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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Evx2

Z-value: 0.33

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Transcription factors associated with Evx2

Gene Symbol Gene ID Gene Info
ENSMUSG00000001815.16 Evx2

Activity profile of Evx2 motif

Sorted Z-values of Evx2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Evx2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr2_-_154916367 1.26 ENSMUST00000137242.2
ENSMUST00000054607.16
S-adenosylhomocysteine hydrolase
chr1_+_36800874 1.03 ENSMUST00000027291.7
zeta-chain (TCR) associated protein kinase
chr7_-_48493388 0.92 ENSMUST00000167786.4
cysteine and glycine-rich protein 3
chr7_+_51528788 0.82 ENSMUST00000107591.9
growth arrest specific 2
chr6_+_116627635 0.59 ENSMUST00000204555.2
DEPP1 autophagy regulator
chr14_-_64654397 0.58 ENSMUST00000210428.2
methionine sulfoxide reductase A
chr11_-_113600346 0.54 ENSMUST00000173655.8
ENSMUST00000100248.6
cleavage and polyadenylation specific factor 4-like
chr9_-_107556823 0.52 ENSMUST00000010205.9
guanine nucleotide binding protein, alpha transducing 1
chr10_-_128425519 0.49 ENSMUST00000082059.7
erb-b2 receptor tyrosine kinase 3
chr2_-_132089667 0.42 ENSMUST00000110163.8
ENSMUST00000180286.2
ENSMUST00000028816.9
transmembrane protein 230
chr9_+_47441471 0.39 ENSMUST00000114548.8
ENSMUST00000152459.8
ENSMUST00000143026.9
ENSMUST00000085909.9
ENSMUST00000114547.8
ENSMUST00000239368.2
ENSMUST00000214542.2
ENSMUST00000034581.4
cell adhesion molecule 1
chr11_-_113600838 0.35 ENSMUST00000018871.8
cleavage and polyadenylation specific factor 4-like
chr1_+_91729175 0.31 ENSMUST00000007949.4
ENSMUST00000186075.2
twist basic helix-loop-helix transcription factor 2
chr2_+_91087668 0.29 ENSMUST00000111349.9
ENSMUST00000131711.8
protein kinase C and casein kinase substrate in neurons 3
chrX_+_57075981 0.29 ENSMUST00000088627.11
zinc finger protein of the cerebellum 3
chrM_+_10167 0.28 ENSMUST00000082414.1
mitochondrially encoded NADH dehydrogenase 4
chr10_+_39488930 0.28 ENSMUST00000019987.7
TRAF3 interacting protein 2
chr9_-_50472605 0.27 ENSMUST00000034568.7
testis expressed 12
chr11_+_116734104 0.27 ENSMUST00000106370.10
methyltransferase like 23
chr7_+_141503411 0.27 ENSMUST00000078200.12
ENSMUST00000018971.15
BR serine/threonine kinase 2
chr4_+_100336003 0.26 ENSMUST00000133493.9
ENSMUST00000092730.5
ubiquitin-conjugating enzyme E2U (putative)
chr2_+_91087156 0.26 ENSMUST00000144394.8
ENSMUST00000028694.12
ENSMUST00000168916.8
ENSMUST00000156919.8
protein kinase C and casein kinase substrate in neurons 3
chr9_-_50472620 0.26 ENSMUST00000217236.2
testis expressed 12
chr14_-_36820304 0.23 ENSMUST00000022337.11
cadherin-related family member 1
chrX_+_57076359 0.22 ENSMUST00000088631.11
ENSMUST00000088629.4
zinc finger protein of the cerebellum 3
chr16_-_45544960 0.22 ENSMUST00000096057.5
transgelin 3
chr11_-_61157986 0.22 ENSMUST00000066277.10
ENSMUST00000074127.14
ENSMUST00000108715.3
aldehyde dehydrogenase family 3, subfamily A2
chr10_+_80538115 0.21 ENSMUST00000218184.2
IZUMO family member 4
chr18_+_12874390 0.21 ENSMUST00000121018.8
ENSMUST00000119108.8
ENSMUST00000186263.2
ENSMUST00000191078.7
calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)
chr7_-_24423715 0.21 ENSMUST00000081657.6
Ly6/PLAUR domain containing 11
chr4_-_42661893 0.20 ENSMUST00000108006.4
interleukin 11 receptor, alpha chain 2
chr19_+_5138562 0.20 ENSMUST00000238093.2
ENSMUST00000025811.6
ENSMUST00000237025.2
Yip1 interacting factor homolog A (S. cerevisiae)
chr7_+_141503583 0.19 ENSMUST00000172652.8
BR serine/threonine kinase 2
chr2_-_84545504 0.18 ENSMUST00000035840.6
zinc finger, DHHC domain containing 5
chr18_+_24737009 0.17 ENSMUST00000234266.2
ENSMUST00000025120.8
elongator acetyltransferase complex subunit 2
chr3_+_63148887 0.17 ENSMUST00000194324.6
membrane metallo endopeptidase
chr1_+_172383499 0.16 ENSMUST00000061835.10
V-set and immunoglobulin domain containing 8
chr6_+_122603369 0.15 ENSMUST00000049644.9
developmental pluripotency-associated 3
chr14_-_59602882 0.15 ENSMUST00000160425.8
ENSMUST00000095157.11
PHD finger protein 11D
chr14_-_59602859 0.15 ENSMUST00000161031.2
PHD finger protein 11D
chrM_+_7758 0.14 ENSMUST00000082407.1
mitochondrially encoded ATP synthase 8
chr3_-_129518723 0.12 ENSMUST00000199615.5
ENSMUST00000197079.5
epidermal growth factor
chr6_-_68968278 0.12 ENSMUST00000197966.2
immunoglobulin kappa variable 4-81
chr14_-_44987797 0.11 ENSMUST00000226900.2
predicted gene 8267
chr11_-_65160810 0.11 ENSMUST00000108695.9
myocardin
chrX_-_110446022 0.11 ENSMUST00000156639.2
ribosomal protein S6 kinase polypeptide 6
chr6_-_69394425 0.11 ENSMUST00000199160.2
immunoglobulin kappa chain variable 4-61
chrM_+_7779 0.10 ENSMUST00000082408.1
mitochondrially encoded ATP synthase 6
chr16_+_91184661 0.10 ENSMUST00000139503.2
interferon (alpha and beta) receptor 2
chr10_-_128885867 0.10 ENSMUST00000216460.2
olfactory receptor 765
chr8_+_114362181 0.10 ENSMUST00000179926.9
MON1 homolog B, secretory traffciking associated
chr17_-_37409147 0.10 ENSMUST00000216376.2
ENSMUST00000217372.2
olfactory receptor 91
chr19_-_5610628 0.10 ENSMUST00000025861.3
ovo like zinc finger 1
chr2_+_167345009 0.09 ENSMUST00000078050.7
ring finger protein 114
chr11_+_116547932 0.09 ENSMUST00000116318.3
photoreceptor disc component
chr6_-_69261303 0.08 ENSMUST00000103349.2
immunoglobulin kappa variable 4-69
chr1_-_92423800 0.08 ENSMUST00000204766.2
ENSMUST00000204009.3
olfactory receptor 1415
chr8_+_114362419 0.08 ENSMUST00000035777.10
MON1 homolog B, secretory traffciking associated
chr3_-_15640045 0.08 ENSMUST00000192382.6
ENSMUST00000195778.3
ENSMUST00000091319.7
signal-regulatory protein beta 1B
chr17_+_46807637 0.08 ENSMUST00000046497.8
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr2_-_86208737 0.08 ENSMUST00000217435.2
olfactory receptor 1057
chr6_-_69678271 0.07 ENSMUST00000103363.2
immunoglobulin kappa variable 4-50
chr3_-_151541603 0.07 ENSMUST00000106126.2
prostaglandin F receptor
chr6_-_69377328 0.07 ENSMUST00000198345.2
immunoglobulin kappa variable 4-62
chr2_-_164427367 0.07 ENSMUST00000109342.2
WAP four-disulfide core domain 6A
chr3_-_15491482 0.07 ENSMUST00000099201.9
ENSMUST00000194144.3
ENSMUST00000192700.3
signal-regulatory protein beta 1A
chr6_-_124756645 0.07 ENSMUST00000147669.2
ENSMUST00000128697.8
ENSMUST00000032218.10
ENSMUST00000112475.9
leucine rich repeat containing 23
chr17_+_38143840 0.07 ENSMUST00000213857.2
olfactory receptor 125
chr7_+_6225277 0.07 ENSMUST00000072662.12
ENSMUST00000155314.2
zinc finger and SCAN domain containing 5B
chr1_+_135768409 0.07 ENSMUST00000189826.7
troponin T2, cardiac
chr11_-_65160767 0.06 ENSMUST00000102635.10
myocardin
chr17_-_36773221 0.06 ENSMUST00000169950.2
ENSMUST00000057502.14
histocompatibility 2, M region locus 10.4
chr12_+_52746158 0.06 ENSMUST00000095737.5
A kinase (PRKA) anchor protein 6
chr7_+_6441687 0.06 ENSMUST00000218906.2
olfactory receptor 1344
chr16_+_3648742 0.06 ENSMUST00000214238.2
ENSMUST00000214590.2
olfactory receptor 15
chr15_-_9529898 0.05 ENSMUST00000228782.2
ENSMUST00000003981.6
interleukin 7 receptor
chr6_-_69355456 0.05 ENSMUST00000196595.2
immunoglobulin kappa variable 4-63
chr7_+_114342929 0.05 ENSMUST00000161800.2
INSC spindle orientation adaptor protein
chr11_-_120269517 0.05 ENSMUST00000026448.10
Fanconi anemia core complex associated protein 100
chr3_+_94744844 0.05 ENSMUST00000107270.9
pogo transposable element with ZNF domain
chr6_-_69162381 0.05 ENSMUST00000103344.3
immunoglobulin kappa variable 4-74
chr2_+_118877610 0.04 ENSMUST00000153300.8
ENSMUST00000028799.12
kinetochore scaffold 1
chr1_-_92412835 0.04 ENSMUST00000214928.3
olfactory receptor 1416
chr14_+_73411249 0.04 ENSMUST00000166875.2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr6_-_68994064 0.04 ENSMUST00000103341.4
immunoglobulin kappa variable 4-80
chr13_+_38388904 0.03 ENSMUST00000091641.13
ENSMUST00000178564.2
small nuclear ribonucleoprotein 48 (U11/U12)
chr7_-_86016045 0.03 ENSMUST00000213255.2
ENSMUST00000216700.2
ENSMUST00000213869.2
olfactory receptor 305
chr19_-_13827773 0.03 ENSMUST00000215350.2
olfactory receptor 1501
chr5_-_84565218 0.03 ENSMUST00000113401.4
Eph receptor A5
chr19_-_13828056 0.03 ENSMUST00000208493.3
olfactory receptor 1501
chr17_+_88748139 0.03 ENSMUST00000112238.9
ENSMUST00000155640.2
forkhead box N2
chr14_+_53521353 0.03 ENSMUST00000103625.3
T cell receptor alpha variable 3N-3
chr10_+_70010839 0.02 ENSMUST00000156001.8
ENSMUST00000135607.2
coiled-coil domain containing 6
chr7_+_12700030 0.02 ENSMUST00000210619.2
zinc finger protein 324
chr6_-_69204417 0.02 ENSMUST00000103346.3
immunoglobulin kappa chain variable 4-72
chr10_+_112151245 0.02 ENSMUST00000218445.2
potassium voltage gated channel, Shaw-related subfamily, member 2
chrX_-_166907286 0.02 ENSMUST00000239138.2
FERM and PDZ domain containing 4
chr19_+_41921903 0.02 ENSMUST00000224258.2
ENSMUST00000026154.9
ENSMUST00000224896.2
zinc finger, DHHC domain containing 16
chr11_-_6217718 0.01 ENSMUST00000004507.11
ENSMUST00000151446.2
DEAD box helicase 56
chr17_-_37430949 0.01 ENSMUST00000214994.2
ENSMUST00000216341.2
olfactory receptor 92
chr2_-_111820618 0.01 ENSMUST00000216948.2
ENSMUST00000214935.2
ENSMUST00000217452.2
ENSMUST00000215045.2
olfactory receptor 1309
chr7_+_29515485 0.01 ENSMUST00000178162.3
ENSMUST00000032796.14
zinc finger protein 790
chr6_-_68887922 0.01 ENSMUST00000103337.3
immunoglobulin kappa variable 4-86
chr2_-_86257093 0.01 ENSMUST00000217481.2
olfactory receptor 1062
chr17_+_37148015 0.01 ENSMUST00000179968.8
ENSMUST00000130367.8
ENSMUST00000053434.15
ENSMUST00000130801.8
ENSMUST00000144182.8
ENSMUST00000123715.8
tripartite motif-containing 26
chr19_+_12364643 0.01 ENSMUST00000217062.3
ENSMUST00000216145.2
ENSMUST00000213657.2
olfactory receptor 1440
chr15_-_102275403 0.00 ENSMUST00000229464.2
Sp7 transcription factor 7
chr6_-_69020489 0.00 ENSMUST00000103342.4
immunoglobulin kappa variable 4-79
chr6_-_69245427 0.00 ENSMUST00000103348.3
immunoglobulin kappa chain variable 4-70
chr17_+_17622934 0.00 ENSMUST00000115576.3
limb and CNS expressed 1
chr2_-_86109346 0.00 ENSMUST00000217294.2
ENSMUST00000217245.2
ENSMUST00000216432.2
olfactory receptor 1051

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.3 0.9 GO:1903920 positive regulation of actin filament severing(GO:1903920)
0.2 1.0 GO:0043366 beta selection(GO:0043366)
0.1 0.5 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.1 0.5 GO:0051342 sensory perception of umami taste(GO:0050917) regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342)
0.1 0.9 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 0.4 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.5 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.2 GO:0006714 sesquiterpenoid metabolic process(GO:0006714) phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173)
0.1 0.2 GO:0019085 early viral transcription(GO:0019085)
0.1 0.2 GO:2000722 regulation of phenotypic switching(GO:1900239) negative regulation of vascular associated smooth muscle cell migration(GO:1904753) regulation of cardiac vascular smooth muscle cell differentiation(GO:2000722) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.0 0.2 GO:1901536 negative regulation of DNA demethylation(GO:1901536)
0.0 0.1 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.3 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.0 0.2 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.1 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.6 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.1 GO:1900127 positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.0 0.1 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.0 0.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.3 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0000801 central element(GO:0000801)
0.0 0.9 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.3 GO:0033503 HULC complex(GO:0033503)
0.0 1.0 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0070852 cell body fiber(GO:0070852)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.2 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.2 GO:0001940 male pronucleus(GO:0001940)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.6 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 0.9 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 0.2 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0 0.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.1 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904) type I interferon receptor activity(GO:0004905) type I interferon binding(GO:0019962)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 1.0 GO:0001784 phosphotyrosine binding(GO:0001784)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.5 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 1.0 PID PI3KCI PATHWAY Class I PI3K signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation