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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Arid5b

Z-value: 0.47

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Transcription factors associated with Arid5b

Gene Symbol Gene ID Gene Info
Arid5b
ENSMUSG00000019947.11 Arid5b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Arid5bmm39_v1_chr10_-_68114543_68114570-0.192.7e-01Click!

Activity profile of Arid5b motif

Sorted Z-values of Arid5b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Arid5b

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_41435846 2.38 ENSMUST00000031910.8
Prss1
protease, serine 1 (trypsin 1)
chr6_+_41369290 1.77 ENSMUST00000049079.9
Gm5771
predicted gene 5771
chr1_+_174000304 1.28 ENSMUST00000027817.8
Spta1
spectrin alpha, erythrocytic 1
chr18_+_36661198 1.02 ENSMUST00000237174.2
ENSMUST00000236124.2
ENSMUST00000236779.2
ENSMUST00000235181.2
ENSMUST00000074298.13
ENSMUST00000115694.3
ENSMUST00000236126.2
Slc4a9
solute carrier family 4, sodium bicarbonate cotransporter, member 9
chr2_-_151586063 0.94 ENSMUST00000109869.2
Psmf1
proteasome (prosome, macropain) inhibitor subunit 1
chr6_-_125168453 0.92 ENSMUST00000189959.2
Ncapd2
non-SMC condensin I complex, subunit D2
chr1_-_170755136 0.91 ENSMUST00000046322.14
ENSMUST00000159171.2
Fcrla
Fc receptor-like A
chr1_+_87603952 0.90 ENSMUST00000170300.8
ENSMUST00000167032.2
Inpp5d
inositol polyphosphate-5-phosphatase D
chr17_+_71326510 0.84 ENSMUST00000073211.13
ENSMUST00000024847.14
Myom1
myomesin 1
chr9_-_45896110 0.80 ENSMUST00000215060.2
ENSMUST00000213853.2
ENSMUST00000216334.2
Pafah1b2
platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
chr13_+_28441511 0.72 ENSMUST00000223428.2
Rps18-ps5
ribosomal protein S18, pseudogene 5
chr2_-_30720345 0.61 ENSMUST00000041726.4
Asb6
ankyrin repeat and SOCS box-containing 6
chr3_+_103767581 0.56 ENSMUST00000029433.9
Ptpn22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr17_+_71326542 0.56 ENSMUST00000179759.3
Myom1
myomesin 1
chr6_+_129374441 0.47 ENSMUST00000112081.9
ENSMUST00000112079.3
Clec1b
C-type lectin domain family 1, member b
chr3_+_95496270 0.47 ENSMUST00000176674.8
ENSMUST00000177389.8
ENSMUST00000176755.8
ENSMUST00000177399.2
Golph3l
golgi phosphoprotein 3-like
chr3_-_20296337 0.47 ENSMUST00000001921.3
Cpa3
carboxypeptidase A3, mast cell
chr3_+_95496239 0.44 ENSMUST00000177390.8
ENSMUST00000060323.12
ENSMUST00000098861.11
Golph3l
golgi phosphoprotein 3-like
chr18_+_42669322 0.42 ENSMUST00000236418.2
Tcerg1
transcription elongation regulator 1 (CA150)
chr9_+_86904067 0.42 ENSMUST00000168529.9
Cyb5r4
cytochrome b5 reductase 4
chr7_-_127185512 0.41 ENSMUST00000205839.2
Ccdc189
coiled-coil domain containing 189
chr9_-_45895635 0.36 ENSMUST00000215427.2
Pafah1b2
platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
chr6_-_16898440 0.35 ENSMUST00000031533.11
Tfec
transcription factor EC
chrX_-_156275231 0.35 ENSMUST00000112529.8
Sms
spermine synthase
chr4_+_132366298 0.35 ENSMUST00000135299.8
ENSMUST00000020197.14
ENSMUST00000180250.8
ENSMUST00000081726.13
ENSMUST00000079157.11
Eya3
EYA transcriptional coactivator and phosphatase 3
chr16_+_57173456 0.34 ENSMUST00000159816.8
Filip1l
filamin A interacting protein 1-like
chr10_+_94412116 0.29 ENSMUST00000117929.2
Tmcc3
transmembrane and coiled coil domains 3
chr9_-_42372710 0.29 ENSMUST00000066179.14
Tbcel
tubulin folding cofactor E-like
chr14_-_86986541 0.28 ENSMUST00000226254.2
Diaph3
diaphanous related formin 3
chr7_-_44624165 0.27 ENSMUST00000212836.2
ENSMUST00000212255.2
ENSMUST00000063761.8
Cpt1c
carnitine palmitoyltransferase 1c
chr15_-_36283244 0.27 ENSMUST00000228358.2
ENSMUST00000022890.10
Rnf19a
ring finger protein 19A
chr10_-_6930376 0.27 ENSMUST00000105617.8
Ipcef1
interaction protein for cytohesin exchange factors 1
chr3_-_19319155 0.26 ENSMUST00000091314.11
Pde7a
phosphodiesterase 7A
chr6_+_120643323 0.25 ENSMUST00000112686.8
Cecr2
CECR2, histone acetyl-lysine reader
chrX_-_100266032 0.25 ENSMUST00000120389.8
ENSMUST00000156473.8
ENSMUST00000077876.4
Snx12
sorting nexin 12
chr13_-_20008397 0.24 ENSMUST00000222664.2
ENSMUST00000065335.3
Gpr141
G protein-coupled receptor 141
chr17_+_32671689 0.20 ENSMUST00000237491.2
Cyp4f39
cytochrome P450, family 4, subfamily f, polypeptide 39
chr1_+_180158035 0.19 ENSMUST00000070181.7
Itpkb
inositol 1,4,5-trisphosphate 3-kinase B
chr12_-_91712783 0.19 ENSMUST00000166967.2
Ston2
stonin 2
chr19_-_7688628 0.18 ENSMUST00000025666.8
Slc22a19
solute carrier family 22 (organic anion transporter), member 19
chr5_-_31854942 0.17 ENSMUST00000031018.10
Rbks
ribokinase
chr10_+_102376109 0.17 ENSMUST00000055355.6
Rassf9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr12_-_114321838 0.16 ENSMUST00000125484.3
Ighv13-2
immunoglobulin heavy variable 13-2
chr9_-_45896075 0.15 ENSMUST00000217636.2
Pafah1b2
platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
chr9_-_42368880 0.12 ENSMUST00000125995.8
Tbcel
tubulin folding cofactor E-like
chr13_+_109822527 0.12 ENSMUST00000074103.12
Pde4d
phosphodiesterase 4D, cAMP specific
chr9_+_104930438 0.12 ENSMUST00000149243.8
ENSMUST00000035177.15
ENSMUST00000214036.2
Mrpl3
mitochondrial ribosomal protein L3
chr11_+_11414256 0.11 ENSMUST00000020410.11
Spata48
spermatogenesis associated 48
chr11_-_32217547 0.11 ENSMUST00000109389.9
ENSMUST00000129010.2
ENSMUST00000020530.12
Nprl3
nitrogen permease regulator-like 3
chr6_+_68414401 0.11 ENSMUST00000103324.3
Igkv15-103
immunoglobulin kappa chain variable 15-103
chr14_-_26256025 0.10 ENSMUST00000139075.8
ENSMUST00000102956.8
Slmap
sarcolemma associated protein
chr19_+_13339600 0.10 ENSMUST00000215096.2
Olfr1467
olfactory receptor 1467
chr3_+_32583681 0.10 ENSMUST00000147350.8
Mfn1
mitofusin 1
chr15_-_55411560 0.10 ENSMUST00000165356.2
Mrpl13
mitochondrial ribosomal protein L13
chr5_+_136112765 0.10 ENSMUST00000042135.14
Rasa4
RAS p21 protein activator 4
chr15_-_44291699 0.09 ENSMUST00000038719.8
Nudcd1
NudC domain containing 1
chr15_+_44291470 0.09 ENSMUST00000226827.2
ENSMUST00000060652.5
Eny2
ENY2 transcription and export complex 2 subunit
chr8_-_46542730 0.09 ENSMUST00000144244.2
Snx25
sorting nexin 25
chr16_+_58548273 0.08 ENSMUST00000023426.12
ENSMUST00000162057.8
ENSMUST00000162191.2
Cldnd1
claudin domain containing 1
chr8_-_83128437 0.08 ENSMUST00000209573.3
Il15
interleukin 15
chr17_+_37670473 0.08 ENSMUST00000178766.3
ENSMUST00000215398.2
Olfr104-ps
olfactory receptor 104, pseudogene
chr7_-_101859033 0.07 ENSMUST00000211005.2
Nup98
nucleoporin 98
chr4_-_129556234 0.07 ENSMUST00000003828.11
Kpna6
karyopherin (importin) alpha 6
chr7_+_107679062 0.06 ENSMUST00000213601.2
Olfr481
olfactory receptor 481
chr6_-_68857658 0.06 ENSMUST00000198756.2
Gm42543
predicted gene 42543
chr18_+_77017713 0.06 ENSMUST00000026487.6
ENSMUST00000136800.2
Ier3ip1
immediate early response 3 interacting protein 1
chr11_-_17903861 0.06 ENSMUST00000076661.7
Etaa1
Ewing tumor-associated antigen 1
chr6_-_57821483 0.05 ENSMUST00000226191.2
Vmn1r21
vomeronasal 1 receptor 21
chr2_+_181023120 0.05 ENSMUST00000126611.8
Lime1
Lck interacting transmembrane adaptor 1
chr2_-_34716083 0.05 ENSMUST00000113077.8
ENSMUST00000028220.10
Fbxw2
F-box and WD-40 domain protein 2
chr16_+_57173632 0.05 ENSMUST00000099667.3
Filip1l
filamin A interacting protein 1-like
chr16_-_17540805 0.05 ENSMUST00000012259.9
ENSMUST00000232236.2
Med15
mediator complex subunit 15
chr12_+_103524690 0.05 ENSMUST00000187155.7
Ppp4r4
protein phosphatase 4, regulatory subunit 4
chr8_+_69723732 0.04 ENSMUST00000212549.2
D130040H23Rik
RIKEN cDNA D130040H23 gene
chr9_-_58065800 0.04 ENSMUST00000168864.4
Islr
immunoglobulin superfamily containing leucine-rich repeat
chr1_+_31215482 0.04 ENSMUST00000062560.14
Lgsn
lengsin, lens protein with glutamine synthetase domain
chr2_+_84508734 0.04 ENSMUST00000102645.4
Med19
mediator complex subunit 19
chr7_+_33794856 0.04 ENSMUST00000108083.2
Scgb1b30
secretoglobin, family 1B, member 30
chr1_+_163607143 0.04 ENSMUST00000077642.12
ENSMUST00000027877.7
Kifap3
kinesin-associated protein 3
chr5_+_136112817 0.03 ENSMUST00000100570.10
Rasa4
RAS p21 protein activator 4
chr12_-_103956176 0.03 ENSMUST00000151709.3
ENSMUST00000176246.3
ENSMUST00000074693.13
ENSMUST00000120251.9
Serpina11
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
chr6_+_97187650 0.03 ENSMUST00000044681.7
Arl6ip5
ADP-ribosylation factor-like 6 interacting protein 5
chr8_+_105558204 0.03 ENSMUST00000059449.7
Ces2b
carboxyesterase 2B
chr9_-_101076198 0.03 ENSMUST00000066773.9
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr12_-_113617344 0.03 ENSMUST00000103447.2
Ighv2-4
immunoglobulin heavy variable V2-4
chr8_-_62576140 0.03 ENSMUST00000034052.14
ENSMUST00000034054.9
Anxa10
annexin A10
chr18_+_37864045 0.02 ENSMUST00000192535.2
Pcdhgb5
protocadherin gamma subfamily B, 5
chr10_+_115979787 0.02 ENSMUST00000105271.9
Ptprr
protein tyrosine phosphatase, receptor type, R
chr6_+_106095726 0.01 ENSMUST00000113258.8
ENSMUST00000079416.6
Cntn4
contactin 4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0045659 negative regulation of neutrophil differentiation(GO:0045659)
0.2 0.6 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523) positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.1 0.4 GO:0006597 spermine biosynthetic process(GO:0006597)
0.1 0.9 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 1.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.2 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 0.9 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.2 GO:0006014 D-ribose metabolic process(GO:0006014)
0.0 0.5 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.0 0.4 GO:0042168 heme metabolic process(GO:0042168)
0.0 0.2 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.0 1.3 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.0 0.3 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 4.0 GO:0007586 digestion(GO:0007586)
0.0 0.2 GO:0002238 response to molecule of fungal origin(GO:0002238)
0.0 0.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.1 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.0 0.2 GO:0001842 neural fold formation(GO:0001842)
0.0 1.3 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.0 0.3 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.1 GO:0071350 interleukin-15-mediated signaling pathway(GO:0035723) extrathymic T cell selection(GO:0045062) cellular response to interleukin-15(GO:0071350)
0.0 0.1 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.0 0.0 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.0 GO:0080163 regulation of protein serine/threonine phosphatase activity(GO:0080163)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0032437 cuticular plate(GO:0032437)
0.2 0.9 GO:0000799 nuclear condensin complex(GO:0000799)
0.1 0.2 GO:0090537 CERF complex(GO:0090537)
0.1 1.4 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.1 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.0 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.9 GO:0031985 Golgi cisterna(GO:0031985)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.1 0.9 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312) PTB domain binding(GO:0051425)
0.1 1.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 1.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.3 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.9 GO:0070628 proteasome binding(GO:0070628)
0.0 0.4 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.9 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 4.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.0 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211)
0.0 0.2 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.4 GO:0070064 proline-rich region binding(GO:0070064)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.9 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.9 PID AURORA B PATHWAY Aurora B signaling
0.0 0.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.9 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)