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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Creb3l2

Z-value: 3.28

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Transcription factors associated with Creb3l2

Gene Symbol Gene ID Gene Info
Creb3l2
ENSMUSG00000038648.6 Creb3l2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Creb3l2mm39_v1_chr6_-_37419030_374191170.661.0e-05Click!

Activity profile of Creb3l2 motif

Sorted Z-values of Creb3l2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Creb3l2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr5_-_31102829 24.90 ENSMUST00000031051.8
Cgref1
cell growth regulator with EF hand domain 1
chr17_-_26417982 19.20 ENSMUST00000142410.2
ENSMUST00000120333.8
ENSMUST00000039113.14
Pdia2
protein disulfide isomerase associated 2
chrX_+_8137372 17.49 ENSMUST00000127103.8
ENSMUST00000115591.8
Slc38a5
solute carrier family 38, member 5
chr10_+_128745214 17.27 ENSMUST00000220308.2
Cd63
CD63 antigen
chr7_+_78563964 16.93 ENSMUST00000120331.4
Isg20
interferon-stimulated protein
chr10_+_12966532 16.88 ENSMUST00000121646.8
ENSMUST00000121325.8
ENSMUST00000121766.8
Plagl1
pleiomorphic adenoma gene-like 1
chrX_+_8137620 15.99 ENSMUST00000033512.11
Slc38a5
solute carrier family 38, member 5
chrX_+_8137881 14.68 ENSMUST00000115590.2
Slc38a5
solute carrier family 38, member 5
chr7_+_78564062 13.12 ENSMUST00000205981.2
Isg20
interferon-stimulated protein
chr2_+_129040677 11.52 ENSMUST00000028880.10
Slc20a1
solute carrier family 20, member 1
chr2_+_84670543 11.41 ENSMUST00000111624.8
Slc43a1
solute carrier family 43, member 1
chr2_+_84670956 10.97 ENSMUST00000111625.2
Slc43a1
solute carrier family 43, member 1
chr7_+_78563513 10.37 ENSMUST00000038142.15
Isg20
interferon-stimulated protein
chr2_+_150628655 10.32 ENSMUST00000045441.8
Pygb
brain glycogen phosphorylase
chr11_+_100306523 9.89 ENSMUST00000001595.10
ENSMUST00000107400.3
Fkbp10
FK506 binding protein 10
chr6_-_83294526 9.39 ENSMUST00000005810.9
Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chrX_-_8011952 9.16 ENSMUST00000115615.9
ENSMUST00000115616.8
ENSMUST00000115621.9
Rbm3
RNA binding motif (RNP1, RRM) protein 3
chrX_-_8011918 8.47 ENSMUST00000115619.8
ENSMUST00000115617.10
ENSMUST00000040010.10
Rbm3
RNA binding motif (RNP1, RRM) protein 3
chr14_-_56499690 8.38 ENSMUST00000015581.6
Gzmb
granzyme B
chr19_+_6135013 8.30 ENSMUST00000025704.3
Cdca5
cell division cycle associated 5
chr4_-_131802561 7.31 ENSMUST00000105970.8
ENSMUST00000105975.8
Epb41
erythrocyte membrane protein band 4.1
chr4_-_108263873 7.22 ENSMUST00000184609.2
Gpx7
glutathione peroxidase 7
chr19_+_46044972 6.97 ENSMUST00000111899.8
ENSMUST00000099392.10
ENSMUST00000062322.11
Pprc1
peroxisome proliferative activated receptor, gamma, coactivator-related 1
chr11_-_94544748 6.94 ENSMUST00000039949.5
Eme1
essential meiotic structure-specific endonuclease 1
chr2_+_130116344 6.79 ENSMUST00000103198.11
Nop56
NOP56 ribonucleoprotein
chr1_+_63216281 6.67 ENSMUST00000188524.2
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr2_+_130116357 6.37 ENSMUST00000136621.9
ENSMUST00000141872.2
Nop56
NOP56 ribonucleoprotein
chr19_-_40576782 6.25 ENSMUST00000176939.8
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr19_-_40576897 6.12 ENSMUST00000025979.13
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr15_+_79575046 6.11 ENSMUST00000046463.10
Gtpbp1
GTP binding protein 1
chr4_-_131802606 6.01 ENSMUST00000146021.8
Epb41
erythrocyte membrane protein band 4.1
chr1_+_63215976 5.92 ENSMUST00000129339.8
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr16_-_78173645 5.68 ENSMUST00000023570.14
Btg3
BTG anti-proliferation factor 3
chr11_+_44409775 5.53 ENSMUST00000019333.10
Rnf145
ring finger protein 145
chr7_+_79042052 5.52 ENSMUST00000118959.8
ENSMUST00000036865.13
Fanci
Fanconi anemia, complementation group I
chrX_+_49930311 5.42 ENSMUST00000114887.9
Stk26
serine/threonine kinase 26
chr6_-_8778439 5.29 ENSMUST00000115520.8
ENSMUST00000038403.12
ENSMUST00000115518.8
Ica1
islet cell autoantigen 1
chr3_+_104545974 4.89 ENSMUST00000046212.2
Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr19_-_40576817 4.64 ENSMUST00000175932.2
ENSMUST00000176955.8
ENSMUST00000149476.3
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr4_-_155737841 4.50 ENSMUST00000030937.2
Mmp23
matrix metallopeptidase 23
chr2_-_92201342 4.33 ENSMUST00000176810.8
ENSMUST00000090582.11
ENSMUST00000068586.13
Large2
LARGE xylosyl- and glucuronyltransferase 2
chr8_-_125390107 4.24 ENSMUST00000034464.8
2310022B05Rik
RIKEN cDNA 2310022B05 gene
chr6_-_8778106 4.20 ENSMUST00000151758.2
ENSMUST00000115519.8
ENSMUST00000153390.8
Ica1
islet cell autoantigen 1
chr5_+_31212165 4.07 ENSMUST00000202795.4
ENSMUST00000201182.4
ENSMUST00000200953.4
Cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr6_+_87864796 4.04 ENSMUST00000113607.10
ENSMUST00000049966.6
Copg1
coatomer protein complex, subunit gamma 1
chr12_+_17594795 3.91 ENSMUST00000171737.3
Odc1
ornithine decarboxylase, structural 1
chr5_+_31212110 3.84 ENSMUST00000013773.12
ENSMUST00000201838.4
Cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr11_-_120534469 3.80 ENSMUST00000141254.8
ENSMUST00000170556.8
ENSMUST00000151876.8
ENSMUST00000026133.15
ENSMUST00000139706.2
Pycr1
pyrroline-5-carboxylate reductase 1
chr3_-_37778470 3.74 ENSMUST00000108105.2
ENSMUST00000079755.5
ENSMUST00000099128.2
Gm5148
predicted gene 5148
chr18_-_60981981 3.51 ENSMUST00000177172.8
ENSMUST00000175934.8
ENSMUST00000176630.8
Tcof1
treacle ribosome biogenesis factor 1
chr19_-_4251589 3.21 ENSMUST00000237923.2
ENSMUST00000025740.8
ENSMUST00000237723.2
Rad9a
RAD9 checkpoint clamp component A
chr5_+_108416763 3.12 ENSMUST00000031190.5
Dr1
down-regulator of transcription 1
chr11_-_97673203 3.03 ENSMUST00000128801.2
ENSMUST00000103146.5
Rpl23
ribosomal protein L23
chr7_-_79765042 2.99 ENSMUST00000206714.2
ENSMUST00000107384.10
Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr9_-_107166543 2.92 ENSMUST00000192054.2
Mapkapk3
mitogen-activated protein kinase-activated protein kinase 3
chr11_+_109253598 2.91 ENSMUST00000106702.4
ENSMUST00000020930.14
Gna13
guanine nucleotide binding protein, alpha 13
chr15_-_83234372 2.90 ENSMUST00000226124.2
ENSMUST00000067215.9
Arfgap3
ADP-ribosylation factor GTPase activating protein 3
chr16_+_4867876 2.88 ENSMUST00000230703.2
ENSMUST00000052449.6
Ubn1
ubinuclein 1
chr2_+_31864438 2.79 ENSMUST00000065398.13
Nup214
nucleoporin 214
chr6_+_56809044 2.77 ENSMUST00000031795.8
Fkbp9
FK506 binding protein 9
chr17_-_12988492 2.67 ENSMUST00000024599.14
Igf2r
insulin-like growth factor 2 receptor
chr14_-_70680882 2.64 ENSMUST00000000793.13
Polr3d
polymerase (RNA) III (DNA directed) polypeptide D
chr15_+_34495441 2.62 ENSMUST00000052290.14
ENSMUST00000079028.6
Pop1
processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
chr14_+_63673843 2.42 ENSMUST00000121288.2
Fam167a
family with sequence similarity 167, member A
chr5_-_137608886 2.42 ENSMUST00000142675.8
Pcolce
procollagen C-endopeptidase enhancer protein
chr7_-_105289515 2.42 ENSMUST00000133519.8
ENSMUST00000209550.2
ENSMUST00000210911.2
ENSMUST00000084782.10
ENSMUST00000131446.8
Arfip2
ADP-ribosylation factor interacting protein 2
chr2_+_69691906 2.39 ENSMUST00000090852.11
ENSMUST00000166411.8
Ssb
Sjogren syndrome antigen B
chr17_+_29251602 2.32 ENSMUST00000130216.3
Srsf3
serine and arginine-rich splicing factor 3
chr4_-_149858694 2.22 ENSMUST00000105686.3
Slc25a33
solute carrier family 25, member 33
chr5_-_35836761 2.16 ENSMUST00000114233.3
Htra3
HtrA serine peptidase 3
chr14_-_70588803 2.15 ENSMUST00000143153.2
ENSMUST00000127000.2
ENSMUST00000068044.14
ENSMUST00000022688.10
Slc39a14
solute carrier family 39 (zinc transporter), member 14
chr6_-_38276157 2.14 ENSMUST00000058524.3
Zc3hav1l
zinc finger CCCH-type, antiviral 1-like
chr14_-_70680659 2.14 ENSMUST00000180358.3
Polr3d
polymerase (RNA) III (DNA directed) polypeptide D
chr2_-_35869636 2.10 ENSMUST00000028248.11
ENSMUST00000112976.9
Ttll11
tubulin tyrosine ligase-like family, member 11
chr15_+_84807640 2.07 ENSMUST00000230411.2
Nup50
nucleoporin 50
chr9_-_67739607 2.06 ENSMUST00000054500.7
C2cd4a
C2 calcium-dependent domain containing 4A
chr6_-_22356175 1.98 ENSMUST00000081288.14
Fam3c
family with sequence similarity 3, member C
chr9_-_118917275 1.91 ENSMUST00000214470.2
Plcd1
phospholipase C, delta 1
chr2_+_69691982 1.90 ENSMUST00000112260.3
Ssb
Sjogren syndrome antigen B
chr4_+_128548479 1.90 ENSMUST00000030588.13
ENSMUST00000136377.8
Phc2
polyhomeotic 2
chr13_-_103911092 1.85 ENSMUST00000074616.7
Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr17_+_69569184 1.84 ENSMUST00000224951.2
Epb41l3
erythrocyte membrane protein band 4.1 like 3
chr11_-_5049223 1.83 ENSMUST00000079949.13
Ewsr1
Ewing sarcoma breakpoint region 1
chr15_+_84807582 1.82 ENSMUST00000165443.4
Nup50
nucleoporin 50
chr2_+_144210881 1.81 ENSMUST00000028911.15
ENSMUST00000147747.8
ENSMUST00000183618.3
Kat14
Pet117
lysine acetyltransferase 14
PET117 homolog
chr14_+_26359191 1.75 ENSMUST00000022429.9
Arf4
ADP-ribosylation factor 4
chr4_+_148675939 1.67 ENSMUST00000006611.9
Srm
spermidine synthase
chr6_-_22356067 1.65 ENSMUST00000163963.8
Fam3c
family with sequence similarity 3, member C
chr2_+_180367056 1.60 ENSMUST00000094218.4
Slc17a9
solute carrier family 17, member 9
chr5_-_137608726 1.54 ENSMUST00000197912.5
Pcolce
procollagen C-endopeptidase enhancer protein
chr4_+_119280002 1.52 ENSMUST00000094819.5
Zmynd12
zinc finger, MYND domain containing 12
chr19_+_46561801 1.31 ENSMUST00000026011.8
Sfxn2
sideroflexin 2
chr6_-_13871454 1.29 ENSMUST00000185219.2
ENSMUST00000185361.2
ENSMUST00000155856.2
2610001J05Rik
RIKEN cDNA 2610001J05 gene
chr17_-_29566774 1.28 ENSMUST00000095427.12
ENSMUST00000118366.9
Mtch1
mitochondrial carrier 1
chr10_-_18890281 1.27 ENSMUST00000146388.2
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr11_-_103844870 1.17 ENSMUST00000103075.11
Nsf
N-ethylmaleimide sensitive fusion protein
chr10_-_119075910 1.17 ENSMUST00000020315.13
Cand1
cullin associated and neddylation disassociated 1
chr3_-_107993906 1.12 ENSMUST00000102638.8
ENSMUST00000102637.8
Ampd2
adenosine monophosphate deaminase 2
chr6_-_22356098 1.06 ENSMUST00000165576.8
Fam3c
family with sequence similarity 3, member C
chr2_-_92201311 0.98 ENSMUST00000176774.8
Large2
LARGE xylosyl- and glucuronyltransferase 2
chr7_-_45116316 0.93 ENSMUST00000033093.10
Bax
BCL2-associated X protein
chr1_+_72863641 0.93 ENSMUST00000047328.11
Igfbp2
insulin-like growth factor binding protein 2
chr3_+_96604390 0.91 ENSMUST00000162778.3
ENSMUST00000064900.16
Pias3
protein inhibitor of activated STAT 3
chr19_-_6817955 0.91 ENSMUST00000239527.1
RPS6KA4
ribosomal protein S6 kinase, polypeptide 4
chr15_-_75550581 0.90 ENSMUST00000000958.9
Top1mt
DNA topoisomerase 1, mitochondrial
chr5_+_137517140 0.88 ENSMUST00000031727.10
Gigyf1
GRB10 interacting GYF protein 1
chr17_+_87415049 0.84 ENSMUST00000041369.8
ENSMUST00000234803.2
Socs5
suppressor of cytokine signaling 5
chr10_+_61516078 0.83 ENSMUST00000220372.2
ENSMUST00000020285.10
ENSMUST00000219506.2
ENSMUST00000218474.2
Sar1a
secretion associated Ras related GTPase 1A
chr4_+_148123490 0.83 ENSMUST00000097788.11
Mthfr
methylenetetrahydrofolate reductase
chr2_+_68691778 0.71 ENSMUST00000028426.9
Cers6
ceramide synthase 6
chrX_-_135641869 0.69 ENSMUST00000166930.8
ENSMUST00000113095.8
Morf4l2
mortality factor 4 like 2
chr3_+_96604415 0.65 ENSMUST00000107077.4
Pias3
protein inhibitor of activated STAT 3
chr17_-_56583715 0.63 ENSMUST00000058136.9
Ticam1
toll-like receptor adaptor molecule 1
chr14_+_26359390 0.54 ENSMUST00000112318.10
Arf4
ADP-ribosylation factor 4
chr18_+_75151780 0.53 ENSMUST00000236220.2
ENSMUST00000039608.9
ENSMUST00000235692.2
Dym
dymeclin
chr6_-_13871475 0.48 ENSMUST00000139231.2
2610001J05Rik
RIKEN cDNA 2610001J05 gene
chrX_+_73372664 0.40 ENSMUST00000004326.4
Plxna3
plexin A3
chr4_+_148123554 0.39 ENSMUST00000141283.8
Mthfr
methylenetetrahydrofolate reductase
chr15_-_102419115 0.26 ENSMUST00000171565.8
Map3k12
mitogen-activated protein kinase kinase kinase 12
chr16_-_30369378 0.25 ENSMUST00000140402.8
Tmem44
transmembrane protein 44
chr19_+_46045675 0.25 ENSMUST00000126127.8
ENSMUST00000147640.2
Pprc1
peroxisome proliferative activated receptor, gamma, coactivator-related 1
chr2_+_68691902 0.23 ENSMUST00000176018.2
Cers6
ceramide synthase 6
chr6_+_70821481 0.22 ENSMUST00000034093.15
ENSMUST00000162950.2
Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
chr2_+_71283620 0.18 ENSMUST00000037210.9
Metap1d
methionyl aminopeptidase type 1D (mitochondrial)
chr7_-_24950145 0.17 ENSMUST00000116343.3
ENSMUST00000045847.15
Erf
Ets2 repressor factor
chr5_+_137516810 0.16 ENSMUST00000197624.5
Gigyf1
GRB10 interacting GYF protein 1
chrX_+_151922936 0.16 ENSMUST00000039720.11
ENSMUST00000144175.3
Rragb
Ras-related GTP binding B
chr5_+_63969706 0.13 ENSMUST00000081747.8
ENSMUST00000196575.5
0610040J01Rik
RIKEN cDNA 0610040J01 gene
chr2_-_155315708 0.13 ENSMUST00000109670.8
ENSMUST00000123293.8
Ncoa6
nuclear receptor coactivator 6
chr19_+_34899778 0.13 ENSMUST00000223907.2
Kif20b
kinesin family member 20B
chrX_-_135642025 0.12 ENSMUST00000155207.8
ENSMUST00000080411.13
ENSMUST00000169418.8
Morf4l2
mortality factor 4 like 2
chr6_-_145021816 0.10 ENSMUST00000111742.8
ENSMUST00000048252.11
Bcat1
branched chain aminotransferase 1, cytosolic
chr14_+_58063668 0.10 ENSMUST00000022538.5
Mrpl57
mitochondrial ribosomal protein L57
chr16_-_20972750 0.09 ENSMUST00000170665.3
Teddm3
transmembrane epididymal family member 3
chr7_+_30121147 0.08 ENSMUST00000108176.9
Nfkbid
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
chr4_+_109533753 0.06 ENSMUST00000102724.5
Faf1
Fas-associated factor 1
chr8_-_95328260 0.06 ENSMUST00000212765.2
ENSMUST00000213008.2
ENSMUST00000212159.2
ENSMUST00000213022.2
ENSMUST00000212258.2
ENSMUST00000212788.2
ENSMUST00000212791.2
Psme3ip1
proteasome activator subunit 3 interacting protein 1
chr11_+_51475584 0.04 ENSMUST00000167797.8
ENSMUST00000020625.7
Phykpl
5-phosphohydroxy-L-lysine phospholyase
chr5_+_31026967 0.04 ENSMUST00000114716.4
Tmem214
transmembrane protein 214

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 40.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
5.7 17.0 GO:0006592 ornithine biosynthetic process(GO:0006592)
2.9 17.3 GO:2000680 regulation of rubidium ion transport(GO:2000680)
2.7 48.2 GO:0015816 glycine transport(GO:0015816)
2.3 6.9 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
1.7 8.4 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
1.7 8.3 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
1.1 7.9 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
1.1 4.3 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
1.0 3.0 GO:1990773 regulation of matrix metallopeptidase secretion(GO:1904464) matrix metallopeptidase secretion(GO:1990773)
0.8 3.9 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.8 3.8 GO:0006561 proline biosynthetic process(GO:0006561)
0.8 3.0 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.7 13.3 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.7 22.4 GO:0015804 neutral amino acid transport(GO:0015804)
0.5 5.2 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.4 2.2 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.4 5.3 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.4 2.6 GO:0016078 tRNA catabolic process(GO:0016078)
0.4 1.3 GO:0002631 regulation of granuloma formation(GO:0002631) negative regulation of granuloma formation(GO:0002632) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429)
0.4 4.9 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.4 10.3 GO:0005980 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.3 11.5 GO:0006817 phosphate ion transport(GO:0006817)
0.3 17.6 GO:0035196 production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.3 4.0 GO:0051683 establishment of Golgi localization(GO:0051683)
0.3 13.2 GO:0000154 rRNA modification(GO:0000154)
0.3 3.5 GO:0014029 neural crest formation(GO:0014029)
0.3 9.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.3 1.9 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.3 0.9 GO:1990117 release of matrix enzymes from mitochondria(GO:0032976) B cell receptor apoptotic signaling pathway(GO:1990117)
0.3 2.1 GO:0051013 microtubule severing(GO:0051013)
0.3 1.7 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.3 12.2 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175)
0.3 7.8 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.3 10.1 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.2 3.2 GO:0000076 DNA replication checkpoint(GO:0000076)
0.2 0.8 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.2 5.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.2 12.6 GO:0006414 translational elongation(GO:0006414)
0.2 1.8 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.2 5.4 GO:0030033 microvillus assembly(GO:0030033)
0.2 1.6 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 7.2 GO:0046039 GTP metabolic process(GO:0046039)
0.1 14.8 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 2.9 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.1 0.8 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 2.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 23.3 GO:0007050 cell cycle arrest(GO:0007050)
0.1 4.8 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 1.8 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.1 0.9 GO:0006265 DNA topological change(GO:0006265)
0.1 2.4 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.1 1.0 GO:0044351 macropinocytosis(GO:0044351)
0.1 0.2 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734)
0.1 1.2 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 0.4 GO:0021636 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 2.8 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 1.0 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.8 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 1.6 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 3.1 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 4.2 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 2.8 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 0.9 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.2 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.3 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.1 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.0 1.2 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 4.3 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 6.7 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 5.5 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.2 GO:1990253 positive regulation of TORC1 signaling(GO:1904263) cellular response to leucine starvation(GO:1990253)
0.0 3.0 GO:0001841 neural tube formation(GO:0001841)
0.0 1.3 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.0 1.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 0.9 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.1 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 2.3 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 1.3 GO:0055072 iron ion homeostasis(GO:0055072)
0.0 4.3 GO:0006979 response to oxidative stress(GO:0006979)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 17.3 GO:0031904 endosome lumen(GO:0031904)
1.8 12.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.7 8.4 GO:0044194 cytolytic granule(GO:0044194)
1.5 13.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
1.4 6.9 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.7 40.4 GO:0015030 Cajal body(GO:0015030)
0.7 8.3 GO:0008278 cohesin complex(GO:0008278)
0.6 3.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.4 2.6 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.4 6.1 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.3 2.8 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.3 0.9 GO:0097144 BAX complex(GO:0097144)
0.3 5.5 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.3 4.0 GO:0030126 COPI vesicle coat(GO:0030126)
0.2 4.9 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 4.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 13.3 GO:0099738 cell cortex region(GO:0099738)
0.2 2.7 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 18.4 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 1.9 GO:0035102 PRC1 complex(GO:0035102)
0.1 6.7 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 2.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.6 GO:0097342 ripoptosome(GO:0097342)
0.1 7.9 GO:0016363 nuclear matrix(GO:0016363)
0.1 1.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 65.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 2.4 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 3.2 GO:0005643 nuclear pore(GO:0005643)
0.0 0.2 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.8 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 1.2 GO:0043198 dendritic shaft(GO:0043198)
0.0 16.7 GO:0016604 nuclear body(GO:0016604)
0.0 2.3 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.9 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 28.8 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 6.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.9 GO:0031966 mitochondrial membrane(GO:0031966)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.1 40.4 GO:0008859 exoribonuclease II activity(GO:0008859)
5.7 17.0 GO:0004349 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
3.4 48.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
2.6 7.9 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
2.6 10.3 GO:0008184 glycogen phosphorylase activity(GO:0008184)
2.3 11.5 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
2.0 17.6 GO:0043023 ribosomal large subunit binding(GO:0043023)
1.8 7.2 GO:0004096 catalase activity(GO:0004096)
1.6 19.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
1.6 9.4 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
1.2 3.5 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.9 2.6 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.9 6.9 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.8 3.8 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.7 3.0 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.7 13.2 GO:1990226 histone methyltransferase binding(GO:1990226)
0.7 2.9 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.6 3.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.6 12.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.6 5.3 GO:0042285 xylosyltransferase activity(GO:0042285)
0.5 4.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.5 6.6 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.5 22.4 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.5 12.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.4 3.0 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.4 1.2 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.4 13.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.4 3.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.3 5.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 4.8 GO:0001056 RNA polymerase III activity(GO:0001056)
0.2 2.8 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.2 2.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 5.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 1.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.9 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 2.2 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.1 1.9 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 4.3 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 2.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 1.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 3.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.9 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.9 GO:0051434 BH3 domain binding(GO:0051434)
0.1 7.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 2.2 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 4.0 GO:0016504 peptidase activator activity(GO:0016504)
0.1 1.2 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.1 3.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 2.4 GO:0070273 GTP-dependent protein binding(GO:0030742) phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 0.2 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 3.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.6 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 4.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 26.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 13.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.7 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 1.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 7.8 GO:0003682 chromatin binding(GO:0003682)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 14.2 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.3 8.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2 2.9 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 8.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 1.6 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 2.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 13.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 10.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.4 PID ARF 3PATHWAY Arf1 pathway
0.1 1.8 PID BARD1 PATHWAY BARD1 signaling events
0.1 2.9 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.3 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 3.0 PID P53 REGULATION PATHWAY p53 pathway
0.0 4.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 3.2 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.8 PID IL4 2PATHWAY IL4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 70.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.7 20.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.5 40.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.5 10.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.3 5.6 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.3 9.1 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.3 15.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.3 4.9 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 7.9 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.2 6.7 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.2 9.3 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 17.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 11.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.9 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 3.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 3.2 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.1 2.9 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.1 1.3 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 13.0 REACTOME TRANSLATION Genes involved in Translation
0.1 1.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 2.3 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.1 4.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.6 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.9 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion