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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for E2f7

Z-value: 2.67

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Transcription factors associated with E2f7

Gene Symbol Gene ID Gene Info
E2f7
ENSMUSG00000020185.17 E2f7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f7mm39_v1_chr10_+_110581293_1105814330.791.1e-08Click!

Activity profile of E2f7 motif

Sorted Z-values of E2f7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f7

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_-_76756772 24.12 ENSMUST00000166101.2
Sptb
spectrin beta, erythrocytic
chr8_+_75836187 16.93 ENSMUST00000164309.3
ENSMUST00000212426.2
ENSMUST00000212811.2
Mcm5
minichromosome maintenance complex component 5
chr10_+_115653152 14.50 ENSMUST00000080630.11
ENSMUST00000179196.3
ENSMUST00000035563.15
Tspan8
tetraspanin 8
chr4_+_108436639 13.74 ENSMUST00000102744.4
Orc1
origin recognition complex, subunit 1
chr10_-_69188716 13.73 ENSMUST00000119827.8
ENSMUST00000020099.13
Cdk1
cyclin-dependent kinase 1
chr12_+_24758240 12.91 ENSMUST00000020980.12
Rrm2
ribonucleotide reductase M2
chr12_+_24758968 12.68 ENSMUST00000154588.2
Rrm2
ribonucleotide reductase M2
chr6_-_88875646 12.15 ENSMUST00000058011.8
Mcm2
minichromosome maintenance complex component 2
chr13_-_22017677 10.64 ENSMUST00000081342.7
H2ac24
H2A clustered histone 24
chr13_-_100912308 10.13 ENSMUST00000075550.4
Cenph
centromere protein H
chr11_+_102139671 10.06 ENSMUST00000100392.5
Hrob
homologous recombination factor with OB-fold
chr14_-_20438890 9.93 ENSMUST00000022345.7
Dnajc9
DnaJ heat shock protein family (Hsp40) member C9
chr1_-_128287347 8.80 ENSMUST00000190495.2
ENSMUST00000027601.11
Mcm6
minichromosome maintenance complex component 6
chr12_+_24758724 8.60 ENSMUST00000153058.8
Rrm2
ribonucleotide reductase M2
chr2_+_72306503 7.77 ENSMUST00000102691.11
ENSMUST00000157019.2
Cdca7
cell division cycle associated 7
chr3_+_108291145 7.47 ENSMUST00000090561.10
ENSMUST00000102629.8
ENSMUST00000128089.2
Psrc1
proline/serine-rich coiled-coil 1
chr10_+_11157326 7.23 ENSMUST00000070300.5
Fbxo30
F-box protein 30
chr13_-_55477535 7.16 ENSMUST00000021941.8
Mxd3
Max dimerization protein 3
chr12_+_73333641 7.07 ENSMUST00000153941.8
ENSMUST00000122920.8
ENSMUST00000101313.4
Slc38a6
solute carrier family 38, member 6
chr13_-_22227114 6.85 ENSMUST00000091741.6
H2ac11
H2A clustered histone 11
chr13_+_22227359 6.54 ENSMUST00000110452.2
H2bc11
H2B clustered histone 11
chr6_-_67014383 6.41 ENSMUST00000043098.9
Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr11_+_85202058 6.32 ENSMUST00000020835.16
Ppm1d
protein phosphatase 1D magnesium-dependent, delta isoform
chr17_-_35827676 6.20 ENSMUST00000160885.2
ENSMUST00000159009.2
ENSMUST00000161012.8
Tcf19
transcription factor 19
chr10_+_11157047 5.92 ENSMUST00000129456.8
Fbxo30
F-box protein 30
chr9_+_64188857 5.63 ENSMUST00000215031.2
ENSMUST00000213165.2
ENSMUST00000213289.2
ENSMUST00000216594.2
ENSMUST00000034964.7
Tipin
timeless interacting protein
chr13_-_21937997 5.38 ENSMUST00000074752.4
H2ac15
H2A clustered histone 15
chr2_+_27776428 5.26 ENSMUST00000028280.14
Col5a1
collagen, type V, alpha 1
chr4_+_132495636 4.98 ENSMUST00000102561.11
Rpa2
replication protein A2
chr16_+_38167352 4.87 ENSMUST00000050273.9
ENSMUST00000120495.2
ENSMUST00000119704.2
Cox17
Gm21987
cytochrome c oxidase assembly protein 17, copper chaperone
predicted gene 21987
chr4_+_126450728 4.68 ENSMUST00000048391.15
Clspn
claspin
chr13_+_21994588 4.59 ENSMUST00000091745.6
H2ac23
H2A clustered histone 23
chr13_-_47259652 4.39 ENSMUST00000021807.13
ENSMUST00000135278.8
Dek
DEK proto-oncogene (DNA binding)
chr6_-_67014348 4.30 ENSMUST00000204369.2
Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr2_+_11176891 4.28 ENSMUST00000028118.9
Prkcq
protein kinase C, theta
chr4_+_124608569 4.08 ENSMUST00000030734.5
Sf3a3
splicing factor 3a, subunit 3
chr11_-_70300836 4.00 ENSMUST00000019065.10
ENSMUST00000135148.2
Pelp1
proline, glutamic acid and leucine rich protein 1
chr13_-_21967540 3.94 ENSMUST00000189457.2
H3c11
H3 clustered histone 11
chr13_+_21900554 3.79 ENSMUST00000070124.5
H2ac13
H2A clustered histone 13
chr13_+_21938258 3.70 ENSMUST00000091709.3
H2bc15
H2B clustered histone 15
chr13_+_22220000 3.69 ENSMUST00000110455.4
H2bc12
H2B clustered histone 12
chr4_+_98812047 3.67 ENSMUST00000030289.9
Usp1
ubiquitin specific peptidase 1
chr15_-_27681584 3.53 ENSMUST00000226145.2
ENSMUST00000226170.2
Otulinl
OTU deubiquitinase with linear linkage specificity like
chr4_+_98812082 3.48 ENSMUST00000091358.11
Usp1
ubiquitin specific peptidase 1
chr13_-_22219738 3.35 ENSMUST00000091742.6
H2ac12
H2A clustered histone 12
chr11_-_87295292 3.23 ENSMUST00000067692.13
Rad51c
RAD51 paralog C
chr7_+_27869115 3.18 ENSMUST00000042405.8
Fbl
fibrillarin
chr1_+_74545203 3.13 ENSMUST00000087215.7
Cnot9
CCR4-NOT transcription complex, subunit 9
chr4_-_108436514 2.89 ENSMUST00000079213.6
Prpf38a
PRP38 pre-mRNA processing factor 38 (yeast) domain containing A
chr15_-_81756076 2.76 ENSMUST00000023117.10
Phf5a
PHD finger protein 5A
chr12_+_116369017 2.70 ENSMUST00000084828.5
ENSMUST00000222469.2
ENSMUST00000221114.2
ENSMUST00000221970.2
Ncapg2
non-SMC condensin II complex, subunit G2
chr1_-_74544946 2.65 ENSMUST00000044260.11
ENSMUST00000186282.7
Usp37
ubiquitin specific peptidase 37
chr17_+_35069347 2.64 ENSMUST00000097343.11
ENSMUST00000173357.8
ENSMUST00000173065.8
ENSMUST00000165953.3
Nelfe
negative elongation factor complex member E, Rdbp
chr12_-_11315755 2.59 ENSMUST00000166117.4
ENSMUST00000219600.2
ENSMUST00000218487.2
Gen1
GEN1, Holliday junction 5' flap endonuclease
chr16_+_76810588 2.50 ENSMUST00000239066.2
ENSMUST00000023580.8
Usp25
ubiquitin specific peptidase 25
chrX_-_73009933 2.47 ENSMUST00000114372.3
ENSMUST00000033761.13
Hcfc1
host cell factor C1
chr13_-_97334859 2.44 ENSMUST00000022169.10
Hexb
hexosaminidase B
chr7_-_28297565 2.44 ENSMUST00000040531.9
ENSMUST00000108283.8
Samd4b
Pak4
sterile alpha motif domain containing 4B
p21 (RAC1) activated kinase 4
chr18_+_44237474 2.41 ENSMUST00000081271.7
Spink12
serine peptidase inhibitor, Kazal type 12
chr18_+_44237577 2.35 ENSMUST00000239465.2
Spink12
serine peptidase inhibitor, Kazal type 12
chr11_-_95733235 2.28 ENSMUST00000059026.10
Abi3
ABI family member 3
chr7_+_44465806 2.24 ENSMUST00000207103.2
ENSMUST00000118125.9
Nup62
Il4i1
nucleoporin 62
interleukin 4 induced 1
chr9_+_46194293 2.16 ENSMUST00000074957.5
Bud13
BUD13 homolog
chr4_+_94627513 2.08 ENSMUST00000073939.13
ENSMUST00000102798.8
Tek
TEK receptor tyrosine kinase
chr6_-_113717689 1.93 ENSMUST00000032440.6
Sec13
SEC13 homolog, nuclear pore and COPII coat complex component
chr1_+_180396478 1.76 ENSMUST00000027777.12
Parp1
poly (ADP-ribose) polymerase family, member 1
chr7_+_44465714 1.73 ENSMUST00000208172.2
Nup62
nucleoporin 62
chr13_-_21934675 1.71 ENSMUST00000102983.2
H4c12
H4 clustered histone 12
chr7_-_4687916 1.61 ENSMUST00000206306.2
ENSMUST00000205952.2
ENSMUST00000079970.6
Hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr13_+_23758555 1.60 ENSMUST00000090776.7
H2ac7
H2A clustered histone 7
chr7_+_27869192 1.58 ENSMUST00000208967.2
Fbl
fibrillarin
chr9_+_3017408 1.55 ENSMUST00000099049.4
Gm10719
predicted gene 10719
chr15_+_97990431 1.54 ENSMUST00000229280.2
ENSMUST00000163507.8
ENSMUST00000230445.2
Pfkm
phosphofructokinase, muscle
chr11_+_26337194 1.50 ENSMUST00000136830.2
ENSMUST00000109509.8
Fancl
Fanconi anemia, complementation group L
chr15_-_97991114 1.36 ENSMUST00000180657.2
Senp1
SUMO1/sentrin specific peptidase 1
chr9_+_3013140 1.34 ENSMUST00000143083.3
Gm10721
predicted gene 10721
chr6_-_30509705 1.33 ENSMUST00000064330.13
ENSMUST00000102991.9
ENSMUST00000115157.8
ENSMUST00000148638.2
Tmem209
transmembrane protein 209
chr3_-_143908111 1.32 ENSMUST00000121796.8
Lmo4
LIM domain only 4
chr15_-_27681643 1.31 ENSMUST00000100739.5
Otulinl
OTU deubiquitinase with linear linkage specificity like
chr11_+_87018079 1.28 ENSMUST00000139532.2
Trim37
tripartite motif-containing 37
chr17_+_13135216 1.21 ENSMUST00000089024.13
ENSMUST00000151287.8
Tcp1
t-complex protein 1
chr2_+_112092271 1.20 ENSMUST00000028553.4
Nop10
NOP10 ribonucleoprotein
chr9_+_3015654 1.19 ENSMUST00000099050.4
Gm10720
predicted gene 10720
chr3_-_143908060 1.10 ENSMUST00000121112.6
Lmo4
LIM domain only 4
chr11_-_77404160 1.05 ENSMUST00000060417.11
Trp53i13
transformation related protein 53 inducible protein 13
chr9_+_3025417 1.03 ENSMUST00000075573.7
Gm10717
predicted gene 10717
chr13_-_21900313 1.01 ENSMUST00000091756.2
H2bc13
H2B clustered histone 13
chr3_+_60408678 0.90 ENSMUST00000191747.6
ENSMUST00000194069.6
Mbnl1
muscleblind like splicing factor 1
chr2_-_157046386 0.83 ENSMUST00000029170.8
Rbl1
RB transcriptional corepressor like 1
chr11_-_40583493 0.82 ENSMUST00000040167.11
Mat2b
methionine adenosyltransferase II, beta
chr11_+_87938128 0.78 ENSMUST00000139129.9
Srsf1
serine and arginine-rich splicing factor 1
chr9_+_3037111 0.74 ENSMUST00000177969.2
Gm10715
predicted gene 10715
chr3_+_88439616 0.67 ENSMUST00000172699.2
Mex3a
mex3 RNA binding family member A
chr17_+_35827997 0.66 ENSMUST00000164242.9
ENSMUST00000045956.14
Cchcr1
coiled-coil alpha-helical rod protein 1
chr17_-_35069136 0.60 ENSMUST00000046022.16
Skiv2l
superkiller viralicidic activity 2-like (S. cerevisiae)
chr14_+_79689230 0.60 ENSMUST00000100359.3
ENSMUST00000226192.2
Kbtbd6
kelch repeat and BTB (POZ) domain containing 6
chr3_-_105594865 0.57 ENSMUST00000090680.11
Ddx20
DEAD box helicase 20
chr15_-_79430942 0.54 ENSMUST00000054014.9
ENSMUST00000229877.2
Ddx17
DEAD box helicase 17
chr16_-_45352346 0.53 ENSMUST00000232600.2
Gm17783
predicted gene, 17783
chr6_+_56809044 0.52 ENSMUST00000031795.8
Fkbp9
FK506 binding protein 9
chr1_-_190915441 0.51 ENSMUST00000027941.14
Atf3
activating transcription factor 3
chr3_+_103187162 0.51 ENSMUST00000106860.6
Trim33
tripartite motif-containing 33
chr9_-_111100859 0.50 ENSMUST00000035079.10
Mlh1
mutL homolog 1
chr4_+_33062999 0.48 ENSMUST00000108162.8
ENSMUST00000024035.9
Gabrr2
gamma-aminobutyric acid (GABA) C receptor, subunit rho 2
chr6_+_113054592 0.46 ENSMUST00000113157.8
Setd5
SET domain containing 5
chr4_+_98812144 0.41 ENSMUST00000169053.2
Usp1
ubiquitin specific peptidase 1
chr11_-_69451012 0.35 ENSMUST00000004036.6
Efnb3
ephrin B3
chr17_+_38143840 0.33 ENSMUST00000213857.2
Olfr125
olfactory receptor 125
chr7_+_92210348 0.33 ENSMUST00000032842.13
ENSMUST00000085017.5
Ccdc90b
coiled-coil domain containing 90B
chr2_+_130509530 0.31 ENSMUST00000103193.5
Itpa
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
chr11_-_69214593 0.27 ENSMUST00000092973.6
Cntrob
centrobin, centrosomal BRCA2 interacting protein
chr12_-_73333472 0.20 ENSMUST00000116420.4
ENSMUST00000221189.2
Trmt5
TRM5 tRNA methyltransferase 5
chr9_+_111100893 0.20 ENSMUST00000135807.2
ENSMUST00000060711.8
Epm2aip1
EPM2A (laforin) interacting protein 1
chr8_-_106074585 0.17 ENSMUST00000014922.5
Fhod1
formin homology 2 domain containing 1
chrX_+_151789457 0.15 ENSMUST00000095755.4
Usp51
ubiquitin specific protease 51
chr6_-_30509737 0.14 ENSMUST00000154547.3
ENSMUST00000115160.10
Tmem209
transmembrane protein 209
chr11_-_6394352 0.14 ENSMUST00000093346.6
H2az2
H2A.Z histone variant 2
chr16_-_37205302 0.13 ENSMUST00000114781.8
ENSMUST00000114780.8
Stxbp5l
syntaxin binding protein 5-like
chr13_-_21994366 0.13 ENSMUST00000091749.4
H2bc23
H2B clustered histone 23
chr10_+_59538467 0.12 ENSMUST00000171409.8
Micu1
mitochondrial calcium uptake 1
chr17_+_28910302 0.12 ENSMUST00000004990.14
ENSMUST00000114754.8
ENSMUST00000062694.16
Mapk14
mitogen-activated protein kinase 14
chr3_+_88049633 0.07 ENSMUST00000001455.13
ENSMUST00000119251.8
Mef2d
myocyte enhancer factor 2D
chr4_+_94627755 0.05 ENSMUST00000071168.6
Tek
TEK receptor tyrosine kinase
chr1_+_172348611 0.04 ENSMUST00000085894.12
ENSMUST00000161140.8
ENSMUST00000162988.8
Cfap45
cilia and flagella associated protein 45
chr5_-_92496730 0.03 ENSMUST00000038816.13
ENSMUST00000118006.3
Cxcl10
chemokine (C-X-C motif) ligand 10

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.7 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
1.7 20.9 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.6 4.9 GO:1904959 regulation of cytochrome-c oxidase activity(GO:1904959)
1.6 4.8 GO:0000494 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
1.5 34.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.3 5.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
1.1 12.4 GO:0090166 Golgi disassembly(GO:0090166)
1.1 5.6 GO:0048478 replication fork protection(GO:0048478)
0.8 2.4 GO:0098749 cerebellar neuron development(GO:0098749)
0.8 10.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.7 4.0 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.6 3.2 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.6 7.6 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.6 2.5 GO:0019046 release from viral latency(GO:0019046)
0.6 1.8 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.5 4.4 GO:0044838 cell quiescence(GO:0044838)
0.5 4.3 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
0.5 4.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.5 24.1 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.5 3.1 GO:2000327 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.5 16.9 GO:0006270 DNA replication initiation(GO:0006270)
0.4 2.1 GO:0048014 Tie signaling pathway(GO:0048014)
0.4 8.2 GO:0051382 kinetochore assembly(GO:0051382)
0.4 6.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.3 2.4 GO:0007341 penetration of zona pellucida(GO:0007341)
0.3 1.5 GO:0061622 glycolytic process through glucose-1-phosphate(GO:0061622)
0.3 2.6 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.2 0.5 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic metaphase plate congression(GO:0051311)
0.2 2.6 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.2 1.2 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.2 5.0 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.2 14.5 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.2 1.3 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.2 6.2 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.2 2.7 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.2 7.5 GO:0060236 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.1 2.4 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.1 0.8 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 9.9 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 0.5 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 2.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 2.5 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 1.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 1.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724) protein desumoylation(GO:0016926)
0.1 4.0 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 0.8 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.3 GO:1902410 mitotic cytokinetic process(GO:1902410)
0.1 3.8 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 0.6 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.1 0.2 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.3 GO:0009146 purine nucleoside triphosphate catabolic process(GO:0009146)
0.0 0.5 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.3 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.2 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.2 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.2 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 0.0 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.0 4.8 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.8 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 1.6 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 1.2 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 0.1 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 34.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
3.0 24.1 GO:0008091 spectrin(GO:0008091)
2.4 25.9 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
1.8 5.3 GO:0005588 collagen type V trimer(GO:0005588)
1.6 23.5 GO:0042555 MCM complex(GO:0042555)
0.8 5.6 GO:0031298 replication fork protection complex(GO:0031298)
0.7 2.6 GO:0032021 NELF complex(GO:0032021)
0.6 3.2 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.6 4.8 GO:0001652 dense fibrillar component(GO:0001651) granular component(GO:0001652)
0.4 4.0 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.3 5.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.3 1.5 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.3 21.2 GO:0005876 spindle microtubule(GO:0005876)
0.3 1.2 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.3 0.8 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.2 2.7 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.2 2.7 GO:0000796 condensin complex(GO:0000796)
0.2 4.0 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 0.6 GO:0055087 Ski complex(GO:0055087)
0.2 1.9 GO:0061700 GATOR2 complex(GO:0061700)
0.2 0.5 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.2 0.5 GO:0005715 chiasma(GO:0005712) late recombination nodule(GO:0005715)
0.1 5.7 GO:0071011 precatalytic spliceosome(GO:0071011)
0.1 2.4 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 2.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 5.6 GO:0016235 aggresome(GO:0016235)
0.1 1.5 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 5.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.6 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 8.2 GO:0000776 kinetochore(GO:0000776)
0.0 4.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 7.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.5 GO:0000502 proteasome complex(GO:0000502)
0.0 2.1 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.8 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 4.4 GO:0043292 contractile fiber(GO:0043292)
0.0 14.5 GO:0009986 cell surface(GO:0009986)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 34.2 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.6 29.1 GO:0003688 DNA replication origin binding(GO:0003688)
1.6 4.8 GO:0036009 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
1.4 10.1 GO:0043515 kinetochore binding(GO:0043515)
1.3 6.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.7 2.2 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.7 5.8 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.7 4.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.5 13.7 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.5 24.1 GO:0030506 ankyrin binding(GO:0030506)
0.5 2.4 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.5 4.9 GO:0016531 copper chaperone activity(GO:0016531)
0.4 5.0 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.3 1.4 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.3 5.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 1.5 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.2 1.7 GO:0051425 PTB domain binding(GO:0051425)
0.2 8.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 2.5 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.2 1.8 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.2 4.3 GO:0004697 protein kinase C activity(GO:0004697)
0.2 1.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 0.5 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.1 0.8 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 0.3 GO:0035870 dITP diphosphatase activity(GO:0035870)
0.1 10.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 2.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 0.9 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 14.5 GO:0005178 integrin binding(GO:0005178)
0.1 3.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.5 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 9.4 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 2.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 15.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.7 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 6.9 GO:0031072 heat shock protein binding(GO:0031072)
0.0 4.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 3.8 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 1.7 GO:0008026 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) ATP-dependent helicase activity(GO:0008026) RNA-dependent ATPase activity(GO:0008186) purine NTP-dependent helicase activity(GO:0070035)
0.0 0.5 GO:0070410 co-SMAD binding(GO:0070410)
0.0 7.5 GO:0008017 microtubule binding(GO:0008017)
0.0 5.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 13.2 GO:0003682 chromatin binding(GO:0003682)
0.0 0.5 GO:0004890 GABA-A receptor activity(GO:0004890)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 13.7 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5 27.0 PID ATR PATHWAY ATR signaling pathway
0.4 46.2 PID E2F PATHWAY E2F transcription factor network
0.3 9.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 10.7 PID AURORA A PATHWAY Aurora A signaling
0.1 5.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.5 PID P53 REGULATION PATHWAY p53 pathway
0.1 9.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.0 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 4.0 PID ENDOTHELIN PATHWAY Endothelins
0.1 1.8 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 4.6 PID SHP2 PATHWAY SHP2 signaling
0.0 2.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.4 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.5 PID ATF2 PATHWAY ATF-2 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 37.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
2.5 59.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.6 7.6 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.5 24.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 10.1 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 5.0 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 2.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 4.3 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.1 2.1 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 4.0 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 1.5 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 1.9 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 4.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 5.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.6 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 1.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 5.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 3.2 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.5 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.7 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.5 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport