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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Foxl1

Z-value: 0.62

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Transcription factors associated with Foxl1

Gene Symbol Gene ID Gene Info
Foxl1
ENSMUSG00000097084.2 Foxl1
Foxl1
ENSMUSG00000097084.2 Foxl1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxl1mm39_v1_chr8_+_121854566_1218546790.676.6e-06Click!

Activity profile of Foxl1 motif

Sorted Z-values of Foxl1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxl1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr17_+_41121979 4.89 ENSMUST00000024721.8
ENSMUST00000233740.2
Rhag
Rhesus blood group-associated A glycoprotein
chr11_+_31822211 2.03 ENSMUST00000020543.13
ENSMUST00000109412.9
Cpeb4
cytoplasmic polyadenylation element binding protein 4
chr4_+_11191726 1.19 ENSMUST00000029866.16
ENSMUST00000108324.4
Ccne2
cyclin E2
chr9_+_71123061 0.99 ENSMUST00000034723.6
Aldh1a2
aldehyde dehydrogenase family 1, subfamily A2
chr13_+_23922783 0.80 ENSMUST00000040914.3
H1f2
H1.2 linker histone, cluster member
chr13_+_23947641 0.70 ENSMUST00000055770.4
H1f1
H1.1 linker histone, cluster member
chr4_-_120874376 0.68 ENSMUST00000043200.8
Smap2
small ArfGAP 2
chr7_-_119078472 0.66 ENSMUST00000209095.2
ENSMUST00000033263.6
ENSMUST00000207261.2
Umod
uromodulin
chr4_+_11191354 0.52 ENSMUST00000170901.8
Ccne2
cyclin E2
chr10_-_127190280 0.49 ENSMUST00000059718.6
Inhbe
inhibin beta-E
chr3_-_122828592 0.47 ENSMUST00000029761.14
Myoz2
myozenin 2
chr2_+_18059982 0.39 ENSMUST00000028076.15
Mllt10
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
chr18_-_15284476 0.35 ENSMUST00000025992.7
Kctd1
potassium channel tetramerisation domain containing 1
chr8_+_93553901 0.32 ENSMUST00000034187.9
Mmp2
matrix metallopeptidase 2
chr6_-_102441628 0.32 ENSMUST00000032159.7
Cntn3
contactin 3
chr7_-_119078330 0.27 ENSMUST00000207460.2
Umod
uromodulin
chr13_-_23806530 0.27 ENSMUST00000062045.4
H1f4
H1.4 linker histone, cluster member
chr10_-_102326286 0.26 ENSMUST00000020040.5
Nts
neurotensin
chrX_+_132751729 0.26 ENSMUST00000033602.9
Tnmd
tenomodulin
chr8_+_15107646 0.23 ENSMUST00000033842.4
Myom2
myomesin 2
chr10_+_87926932 0.21 ENSMUST00000048621.8
Pmch
pro-melanin-concentrating hormone
chr10_+_56253418 0.20 ENSMUST00000068581.9
ENSMUST00000217789.2
Gja1
gap junction protein, alpha 1
chr18_+_37864045 0.19 ENSMUST00000192535.2
Pcdhgb5
protocadherin gamma subfamily B, 5
chr6_+_106095726 0.18 ENSMUST00000113258.8
ENSMUST00000079416.6
Cntn4
contactin 4
chr11_+_54517164 0.17 ENSMUST00000239168.2
Rapgef6
Rap guanine nucleotide exchange factor (GEF) 6
chr15_-_11905697 0.16 ENSMUST00000066529.5
ENSMUST00000228603.2
Npr3
natriuretic peptide receptor 3
chr16_+_44913974 0.16 ENSMUST00000099498.10
Ccdc80
coiled-coil domain containing 80
chr3_-_146475974 0.14 ENSMUST00000106137.8
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr18_+_37637317 0.12 ENSMUST00000052179.8
Pcdhb20
protocadherin beta 20
chr1_+_66426127 0.12 ENSMUST00000145419.8
Map2
microtubule-associated protein 2
chr6_-_14755249 0.08 ENSMUST00000045096.6
Ppp1r3a
protein phosphatase 1, regulatory subunit 3A
chr16_-_22258469 0.07 ENSMUST00000079601.13
Etv5
ets variant 5
chr1_+_179788037 0.05 ENSMUST00000097453.9
ENSMUST00000111117.8
Cdc42bpa
CDC42 binding protein kinase alpha
chr1_-_169938060 0.04 ENSMUST00000027985.8
ENSMUST00000194690.6
Ddr2
discoidin domain receptor family, member 2
chr5_-_87847268 0.04 ENSMUST00000196869.5
ENSMUST00000199624.5
ENSMUST00000198057.5
ENSMUST00000082370.10
Csn2
casein beta
chr9_-_101076198 0.02 ENSMUST00000066773.9
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr3_-_82957104 0.02 ENSMUST00000048246.5
Fgb
fibrinogen beta chain

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.9 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 0.9 GO:0072218 ascending thin limb development(GO:0072021) thick ascending limb development(GO:0072023) metanephric ascending thin limb development(GO:0072218) metanephric thick ascending limb development(GO:0072233)
0.2 2.0 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 1.0 GO:0035799 ureter maturation(GO:0035799)
0.1 0.2 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.1 0.2 GO:0003294 atrial ventricular junction remodeling(GO:0003294) regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.1 0.3 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 1.7 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.2 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.0 GO:1903487 regulation of lactation(GO:1903487)
0.0 0.1 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 2.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.9 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.1 1.0 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 2.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 0.5 GO:0051373 FATZ binding(GO:0051373)
0.1 0.9 GO:0019864 IgG binding(GO:0019864)
0.0 1.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.5 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.2 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.5 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.9 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.7 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.5 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation