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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Foxa2_Foxa1

Z-value: 2.75

Motif logo

Transcription factors associated with Foxa2_Foxa1

Gene Symbol Gene ID Gene Info
ENSMUSG00000037025.12 Foxa2
ENSMUSG00000035451.8 Foxa1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxa2mm39_v1_chr2_-_147888816_1478889120.821.1e-09Click!
Foxa1mm39_v1_chr12_-_57592907_575929260.511.3e-03Click!

Activity profile of Foxa2_Foxa1 motif

Sorted Z-values of Foxa2_Foxa1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxa2_Foxa1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr3_-_113166153 25.35 ENSMUST00000098673.5
amylase 2a5
chr6_+_30541581 25.27 ENSMUST00000096066.5
carboxypeptidase A2, pancreatic
chr17_-_31363245 23.03 ENSMUST00000024826.8
trefoil factor 2 (spasmolytic protein 1)
chr3_-_20329823 21.99 ENSMUST00000011607.6
carboxypeptidase B1 (tissue)
chr9_+_46179899 20.34 ENSMUST00000121598.8
apolipoprotein A-V
chr7_+_140343652 15.99 ENSMUST00000026552.9
ENSMUST00000209253.2
ENSMUST00000210235.2
cytochrome P450, family 2, subfamily e, polypeptide 1
chr1_-_130589321 14.75 ENSMUST00000137276.3
complement component 4 binding protein
chr14_-_52151537 14.51 ENSMUST00000227402.2
ENSMUST00000227237.2
N-myc downstream regulated gene 2
chr1_-_130589349 14.32 ENSMUST00000027657.14
complement component 4 binding protein
chr7_+_130633776 13.88 ENSMUST00000084509.7
ENSMUST00000213064.3
ENSMUST00000208311.4
deleted in malignant brain tumors 1
chr4_-_57916283 13.00 ENSMUST00000063816.6
RIKEN cDNA D630039A03 gene
chr3_-_113325938 12.32 ENSMUST00000132353.2
amylase 2a1
chr17_+_25097199 12.27 ENSMUST00000050714.8
insulin-like growth factor binding protein, acid labile subunit
chr15_+_10224052 12.06 ENSMUST00000128450.8
ENSMUST00000148257.8
ENSMUST00000128921.8
prolactin receptor
chr5_-_89605622 11.15 ENSMUST00000049209.13
vitamin D binding protein
chr2_-_134396268 10.40 ENSMUST00000028704.3
hydroxyacid oxidase 1, liver
chr15_-_96929086 9.89 ENSMUST00000230086.2
solute carrier family 38, member 4
chr17_-_12894716 9.76 ENSMUST00000024596.10
solute carrier family 22 (organic cation transporter), member 1
chr4_-_6275629 9.71 ENSMUST00000029905.2
cytochrome P450, family 7, subfamily a, polypeptide 1
chr6_-_136899167 9.17 ENSMUST00000032343.7
endoplasmic reticulum protein 27
chr17_+_12597490 8.96 ENSMUST00000014578.7
plasminogen
chr12_-_81014849 8.87 ENSMUST00000095572.5
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr12_-_81014755 8.80 ENSMUST00000218342.2
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr7_-_126651847 8.65 ENSMUST00000205424.2
zymogen granule protein 16
chr12_-_103871146 8.20 ENSMUST00000074051.6
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr13_+_4099001 7.72 ENSMUST00000118717.10
aldo-keto reductase family 1, member C14
chr19_+_23118545 7.67 ENSMUST00000036884.3
Kruppel-like factor 9
chr4_+_150938376 7.54 ENSMUST00000073600.9
ERBB receptor feedback inhibitor 1
chr2_+_58645189 7.41 ENSMUST00000102755.4
ENSMUST00000230627.2
ENSMUST00000229923.2
uridine phosphorylase 2
chr3_+_20011405 6.97 ENSMUST00000108325.9
ceruloplasmin
chr6_+_129510331 6.93 ENSMUST00000204956.2
ENSMUST00000204639.2
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr12_+_8027767 6.86 ENSMUST00000037520.14
apolipoprotein B
chr10_-_95678786 6.69 ENSMUST00000211096.2
predicted gene, 33543
chr12_+_8027640 6.61 ENSMUST00000171271.8
ENSMUST00000037811.13
apolipoprotein B
chr7_-_105249308 6.59 ENSMUST00000210531.2
ENSMUST00000033185.10
hemopexin
chr10_+_111342147 6.57 ENSMUST00000164773.2
pleckstrin homology like domain, family A, member 1
chr15_-_96918203 6.57 ENSMUST00000166223.2
solute carrier family 38, member 4
chr16_+_22710785 6.34 ENSMUST00000023583.7
ENSMUST00000232098.2
alpha-2-HS-glycoprotein
chr10_+_87697155 6.26 ENSMUST00000122100.3
insulin-like growth factor 1
chr6_+_129510117 6.14 ENSMUST00000032264.9
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr2_+_58644922 6.04 ENSMUST00000059102.13
uridine phosphorylase 2
chr8_-_45747883 6.02 ENSMUST00000026907.6
kallikrein B, plasma 1
chr3_+_107137924 6.00 ENSMUST00000179399.3
RIKEN cDNA A630076J17 gene
chr10_-_95678748 5.99 ENSMUST00000210336.2
predicted gene, 33543
chr6_+_129510145 5.77 ENSMUST00000204487.3
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr6_-_23132977 5.68 ENSMUST00000031707.14
aminoadipate-semialdehyde synthase
chr9_-_107546195 5.61 ENSMUST00000192990.6
solute carrier family 38, member 3
chr3_+_122277372 5.56 ENSMUST00000197073.2
breast cancer anti-estrogen resistance 3
chr5_-_87054796 5.28 ENSMUST00000031181.16
ENSMUST00000113333.2
UDP glucuronosyltransferase 2 family, polypeptide B34
chr10_+_23727325 5.17 ENSMUST00000020190.8
vanin 3
chr15_-_96917804 5.15 ENSMUST00000231039.2
solute carrier family 38, member 4
chr3_-_146302343 5.08 ENSMUST00000029836.9
deoxyribonuclease II beta
chr2_-_160701523 5.01 ENSMUST00000103112.8
zinc fingers and homeoboxes 3
chr1_+_67162176 4.99 ENSMUST00000027144.8
carbamoyl-phosphate synthetase 1
chr15_+_4756684 4.93 ENSMUST00000161997.8
ENSMUST00000022788.15
complement component 6
chr3_+_20011251 4.93 ENSMUST00000108328.8
ceruloplasmin
chr18_-_39051695 4.92 ENSMUST00000040647.11
fibroblast growth factor 1
chr11_-_59927688 4.88 ENSMUST00000102692.10
phosphatidylethanolamine N-methyltransferase
chr12_-_103739847 4.86 ENSMUST00000078869.6
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr9_-_71070506 4.79 ENSMUST00000074465.9
aquaporin 9
chr9_-_107546166 4.70 ENSMUST00000177567.8
solute carrier family 38, member 3
chr2_-_62313981 4.63 ENSMUST00000136686.2
ENSMUST00000102733.10
glucagon
chr15_+_4756657 4.62 ENSMUST00000162585.8
complement component 6
chrX_+_100419965 4.58 ENSMUST00000119080.8
gap junction protein, beta 1
chr3_+_20011201 4.57 ENSMUST00000091309.12
ENSMUST00000108329.8
ENSMUST00000003714.13
ceruloplasmin
chr7_+_100966289 4.52 ENSMUST00000163799.9
ENSMUST00000164479.9
START domain containing 10
chr5_+_90708962 4.39 ENSMUST00000094615.8
ENSMUST00000200765.2
albumin superfamily member 1
chr13_+_23991010 4.37 ENSMUST00000006786.11
ENSMUST00000099697.3
solute carrier family 17 (sodium phosphate), member 2
chr14_-_30665232 4.26 ENSMUST00000006704.17
ENSMUST00000163118.2
inter-alpha trypsin inhibitor, heavy chain 1
chr11_+_78389913 4.25 ENSMUST00000017488.5
vitronectin
chr1_+_130793406 4.15 ENSMUST00000038829.7
Fc fragment of IgM receptor
chr6_-_83633064 3.99 ENSMUST00000014686.3
C-type lectin domain family 4, member f
chr16_+_17149235 3.76 ENSMUST00000023450.15
ENSMUST00000231884.2
serine (or cysteine) peptidase inhibitor, clade D, member 1
chr19_+_42078859 3.74 ENSMUST00000235932.2
ENSMUST00000066778.6
phosphatidylinositol 4-kinase type 2 alpha
chr13_+_41013230 3.72 ENSMUST00000110191.10
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr15_-_5137975 3.69 ENSMUST00000118365.3
caspase recruitment domain family, member 6
chr19_-_58443593 3.69 ENSMUST00000135730.2
ENSMUST00000152507.8
glial cell line derived neurotrophic factor family receptor alpha 1
chr16_-_38115172 3.69 ENSMUST00000023504.5
nuclear receptor subfamily 1, group I, member 2
chr15_+_102012782 3.66 ENSMUST00000230474.2
tensin 2
chr11_+_69983531 3.62 ENSMUST00000124721.2
asialoglycoprotein receptor 2
chr11_+_69983459 3.58 ENSMUST00000102572.8
asialoglycoprotein receptor 2
chr17_+_43671314 3.54 ENSMUST00000226087.2
adhesion G protein-coupled receptor F5
chr11_+_69983479 3.51 ENSMUST00000143772.8
asialoglycoprotein receptor 2
chr19_-_40175709 3.42 ENSMUST00000051846.13
cytochrome P450, family 2, subfamily c, polypeptide 70
chr7_+_119499322 3.33 ENSMUST00000106516.2
LYR motif containing 1
chr5_+_102629240 3.27 ENSMUST00000073302.12
ENSMUST00000094559.9
Rho GTPase activating protein 24
chr8_+_46111703 3.24 ENSMUST00000134675.8
ENSMUST00000139869.8
ENSMUST00000126067.8
sorbin and SH3 domain containing 2
chr19_-_58443830 3.23 ENSMUST00000026076.14
glial cell line derived neurotrophic factor family receptor alpha 1
chr6_+_142244145 3.22 ENSMUST00000041993.3
islet amyloid polypeptide
chr19_+_7034149 3.21 ENSMUST00000040261.7
mono-ADP ribosylhydrolase 1
chr4_-_63072367 3.21 ENSMUST00000030041.5
alpha 1 microglobulin/bikunin precursor
chr12_-_103704417 3.19 ENSMUST00000095450.11
ENSMUST00000187220.2
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr4_+_144619647 3.16 ENSMUST00000154208.8
dehydrogenase/reductase (SDR family) member 3
chr6_+_34686543 3.15 ENSMUST00000031775.13
caldesmon 1
chr2_-_102231208 3.14 ENSMUST00000102573.8
tripartite motif-containing 44
chr12_-_103829810 3.11 ENSMUST00000085056.8
ENSMUST00000072876.12
ENSMUST00000124717.2
serine (or cysteine) peptidase inhibitor, clade A, member 1A
chr4_+_144619696 3.03 ENSMUST00000142808.8
dehydrogenase/reductase (SDR family) member 3
chr15_+_10177709 2.99 ENSMUST00000124470.8
prolactin receptor
chr4_+_102427247 2.89 ENSMUST00000097950.9
phosphodiesterase 4B, cAMP specific
chr15_-_5137951 2.83 ENSMUST00000141020.2
caspase recruitment domain family, member 6
chr1_-_97904958 2.82 ENSMUST00000161567.8
peptidylglycine alpha-amidating monooxygenase
chr4_+_104623505 2.82 ENSMUST00000031663.10
ENSMUST00000065072.7
complement component 8, beta polypeptide
chr17_-_31852128 2.74 ENSMUST00000236909.2
cystathionine beta-synthase
chr7_+_67305162 2.71 ENSMUST00000107470.2
tetratricopeptide repeat domain 23
chr17_+_29077385 2.69 ENSMUST00000056866.8
patatin-like phospholipase domain containing 1
chr13_-_60325170 2.63 ENSMUST00000065086.6
growth arrest specific 1
chrX_+_149377416 2.61 ENSMUST00000112713.3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr10_-_67120959 2.53 ENSMUST00000159002.2
ENSMUST00000077839.13
nuclear receptor binding factor 2
chr19_+_44980565 2.51 ENSMUST00000179305.2
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr18_-_84104507 2.48 ENSMUST00000060303.10
teashirt zinc finger family member 1
chr10_-_61814852 2.46 ENSMUST00000105453.8
ENSMUST00000105452.9
ENSMUST00000105454.3
collagen, type XIII, alpha 1
chr18_+_36797113 2.42 ENSMUST00000036765.8
eukaryotic translation initiation factor 4E binding protein 3
chr1_-_136888118 2.36 ENSMUST00000192357.6
ENSMUST00000027649.14
nuclear receptor subfamily 5, group A, member 2
chr18_-_84104574 2.35 ENSMUST00000175783.3
teashirt zinc finger family member 1
chr9_+_46139878 2.34 ENSMUST00000034588.9
ENSMUST00000132155.2
apolipoprotein A-I
chr9_+_44951075 2.33 ENSMUST00000217097.2
myelin protein zero-like 2
chr6_+_34686373 2.32 ENSMUST00000115021.8
caldesmon 1
chr4_+_148686985 2.31 ENSMUST00000105701.9
ENSMUST00000052060.7
mannan-binding lectin serine peptidase 2
chr8_-_122671588 2.27 ENSMUST00000057653.8
carbonic anhydrase 5a, mitochondrial
chr15_+_3300249 2.24 ENSMUST00000082424.12
ENSMUST00000159158.9
ENSMUST00000159216.10
ENSMUST00000160311.3
selenoprotein P
chr2_-_51862941 2.21 ENSMUST00000145481.8
ENSMUST00000112705.9
N-myc (and STAT) interactor
chr2_-_25982160 2.17 ENSMUST00000114159.9
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr11_+_114741948 2.15 ENSMUST00000133245.2
ENSMUST00000122967.3
G protein-coupled receptor, family C, group 5, member C
chr14_+_48358267 2.09 ENSMUST00000073150.6
pellino 2
chr19_-_58444336 2.07 ENSMUST00000131877.2
glial cell line derived neurotrophic factor family receptor alpha 1
chr9_+_74860133 2.06 ENSMUST00000215370.2
family with sequence similarity 214, member A
chr2_-_104573179 1.98 ENSMUST00000028595.8
DEP domain containing 7
chr14_+_73475335 1.98 ENSMUST00000044405.8
lysophosphatidic acid receptor 6
chr9_-_44714263 1.97 ENSMUST00000044694.8
tetratricopeptide repeat domain 36
chr13_+_112604037 1.94 ENSMUST00000183868.8
interleukin 6 signal transducer
chr17_-_31383976 1.93 ENSMUST00000235870.2
trefoil factor 1
chr11_-_68277631 1.88 ENSMUST00000021284.4
netrin 1
chr10_-_93146937 1.88 ENSMUST00000008542.12
ELK3, member of ETS oncogene family
chr18_+_51250748 1.87 ENSMUST00000116639.4
proline rich 16
chr2_+_164245114 1.84 ENSMUST00000017151.2
recombination signal binding protein for immunoglobulin kappa J region-like
chr5_+_102629365 1.83 ENSMUST00000112854.8
Rho GTPase activating protein 24
chr2_+_71884943 1.81 ENSMUST00000028525.6
Rap guanine nucleotide exchange factor (GEF) 4
chr5_-_66238313 1.81 ENSMUST00000202700.4
ENSMUST00000094757.9
ENSMUST00000113724.6
RNA binding motif protein 47
chr13_+_89687915 1.74 ENSMUST00000022108.9
hyaluronan and proteoglycan link protein 1
chr10_+_96453408 1.73 ENSMUST00000218953.2
BTG anti-proliferation factor 1
chr1_+_87501721 1.73 ENSMUST00000166259.8
ENSMUST00000172222.8
ENSMUST00000163606.8
neuraminidase 2
chr15_+_59520199 1.73 ENSMUST00000067543.8
tribbles pseudokinase 1
chr1_-_87501548 1.71 ENSMUST00000068681.12
neuronal guanine nucleotide exchange factor
chr7_-_100306160 1.67 ENSMUST00000107046.8
ENSMUST00000107045.9
ENSMUST00000139708.9
pleckstrin homology domain containing, family B (evectins) member 1
chr14_-_100522101 1.64 ENSMUST00000228216.2
Kruppel-like factor 12
chr2_+_158148413 1.63 ENSMUST00000109491.8
ENSMUST00000016168.9
lipopolysaccharide binding protein
chr12_-_32000209 1.61 ENSMUST00000176084.2
ENSMUST00000176103.8
ENSMUST00000167458.9
high mobility group box transcription factor 1
chr19_+_56414114 1.61 ENSMUST00000238892.2
caspase 7
chr13_-_60324755 1.55 ENSMUST00000223933.2
growth arrest specific 1
chr4_+_102112189 1.52 ENSMUST00000106908.9
phosphodiesterase 4B, cAMP specific
chr1_+_132226308 1.51 ENSMUST00000046071.5
kelch domain containing 8A
chr10_-_41487315 1.50 ENSMUST00000219054.2
coiled-coil domain containing 162
chr11_+_108814007 1.44 ENSMUST00000106711.2
axin 2
chrX_+_93278526 1.40 ENSMUST00000113908.8
ENSMUST00000113916.10
kelch-like 15
chr12_-_32000169 1.37 ENSMUST00000176520.8
high mobility group box transcription factor 1
chr1_-_170695328 1.37 ENSMUST00000027974.7
activating transcription factor 6
chrX_+_93278203 1.37 ENSMUST00000153900.8
kelch-like 15
chr1_+_34275665 1.36 ENSMUST00000194192.3
dystonin
chr4_+_34893772 1.34 ENSMUST00000029975.10
ENSMUST00000135871.8
ENSMUST00000108130.2
glycoprotein hormones, alpha subunit
chr1_+_157353696 1.34 ENSMUST00000111700.8
SEC16 homolog B (S. cerevisiae)
chr4_-_103072343 1.33 ENSMUST00000150285.8
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
chr6_-_87365859 1.30 ENSMUST00000032127.6
gastrokine 3
chr11_-_46581135 1.29 ENSMUST00000169584.8
T cell immunoglobulin and mucin domain containing 2
chr3_-_131138541 1.29 ENSMUST00000090246.5
ENSMUST00000126569.2
sphingomyelin synthase 2
chr12_-_108241597 1.29 ENSMUST00000222310.2
coiled-coil domain containing 85C
chr14_+_20732804 1.28 ENSMUST00000228545.2
Sec24 related gene family, member C (S. cerevisiae)
chr9_-_53447908 1.26 ENSMUST00000150244.2
ataxia telangiectasia mutated
chr1_+_75119472 1.26 ENSMUST00000189650.7
reticulophagy regulator family member 2
chr6_-_59001455 1.25 ENSMUST00000089860.12
family with sequence similarity 13, member A
chr10_-_93146825 1.23 ENSMUST00000151153.2
ELK3, member of ETS oncogene family
chr9_-_59260713 1.22 ENSMUST00000026265.8
Bardet-Biedl syndrome 4 (human)
chr7_+_28524627 1.22 ENSMUST00000066264.13
enoyl coenzyme A hydratase 1, peroxisomal
chr3_-_82811269 1.20 ENSMUST00000029632.7
lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
chr15_+_59520493 1.18 ENSMUST00000118228.2
tribbles pseudokinase 1
chr2_-_51863203 1.18 ENSMUST00000028314.9
N-myc (and STAT) interactor
chr5_-_90788323 1.15 ENSMUST00000202784.4
ENSMUST00000031317.10
ENSMUST00000201370.2
Ras association (RalGDS/AF-6) domain family member 6
chrX_+_93278588 1.12 ENSMUST00000096369.10
ENSMUST00000113911.9
kelch-like 15
chr6_+_14901343 1.12 ENSMUST00000115477.8
forkhead box P2
chr15_-_50753792 1.10 ENSMUST00000185183.2
transcriptional repressor GATA binding 1
chr17_-_34847354 1.10 ENSMUST00000167097.9
palmitoyl-protein thioesterase 2
chr11_-_86884507 1.10 ENSMUST00000018571.5
yippee like 2
chr12_+_112645237 1.09 ENSMUST00000174780.2
ENSMUST00000169593.2
ENSMUST00000173942.2
zinc finger and BTB domain containing 42
chr8_+_107329983 1.07 ENSMUST00000000312.12
ENSMUST00000167688.2
cadherin 1
chr8_-_45715049 1.07 ENSMUST00000034064.5
coagulation factor XI
chr9_+_44309727 1.06 ENSMUST00000213268.2
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr11_-_70350783 1.05 ENSMUST00000019064.9
chemokine (C-X-C motif) ligand 16
chr16_-_43836681 1.05 ENSMUST00000036174.10
GRAM domain containing 1C
chr7_-_80053063 1.03 ENSMUST00000147150.2
furin (paired basic amino acid cleaving enzyme)
chr1_+_75119419 1.03 ENSMUST00000097694.11
ENSMUST00000190240.7
reticulophagy regulator family member 2
chr3_+_85946145 1.02 ENSMUST00000238331.2
SH3 domain protein D19
chr2_+_120807498 1.00 ENSMUST00000067582.14
transmembrane protein 62
chr17_+_48037758 1.00 ENSMUST00000024782.12
ENSMUST00000144955.2
progastricsin (pepsinogen C)
chr15_-_3333003 0.99 ENSMUST00000165386.2
coiled-coil domain containing 152
chr1_-_74924481 0.98 ENSMUST00000159232.2
ENSMUST00000068631.4
FEV transcription factor, ETS family member
chr5_-_90788460 0.97 ENSMUST00000202704.4
Ras association (RalGDS/AF-6) domain family member 6
chr6_-_134768288 0.97 ENSMUST00000149776.3
dual specificity phosphatase 16
chr14_-_100521888 0.95 ENSMUST00000226774.2
Kruppel-like factor 12
chr7_-_65020655 0.93 ENSMUST00000032729.8
tight junction protein 1
chr9_-_53448028 0.91 ENSMUST00000232179.2
ataxia telangiectasia mutated
chr12_-_103623418 0.91 ENSMUST00000044159.7
serine (or cysteine) peptidase inhibitor, clade A, member 6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 22.7 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
3.4 10.3 GO:0006867 asparagine transport(GO:0006867) positive regulation of glutamine transport(GO:2000487)
3.3 23.0 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
3.2 16.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
2.5 15.0 GO:0038161 prolactin signaling pathway(GO:0038161)
2.4 14.5 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
2.4 9.6 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
2.1 10.4 GO:0009441 glycolate metabolic process(GO:0009441)
1.9 9.7 GO:1904253 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
1.9 5.7 GO:0006553 lysine metabolic process(GO:0006553)
1.6 9.8 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
1.3 7.5 GO:1903243 negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
1.2 3.7 GO:0002276 basophil activation involved in immune response(GO:0002276)
1.2 4.8 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
1.2 18.9 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
1.1 3.4 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
1.1 15.4 GO:0006642 triglyceride mobilization(GO:0006642)
1.1 7.7 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
1.0 2.9 GO:0045643 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.9 6.6 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) heme transport(GO:0015886) positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.9 2.7 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.9 6.3 GO:1904073 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.8 22.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.7 3.7 GO:0042908 xenobiotic transport(GO:0042908)
0.7 2.2 GO:1900477 negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter(GO:1900477)
0.7 2.2 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.7 5.0 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.7 5.0 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.7 4.9 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.7 4.8 GO:0060023 soft palate development(GO:0060023)
0.6 16.0 GO:0017144 drug metabolic process(GO:0017144)
0.6 4.6 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.6 11.2 GO:0042359 vitamin D metabolic process(GO:0042359)
0.6 3.9 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.5 0.5 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.5 1.6 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.5 13.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.5 3.7 GO:0036438 maintenance of lens transparency(GO:0036438)
0.5 16.6 GO:0046688 response to copper ion(GO:0046688)
0.5 5.1 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.5 1.0 GO:0002760 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.5 3.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.5 1.8 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.4 4.6 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.4 3.2 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.4 1.2 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.4 1.2 GO:1990164 histone H3-S28 phosphorylation(GO:0043988) histone H2A phosphorylation(GO:1990164)
0.4 21.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.4 2.8 GO:0031179 peptide modification(GO:0031179)
0.3 4.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.3 1.6 GO:0072733 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.3 0.6 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.3 1.2 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.3 3.5 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.3 7.4 GO:0042572 retinol metabolic process(GO:0042572)
0.3 2.2 GO:0001887 selenium compound metabolic process(GO:0001887)
0.3 3.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 5.1 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.3 1.1 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.3 4.8 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.3 2.6 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.3 1.0 GO:0090472 dibasic protein processing(GO:0090472)
0.2 2.7 GO:0008063 Toll signaling pathway(GO:0008063)
0.2 1.4 GO:0032423 regulation of mismatch repair(GO:0032423) negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.2 2.5 GO:0033564 Cdc42 protein signal transduction(GO:0032488) anterior/posterior axon guidance(GO:0033564)
0.2 3.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.2 1.3 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.2 33.7 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 0.7 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
0.2 1.7 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.2 1.7 GO:0006689 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
0.2 4.1 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.2 4.0 GO:0051132 NK T cell activation(GO:0051132)
0.2 2.4 GO:0061113 pancreas morphogenesis(GO:0061113)
0.2 1.0 GO:0051611 regulation of serotonin uptake(GO:0051611)
0.2 2.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 1.1 GO:0060066 oviduct development(GO:0060066)
0.2 0.7 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 6.3 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.2 0.9 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.2 1.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.6 GO:0010159 specification of organ position(GO:0010159)
0.1 0.8 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.1 2.6 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.1 1.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 1.6 GO:0032275 luteinizing hormone secretion(GO:0032275)
0.1 5.7 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 5.2 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.1 0.4 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.6 GO:1903445 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.1 1.1 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.1 1.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 1.7 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 3.4 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 1.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 0.9 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 1.8 GO:0014850 response to muscle activity(GO:0014850)
0.1 1.7 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.1 2.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 1.4 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.1 0.8 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 13.4 GO:0055088 lipid homeostasis(GO:0055088)
0.1 12.6 GO:0009166 nucleotide catabolic process(GO:0009166)
0.1 0.3 GO:0071698 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 1.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.4 GO:0060346 bone trabecula formation(GO:0060346)
0.1 1.9 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 0.2 GO:2000328 regulation of T-helper 17 cell lineage commitment(GO:2000328)
0.1 4.4 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 1.3 GO:0072189 ureter development(GO:0072189)
0.1 1.5 GO:0045792 negative regulation of cell size(GO:0045792)
0.1 0.9 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 5.5 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.1 0.3 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.1 0.5 GO:0030578 PML body organization(GO:0030578) positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.1 0.5 GO:0007256 activation of JNKK activity(GO:0007256) negative regulation of defense response to bacterium(GO:1900425)
0.1 0.2 GO:0071895 odontoblast differentiation(GO:0071895)
0.1 0.9 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.8 GO:0015697 quaternary ammonium group transport(GO:0015697)
0.1 0.2 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.1 0.2 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.1 0.6 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 0.7 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 0.3 GO:0010157 response to chlorate(GO:0010157)
0.1 0.4 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.1 0.5 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.1 0.5 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.1 0.5 GO:0008228 opsonization(GO:0008228)
0.1 0.2 GO:0052564 interleukin-15 production(GO:0032618) response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572)
0.1 3.7 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 2.6 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 12.6 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.8 GO:0042048 olfactory behavior(GO:0042048)
0.0 1.3 GO:0097286 iron ion import(GO:0097286)
0.0 0.2 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 1.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.3 GO:1904222 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.1 GO:0097535 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.0 2.1 GO:0006094 gluconeogenesis(GO:0006094)
0.0 0.1 GO:1904016 response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 4.2 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 0.5 GO:0060746 parental behavior(GO:0060746)
0.0 0.4 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.3 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.3 GO:0021559 trigeminal nerve development(GO:0021559)
0.0 0.2 GO:0070268 cornification(GO:0070268)
0.0 1.1 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.6 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.0 GO:0022601 menstrual cycle phase(GO:0022601)
0.0 0.5 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 1.0 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.1 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.3 GO:0008211 glucocorticoid metabolic process(GO:0008211)
0.0 0.3 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.9 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.0 1.5 GO:0033077 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 0.3 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.2 GO:0080009 mRNA methylation(GO:0080009)
0.0 1.9 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.0 GO:0035038 female pronucleus assembly(GO:0035038)
0.0 0.1 GO:0042706 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.5 GO:0034359 mature chylomicron(GO:0034359)
2.1 12.7 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
1.9 18.5 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
1.5 12.4 GO:0005579 membrane attack complex(GO:0005579)
1.2 13.5 GO:0045098 type III intermediate filament(GO:0045098)
1.2 12.9 GO:0005796 Golgi lumen(GO:0005796)
1.1 22.7 GO:0042627 chylomicron(GO:0042627)
1.1 13.9 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.9 2.8 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.9 2.6 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.7 18.9 GO:0000421 autophagosome membrane(GO:0000421)
0.5 5.5 GO:0030478 actin cap(GO:0030478)
0.4 1.8 GO:0044316 cone cell pedicle(GO:0044316)
0.3 6.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.3 2.5 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.3 19.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 4.9 GO:0005922 connexon complex(GO:0005922)
0.1 1.5 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.5 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 0.3 GO:0016939 kinesin II complex(GO:0016939)
0.1 1.2 GO:0034464 BBSome(GO:0034464)
0.1 14.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 37.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 5.0 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 2.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 14.4 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.1 1.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 4.9 GO:0031526 brush border membrane(GO:0031526)
0.1 0.5 GO:0031673 H zone(GO:0031673)
0.1 2.8 GO:0005581 collagen trimer(GO:0005581)
0.1 0.8 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 1.0 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 0.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.7 GO:0097542 ciliary tip(GO:0097542)
0.1 5.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 11.6 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.9 GO:0071437 invadopodium(GO:0071437)
0.1 107.9 GO:0005615 extracellular space(GO:0005615)
0.0 1.2 GO:0005771 multivesicular body(GO:0005771)
0.0 0.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 2.2 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.4 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.8 GO:0071564 npBAF complex(GO:0071564)
0.0 6.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.3 GO:0045178 basal part of cell(GO:0045178)
0.0 4.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.5 GO:0005811 lipid particle(GO:0005811)
0.0 1.5 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.1 GO:0001652 granular component(GO:0001652)
0.0 0.5 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.5 GO:0030904 retromer complex(GO:0030904)
0.0 0.3 GO:0044294 dendritic growth cone(GO:0044294)
0.0 4.6 GO:0005938 cell cortex(GO:0005938)
0.0 0.2 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.6 GO:0031201 SNARE complex(GO:0031201)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 25.3 GO:0004556 alpha-amylase activity(GO:0004556)
3.5 10.6 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) norepinephrine transmembrane transporter activity(GO:0005333) acetate ester transmembrane transporter activity(GO:1901375)
3.4 20.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
3.0 15.0 GO:0004925 prolactin receptor activity(GO:0004925)
2.8 11.2 GO:1902271 D3 vitamins binding(GO:1902271)
2.6 10.4 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
2.6 10.3 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
2.2 13.5 GO:0004850 uridine phosphorylase activity(GO:0004850)
2.2 17.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
1.7 5.0 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
1.7 23.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
1.4 15.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
1.4 42.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.3 7.7 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
1.2 13.5 GO:0035473 lipase binding(GO:0035473)
1.1 6.6 GO:0015232 heme transporter activity(GO:0015232)
1.1 6.3 GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294)
1.0 5.1 GO:0004531 deoxyribonuclease II activity(GO:0004531)
1.0 4.8 GO:0015205 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.9 18.9 GO:0030957 Tat protein binding(GO:0030957)
0.9 3.7 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.9 3.7 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.9 2.7 GO:0050421 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitric oxide binding(GO:0070026)
0.9 6.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.8 3.2 GO:0019862 IgA binding(GO:0019862)
0.8 2.3 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
0.8 3.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.7 2.2 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.7 2.8 GO:0016842 amidine-lyase activity(GO:0016842)
0.6 1.9 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.6 8.9 GO:1990405 protein antigen binding(GO:1990405)
0.5 2.2 GO:0005118 sevenless binding(GO:0005118)
0.5 19.4 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.5 4.0 GO:0005534 galactose binding(GO:0005534)
0.4 4.9 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.4 1.3 GO:0070287 ferritin receptor activity(GO:0070287)
0.4 12.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.4 1.1 GO:0015152 glucose-6-phosphate transmembrane transporter activity(GO:0015152)
0.3 1.7 GO:0052796 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.3 19.2 GO:0005044 scavenger receptor activity(GO:0005044)
0.3 2.6 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.3 4.6 GO:0005243 gap junction channel activity(GO:0005243)
0.3 4.4 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.3 1.6 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.2 4.9 GO:0044548 S100 protein binding(GO:0044548)
0.2 9.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 0.9 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.2 1.3 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 5.7 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.2 29.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 2.3 GO:0001846 opsonin binding(GO:0001846)
0.2 2.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.9 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.1 1.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 2.9 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 1.2 GO:0034452 dynactin binding(GO:0034452)
0.1 2.7 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 1.8 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 2.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 16.7 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 2.2 GO:0008430 selenium binding(GO:0008430)
0.1 2.4 GO:0035497 cAMP response element binding(GO:0035497)
0.1 4.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 5.7 GO:0030552 cAMP binding(GO:0030552)
0.1 1.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.9 GO:0071253 connexin binding(GO:0071253)
0.1 0.2 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 1.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.2 GO:0001972 retinoic acid binding(GO:0001972)
0.1 5.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 0.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 1.4 GO:0070411 I-SMAD binding(GO:0070411)
0.1 5.9 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 2.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.2 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 4.1 GO:0019213 deacetylase activity(GO:0019213)
0.1 0.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.5 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.5 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 1.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 2.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0052597 diamine oxidase activity(GO:0052597) histamine oxidase activity(GO:0052598) methylputrescine oxidase activity(GO:0052599) propane-1,3-diamine oxidase activity(GO:0052600)
0.0 0.6 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.6 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.3 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.0 0.5 GO:0070097 delta-catenin binding(GO:0070097)
0.0 1.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.7 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 1.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.8 GO:0051400 BH domain binding(GO:0051400)
0.0 5.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0042731 PH domain binding(GO:0042731)
0.0 6.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.4 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 1.1 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 7.8 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.3 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.2 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.7 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.6 GO:0005521 lamin binding(GO:0005521)
0.0 6.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.6 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.7 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 9.8 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.5 GO:0016836 hydro-lyase activity(GO:0016836)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 24.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 10.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 4.9 PID IGF1 PATHWAY IGF1 pathway
0.2 15.0 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.2 1.6 PID IL6 7 PATHWAY IL6-mediated signaling events
0.2 8.6 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 0.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 12.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.7 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 9.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 11.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 21.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 6.1 PID FGF PATHWAY FGF signaling pathway
0.1 3.3 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 1.4 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.1 1.9 PID IL27 PATHWAY IL27-mediated signaling events
0.1 5.2 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 2.2 PID ATM PATHWAY ATM pathway
0.1 1.6 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 3.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.5 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.9 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.2 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.9 PID IL3 PATHWAY IL3-mediated signaling events
0.0 7.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.5 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.5 PID BMP PATHWAY BMP receptor signaling
0.0 0.9 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.1 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.3 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 3.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 16.0 REACTOME XENOBIOTICS Genes involved in Xenobiotics
1.6 17.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
1.2 36.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.8 17.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.8 10.5 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.7 13.5 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.5 9.7 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.5 31.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.5 14.3 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.4 15.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.3 4.8 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.3 7.1 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.3 12.2 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.3 15.0 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.3 5.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.2 1.9 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 4.8 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.2 4.6 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 2.5 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.2 3.6 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.2 2.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.2 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 1.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 4.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 2.4 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 1.0 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 3.5 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 5.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 4.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 1.7 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 2.0 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 5.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.6 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 2.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 18.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 1.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 6.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 2.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 1.8 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 0.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.2 REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH Genes involved in NCAM signaling for neurite out-growth
0.0 3.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.0 0.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 7.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.3 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.0 0.4 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.1 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.4 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression