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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Grhl1

Z-value: 3.16

Motif logo

Transcription factors associated with Grhl1

Gene Symbol Gene ID Gene Info
ENSMUSG00000020656.17 Grhl1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Grhl1mm39_v1_chr12_+_24622274_246223070.105.8e-01Click!

Activity profile of Grhl1 motif

Sorted Z-values of Grhl1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Grhl1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr8_-_93956143 20.32 ENSMUST00000176282.2
ENSMUST00000034173.14
carboxylesterase 1E
chr9_-_78254422 19.47 ENSMUST00000034902.12
glutathione S-transferase, alpha 2 (Yc2)
chr9_-_78254443 16.16 ENSMUST00000129247.2
glutathione S-transferase, alpha 2 (Yc2)
chrX_-_37545311 14.60 ENSMUST00000074913.12
ENSMUST00000016678.14
ENSMUST00000061755.9
lysosomal-associated membrane protein 2
chr17_-_56312555 13.87 ENSMUST00000043785.8
signal transducing adaptor family member 2
chr11_+_72326391 12.71 ENSMUST00000100903.3
gamma-glutamyltransferase 6
chr4_+_140970161 10.52 ENSMUST00000138096.8
ENSMUST00000006618.9
ENSMUST00000125392.8
Rho guanine nucleotide exchange factor (GEF) 19
chr17_+_56312672 10.22 ENSMUST00000133998.8
MPN domain containing
chr18_+_56565188 9.92 ENSMUST00000070166.6
GRAM domain containing 3
chr9_+_78197205 9.77 ENSMUST00000119823.8
ENSMUST00000121273.2
glutathione S-transferase alpha 5
chr7_+_100970435 8.50 ENSMUST00000210192.2
ENSMUST00000172630.8
START domain containing 10
chr19_+_18609291 7.90 ENSMUST00000042392.14
ENSMUST00000237347.2
nicotinamide riboside kinase 1
chr2_-_30095805 7.90 ENSMUST00000113663.9
ENSMUST00000044038.10
kynurenine aminotransferase 1
chr14_-_73622638 7.77 ENSMUST00000228637.2
ENSMUST00000022704.9
integral membrane protein 2B
chr1_+_135746330 7.69 ENSMUST00000038760.10
ladinin
chr2_-_30095784 7.67 ENSMUST00000113662.8
kynurenine aminotransferase 1
chr15_-_75886166 7.67 ENSMUST00000060807.12
family with sequence similarity 83, member H
chr7_+_100971034 7.58 ENSMUST00000173270.8
START domain containing 10
chr13_+_8935537 7.42 ENSMUST00000169314.9
isopentenyl-diphosphate delta isomerase
chr7_+_100970910 7.17 ENSMUST00000174291.8
ENSMUST00000167888.9
ENSMUST00000172662.2
START domain containing 10
chr7_+_65343156 5.79 ENSMUST00000032726.14
ENSMUST00000107495.5
ENSMUST00000143508.3
ENSMUST00000129166.3
ENSMUST00000206517.2
ENSMUST00000206837.2
ENSMUST00000206628.2
ENSMUST00000206361.2
TM2 domain containing 3
chr19_+_18609343 4.73 ENSMUST00000159572.9
nicotinamide riboside kinase 1
chr14_-_57370706 4.20 ENSMUST00000160703.2
gap junction protein, beta 6
chr4_+_108691798 3.91 ENSMUST00000030296.9
thioredoxin domain containing 12 (endoplasmic reticulum)
chr16_+_43993599 3.62 ENSMUST00000119746.8
ENSMUST00000088356.10
ENSMUST00000169582.3
upstream transcription factor family member 3
chr3_+_79793237 2.98 ENSMUST00000029567.9
golgi associated kinase 1B
chr17_+_29487881 2.92 ENSMUST00000234845.2
ENSMUST00000235038.2
ENSMUST00000235050.2
ENSMUST00000120346.9
ENSMUST00000234377.2
ENSMUST00000235074.2
ENSMUST00000235040.2
ENSMUST00000234256.2
ENSMUST00000234459.2
cDNA sequence BC004004
chr4_-_155170738 2.68 ENSMUST00000030914.4
retention in endoplasmic reticulum sorting receptor 1
chr17_-_34847354 2.67 ENSMUST00000167097.9
palmitoyl-protein thioesterase 2
chr17_+_29487762 2.51 ENSMUST00000064709.13
ENSMUST00000234711.2
cDNA sequence BC004004
chr1_-_52766615 2.44 ENSMUST00000156876.8
ENSMUST00000087701.4
major facilitator superfamily domain containing 6
chr7_-_101714251 2.23 ENSMUST00000130074.2
ENSMUST00000131104.3
ENSMUST00000096639.12
ring finger protein 121
chr1_-_131207279 2.19 ENSMUST00000062108.10
inhibitor of kappaB kinase epsilon
chr3_-_10400710 2.02 ENSMUST00000078748.4
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr8_+_46081213 1.84 ENSMUST00000130850.8
sorbin and SH3 domain containing 2
chr4_-_19570073 1.82 ENSMUST00000029885.5
copine III
chr2_+_172392678 1.79 ENSMUST00000099058.10
transcription factor AP-2, gamma
chr18_-_25886908 1.78 ENSMUST00000115816.3
ENSMUST00000223704.2
CUGBP, Elav-like family member 4
chr12_+_24622274 1.78 ENSMUST00000085553.13
grainyhead like transcription factor 1
chr3_-_87171005 1.71 ENSMUST00000146512.2
Fc receptor-like S, scavenger receptor
chr2_+_84891281 1.71 ENSMUST00000238769.2
tankyrase 1 binding protein 1
chr5_-_86666408 1.66 ENSMUST00000140095.2
ENSMUST00000134179.8
transmembrane protease, serine 11g
chr4_+_155171034 1.65 ENSMUST00000030915.11
ENSMUST00000155775.8
ENSMUST00000127457.2
MORN repeat containing 1
chr5_-_117254146 1.62 ENSMUST00000166397.3
suppressor of defective silencing 3 homolog (S. cerevisiae)
chr2_-_127383305 1.62 ENSMUST00000103214.3
prominin 2
chr17_-_34847013 1.51 ENSMUST00000166040.9
palmitoyl-protein thioesterase 2
chr9_-_44179479 1.51 ENSMUST00000213803.2
NLR family member X1
chr2_-_179931672 1.39 ENSMUST00000038529.2
RBBP8 N-terminal like
chr2_-_144174066 1.38 ENSMUST00000037423.4
ovo like zinc finger 2
chr4_+_133793208 1.35 ENSMUST00000137053.2
crystallin beta-gamma domain containing 2
chr7_+_12661337 1.25 ENSMUST00000045870.5
ring finger protein 225
chr18_-_25887173 1.22 ENSMUST00000225477.2
CUGBP, Elav-like family member 4
chr17_+_7592045 1.19 ENSMUST00000095726.11
ENSMUST00000128533.8
ENSMUST00000129709.8
ENSMUST00000147803.8
ENSMUST00000140192.8
ENSMUST00000138222.8
ENSMUST00000144861.2
t-complex protein 10a
chr17_+_35844091 1.19 ENSMUST00000025273.9
psoriasis susceptibility 1 candidate 2 (human)
chr2_-_127383332 1.12 ENSMUST00000028855.14
prominin 2
chr5_-_86824205 1.01 ENSMUST00000038448.7
transmembrane protease, serine 11B
chr19_-_18609118 0.92 ENSMUST00000025631.7
ENSMUST00000236615.2
osteoclast stimulating factor 1
chr12_+_76464372 0.86 ENSMUST00000220187.2
protein phosphatase 1, regulatory subunit 36
chrX_+_99773784 0.82 ENSMUST00000113744.2
glycerophosphodiester phosphodiesterase domain containing 2
chr17_+_13574834 0.81 ENSMUST00000233944.2
ENSMUST00000097403.4
t-complex protein 10c
chr19_-_5610628 0.78 ENSMUST00000025861.3
ovo like zinc finger 1
chr3_-_87170903 0.75 ENSMUST00000090986.11
Fc receptor-like S, scavenger receptor
chr2_-_30857858 0.75 ENSMUST00000028200.9
torsin family 1, member A (torsin A)
chr4_+_135455427 0.73 ENSMUST00000102546.4
interleukin 22 receptor, alpha 1
chr2_+_24166920 0.73 ENSMUST00000168941.8
ENSMUST00000028360.8
ENSMUST00000123053.8
interleukin 1 family, member 5 (delta)
chr18_-_25886750 0.72 ENSMUST00000224553.2
ENSMUST00000025117.14
CUGBP, Elav-like family member 4
chr3_+_92292990 0.71 ENSMUST00000059845.2
ENSMUST00000191886.2
small proline-rich protein 2H
chr9_-_44179758 0.71 ENSMUST00000034621.16
ENSMUST00000168499.9
NLR family member X1
chr6_+_139576475 0.67 ENSMUST00000187618.7
ENSMUST00000186585.3
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr7_+_45204350 0.62 ENSMUST00000210300.2
hydroxysteroid (17-beta) dehydrogenase 14
chr16_-_26808724 0.57 ENSMUST00000089832.6
geminin coiled-coil domain containing
chr3_+_92223927 0.55 ENSMUST00000061038.4
small proline-rich protein 2B
chr2_+_28403255 0.54 ENSMUST00000028170.15
ral guanine nucleotide dissociation stimulator
chr19_+_4008645 0.54 ENSMUST00000179433.8
aldehyde dehydrogenase 3 family, member B3
chr7_+_30487322 0.53 ENSMUST00000189673.7
ENSMUST00000190990.7
ENSMUST00000189962.7
ENSMUST00000187493.7
ENSMUST00000098559.3
keratinocyte differentiation associated protein
chr12_-_54703281 0.49 ENSMUST00000056228.8
serine palmitoyltransferase, small subunit A
chr8_+_124204598 0.48 ENSMUST00000001520.13
AFG3-like AAA ATPase 1
chrX_+_99773523 0.44 ENSMUST00000019503.14
glycerophosphodiester phosphodiesterase domain containing 2
chr2_+_149672814 0.43 ENSMUST00000137280.2
ENSMUST00000149705.2
synapse differentiation inducing 1
chr6_-_113354468 0.42 ENSMUST00000099118.8
transcriptional adaptor 3
chr18_-_46413886 0.36 ENSMUST00000236999.2
protein geranylgeranyltransferase type I, beta subunit
chr11_-_105346120 0.34 ENSMUST00000138977.8
membrane associated ring-CH-type finger 10
chr7_-_29217967 0.30 ENSMUST00000181975.8
signal-induced proliferation-associated 1 like 3
chr12_+_76464301 0.28 ENSMUST00000063977.9
protein phosphatase 1, regulatory subunit 36
chr9_+_15150341 0.26 ENSMUST00000034413.8
V-set and transmembrane domain containing 5
chr6_-_131293361 0.25 ENSMUST00000121078.2
serine/threonine/tyrosine kinase 1
chr15_-_63680596 0.22 ENSMUST00000110125.9
ENSMUST00000173503.3
gasdermin C
chr18_-_64794338 0.19 ENSMUST00000025482.10
ATPase, class I, type 8B, member 1
chr17_+_37148015 0.18 ENSMUST00000179968.8
ENSMUST00000130367.8
ENSMUST00000053434.15
ENSMUST00000130801.8
ENSMUST00000144182.8
ENSMUST00000123715.8
tripartite motif-containing 26
chr4_+_112089442 0.18 ENSMUST00000038455.12
ENSMUST00000170945.2
selection and upkeep of intraepithelial T cells 3
chr9_-_7872970 0.17 ENSMUST00000115672.2
baculoviral IAP repeat-containing 3
chr3_+_92195873 0.17 ENSMUST00000090872.7
small proline-rich protein 2A3
chr17_+_43700327 0.09 ENSMUST00000113599.2
ENSMUST00000224278.2
ENSMUST00000225466.2
adhesion G protein-coupled receptor F5
chr2_+_149672708 0.06 ENSMUST00000109935.8
synapse differentiation inducing 1
chrX_-_111608339 0.04 ENSMUST00000039887.4
premature ovarian failure 1B
chr2_+_149672760 0.00 ENSMUST00000109934.2
ENSMUST00000140870.8
synapse differentiation inducing 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.6 GO:0097052 L-kynurenine metabolic process(GO:0097052)
4.9 14.6 GO:0071211 protein targeting to vacuole involved in autophagy(GO:0071211)
2.3 23.2 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
1.3 43.0 GO:0035634 response to stilbenoid(GO:0035634)
1.0 7.8 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.9 12.7 GO:0006751 glutathione catabolic process(GO:0006751)
0.7 2.7 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.5 5.4 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.4 1.8 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.4 12.6 GO:0019363 pyridine nucleotide biosynthetic process(GO:0019363)
0.3 1.8 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.3 3.7 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.3 0.8 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.2 2.2 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.2 2.7 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.2 1.4 GO:0060214 endocardium formation(GO:0060214)
0.1 1.8 GO:0002934 desmosome organization(GO:0002934)
0.1 8.4 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.1 3.9 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.1 3.6 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.7 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.1 1.3 GO:0090527 actin filament reorganization(GO:0090527)
0.1 2.2 GO:0010884 positive regulation of lipid storage(GO:0010884)
0.1 0.4 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 1.7 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 10.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.5 GO:0034982 mitochondrial protein processing(GO:0034982)
0.0 1.3 GO:0031424 keratinization(GO:0031424)
0.0 0.2 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.0 1.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 4.2 GO:0042471 ear morphogenesis(GO:0042471)
0.0 0.7 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 1.5 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.5 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 1.7 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.6 GO:0006270 DNA replication initiation(GO:0006270)
0.0 1.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 14.6 GO:0097637 platelet dense granule membrane(GO:0031088) intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
1.3 23.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.5 2.7 GO:0044393 microspike(GO:0044393)
0.2 7.7 GO:0045095 keratin filament(GO:0045095)
0.2 4.2 GO:0005922 connexon complex(GO:0005922)
0.2 7.8 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 0.5 GO:0005745 m-AAA complex(GO:0005745)
0.1 9.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.7 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 1.6 GO:0016580 Sin3 complex(GO:0016580)
0.1 3.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 0.5 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 2.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 7.7 GO:0005604 basement membrane(GO:0005604)
0.0 11.8 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.3 GO:0061689 tricellular tight junction(GO:0061689)
0.0 7.4 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.5 GO:0042599 lamellar body(GO:0042599)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 2.2 GO:0016605 PML body(GO:0016605)
0.0 2.2 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.6 GO:0047312 L-phenylalanine:pyruvate aminotransferase activity(GO:0047312) glutamine-phenylpyruvate transaminase activity(GO:0047316) L-glutamine:pyruvate aminotransferase activity(GO:0047945)
4.2 12.6 GO:0061769 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
1.5 7.4 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
1.3 3.9 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
1.3 7.7 GO:1990254 keratin filament binding(GO:1990254)
1.2 35.6 GO:0043295 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
1.1 12.7 GO:0036374 glutathione hydrolase activity(GO:0036374)
1.0 20.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.5 4.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.4 2.2 GO:0008384 IkappaB kinase activity(GO:0008384)
0.3 3.6 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.3 2.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 1.7 GO:0071532 ankyrin repeat binding(GO:0071532)
0.2 0.7 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 0.7 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.1 1.3 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 7.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 0.5 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 2.7 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.1 0.7 GO:0051787 misfolded protein binding(GO:0051787)
0.1 10.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.5 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.4 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.1 3.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.7 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 2.7 GO:0015485 cholesterol binding(GO:0015485)
0.0 1.6 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 23.9 GO:0008289 lipid binding(GO:0008289)
0.0 1.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 12.6 GO:0008233 peptidase activity(GO:0008233)
0.0 5.6 GO:0045296 cadherin binding(GO:0045296)
0.0 1.8 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 16.1 GO:0019904 protein domain specific binding(GO:0019904)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 45.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.3 7.8 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 7.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 4.2 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 14.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.2 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 2.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.5 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 1.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression