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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hmx3

Z-value: 0.61

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Transcription factors associated with Hmx3

Gene Symbol Gene ID Gene Info
Hmx3
ENSMUSG00000040148.6 Hmx3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hmx3mm39_v1_chr7_+_131144596_1311445960.298.4e-02Click!

Activity profile of Hmx3 motif

Sorted Z-values of Hmx3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hmx3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_150510116 1.69 ENSMUST00000028944.4
Acss1
acyl-CoA synthetase short-chain family member 1
chr1_-_45542442 1.45 ENSMUST00000086430.5
Col5a2
collagen, type V, alpha 2
chr11_-_20282684 1.43 ENSMUST00000004634.7
ENSMUST00000109594.8
Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr6_+_86348286 1.37 ENSMUST00000089558.7
Snrpg
small nuclear ribonucleoprotein polypeptide G
chr7_+_79944198 1.24 ENSMUST00000163812.9
ENSMUST00000047558.14
ENSMUST00000174199.8
ENSMUST00000173824.8
ENSMUST00000174172.8
Prc1
protein regulator of cytokinesis 1
chr7_+_126808016 0.90 ENSMUST00000206204.2
ENSMUST00000206772.2
Mylpf
myosin light chain, phosphorylatable, fast skeletal muscle
chr11_+_114559350 0.87 ENSMUST00000106602.10
ENSMUST00000077915.10
ENSMUST00000106599.8
ENSMUST00000082092.5
Rpl38
ribosomal protein L38
chr5_+_146885450 0.87 ENSMUST00000146511.8
ENSMUST00000132102.2
Gtf3a
general transcription factor III A
chr5_+_110987839 0.85 ENSMUST00000200172.2
ENSMUST00000066160.3
Chek2
checkpoint kinase 2
chr7_+_25380195 0.73 ENSMUST00000205658.2
B9d2
B9 protein domain 2
chr1_-_93088562 0.64 ENSMUST00000143419.2
Mab21l4
mab-21-like 4
chr7_-_126807581 0.64 ENSMUST00000120705.3
Tbc1d10b
TBC1 domain family, member 10b
chr7_+_78922947 0.61 ENSMUST00000037315.13
Abhd2
abhydrolase domain containing 2
chr7_+_24967094 0.59 ENSMUST00000169266.8
Cic
capicua transcriptional repressor
chr7_-_131918926 0.58 ENSMUST00000080215.6
Chst15
carbohydrate sulfotransferase 15
chr3_+_96537235 0.57 ENSMUST00000048915.11
ENSMUST00000196456.5
ENSMUST00000198027.5
Rbm8a
RNA binding motif protein 8a
chr15_+_9436114 0.56 ENSMUST00000042360.5
ENSMUST00000226688.2
Capsl
calcyphosine-like
chr8_-_23727639 0.56 ENSMUST00000033950.7
Gins4
GINS complex subunit 4 (Sld5 homolog)
chr7_+_25380263 0.55 ENSMUST00000205325.2
ENSMUST00000206913.2
B9d2
B9 protein domain 2
chr2_+_3115250 0.54 ENSMUST00000072955.12
Fam171a1
family with sequence similarity 171, member A1
chr3_+_96537484 0.54 ENSMUST00000200647.2
Rbm8a
RNA binding motif protein 8a
chr9_-_56151334 0.52 ENSMUST00000188142.7
Peak1
pseudopodium-enriched atypical kinase 1
chr6_-_87312743 0.49 ENSMUST00000042025.12
ENSMUST00000205033.2
Antxr1
anthrax toxin receptor 1
chr8_+_107757847 0.45 ENSMUST00000034388.10
Vps4a
vacuolar protein sorting 4A
chr9_-_110453427 0.44 ENSMUST00000196876.2
ENSMUST00000035069.14
Nradd
neurotrophin receptor associated death domain
chr1_-_149836974 0.43 ENSMUST00000190507.2
ENSMUST00000070200.15
Pla2g4a
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr7_-_30259025 0.41 ENSMUST00000043975.11
ENSMUST00000156241.2
Lin37
lin-37 homolog (C. elegans)
chrX_+_149377416 0.41 ENSMUST00000112713.3
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr5_-_53864874 0.40 ENSMUST00000031093.5
Cckar
cholecystokinin A receptor
chrX_+_158491589 0.39 ENSMUST00000080394.13
Sh3kbp1
SH3-domain kinase binding protein 1
chr7_-_30259253 0.39 ENSMUST00000108164.8
Lin37
lin-37 homolog (C. elegans)
chr15_-_79658608 0.37 ENSMUST00000229644.2
ENSMUST00000023055.8
Dnal4
dynein, axonemal, light chain 4
chr4_-_62389098 0.35 ENSMUST00000135811.2
ENSMUST00000120095.8
ENSMUST00000030087.14
ENSMUST00000107452.8
ENSMUST00000155522.8
Wdr31
WD repeat domain 31
chr11_+_96209093 0.34 ENSMUST00000049241.9
Hoxb4
homeobox B4
chr19_+_13208692 0.34 ENSMUST00000207246.4
Olfr1463
olfactory receptor 1463
chr2_+_130266253 0.33 ENSMUST00000128994.8
ENSMUST00000028900.11
Vps16
VSP16 CORVET/HOPS core subunit
chr6_-_129599645 0.33 ENSMUST00000032252.8
Klrk1
killer cell lectin-like receptor subfamily K, member 1
chr10_+_99099084 0.32 ENSMUST00000020118.5
ENSMUST00000220291.2
Dusp6
dual specificity phosphatase 6
chr12_+_108145802 0.32 ENSMUST00000221167.2
Ccnk
cyclin K
chr4_+_80752360 0.29 ENSMUST00000133655.8
ENSMUST00000006151.13
Tyrp1
tyrosinase-related protein 1
chr4_+_19818718 0.29 ENSMUST00000035890.8
Slc7a13
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
chr15_-_79658584 0.28 ENSMUST00000069877.12
Dnal4
dynein, axonemal, light chain 4
chr19_+_8779903 0.28 ENSMUST00000172175.3
Zbtb3
zinc finger and BTB domain containing 3
chr12_+_108145997 0.27 ENSMUST00000101055.5
Ccnk
cyclin K
chr9_+_106048116 0.26 ENSMUST00000020490.13
Wdr82
WD repeat domain containing 82
chr19_+_41921903 0.25 ENSMUST00000224258.2
ENSMUST00000026154.9
ENSMUST00000224896.2
Zdhhc16
zinc finger, DHHC domain containing 16
chr14_+_54598283 0.25 ENSMUST00000000985.7
Oxa1l
oxidase assembly 1-like
chr4_+_80752535 0.24 ENSMUST00000102831.8
Tyrp1
tyrosinase-related protein 1
chr2_-_152857239 0.24 ENSMUST00000028972.9
Pdrg1
p53 and DNA damage regulated 1
chr10_-_80257681 0.22 ENSMUST00000156244.2
Tcf3
transcription factor 3
chr11_+_6366259 0.21 ENSMUST00000213200.2
Ppia
peptidylprolyl isomerase A
chr9_-_123507847 0.20 ENSMUST00000170591.2
ENSMUST00000171647.9
Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr2_+_74528071 0.20 ENSMUST00000059272.10
Hoxd9
homeobox D9
chr3_-_49711765 0.20 ENSMUST00000035931.13
Pcdh18
protocadherin 18
chr7_+_3648264 0.20 ENSMUST00000206287.2
ENSMUST00000038913.16
Cnot3
CCR4-NOT transcription complex, subunit 3
chr15_+_21111428 0.19 ENSMUST00000075132.8
Cdh12
cadherin 12
chr3_-_154760978 0.17 ENSMUST00000064076.6
Tnni3k
TNNI3 interacting kinase
chr3_-_49711706 0.16 ENSMUST00000191794.2
Pcdh18
protocadherin 18
chr10_+_115405891 0.16 ENSMUST00000173620.2
A930009A15Rik
RIKEN cDNA A930009A15 gene
chr7_+_83281193 0.16 ENSMUST00000117410.2
Stard5
StAR-related lipid transfer (START) domain containing 5
chr13_+_23930717 0.15 ENSMUST00000099703.5
H2bc3
H2B clustered histone 3
chr19_-_13126896 0.15 ENSMUST00000213493.2
Olfr1459
olfactory receptor 1459
chr5_-_87630117 0.13 ENSMUST00000079811.13
ENSMUST00000144144.3
Ugt2a2
UDP glucuronosyltransferase 2 family, polypeptide A2
chr2_+_59442378 0.13 ENSMUST00000112568.8
ENSMUST00000037526.11
Tanc1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr11_-_99265721 0.12 ENSMUST00000006963.3
Krt28
keratin 28
chr8_-_33374825 0.09 ENSMUST00000238791.2
Nrg1
neuregulin 1
chr17_-_36008863 0.08 ENSMUST00000146472.8
Ddr1
discoidin domain receptor family, member 1
chr2_-_45002902 0.08 ENSMUST00000076836.13
ENSMUST00000176732.8
ENSMUST00000200844.4
Zeb2
zinc finger E-box binding homeobox 2
chr15_+_66542598 0.08 ENSMUST00000065916.14
Tg
thyroglobulin
chr12_+_52746158 0.06 ENSMUST00000095737.5
Akap6
A kinase (PRKA) anchor protein 6
chr4_-_45532470 0.06 ENSMUST00000147448.2
Shb
src homology 2 domain-containing transforming protein B
chr9_+_21867043 0.05 ENSMUST00000053583.7
Swsap1
SWIM type zinc finger 7 associated protein 1
chr4_+_65523223 0.04 ENSMUST00000050850.14
ENSMUST00000107366.2
Trim32
tripartite motif-containing 32
chr8_+_10299288 0.01 ENSMUST00000214643.2
Myo16
myosin XVI

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0019413 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate biosynthetic process(GO:0019542)
0.5 1.4 GO:0015825 L-serine transport(GO:0015825)
0.4 1.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 0.8 GO:0051325 interphase(GO:0051325) mitotic interphase(GO:0051329)
0.2 0.5 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.1 0.4 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.1 0.3 GO:0030887 positive regulation of myeloid dendritic cell activation(GO:0030887)
0.1 0.6 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 0.5 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.1 0.9 GO:0048318 axial mesoderm development(GO:0048318)
0.1 0.6 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.1 0.4 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 0.4 GO:0090274 reduction of food intake in response to dietary excess(GO:0002023) positive regulation of somatostatin secretion(GO:0090274)
0.1 0.2 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.1 0.6 GO:2000582 regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.3 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.1 0.2 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 0.3 GO:0048539 bone marrow development(GO:0048539)
0.0 0.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.3 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.6 GO:0032570 response to progesterone(GO:0032570)
0.0 0.2 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 1.1 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.3 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.1 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0005588 collagen type V trimer(GO:0005588)
0.3 0.9 GO:0070992 translation initiation complex(GO:0070992)
0.2 0.6 GO:0002944 cyclin K-CDK12 complex(GO:0002944) cyclin K-CDK13 complex(GO:0002945)
0.2 0.6 GO:0000811 GINS complex(GO:0000811)
0.1 0.4 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 1.4 GO:0005687 U4 snRNP(GO:0005687)
0.1 1.3 GO:0036038 MKS complex(GO:0036038)
0.1 0.5 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 0.6 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 1.2 GO:0070938 contractile ring(GO:0070938)
0.0 0.3 GO:0033263 CORVET complex(GO:0033263)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.5 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.0 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.4 GO:0042588 zymogen granule(GO:0042588)
0.0 1.3 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.2 1.6 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 0.3 GO:0032394 MHC class Ib receptor activity(GO:0032394)
0.1 1.4 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 0.5 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 0.6 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 0.9 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.4 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.4 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.6 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 1.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.2 GO:0031013 troponin I binding(GO:0031013)
0.0 0.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 1.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0032052 bile acid binding(GO:0032052)
0.0 1.2 GO:0019894 kinesin binding(GO:0019894)
0.0 0.9 GO:0008307 structural constituent of muscle(GO:0008307)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.4 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID ATM PATHWAY ATM pathway
0.0 1.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.5 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 1.4 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 0.8 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 0.2 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.6 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 1.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.1 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.4 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase