynthetic process(GO:0009099)
0.1 0.2 GO:0009409 response to cold(GO:0009409) cellular response to cold(GO:0070417)
0.1 0.3 GO:0030541 plasmid partitioning(GO:0030541)
0.1 0.5 GO:0007535 donor selection(GO:0007535)
0.1 0.3 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.1 0.7 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.1 0.9 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.2 GO:0009094 L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.1 0.8 GO:0006901 vesicle coating(GO:0006901)
0.1 0.9 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.1 0.6 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 0.2 GO:0070637 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.1 0.2 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.1 13.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 1.2 GO:0009435 NAD biosynthetic process(GO:0009435)
0.1 0.1 GO:0071478 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.1 0.1 GO:0046087 ribonucleoside catabolic process(GO:0042454) cytidine metabolic process(GO:0046087)
0.1 0.8 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 1.4 GO:0071051 nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.1 0.3 GO:0035950 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.1 0.3 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.1 0.7 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.1 1.9 GO:0009267 cellular response to starvation(GO:0009267)
0.1 0.3 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.1 0.2 GO:0070827 chromatin maintenance(GO:0070827)
0.1 0.2 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.1 0.4 GO:0009371 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.1 0.4 GO:0048478 replication fork protection(GO:0048478)
0.1 0.2 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.1 0.5 GO:0060304 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.1 GO:1902931 negative regulation of alcohol biosynthetic process(GO:1902931)
0.1 0.7 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.1 1.8 GO:0044108 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.1 0.6 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.1 0.2 GO:0015809 arginine transport(GO:0015809)
0.1 0.3 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.4 GO:0016584 nucleosome positioning(GO:0016584)
0.1 1.7 GO:0006885 regulation of pH(GO:0006885)
0.1 0.9 GO:0009636 response to toxic substance(GO:0009636)
0.1 0.6 GO:0034965 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.1 0.7 GO:0006613 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 0.5 GO:0016233 telomere capping(GO:0016233)
0.1 0.3 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.1 0.1 GO:0007188 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187) adenylate cyclase-modulating G-protein coupled receptor signaling pathway(GO:0007188)
0.1 0.2 GO:0090220 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.1 0.7 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.2 GO:0015886 heme transport(GO:0015886)
0.1 0.2 GO:0008272 sulfate transport(GO:0008272)
0.1 0.4 GO:0005992 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 0.2 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 0.2 GO:0009147 pyrimidine nucleoside triphosphate metabolic process(GO:0009147)
0.1 0.1 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.1 0.4 GO:0006734 NADH metabolic process(GO:0006734)
0.1 0.5 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 0.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.2 GO:0043069 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.1 0.1 GO:0061572 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.1 0.8 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.1 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.0 0.4 GO:0006857 oligopeptide transport(GO:0006857)
0.0 1.5 GO:0051445 regulation of meiotic nuclear division(GO:0040020) regulation of meiotic cell cycle(GO:0051445)
0.0 0.7 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.0 1.5 GO:0006414 translational elongation(GO:0006414)
0.0 1.2 GO:0046031 purine nucleoside diphosphate metabolic process(GO:0009135) purine ribonucleoside diphosphate metabolic process(GO:0009179) ribonucleoside diphosphate metabolic process(GO:0009185) ADP metabolic process(GO:0046031)
0.0 0.1 GO:0015691 cadmium ion transport(GO:0015691)
0.0 0.0 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.0 0.1 GO:0031564 transcriptional attenuation(GO:0031555) transcription antitermination(GO:0031564)
0.0 0.4 GO:0006415 translational termination(GO:0006415)
0.0 0.2 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.0 1.2 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.4 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.1 GO:0009263 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.1 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.0 0.3 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.5 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.1 GO:0071333 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.0 0.4 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.0 0.1 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.1 GO:0072530 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.0 0.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.4 GO:0045047 protein targeting to ER(GO:0045047)
0.0 0.2 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.0 0.3 GO:0000105 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.0 0.6 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.5 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.4 GO:0000011 vacuole inheritance(GO:0000011)
0.0 0.2 GO:0006639 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.0 0.6 GO:0032392 DNA geometric change(GO:0032392)
0.0 0.7 GO:0006356 regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.0 0.3 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.2 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.0 0.5 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 0.1 GO:0015833 peptide transport(GO:0015833)
0.0 0.1 GO:0015867 ATP transport(GO:0015867)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.2 GO:0070941 eisosome assembly(GO:0070941)
0.0 0.1 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.1 GO:0019419 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.0 0.1 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.0 0.4 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.1 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.0 1.2 GO:1902593 protein import into nucleus(GO:0006606) nuclear import(GO:0051170) single-organism nuclear import(GO:1902593)
0.0 0.2 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.0 0.1 GO:0009097 isoleucine biosynthetic process(GO:0009097)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.0 GO:0000092 mitotic anaphase B(GO:0000092)
0.0 0.1 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.1 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.0 0.1 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.3 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.2 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.1 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay(GO:0070481)
0.0 0.1 GO:0019627 urea metabolic process(GO:0019627)
0.0 0.1 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.0 0.0 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.0 0.2 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.0 0.3 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 0.2 GO:1903338 regulation of cell wall organization or biogenesis(GO:1903338)
0.0 0.1 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.0 0.1 GO:0030042 actin filament depolymerization(GO:0030042)
0.0 0.1 GO:0015883 FAD transport(GO:0015883)
0.0 0.1 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 2.4 GO:0006364 rRNA processing(GO:0006364)
0.0 0.0 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.0 0.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.2 GO:0007323 peptide pheromone maturation(GO:0007323)
0.0 0.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:0016126 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.0 0.0 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.0 0.5 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.1 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.0 0.1 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.1 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.2 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.1 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.1 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.0 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.0 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0 0.4 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.1 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.0 0.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.1 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.0 0.1 GO:0043489 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.0 0.1 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.0 0.1 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.0 0.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.5 GO:0032259 methylation(GO:0032259)
0.0 0.1 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.0 0.1 GO:0007009 plasma membrane organization(GO:0007009)
0.0 0.0 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.4 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.0 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.1 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.1 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.1 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.0 0.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.3 1.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 0.6 GO:0030428 cell septum(GO:0030428)
0.2 0.6 GO:0070545 PeBoW complex(GO:0070545)
0.2 0.8 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.2 0.9 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.2 12.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.4 GO:0034457 Mpp10 complex(GO:0034457)
0.1 1.9 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.4 GO:0072687 meiotic spindle(GO:0072687)
0.1 7.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.3 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.1 1.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 0.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 0.6 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.5 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.1 0.6 GO:0000144 cellular bud neck septin ring(GO:0000144)
0.1 0.3 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.1 1.0 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.1 0.6 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.4 GO:0031391 DNA replication factor C complex(GO:0005663) Rad17 RFC-like complex(GO:0031389) Elg1 RFC-like complex(GO:0031391)
0.1 0.5 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.1 GO:0005940 septin ring(GO:0005940)
0.1 0.5 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.7 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471) proton-transporting V-type ATPase complex(GO:0033176)
0.1 0.2 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.1 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.7 GO:0005791 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.1 0.4 GO:0000136 alpha-1,6-mannosyltransferase complex(GO:0000136)
0.1 0.4 GO:0034455 t-UTP complex(GO:0034455)
0.1 0.2 GO:0031417 NatC complex(GO:0031417)
0.1 0.9 GO:0034399 nuclear periphery(GO:0034399)
0.1 0.4 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 0.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 0.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.3 GO:0005771 multivesicular body(GO:0005771)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 1.7 GO:0005811 lipid particle(GO:0005811)
0.0 0.3 GO:0005871 kinesin complex(GO:0005871)
0.0 0.5 GO:0000792 heterochromatin(GO:0000792)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.7 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 7.2 GO:0005933 cellular bud(GO:0005933)
0.0 0.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.1 GO:0030869 RENT complex(GO:0030869)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.9 GO:0005844 polysome(GO:0005844)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.0 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.1 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.1 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.0 0.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 4.7 GO:0005730 nucleolus(GO:0005730)
0.0 0.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.1 GO:0034448 EGO complex(GO:0034448)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.3 GO:0016586 RSC complex(GO:0016586)
0.0 0.0 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 0.1 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.0 0.9 GO:0044445 cytosolic part(GO:0044445)
0.0 0.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.0 GO:0034518 RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.0 GO:0070985 TFIIK complex(GO:0070985)
0.0 0.1 GO:0045254 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.3 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.1 GO:0000786 nucleosome(GO:0000786)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.0 0.1 GO:0030897 HOPS complex(GO:0030897)
0.0 0.0 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.0 GO:0000131 incipient cellular bud site(GO:0000131)
0.0 0.0 GO:0000417 HIR complex(GO:0000417)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.0 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.7 4.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.5 1.5 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.5 1.9 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.4 1.3 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.4 0.4 GO:0032451 demethylase activity(GO:0032451)
0.3 1.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 1.5 GO:0008443 phosphofructokinase activity(GO:0008443)
0.3 1.2 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.3 1.7 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.3 0.8 GO:0016872 intramolecular lyase activity(GO:0016872)
0.3 0.8 GO:0001187 transcription factor activity, RNA polymerase I CORE element sequence-specific binding(GO:0001169) transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting(GO:0001187)
0.3 1.0 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.2 1.2 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.2 1.0 GO:0016841 ammonia-lyase activity(GO:0016841)
0.2 1.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 0.7 GO:0004100 chitin synthase activity(GO:0004100)
0.2 1.0 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.2 0.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 0.5 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.2 0.6 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.1 1.0 GO:0019201 nucleotide kinase activity(GO:0019201)
0.1 0.1 GO:0019003 GDP binding(GO:0019003)
0.1 0.6 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.1 1.9 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 0.4 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 2.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.1 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.1 1.3 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.1 0.4 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 1.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.7 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 1.1 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 0.7 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.1 1.2 GO:0051213 dioxygenase activity(GO:0051213)
0.1 1.1 GO:0005216 ion channel activity(GO:0005216)
0.1 0.4 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 0.3 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.1 0.2 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.1 1.3 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 1.1 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.3 GO:0009922 fatty acid elongase activity(GO:0009922)
0.1 0.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 18.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 1.5 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.3 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.5 GO:0004312 fatty acid synthase activity(GO:0004312)
0.1 1.3 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.9 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.3 GO:0016725 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 1.3 GO:0030515 snoRNA binding(GO:0030515)
0.1 2.6 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 0.3 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 0.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.2 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.7 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 0.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.3 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.7 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.2 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.1 0.2 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.1 0.9 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.3 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 0.2 GO:0070568 guanylyltransferase activity(GO:0070568)
0.1 0.2 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 0.3 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 0.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.0 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.0 0.2 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.5 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.2 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.1 GO:0019900 kinase binding(GO:0019900)
0.0 0.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.1 GO:0000295 adenine nucleotide transmembrane transporter activity(GO:0000295)
0.0 0.3 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.0 0.3 GO:0004529 exodeoxyribonuclease activity(GO:0004529)
0.0 0.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.2 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 2.5 GO:0003924 GTPase activity(GO:0003924)
0.0 0.1 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.0 0.4 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.0 0.1 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.0 0.2 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.0 0.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.5 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.1 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.1 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.0 GO:0001082 transcription factor activity, RNA polymerase I transcription factor binding(GO:0001082)
0.0 0.3 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.1 GO:0019206 nucleoside kinase activity(GO:0019206)
0.0 0.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.1 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.6 GO:0015926 glucosidase activity(GO:0015926)
0.0 0.4 GO:0050661 NADP binding(GO:0050661)
0.0 0.4 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.6 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.1 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.3 GO:0015266 protein channel activity(GO:0015266)
0.0 0.1 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.1 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.4 GO:0004536 deoxyribonuclease activity(GO:0004536)
0.0 0.3 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.5 GO:0016866 intramolecular transferase activity(GO:0016866)
0.0 0.3 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.0 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.2 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.1 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.0 0.1 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.1 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 0.1 GO:0008762 UDP-N-acetylmuramate dehydrogenase activity(GO:0008762)
0.0 0.1 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.0 0.3 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.8 GO:0003779 actin binding(GO:0003779)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.1 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.0 1.8 GO:0008289 lipid binding(GO:0008289)
0.0 0.5 GO:0030674 protein binding, bridging(GO:0030674) binding, bridging(GO:0060090)
0.0 0.5 GO:0015631 tubulin binding(GO:0015631)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.0 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.0 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.0 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.2 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.1 GO:0019239 deaminase activity(GO:0019239)
0.0 0.1 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.2 GO:0005048 signal sequence binding(GO:0005048)
0.0 0.0 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.0 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.0 GO:0008252 nucleotidase activity(GO:0008252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.3 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.2 PID ATR PATHWAY ATR signaling pathway
0.0 0.0 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 0.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 0.6 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 0.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 0.4 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 0.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.2 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.0 0.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.1 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.1 REACTOME GPCR DOWNSTREAM SIGNALING Genes involved in GPCR downstream signaling
0.0 0.2 REACTOME DNA STRAND ELONGATION Genes involved in DNA strand elongation
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.2 REACTOME M G1 TRANSITION Genes involved in M/G1 Transition
0.0 0.1 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor