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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Foxg1

Z-value: 1.17

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Transcription factors associated with Foxg1

Gene Symbol Gene ID Gene Info
Foxg1
ENSMUSG00000020950.11 Foxg1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxg1mm39_v1_chr12_+_49429790_494298880.173.2e-01Click!

Activity profile of Foxg1 motif

Sorted Z-values of Foxg1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxg1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_106057077 5.33 ENSMUST00000149836.2
Chil3
chitinase-like 3
chr15_+_79775894 4.44 ENSMUST00000177483.8
Apobec3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chr7_+_142558783 4.29 ENSMUST00000009396.13
Tspan32
tetraspanin 32
chr7_+_142558837 3.77 ENSMUST00000207211.2
Tspan32
tetraspanin 32
chr2_-_152672535 3.73 ENSMUST00000146380.2
ENSMUST00000134902.2
ENSMUST00000134357.2
ENSMUST00000109820.5
Bcl2l1
BCL2-like 1
chr1_-_180641159 3.65 ENSMUST00000162118.8
ENSMUST00000159685.2
ENSMUST00000161308.8
H3f3a
H3.3 histone A
chr1_-_180641430 3.48 ENSMUST00000162814.8
H3f3a
H3.3 histone A
chr1_-_180641099 3.45 ENSMUST00000159789.2
ENSMUST00000081026.11
H3f3a
H3.3 histone A
chr10_-_120312374 3.34 ENSMUST00000072777.14
ENSMUST00000159699.2
Hmga2
high mobility group AT-hook 2
chr1_+_82817388 2.90 ENSMUST00000190052.7
ENSMUST00000063380.11
ENSMUST00000187899.7
ENSMUST00000186302.7
ENSMUST00000190046.7
Agfg1
ArfGAP with FG repeats 1
chr15_+_79775819 2.88 ENSMUST00000177350.8
Apobec3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chr2_-_152673032 2.84 ENSMUST00000128172.3
Bcl2l1
BCL2-like 1
chr15_+_103148824 2.75 ENSMUST00000036004.16
ENSMUST00000087351.9
ENSMUST00000231141.2
Hnrnpa1
heterogeneous nuclear ribonucleoprotein A1
chr18_+_68433422 2.58 ENSMUST00000009679.11
ENSMUST00000131075.8
ENSMUST00000025427.14
ENSMUST00000139111.2
Rnmt
RNA (guanine-7-) methyltransferase
chr1_+_82817170 2.56 ENSMUST00000189220.7
ENSMUST00000113444.8
Agfg1
ArfGAP with FG repeats 1
chr1_-_79838897 2.19 ENSMUST00000190724.2
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr1_+_180762587 1.54 ENSMUST00000037361.9
Lefty1
left right determination factor 1
chr7_+_79848138 1.49 ENSMUST00000205822.2
Sema4b
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr5_+_34527230 1.39 ENSMUST00000180376.8
Fam193a
family with sequence homology 193, member A
chr7_-_115423934 1.32 ENSMUST00000169129.8
Sox6
SRY (sex determining region Y)-box 6
chr6_-_72322116 1.27 ENSMUST00000070345.5
Usp39
ubiquitin specific peptidase 39
chr13_-_3968157 1.17 ENSMUST00000223258.2
ENSMUST00000091853.12
Net1
neuroepithelial cell transforming gene 1
chr2_+_120331784 0.83 ENSMUST00000151342.3
Capn3
calpain 3
chr12_-_112964279 0.82 ENSMUST00000011302.9
Brf1
BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
chr1_-_120432477 0.65 ENSMUST00000186432.3
Marco
macrophage receptor with collagenous structure
chr7_+_75498058 0.58 ENSMUST00000171155.4
ENSMUST00000092073.11
ENSMUST00000206019.2
ENSMUST00000205612.2
ENSMUST00000205887.2
Klhl25
kelch-like 25
chr5_-_121329385 0.58 ENSMUST00000054547.9
ENSMUST00000100770.9
Ptpn11
protein tyrosine phosphatase, non-receptor type 11
chr19_+_8595369 0.52 ENSMUST00000010250.4
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr9_+_54493784 0.49 ENSMUST00000167866.2
Idh3a
isocitrate dehydrogenase 3 (NAD+) alpha
chr9_+_54493618 0.48 ENSMUST00000217484.2
Idh3a
isocitrate dehydrogenase 3 (NAD+) alpha
chr3_-_127019496 0.47 ENSMUST00000182064.9
ENSMUST00000182452.8
Ank2
ankyrin 2, brain
chr11_+_3438274 0.43 ENSMUST00000064265.13
Pla2g3
phospholipase A2, group III
chr3_-_94922525 0.41 ENSMUST00000128438.2
ENSMUST00000149747.2
ENSMUST00000019482.8
Zfp687
zinc finger protein 687
chr14_-_24295988 0.41 ENSMUST00000073687.13
ENSMUST00000090398.11
Dlg5
discs large MAGUK scaffold protein 5
chr4_-_108690741 0.39 ENSMUST00000102740.8
ENSMUST00000102741.8
Btf3l4
basic transcription factor 3-like 4
chr9_-_60557076 0.36 ENSMUST00000053171.14
Lrrc49
leucine rich repeat containing 49
chr17_+_34596098 0.35 ENSMUST00000080254.7
Btnl1
butyrophilin-like 1
chr15_-_85466009 0.31 ENSMUST00000023015.15
Wnt7b
wingless-type MMTV integration site family, member 7B
chr5_-_142892457 0.27 ENSMUST00000167721.8
ENSMUST00000163829.2
ENSMUST00000100497.11
Actb
actin, beta
chr2_+_4394425 0.27 ENSMUST00000115037.9
Frmd4a
FERM domain containing 4A
chr9_+_106048116 0.25 ENSMUST00000020490.13
Wdr82
WD repeat domain containing 82
chr13_+_34346936 0.25 ENSMUST00000124996.8
ENSMUST00000147632.3
Psmg4
proteasome (prosome, macropain) assembly chaperone 4
chr2_+_88479038 0.21 ENSMUST00000120518.4
Olfr1192-ps1
olfactory receptor 1192, pseudogene 1
chr1_-_72914036 0.18 ENSMUST00000027377.9
Igfbp5
insulin-like growth factor binding protein 5
chr8_+_112262729 0.18 ENSMUST00000172856.8
Znrf1
zinc and ring finger 1
chr2_-_162929732 0.16 ENSMUST00000094653.6
Gtsf1l
gametocyte specific factor 1-like
chr15_+_66449385 0.15 ENSMUST00000230882.2
ENSMUST00000048188.10
ENSMUST00000230948.2
ENSMUST00000229160.2
Phf20l1
PHD finger protein 20-like 1
chr3_-_50398027 0.15 ENSMUST00000029297.6
ENSMUST00000194462.6
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr10_-_77618376 0.11 ENSMUST00000167358.2
Gm3250
predicted gene 3250
chr18_+_73992446 0.11 ENSMUST00000120033.8
ENSMUST00000179472.8
ENSMUST00000119239.8
Mro
maestro
chr2_-_154400753 0.10 ENSMUST00000109716.9
ENSMUST00000000895.13
ENSMUST00000125793.2
Necab3
N-terminal EF-hand calcium binding protein 3
chr3_-_94922727 0.07 ENSMUST00000132195.8
Zfp687
zinc finger protein 687
chr6_-_40864428 0.06 ENSMUST00000031937.4
Moxd2
monooxygenase, DBH-like 2
chr8_+_84793453 0.06 ENSMUST00000211046.2
ENSMUST00000005600.6
Rfx1
regulatory factor X, 1 (influences HLA class II expression)
chr9_+_64028783 0.02 ENSMUST00000118215.3
Lctl
lactase-like

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 10.6 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
1.6 6.6 GO:0046898 response to cycloheximide(GO:0046898)
0.7 8.1 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.7 2.2 GO:0045297 mating plug formation(GO:0042628) single-organism reproductive behavior(GO:0044704) post-mating behavior(GO:0045297) seminal vesicle development(GO:0061107)
0.6 5.3 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.3 7.3 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.3 2.6 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.3 1.5 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.3 3.3 GO:0060613 fat pad development(GO:0060613)
0.3 5.9 GO:0001675 acrosome assembly(GO:0001675)
0.2 0.8 GO:1990091 sodium-dependent self proteolysis(GO:1990091)
0.2 0.6 GO:2000850 negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.1 1.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 1.0 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 0.3 GO:0072061 inner medullary collecting duct development(GO:0072061)
0.1 0.4 GO:0045186 zonula adherens assembly(GO:0045186)
0.1 0.2 GO:0014734 skeletal muscle hypertrophy(GO:0014734)
0.1 0.3 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.1 1.2 GO:0051451 myoblast migration(GO:0051451)
0.1 0.3 GO:0045062 extrathymic T cell selection(GO:0045062)
0.1 0.8 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.1 0.5 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.5 GO:0015747 urate transport(GO:0015747)
0.0 2.7 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 1.5 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.6 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 1.3 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.1 GO:0006589 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.3 GO:0080182 histone H3-K4 trimethylation(GO:0080182)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 10.6 GO:0001740 Barr body(GO:0001740)
1.6 8.1 GO:0070442 integrin alphaIIb-beta3 complex(GO:0070442)
0.5 6.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 2.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 2.6 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.1 0.8 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.0 0.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 4.0 GO:0005681 spliceosomal complex(GO:0005681)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.3 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
1.1 5.3 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.7 6.6 GO:0051434 BH3 domain binding(GO:0051434)
0.4 1.5 GO:0038100 nodal binding(GO:0038100)
0.3 10.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 1.0 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.2 2.6 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.2 3.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.2 0.8 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.1 0.3 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.1 0.6 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.8 GO:0031432 titin binding(GO:0031432)
0.0 1.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.5 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.1 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0 0.1 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 5.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 2.2 GO:0008201 heparin binding(GO:0008201)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 5.5 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 2.7 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.6 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.2 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 10.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.3 6.6 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 2.6 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.1 1.5 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 1.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.8 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 2.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK