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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Gata4

Z-value: 2.72

Motif logo

Transcription factors associated with Gata4

Gene Symbol Gene ID Gene Info
ENSMUSG00000021944.16 Gata4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gata4mm39_v1_chr14_-_63509131_635091520.153.7e-01Click!

Activity profile of Gata4 motif

Sorted Z-values of Gata4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata4

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr17_-_26417982 36.26 ENSMUST00000142410.2
ENSMUST00000120333.8
ENSMUST00000039113.14
protein disulfide isomerase associated 2
chr2_+_84810802 21.94 ENSMUST00000028467.6
proteoglycan 2, bone marrow
chr17_+_37180437 20.47 ENSMUST00000060524.11
tripartite motif-containing 10
chr6_+_30639217 18.65 ENSMUST00000031806.10
carboxypeptidase A1, pancreatic
chr4_-_46404224 16.86 ENSMUST00000107764.9
hemogen
chr15_-_103159892 16.36 ENSMUST00000133600.8
ENSMUST00000134554.2
ENSMUST00000156927.8
nuclear factor, erythroid derived 2
chr9_+_20940669 16.06 ENSMUST00000001040.7
ENSMUST00000215077.2
intercellular adhesion molecule 4, Landsteiner-Wiener blood group
chr4_-_137157824 15.82 ENSMUST00000102522.5
chymotrypsin-like elastase family, member 3B
chr5_+_90920353 15.73 ENSMUST00000202625.2
platelet factor 4
chr15_-_103160082 15.45 ENSMUST00000149111.8
ENSMUST00000132836.8
nuclear factor, erythroid derived 2
chr10_-_62178453 15.07 ENSMUST00000143179.2
ENSMUST00000130422.8
hexokinase 1
chr9_-_44253588 14.89 ENSMUST00000215091.2
hydroxymethylbilane synthase
chr2_-_120867529 14.51 ENSMUST00000102490.10
erythrocyte membrane protein band 4.2
chr17_-_35285146 14.21 ENSMUST00000174190.2
ENSMUST00000097337.8
megakaryocyte and platelet inhibitory receptor G6b
chr6_+_41279199 13.73 ENSMUST00000031913.5
trypsin 4
chr1_-_132295617 13.72 ENSMUST00000142609.8
transmembrane and coiled-coil domains 2
chr6_-_41291634 13.63 ENSMUST00000064324.12
trypsin 5
chr4_-_87724533 13.00 ENSMUST00000126353.8
ENSMUST00000149357.8
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
chr8_+_85428059 12.14 ENSMUST00000238364.2
ENSMUST00000238562.2
ENSMUST00000037165.6
lymphoblastomic leukemia 1
chr11_-_102360664 11.65 ENSMUST00000103086.4
integrin alpha 2b
chr2_-_120867232 11.38 ENSMUST00000023987.6
erythrocyte membrane protein band 4.2
chr19_+_58748132 11.28 ENSMUST00000026081.5
pancreatic lipase-related protein 2
chr11_-_83177548 11.27 ENSMUST00000163961.3
schlafen 14
chr9_-_21874802 11.11 ENSMUST00000006397.7
erythropoietin receptor
chr17_-_35304582 11.06 ENSMUST00000038507.7
lymphocyte antigen 6 complex, locus G6F
chr2_+_103788321 11.01 ENSMUST00000156813.8
ENSMUST00000170926.8
LIM domain only 2
chr11_+_32226400 10.85 ENSMUST00000020531.9
hemoglobin X, alpha-like embryonic chain in Hba complex
chr11_+_74510413 10.73 ENSMUST00000100866.3
coiled-coil domain containing 92B
chr6_+_30541581 10.39 ENSMUST00000096066.5
carboxypeptidase A2, pancreatic
chr11_+_70529944 10.34 ENSMUST00000055184.7
ENSMUST00000108551.3
glycoprotein 1b, alpha polypeptide
chr1_-_171108754 10.19 ENSMUST00000073120.11
protoporphyrinogen oxidase
chr7_+_99184645 9.87 ENSMUST00000098266.9
ENSMUST00000179755.8
arrestin, beta 1
chr16_+_38182569 9.82 ENSMUST00000023494.13
ENSMUST00000114739.2
popeye domain containing 2
chr9_-_44253630 9.30 ENSMUST00000097558.5
hydroxymethylbilane synthase
chrX_-_106446928 9.14 ENSMUST00000033591.6
integral membrane protein 2A
chr9_+_7558449 8.95 ENSMUST00000018765.4
matrix metallopeptidase 8
chrX_+_92698469 8.89 ENSMUST00000113933.9
phosphate cytidylyltransferase 1, choline, beta isoform
chr7_-_133304244 8.56 ENSMUST00000209636.2
ENSMUST00000153698.3
uroporphyrinogen III synthase
chr1_+_174000304 8.18 ENSMUST00000027817.8
spectrin alpha, erythrocytic 1
chr3_-_14873406 8.15 ENSMUST00000181860.8
ENSMUST00000144327.3
carbonic anhydrase 1
chr11_+_32226893 8.04 ENSMUST00000145569.2
hemoglobin X, alpha-like embryonic chain in Hba complex
chr7_-_98887770 7.91 ENSMUST00000064231.8
monoacylglycerol O-acyltransferase 2
chr7_+_110372860 7.61 ENSMUST00000143786.2
adenosine monophosphate deaminase 3
chr1_-_173161069 7.57 ENSMUST00000038227.6
atypical chemokine receptor 1 (Duffy blood group)
chr7_+_28240262 7.50 ENSMUST00000119180.4
syncollin
chr4_-_87724512 7.47 ENSMUST00000148059.2
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
chr8_-_86107593 7.46 ENSMUST00000122452.8
myosin light chain kinase 3
chr8_-_46664321 7.40 ENSMUST00000034049.5
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
chr17_+_31427023 7.27 ENSMUST00000173776.2
ENSMUST00000048656.15
ubiquitin associated and SH3 domain containing, A
chrX_+_149330371 7.18 ENSMUST00000066337.13
ENSMUST00000112715.2
aminolevulinic acid synthase 2, erythroid
chr11_-_115968373 7.14 ENSMUST00000174822.8
unc-13 homolog D
chr1_-_156301821 6.93 ENSMUST00000188027.2
ENSMUST00000187507.7
ENSMUST00000189661.7
sterol O-acyltransferase 1
chr2_+_84818538 6.88 ENSMUST00000028466.12
proteoglycan 3
chr14_-_70945434 6.79 ENSMUST00000228346.2
exportin 7
chrX_+_92718695 6.66 ENSMUST00000045898.4
phosphate cytidylyltransferase 1, choline, beta isoform
chr11_-_115968745 6.55 ENSMUST00000156545.2
ENSMUST00000075036.9
ENSMUST00000106451.8
unc-13 homolog D
chr17_-_33932346 6.04 ENSMUST00000173392.2
membrane associated ring-CH-type finger 2
chr6_+_125529911 5.88 ENSMUST00000112254.8
ENSMUST00000112253.6
Von Willebrand factor
chr4_+_34893772 5.67 ENSMUST00000029975.10
ENSMUST00000135871.8
ENSMUST00000108130.2
glycoprotein hormones, alpha subunit
chr2_-_153083322 5.29 ENSMUST00000056924.14
pleiomorphic adenoma gene-like 2
chr11_+_101151394 5.25 ENSMUST00000103108.8
WNK lysine deficient protein kinase 4
chr2_+_90927053 5.12 ENSMUST00000132741.3
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_-_115967873 5.09 ENSMUST00000153408.8
unc-13 homolog D
chr2_+_72306503 4.83 ENSMUST00000102691.11
ENSMUST00000157019.2
cell division cycle associated 7
chr10_-_80269436 4.82 ENSMUST00000105346.10
ENSMUST00000020377.13
ENSMUST00000105340.8
ENSMUST00000020379.13
ENSMUST00000105344.8
ENSMUST00000105342.8
ENSMUST00000105345.10
ENSMUST00000105343.8
transcription factor 3
chr11_-_115968576 4.70 ENSMUST00000106450.8
unc-13 homolog D
chr8_+_85428391 4.65 ENSMUST00000238338.2
lymphoblastomic leukemia 1
chr3_-_107129038 4.40 ENSMUST00000029504.9
chymosin
chr3_-_20296337 4.34 ENSMUST00000001921.3
carboxypeptidase A3, mast cell
chr4_-_137137088 3.74 ENSMUST00000024200.7
chymotrypsin-like elastase family, member 3A
chr17_-_31363245 3.72 ENSMUST00000024826.8
trefoil factor 2 (spasmolytic protein 1)
chr5_+_115604321 3.66 ENSMUST00000145785.8
ENSMUST00000031495.11
ENSMUST00000112071.8
ENSMUST00000125568.2
phospholipase A2, group IB, pancreas
chr6_+_129374441 3.58 ENSMUST00000112081.9
ENSMUST00000112079.3
C-type lectin domain family 1, member b
chr7_-_126398165 3.48 ENSMUST00000205890.2
ENSMUST00000205336.2
ENSMUST00000087566.11
aldolase A, fructose-bisphosphate
chr3_+_108272205 3.46 ENSMUST00000090563.7
myosin binding protein H-like
chr9_+_21176582 3.40 ENSMUST00000065005.5
autophagy related 4D, cysteine peptidase
chr2_+_4564553 3.36 ENSMUST00000176828.8
FERM domain containing 4A
chr15_+_57849269 3.32 ENSMUST00000050374.3
family with sequence similarity 83, member A
chr11_+_70396070 3.29 ENSMUST00000019063.3
transmembrane 4 superfamily member 5
chrX_+_55825033 3.25 ENSMUST00000114772.9
ENSMUST00000114768.10
ENSMUST00000155882.8
four and a half LIM domains 1
chr6_+_129374260 3.20 ENSMUST00000032262.14
C-type lectin domain family 1, member b
chr19_-_6065181 3.04 ENSMUST00000236537.2
ENSMUST00000025891.11
calpain 1
chr5_+_64969679 3.00 ENSMUST00000166409.6
ENSMUST00000197879.2
Kruppel-like factor 3 (basic)
chr12_-_91712783 2.99 ENSMUST00000166967.2
stonin 2
chr1_+_12788720 2.94 ENSMUST00000088585.10
sulfatase 1
chr11_+_97917746 2.81 ENSMUST00000017548.7
ribosomal protein L19
chrX_+_55824797 2.80 ENSMUST00000114773.10
four and a half LIM domains 1
chr5_-_73349191 2.74 ENSMUST00000176910.3
FRY like transcription coactivator
chr19_-_6065415 2.68 ENSMUST00000237519.2
calpain 1
chr6_-_129484070 2.47 ENSMUST00000183258.8
ENSMUST00000182784.4
ENSMUST00000032265.13
ENSMUST00000162815.2
oxidized low density lipoprotein (lectin-like) receptor 1
chr4_+_14864076 2.40 ENSMUST00000029875.4
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
chr13_-_23650045 2.39 ENSMUST00000041674.14
ENSMUST00000110434.2
butyrophilin, subfamily 1, member A1
chr3_-_75177378 2.25 ENSMUST00000039047.5
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr11_+_3280401 2.25 ENSMUST00000045153.11
phosphoinositide-3-kinase interacting protein 1
chr3_+_107137924 2.21 ENSMUST00000179399.3
RIKEN cDNA A630076J17 gene
chr15_-_38518458 2.19 ENSMUST00000127848.2
antizyme inhibitor 1
chr6_-_136899167 2.16 ENSMUST00000032343.7
endoplasmic reticulum protein 27
chr13_+_107083613 2.07 ENSMUST00000022203.10
DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)
chr12_+_59113659 2.04 ENSMUST00000021381.6
pinin
chr12_-_69939931 1.78 ENSMUST00000049239.8
ENSMUST00000110570.8
mitogen-activated protein kinase kinase kinase kinase 5
chr9_+_66257747 1.78 ENSMUST00000042824.13
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr6_-_68609426 1.76 ENSMUST00000103328.3
immunoglobulin kappa variable 10-96
chr2_+_14878480 1.65 ENSMUST00000114719.7
calcium channel, voltage-dependent, beta 2 subunit
chrX_+_158623460 1.55 ENSMUST00000112451.8
ENSMUST00000112453.9
SH3-domain kinase binding protein 1
chr18_-_38131766 1.48 ENSMUST00000236588.2
ENSMUST00000237272.2
ENSMUST00000236134.2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr14_-_79718890 1.46 ENSMUST00000022601.7
WW domain binding protein 4
chr10_+_69055215 1.45 ENSMUST00000172261.3
Rho-related BTB domain containing 1
chr15_-_77037756 1.44 ENSMUST00000227314.2
ENSMUST00000227930.2
ENSMUST00000227533.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr2_-_24985137 1.43 ENSMUST00000114373.8
NADPH oxidase activator 1
chr10_+_84412490 1.42 ENSMUST00000020223.8
t-complex 11 (mouse) like 2
chr1_+_45350698 1.42 ENSMUST00000087883.13
collagen, type III, alpha 1
chr18_-_61840654 1.36 ENSMUST00000025472.7
prenylcysteine oxidase 1 like
chr5_+_32616187 1.36 ENSMUST00000015100.15
protein phosphatase 1 catalytic subunit beta
chr1_-_179631190 1.34 ENSMUST00000027768.14
AT hook containing transcription factor 1
chr13_-_73848807 1.33 ENSMUST00000022048.6
solute carrier family 6 (neurotransmitter transporter), member 19
chr15_-_77037972 1.30 ENSMUST00000111581.4
ENSMUST00000166610.8
RNA binding protein, fox-1 homolog (C. elegans) 2
chr19_-_6065799 1.27 ENSMUST00000235138.2
calpain 1
chr11_+_87938519 1.27 ENSMUST00000079866.11
serine and arginine-rich splicing factor 1
chrX_+_111221031 1.25 ENSMUST00000026599.10
ENSMUST00000113415.2
apolipoprotein O-like
chr4_+_40920047 1.19 ENSMUST00000030122.5
serine peptidase inhibitor, Kazal type 4
chr12_-_75596441 1.17 ENSMUST00000218716.2
protein phosphatase 2, regulatory subunit B', epsilon
chr6_+_87405968 1.17 ENSMUST00000032125.7
bone morphogenetic protein 10
chr16_+_91444730 1.16 ENSMUST00000119368.8
ENSMUST00000114037.9
ENSMUST00000114036.9
ENSMUST00000122302.8
Son DNA binding protein
chr10_+_39009951 1.15 ENSMUST00000019991.8
tubulin, epsilon 1
chr1_-_160134873 1.12 ENSMUST00000193185.6
RAB GTPase activating protein 1-like
chr11_+_4959515 1.12 ENSMUST00000101613.3
adaptor protein complex AP-1, beta 1 subunit
chr2_+_109522781 1.10 ENSMUST00000111050.10
brain derived neurotrophic factor
chr2_+_15531281 1.08 ENSMUST00000146205.3
MAM and LDL receptor class A domain containing 1
chr3_+_89043879 1.05 ENSMUST00000107482.10
ENSMUST00000127058.2
pyruvate kinase liver and red blood cell
chr3_+_89043440 1.00 ENSMUST00000047111.13
pyruvate kinase liver and red blood cell
chr2_+_112097087 0.98 ENSMUST00000110987.9
ENSMUST00000028549.14
solute carrier family 12, member 6
chr3_+_61269059 0.98 ENSMUST00000049064.4
RAP2B, member of RAS oncogene family
chr16_-_44379226 0.94 ENSMUST00000114634.3
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr10_+_58207229 0.94 ENSMUST00000238939.2
LIM and senescent cell antigen-like domains 1
chr7_-_44541787 0.93 ENSMUST00000208551.2
ENSMUST00000208253.2
ENSMUST00000207654.2
ENSMUST00000207278.2
mediator complex subunit 25
chr3_+_116653113 0.90 ENSMUST00000040260.11
ferric-chelate reductase 1
chr13_-_59930059 0.87 ENSMUST00000225581.2
predicted gene, 49354
chr4_+_124696336 0.74 ENSMUST00000138807.8
ENSMUST00000030723.3
metal response element binding transcription factor 1
chr11_+_87938626 0.73 ENSMUST00000107920.10
serine and arginine-rich splicing factor 1
chr15_+_55171138 0.69 ENSMUST00000023053.12
ENSMUST00000110217.10
collagen, type XIV, alpha 1
chr7_-_19967753 0.66 ENSMUST00000168580.2
vomeronasal 1 receptor 242
chr2_-_59778560 0.65 ENSMUST00000153136.2
bromodomain adjacent to zinc finger domain, 2B
chr15_-_83317020 0.64 ENSMUST00000231184.2
protein kinase C and casein kinase substrate in neurons 2
chr10_-_18887701 0.63 ENSMUST00000105527.2
tumor necrosis factor, alpha-induced protein 3
chr15_-_83316995 0.59 ENSMUST00000165095.9
protein kinase C and casein kinase substrate in neurons 2
chr18_-_24153363 0.57 ENSMUST00000153337.2
ENSMUST00000148525.2
zinc finger protein 24
chr1_-_106980033 0.57 ENSMUST00000112717.3
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
chr2_-_86109346 0.56 ENSMUST00000217294.2
ENSMUST00000217245.2
ENSMUST00000216432.2
olfactory receptor 1051
chr11_-_94133527 0.54 ENSMUST00000061469.4
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr1_+_177272215 0.49 ENSMUST00000192851.2
ENSMUST00000193480.2
ENSMUST00000195388.2
zinc finger and BTB domain containing 18
chr2_+_61542038 0.46 ENSMUST00000028278.14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chr10_-_13264574 0.43 ENSMUST00000079698.7
phosphatase and actin regulator 2
chr11_+_87938128 0.42 ENSMUST00000139129.9
serine and arginine-rich splicing factor 1
chr6_+_17306334 0.39 ENSMUST00000007799.13
ENSMUST00000115456.6
caveolin 1, caveolae protein
chr9_-_65734826 0.39 ENSMUST00000159109.2
zinc finger protein 609
chr3_+_66892979 0.37 ENSMUST00000162362.8
ENSMUST00000065074.14
ENSMUST00000065047.13
arginine/serine-rich coiled-coil 1
chr17_+_71511642 0.37 ENSMUST00000126681.8
lipin 2
chr16_-_34083549 0.34 ENSMUST00000114949.8
ENSMUST00000114954.8
kalirin, RhoGEF kinase
chr16_-_19334384 0.34 ENSMUST00000054606.2
olfactory receptor 167
chr14_+_53370308 0.32 ENSMUST00000103613.3
T cell receptor alpha variable 6N-6
chr1_-_159981132 0.27 ENSMUST00000039178.12
tenascin N
chr15_-_77037926 0.25 ENSMUST00000228087.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr6_+_68402550 0.24 ENSMUST00000103323.3
immunoglobulin kappa variable 16-104
chr3_+_101917455 0.24 ENSMUST00000066187.6
ENSMUST00000198675.2
nescient helix loop helix 2
chr8_-_4375320 0.22 ENSMUST00000098950.6
ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)
chr9_+_59614877 0.18 ENSMUST00000128944.8
ENSMUST00000098661.10
GRAM domain containing 2
chr14_-_54647647 0.17 ENSMUST00000228488.2
ENSMUST00000195970.5
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr16_-_92622972 0.15 ENSMUST00000023673.14
runt related transcription factor 1
chr6_-_55658242 0.15 ENSMUST00000044767.10
neurogenic differentiation 6
chr10_-_83484467 0.10 ENSMUST00000146876.9
ENSMUST00000176294.2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr3_+_98129463 0.10 ENSMUST00000029469.5
regenerating islet-derived family, member 4
chr12_-_76842263 0.08 ENSMUST00000082431.6
glutathione peroxidase 2
chr3_+_66893031 0.04 ENSMUST00000046542.13
ENSMUST00000162693.8
arginine/serine-rich coiled-coil 1
chr17_-_84495364 0.04 ENSMUST00000060366.7
zinc finger protein 36, C3H type-like 2
chr6_+_41519654 0.03 ENSMUST00000103293.2
T cell receptor beta joining 2-1
chr8_-_18791557 0.01 ENSMUST00000033846.7
angiopoietin 2
chr3_+_101917392 0.01 ENSMUST00000196324.2
nescient helix loop helix 2
chr14_+_53913598 0.00 ENSMUST00000103662.6
T cell receptor alpha variable 9-4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.1 24.2 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
7.3 21.9 GO:0002215 defense response to nematode(GO:0002215)
4.2 20.9 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
3.0 24.1 GO:0002432 granuloma formation(GO:0002432)
2.9 8.6 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780)
2.6 7.9 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
2.4 44.8 GO:0043249 erythrocyte maturation(GO:0043249)
2.3 6.9 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
2.1 31.8 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
2.0 10.2 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
2.0 9.8 GO:0060931 sinoatrial node cell development(GO:0060931)
1.9 15.1 GO:0006735 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
1.9 7.4 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
1.8 5.3 GO:0034378 chylomicron assembly(GO:0034378)
1.7 6.9 GO:0045575 basophil activation(GO:0045575)
1.4 16.8 GO:0001955 blood vessel maturation(GO:0001955)
1.3 9.1 GO:0002317 plasma cell differentiation(GO:0002317)
1.2 7.5 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
1.2 9.9 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
1.2 3.7 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.9 19.4 GO:0007379 segment specification(GO:0007379)
0.8 20.5 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.8 11.1 GO:0061032 visceral serous pericardium development(GO:0061032)
0.8 7.6 GO:0032264 IMP salvage(GO:0032264)
0.8 33.0 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175)
0.7 5.7 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.7 11.3 GO:0019374 galactolipid metabolic process(GO:0019374)
0.7 7.2 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.6 11.0 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.6 4.8 GO:0002326 B cell lineage commitment(GO:0002326)
0.6 4.5 GO:0070294 renal sodium ion absorption(GO:0070294)
0.5 1.6 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.5 2.2 GO:1902269 positive regulation of polyamine transmembrane transport(GO:1902269)
0.5 11.3 GO:0016075 rRNA catabolic process(GO:0016075)
0.5 3.7 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.5 2.9 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.5 3.4 GO:0051697 protein delipidation(GO:0051697)
0.5 1.4 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.4 10.3 GO:0042730 fibrinolysis(GO:0042730)
0.4 7.0 GO:0016540 protein autoprocessing(GO:0016540)
0.4 8.9 GO:0030574 collagen catabolic process(GO:0030574)
0.3 4.3 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.3 0.9 GO:2001178 mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178)
0.3 3.0 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.3 1.4 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 7.3 GO:0038065 collagen-activated signaling pathway(GO:0038065)
0.3 1.1 GO:1904252 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.3 2.4 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.3 8.2 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.2 3.5 GO:0061615 glycolytic process through fructose-6-phosphate(GO:0061615)
0.2 1.0 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.2 2.0 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.2 2.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 15.6 GO:0001541 ovarian follicle development(GO:0001541)
0.2 13.7 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.2 1.1 GO:0046668 axon target recognition(GO:0007412) regulation of retinal cell programmed cell death(GO:0046668)
0.2 2.7 GO:0090527 actin filament reorganization(GO:0090527)
0.2 2.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.2 5.2 GO:0030220 platelet formation(GO:0030220)
0.1 1.5 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 1.5 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 8.1 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 11.7 GO:0070527 platelet aggregation(GO:0070527)
0.1 6.0 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.1 5.9 GO:0030168 platelet activation(GO:0030168)
0.1 1.2 GO:1903242 regulation of cardiac muscle adaptation(GO:0010612) regulation of cardiac muscle hypertrophy in response to stress(GO:1903242)
0.1 1.4 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.1 1.8 GO:0021702 cerebellar Purkinje cell differentiation(GO:0021702)
0.1 0.9 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.1 1.4 GO:0060263 regulation of respiratory burst(GO:0060263)
0.1 1.2 GO:0042407 cristae formation(GO:0042407)
0.1 0.1 GO:0009609 response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609)
0.1 1.3 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.1 6.2 GO:0006611 protein export from nucleus(GO:0006611)
0.1 0.6 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.1 1.1 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.3 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.1 1.2 GO:0036010 protein localization to endosome(GO:0036010)
0.1 2.1 GO:0000154 rRNA modification(GO:0000154)
0.0 3.0 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 2.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 4.2 GO:0032642 regulation of chemokine production(GO:0032642)
0.0 7.5 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.0 1.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:2000196 positive regulation of female gonad development(GO:2000196) positive regulation of progesterone secretion(GO:2000872)
0.0 59.1 GO:0006508 proteolysis(GO:0006508)
0.0 2.8 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.0 0.9 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 1.3 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.4 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 1.2 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 0.2 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 0.7 GO:0030199 collagen fibril organization(GO:0030199)
0.0 6.0 GO:0006887 exocytosis(GO:0006887)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 27.5 GO:0033093 Weibel-Palade body(GO:0033093)
2.4 18.9 GO:0005833 hemoglobin complex(GO:0005833)
1.4 8.2 GO:0032437 cuticular plate(GO:0032437)
1.1 15.7 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.5 11.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.4 9.2 GO:0031143 pseudopodium(GO:0031143)
0.4 4.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 10.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.4 15.1 GO:0097228 sperm principal piece(GO:0097228)
0.3 20.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 11.6 GO:0008305 integrin complex(GO:0008305)
0.2 8.3 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.2 3.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 1.4 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 24.1 GO:0030863 cortical cytoskeleton(GO:0030863)
0.1 4.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 1.4 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 19.0 GO:0032993 protein-DNA complex(GO:0032993)
0.1 1.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 24.2 GO:0000793 condensed chromosome(GO:0000793)
0.1 6.8 GO:0005643 nuclear pore(GO:0005643)
0.1 1.1 GO:0030061 mitochondrial crista(GO:0030061)
0.1 4.7 GO:0030667 secretory granule membrane(GO:0030667)
0.1 2.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 10.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 9.5 GO:0042383 sarcolemma(GO:0042383)
0.0 76.5 GO:0005615 extracellular space(GO:0005615)
0.0 2.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 7.4 GO:0043209 myelin sheath(GO:0043209)
0.0 5.4 GO:0005923 bicellular tight junction(GO:0005923)
0.0 9.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 10.5 GO:0005925 focal adhesion(GO:0005925)
0.0 0.9 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.5 GO:0030027 lamellipodium(GO:0030027)
0.0 1.8 GO:0030427 site of polarized growth(GO:0030427)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.1 24.2 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
3.9 15.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
3.3 9.9 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
3.0 36.3 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
2.9 8.6 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
2.6 15.7 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
2.6 25.9 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
2.4 7.2 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
2.3 11.6 GO:0070051 fibrinogen binding(GO:0070051)
2.1 18.9 GO:0005344 oxygen transporter activity(GO:0005344)
1.9 15.1 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
1.1 33.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.8 5.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.8 7.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.8 8.1 GO:0004064 arylesterase activity(GO:0004064)
0.8 7.6 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.7 11.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.7 2.8 GO:1990932 5.8S rRNA binding(GO:1990932)
0.7 2.1 GO:0008988 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988)
0.7 10.2 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.7 7.4 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.6 4.8 GO:0070644 vitamin D response element binding(GO:0070644)
0.6 2.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.5 2.2 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.5 7.6 GO:0019957 C-C chemokine binding(GO:0019957)
0.5 6.8 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.5 30.1 GO:0050699 WW domain binding(GO:0050699)
0.5 3.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.4 2.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.4 2.0 GO:0004743 pyruvate kinase activity(GO:0004743)
0.4 3.7 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.4 1.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.4 3.6 GO:0050733 RS domain binding(GO:0050733)
0.3 3.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 4.3 GO:0051525 NFAT protein binding(GO:0051525)
0.3 5.9 GO:0019865 immunoglobulin binding(GO:0019865)
0.2 1.0 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.2 1.6 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2 7.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 47.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 11.3 GO:0004521 endoribonuclease activity(GO:0004521)
0.2 2.5 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.2 3.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 2.1 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 1.4 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.1 6.6 GO:0030552 cAMP binding(GO:0030552)
0.1 9.9 GO:0070888 E-box binding(GO:0070888)
0.1 6.9 GO:0008374 O-acyltransferase activity(GO:0008374)
0.1 0.9 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 1.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 1.4 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 1.2 GO:0031433 telethonin binding(GO:0031433)
0.1 24.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 16.2 GO:0005178 integrin binding(GO:0005178)
0.1 0.6 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 23.2 GO:0030246 carbohydrate binding(GO:0030246)
0.1 7.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 3.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.2 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 3.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.5 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 1.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 5.2 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 1.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 4.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.9 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 1.3 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 3.4 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.9 GO:0005179 hormone activity(GO:0005179)
0.0 1.0 GO:0019003 GDP binding(GO:0019003)
0.0 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 3.0 GO:0044325 ion channel binding(GO:0044325)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 26.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.6 28.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.5 6.9 ST JAK STAT PATHWAY Jak-STAT Pathway
0.4 11.6 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.3 25.0 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.3 37.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 4.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 5.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 26.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.0 PID EPO PATHWAY EPO signaling pathway
0.1 8.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.2 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 4.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.1 NABA COLLAGENS Genes encoding collagen proteins
0.0 2.4 PID TNF PATHWAY TNF receptor signaling pathway
0.0 3.1 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.9 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.1 PID SHP2 PATHWAY SHP2 signaling
0.0 1.4 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 2.0 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 1.4 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.9 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 3.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 50.1 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
1.0 16.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.9 15.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.7 7.4 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.6 11.6 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.6 5.7 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.5 15.9 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.3 7.6 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 11.0 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 13.6 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.2 11.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 3.7 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.2 8.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 4.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 23.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 4.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.2 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 4.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 2.4 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 1.5 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 2.6 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 1.4 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.6 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 2.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.6 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 1.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase