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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Cdx2

Z-value: 1.52

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Transcription factors associated with Cdx2

Gene Symbol Gene ID Gene Info
Cdx2
ENSMUSG00000029646.4 Cdx2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cdx2mm39_v1_chr5_-_147244074_147244091-0.231.7e-01Click!

Activity profile of Cdx2 motif

Sorted Z-values of Cdx2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Cdx2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_90603013 9.86 ENSMUST00000069960.12
ENSMUST00000117167.2
S100a9
S100 calcium binding protein A9 (calgranulin B)
chr1_-_45542442 6.72 ENSMUST00000086430.5
Col5a2
collagen, type V, alpha 2
chr7_+_130633776 6.18 ENSMUST00000084509.7
ENSMUST00000213064.3
ENSMUST00000208311.4
Dmbt1
deleted in malignant brain tumors 1
chr8_-_106660470 5.71 ENSMUST00000034368.8
Ctrl
chymotrypsin-like
chr11_-_99328969 5.62 ENSMUST00000017743.3
Krt20
keratin 20
chr14_+_80237691 4.82 ENSMUST00000228749.2
ENSMUST00000088735.4
Olfm4
olfactomedin 4
chr3_-_14843512 4.06 ENSMUST00000094365.11
Car1
carbonic anhydrase 1
chr17_-_31348576 4.00 ENSMUST00000024827.5
Tff3
trefoil factor 3, intestinal
chr6_+_38895902 2.92 ENSMUST00000003017.13
Tbxas1
thromboxane A synthase 1, platelet
chr4_-_63965161 2.89 ENSMUST00000107377.10
Tnc
tenascin C
chr6_-_49191891 2.86 ENSMUST00000031838.9
Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr3_+_57332735 2.73 ENSMUST00000029377.8
Tm4sf4
transmembrane 4 superfamily member 4
chr7_+_140343652 2.58 ENSMUST00000026552.9
ENSMUST00000209253.2
ENSMUST00000210235.2
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr3_-_10273628 2.47 ENSMUST00000029041.6
Fabp4
fatty acid binding protein 4, adipocyte
chr9_+_95519654 2.37 ENSMUST00000015498.9
Pcolce2
procollagen C-endopeptidase enhancer 2
chr9_-_65330231 2.31 ENSMUST00000065894.7
Slc51b
solute carrier family 51, beta subunit
chrX_+_162873183 2.22 ENSMUST00000015545.10
Cltrn
collectrin, amino acid transport regulator
chrX_+_95498965 1.69 ENSMUST00000033553.14
Heph
hephaestin
chr1_+_139429430 1.52 ENSMUST00000027615.7
F13b
coagulation factor XIII, beta subunit
chr17_-_71305003 1.44 ENSMUST00000024846.13
ENSMUST00000232766.2
Myl12a
myosin, light chain 12A, regulatory, non-sarcomeric
chr10_+_97400990 1.32 ENSMUST00000038160.6
Lum
lumican
chr10_+_119655294 1.26 ENSMUST00000105262.9
ENSMUST00000147454.8
ENSMUST00000138410.8
ENSMUST00000144825.8
ENSMUST00000148954.8
ENSMUST00000144959.8
Grip1
glutamate receptor interacting protein 1
chr8_-_34333573 1.00 ENSMUST00000183062.2
Rbpms
RNA binding protein gene with multiple splicing
chr7_+_89814713 0.97 ENSMUST00000207084.2
Picalm
phosphatidylinositol binding clathrin assembly protein
chr10_-_35587888 0.97 ENSMUST00000080898.4
Amd2
S-adenosylmethionine decarboxylase 2
chr6_+_71176811 0.91 ENSMUST00000067492.8
Fabp1
fatty acid binding protein 1, liver
chr14_-_54923517 0.86 ENSMUST00000125265.2
Acin1
apoptotic chromatin condensation inducer 1
chr12_-_102844537 0.79 ENSMUST00000045652.8
ENSMUST00000223554.2
Btbd7
BTB (POZ) domain containing 7
chr11_-_99134885 0.69 ENSMUST00000103132.10
ENSMUST00000038214.7
Krt222
keratin 222
chrX_+_72818003 0.69 ENSMUST00000002081.6
Srpk3
serine/arginine-rich protein specific kinase 3
chr3_-_92393193 0.66 ENSMUST00000054599.8
Sprr1a
small proline-rich protein 1A
chr6_-_122317484 0.59 ENSMUST00000112600.9
Phc1
polyhomeotic 1
chr5_-_135773047 0.59 ENSMUST00000153399.2
Tmem120a
transmembrane protein 120A
chr11_-_76386190 0.54 ENSMUST00000108408.9
Abr
active BCR-related gene
chr2_-_51039112 0.52 ENSMUST00000154545.2
ENSMUST00000017288.9
Rnd3
Rho family GTPase 3
chrX_+_162923474 0.42 ENSMUST00000073973.11
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr11_+_96214078 0.36 ENSMUST00000093944.10
Hoxb3
homeobox B3
chr4_-_9643636 0.33 ENSMUST00000108333.8
ENSMUST00000108334.8
ENSMUST00000108335.8
ENSMUST00000152526.8
ENSMUST00000103004.10
Asph
aspartate-beta-hydroxylase
chr17_+_80614795 0.31 ENSMUST00000223878.2
ENSMUST00000068175.6
ENSMUST00000224391.2
Arhgef33
Rho guanine nucleotide exchange factor (GEF) 33
chr19_-_47680528 0.30 ENSMUST00000026045.14
ENSMUST00000086923.6
Col17a1
collagen, type XVII, alpha 1
chr6_+_17491231 0.28 ENSMUST00000080469.12
Met
met proto-oncogene
chr18_+_65715156 0.25 ENSMUST00000237553.2
ENSMUST00000237712.2
ENSMUST00000182684.8
Zfp532
zinc finger protein 532
chr15_-_101389384 0.22 ENSMUST00000023718.9
Krt83
keratin 83
chrM_+_7758 0.22 ENSMUST00000082407.1
mt-Atp8
mitochondrially encoded ATP synthase 8
chr17_-_71153283 0.21 ENSMUST00000156484.2
Tgif1
TGFB-induced factor homeobox 1
chr8_+_95113066 0.21 ENSMUST00000161576.8
ENSMUST00000034220.8
Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chrM_+_7779 0.17 ENSMUST00000082408.1
mt-Atp6
mitochondrially encoded ATP synthase 6
chr18_+_65715460 0.16 ENSMUST00000169679.8
ENSMUST00000183326.2
Zfp532
zinc finger protein 532
chr19_-_34856853 0.14 ENSMUST00000036584.13
Pank1
pantothenate kinase 1
chr14_+_54923655 0.11 ENSMUST00000038539.8
ENSMUST00000228027.2
1700123O20Rik
RIKEN cDNA 1700123O20 gene
chr5_+_13448833 0.02 ENSMUST00000137798.10
Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chrX_+_13499008 0.01 ENSMUST00000096492.4
Gpr34
G protein-coupled receptor 34

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.9 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
1.7 6.7 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.7 2.9 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.3 1.0 GO:0006597 spermine biosynthetic process(GO:0006597)
0.2 6.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 1.0 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.2 5.6 GO:0045109 intermediate filament organization(GO:0045109)
0.2 2.3 GO:0060050 positive regulation of protein glycosylation(GO:0060050) positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.2 1.3 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.2 2.9 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 2.5 GO:0071285 cellular response to lithium ion(GO:0071285)
0.1 0.3 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.9 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.1 0.4 GO:0015827 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.1 2.6 GO:0017144 drug metabolic process(GO:0017144)
0.1 4.1 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 0.5 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.1 4.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.4 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 1.1 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.1 0.9 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 1.0 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.2 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 1.5 GO:0006825 copper ion transport(GO:0006825)
0.0 4.0 GO:0007586 digestion(GO:0007586)
0.0 2.9 GO:0051028 mRNA transport(GO:0051028)
0.0 0.7 GO:0031424 keratinization(GO:0031424)
0.0 3.0 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.4 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 GO:0005588 collagen type V trimer(GO:0005588)
0.5 6.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.2 4.8 GO:0042581 specific granule(GO:0042581)
0.1 1.0 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 1.3 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.9 GO:0061574 ASAP complex(GO:0061574)
0.1 0.9 GO:0045179 apical cortex(GO:0045179)
0.1 2.1 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.2 GO:1990037 Lewy body core(GO:1990037)
0.0 0.6 GO:0001739 sex chromatin(GO:0001739)
0.0 4.6 GO:0005882 intermediate filament(GO:0005882)
0.0 1.0 GO:0005685 U1 snRNP(GO:0005685)
0.0 1.4 GO:0016460 myosin II complex(GO:0016460)
0.0 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.4 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.7 GO:0001533 cornified envelope(GO:0001533)
0.0 13.6 GO:0031012 extracellular matrix(GO:0031012)
0.0 2.6 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 9.9 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.4 4.1 GO:0004064 arylesterase activity(GO:0004064)
0.3 2.9 GO:0045545 syndecan binding(GO:0045545)
0.2 1.0 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 1.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.0 GO:0019808 polyamine binding(GO:0019808)
0.1 6.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.9 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 5.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 2.9 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.4 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 0.3 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 2.6 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 1.0 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 2.9 GO:0016860 intramolecular oxidoreductase activity(GO:0016860)
0.0 2.4 GO:0016504 peptidase activator activity(GO:0016504)
0.0 2.5 GO:0005504 fatty acid binding(GO:0005504)
0.0 1.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 5.7 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 1.3 GO:0005518 collagen binding(GO:0005518)
0.0 1.4 GO:0035254 glutamate receptor binding(GO:0035254)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 7.0 NABA COLLAGENS Genes encoding collagen proteins
0.1 2.9 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 4.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 7.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.5 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.3 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 9.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 1.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.5 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 2.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.7 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 2.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 3.1 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 0.9 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins