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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hnf4a

Z-value: 10.60

Motif logo

Transcription factors associated with Hnf4a

Gene Symbol Gene ID Gene Info
ENSMUSG00000017950.17 Hnf4a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hnf4amm39_v1_chr2_+_163389068_1633891080.617.7e-05Click!

Activity profile of Hnf4a motif

Sorted Z-values of Hnf4a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf4a

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr19_+_39275518 160.92 ENSMUST00000003137.15
cytochrome P450, family 2, subfamily c, polypeptide 29
chr4_-_62005498 128.85 ENSMUST00000107488.4
ENSMUST00000107472.8
ENSMUST00000084531.11
major urinary protein 3
chr17_-_46749370 103.46 ENSMUST00000087012.7
solute carrier family 22 (organic anion transporter), member 7
chr10_-_128796834 99.95 ENSMUST00000026398.5
methyltransferase like 7B
chr15_-_82648376 97.82 ENSMUST00000055721.6
cytochrome P450, family 2, subfamily d, polypeptide 40
chr19_-_40062174 93.25 ENSMUST00000048959.5
cytochrome P450, family 2, subfamily c, polypeptide 54
chr2_+_172994841 80.60 ENSMUST00000029017.6
phosphoenolpyruvate carboxykinase 1, cytosolic
chr2_-_25390625 74.10 ENSMUST00000040042.11
complement component 8, gamma polypeptide
chr3_+_122688721 69.88 ENSMUST00000023820.6
fatty acid binding protein 2, intestinal
chr4_-_60697274 69.46 ENSMUST00000117932.2
major urinary protein 12
chr19_+_12610668 67.05 ENSMUST00000044976.12
glycine-N-acyltransferase
chr17_-_34962823 66.90 ENSMUST00000069507.9
complement component 4B (Chido blood group)
chr19_+_12610870 66.05 ENSMUST00000119960.2
glycine-N-acyltransferase
chr19_+_39980868 65.62 ENSMUST00000049178.3
cytochrome P450, family 2. subfamily c, polypeptide 37
chr19_-_8382424 64.02 ENSMUST00000064507.12
ENSMUST00000120540.2
ENSMUST00000096269.11
solute carrier family 22, member 30
chr7_-_99345016 62.30 ENSMUST00000107086.9
solute carrier organic anion transporter family, member 2b1
chr9_-_46146928 57.44 ENSMUST00000118649.8
apolipoprotein C-III
chr15_+_82336535 56.17 ENSMUST00000089129.7
ENSMUST00000229313.2
ENSMUST00000231136.2
cytochrome P450, family 2, subfamily d, polypeptide 9
chr19_-_44396092 54.09 ENSMUST00000041331.4
stearoyl-Coenzyme A desaturase 1
chr19_+_38995463 53.52 ENSMUST00000025966.5
cytochrome P450, family 2, subfamily c, polypeptide 55
chr11_+_101258368 50.13 ENSMUST00000019469.3
glucose-6-phosphatase, catalytic
chr7_-_99344779 46.87 ENSMUST00000137914.2
ENSMUST00000207090.2
ENSMUST00000208225.2
solute carrier organic anion transporter family, member 2b1
chr11_+_69945157 45.25 ENSMUST00000108585.9
ENSMUST00000018699.13
asialoglycoprotein receptor 1
chr3_-_121608809 45.18 ENSMUST00000197383.5
ATP-binding cassette, sub-family D (ALD), member 3
chr19_-_44396269 44.34 ENSMUST00000235741.2
stearoyl-Coenzyme A desaturase 1
chr3_-_121608859 44.06 ENSMUST00000029770.8
ATP-binding cassette, sub-family D (ALD), member 3
chrX_+_10118544 43.27 ENSMUST00000049910.13
ornithine transcarbamylase
chr17_-_46749320 41.90 ENSMUST00000233575.2
solute carrier family 22 (organic anion transporter), member 7
chr19_-_39637489 41.71 ENSMUST00000067328.7
cytochrome P450, family 2, subfamily c, polypeptide 67
chr19_+_4771089 41.68 ENSMUST00000238976.3
spectrin beta, non-erythrocytic 2
chr17_-_74257164 40.90 ENSMUST00000024866.6
xanthine dehydrogenase
chrX_+_10118600 40.66 ENSMUST00000115528.3
ornithine transcarbamylase
chr3_+_118355778 38.82 ENSMUST00000039177.12
dihydropyrimidine dehydrogenase
chr19_-_39451509 37.42 ENSMUST00000035488.3
cytochrome P450, family 2, subfamily c, polypeptide 38
chr7_-_105249308 36.30 ENSMUST00000210531.2
ENSMUST00000033185.10
hemopexin
chr9_+_46151994 36.16 ENSMUST00000034585.7
apolipoprotein A-IV
chr9_-_121745354 35.14 ENSMUST00000062474.5
cytochrome P450, family 8, subfamily b, polypeptide 1
chr19_-_8109346 35.06 ENSMUST00000065651.5
solute carrier family 22, member 28
chr7_+_44114815 35.01 ENSMUST00000035929.11
ENSMUST00000146128.8
aspartate dehydrogenase domain containing
chr12_-_103871146 33.70 ENSMUST00000074051.6
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr7_+_44114857 33.60 ENSMUST00000135624.2
aspartate dehydrogenase domain containing
chr7_-_99344832 33.52 ENSMUST00000145381.8
solute carrier organic anion transporter family, member 2b1
chr4_+_134124691 33.25 ENSMUST00000105870.8
platelet-activating factor acetylhydrolase 2
chr8_-_122671588 33.02 ENSMUST00000057653.8
carbonic anhydrase 5a, mitochondrial
chr17_-_35081129 33.00 ENSMUST00000154526.8
complement factor B
chr8_-_93956143 32.86 ENSMUST00000176282.2
ENSMUST00000034173.14
carboxylesterase 1E
chr2_+_58645189 32.58 ENSMUST00000102755.4
ENSMUST00000230627.2
ENSMUST00000229923.2
uridine phosphorylase 2
chr16_+_37400590 32.35 ENSMUST00000159787.8
homogentisate 1, 2-dioxygenase
chr17_-_35081456 32.28 ENSMUST00000025229.11
ENSMUST00000176203.9
ENSMUST00000128767.8
complement factor B
chr16_+_37400500 31.11 ENSMUST00000160847.2
homogentisate 1, 2-dioxygenase
chr15_+_3300249 30.69 ENSMUST00000082424.12
ENSMUST00000159158.9
ENSMUST00000159216.10
ENSMUST00000160311.3
selenoprotein P
chr2_-_134396268 29.36 ENSMUST00000028704.3
hydroxyacid oxidase 1, liver
chr15_+_101184488 29.21 ENSMUST00000229525.2
ENSMUST00000230525.2
autophagy related 101
chr1_+_74324089 28.14 ENSMUST00000113805.8
ENSMUST00000027370.13
ENSMUST00000087226.11
paroxysmal nonkinesiogenic dyskinesia
chr2_+_58644922 27.89 ENSMUST00000059102.13
uridine phosphorylase 2
chr7_+_143027473 27.66 ENSMUST00000052348.12
solute carrier family 22 (organic cation transporter), member 18
chr2_-_27138347 27.20 ENSMUST00000139312.8
sarcosine dehydrogenase
chr8_+_13076024 27.13 ENSMUST00000033820.4
coagulation factor VII
chr14_-_55995912 26.79 ENSMUST00000001497.9
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr4_-_62069046 26.78 ENSMUST00000077719.4
major urinary protein 21
chr5_+_90708962 26.09 ENSMUST00000094615.8
ENSMUST00000200765.2
albumin superfamily member 1
chr7_+_45546365 25.13 ENSMUST00000069772.16
ENSMUST00000210503.2
ENSMUST00000209350.2
transmembrane protein 143
chr1_+_171041583 24.94 ENSMUST00000111328.8
nuclear receptor subfamily 1, group I, member 3
chr3_+_118355811 24.59 ENSMUST00000149101.3
dihydropyrimidine dehydrogenase
chr1_+_171041539 24.11 ENSMUST00000005820.11
ENSMUST00000075469.12
ENSMUST00000155126.8
nuclear receptor subfamily 1, group I, member 3
chr15_-_82291372 23.74 ENSMUST00000230198.2
ENSMUST00000230248.2
ENSMUST00000072776.5
ENSMUST00000229911.2
cytochrome P450, family 2, subfamily d, polypeptide 10
chr4_+_141473983 22.68 ENSMUST00000038161.5
agmatine ureohydrolase (agmatinase)
chr1_+_175459559 21.56 ENSMUST00000040250.15
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr6_-_128503666 21.52 ENSMUST00000143664.2
ENSMUST00000112132.8
PZP, alpha-2-macroglobulin like
chr1_+_175459735 21.42 ENSMUST00000097458.4
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr15_-_82278223 21.34 ENSMUST00000170255.2
cytochrome P450, family 2, subfamily d, polypeptide 11
chr8_+_87350672 21.32 ENSMUST00000034141.18
ENSMUST00000122188.10
lon peptidase 2, peroxisomal
chr15_+_10358611 20.64 ENSMUST00000110541.8
ENSMUST00000110542.8
alanine-glyoxylate aminotransferase 2
chr8_+_13087805 20.61 ENSMUST00000128418.8
ENSMUST00000152034.2
coagulation factor X
chr5_+_114284585 20.26 ENSMUST00000102582.8
acetyl-Coenzyme A carboxylase beta
chr6_+_71176811 19.79 ENSMUST00000067492.8
fatty acid binding protein 1, liver
chr15_+_10358643 19.31 ENSMUST00000022858.8
alanine-glyoxylate aminotransferase 2
chr8_+_13087292 19.25 ENSMUST00000063820.12
ENSMUST00000033821.11
coagulation factor X
chr16_-_30086317 19.19 ENSMUST00000064856.9
carboxypeptidase N, polypeptide 2
chr17_-_35100980 19.14 ENSMUST00000152417.8
ENSMUST00000146299.8
complement component 2 (within H-2S)
predicted gene 20547
chr6_-_125357756 19.12 ENSMUST00000042647.7
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr19_+_44980565 19.03 ENSMUST00000179305.2
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr1_+_139429430 18.98 ENSMUST00000027615.7
coagulation factor XIII, beta subunit
chr11_+_73090270 18.96 ENSMUST00000006105.7
sedoheptulokinase
chr11_-_77784922 18.81 ENSMUST00000017597.5
pipecolic acid oxidase
chr1_+_87983099 18.31 ENSMUST00000138182.8
ENSMUST00000113142.10
UDP glycosyltransferase 1 family, polypeptide A10
chr2_-_110136074 18.31 ENSMUST00000046233.9
butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)
chr15_+_82439273 17.72 ENSMUST00000229103.2
ENSMUST00000068861.8
ENSMUST00000229904.2
cytochrome P450, family 2, subfamily d, polypeptide 12
chr17_-_34822649 17.62 ENSMUST00000015622.8
ring finger protein 5
chr19_-_39801188 17.53 ENSMUST00000162507.2
ENSMUST00000160476.9
ENSMUST00000239028.2
cytochrome P450, family 2, subfamily c, polypeptide 40
chr1_-_136888118 17.09 ENSMUST00000192357.6
ENSMUST00000027649.14
nuclear receptor subfamily 5, group A, member 2
chr2_-_77000878 16.84 ENSMUST00000111833.3
coiled-coil domain containing 141
chr9_-_110576192 16.17 ENSMUST00000199791.2
parathyroid hormone 1 receptor
chr1_+_171052623 16.17 ENSMUST00000111321.8
ENSMUST00000005824.12
ENSMUST00000111320.8
ENSMUST00000111319.2
apolipoprotein A-II
chr11_+_78389913 16.07 ENSMUST00000017488.5
vitronectin
chr11_-_61157986 15.98 ENSMUST00000066277.10
ENSMUST00000074127.14
ENSMUST00000108715.3
aldehyde dehydrogenase family 3, subfamily A2
chr9_-_21913833 15.97 ENSMUST00000115336.10
outer dynein arm docking complex subunit 3
chr10_+_18720760 15.44 ENSMUST00000019998.9
PERP, TP53 apoptosis effector
chr1_+_87983189 15.41 ENSMUST00000173325.2
UDP glycosyltransferase 1 family, polypeptide A10
chr2_+_92205651 15.38 ENSMUST00000028650.9
peroxisomal biogenesis factor 16
chr5_-_104125192 15.33 ENSMUST00000120320.8
hydroxysteroid (17-beta) dehydrogenase 13
chr2_-_69172944 15.22 ENSMUST00000102709.8
ENSMUST00000102710.10
ENSMUST00000180142.2
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr5_-_104125270 14.77 ENSMUST00000112803.3
hydroxysteroid (17-beta) dehydrogenase 13
chr5_-_104125226 14.67 ENSMUST00000048118.15
hydroxysteroid (17-beta) dehydrogenase 13
chr15_+_98997293 14.63 ENSMUST00000061295.7
DnaJ heat shock protein family (Hsp40) member C22
chr9_-_21913896 14.52 ENSMUST00000044926.6
outer dynein arm docking complex subunit 3
chr3_-_10400710 14.27 ENSMUST00000078748.4
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr7_-_45679703 14.25 ENSMUST00000002850.8
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
chr12_+_37292029 14.24 ENSMUST00000160390.2
alkylglycerol monooxygenase
chr4_+_118384183 14.08 ENSMUST00000106367.8
RIKEN cDNA 2610528J11 gene
chr12_+_21366386 14.06 ENSMUST00000076813.8
ENSMUST00000221693.2
ENSMUST00000223345.2
ENSMUST00000222344.2
isoamyl acetate-hydrolyzing esterase 1 homolog
chr7_-_30754792 13.72 ENSMUST00000206328.2
FXYD domain-containing ion transport regulator 1
chr1_+_157353696 13.67 ENSMUST00000111700.8
SEC16 homolog B (S. cerevisiae)
chr4_+_95467653 13.54 ENSMUST00000043335.11
FGGY carbohydrate kinase domain containing
chr5_+_137568982 13.48 ENSMUST00000196471.5
ENSMUST00000198783.5
transferrin receptor 2
chr15_-_76501525 13.21 ENSMUST00000230977.2
solute carrier family 39 (zinc transporter), member 4
chr17_-_46956054 13.05 ENSMUST00000003642.7
kinesin light chain 4
chrX_-_16683578 13.04 ENSMUST00000040820.13
monoamine oxidase B
chr7_+_29931735 12.80 ENSMUST00000108193.2
ENSMUST00000108192.2
polymerase (RNA) II (DNA directed) polypeptide I
chr7_-_30755007 12.59 ENSMUST00000206474.2
ENSMUST00000205807.2
ENSMUST00000039909.13
ENSMUST00000206305.2
ENSMUST00000205439.2
FXYD domain-containing ion transport regulator 1
chr19_-_11058452 12.48 ENSMUST00000025636.8
membrane-spanning 4-domains, subfamily A, member 8A
chr16_-_17745999 12.28 ENSMUST00000003622.16
solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
chr11_+_70410009 12.17 ENSMUST00000057685.3
glycolipid transfer protein domain containing 2
chr12_+_37291728 12.11 ENSMUST00000160768.8
alkylglycerol monooxygenase
chr7_+_29931309 12.06 ENSMUST00000019882.16
ENSMUST00000149654.8
polymerase (RNA) II (DNA directed) polypeptide I
chr8_-_13250535 11.79 ENSMUST00000165605.4
ENSMUST00000209691.2
ENSMUST00000211128.2
ENSMUST00000210317.2
GH regulated TBC protein 1
chr5_+_30437579 11.74 ENSMUST00000145167.9
selenoprotein I
chr3_+_59939175 11.59 ENSMUST00000029325.5
arylacetamide deacetylase
chr12_+_37291632 11.50 ENSMUST00000049874.14
alkylglycerol monooxygenase
chr9_+_44584523 11.39 ENSMUST00000034609.11
ENSMUST00000071219.12
trehalase (brush-border membrane glycoprotein)
chr6_+_72333209 11.23 ENSMUST00000206531.2
transmembrane protein 150A
chr9_-_110576124 11.15 ENSMUST00000199862.5
ENSMUST00000198865.5
parathyroid hormone 1 receptor
chr4_+_97665992 11.07 ENSMUST00000107062.9
ENSMUST00000052018.12
ENSMUST00000107057.8
nuclear factor I/A
chr4_+_95467701 11.05 ENSMUST00000150830.2
ENSMUST00000134012.9
FGGY carbohydrate kinase domain containing
chr7_-_135130374 10.82 ENSMUST00000053716.8
clarin 3
chr6_-_85114725 10.73 ENSMUST00000174769.2
ENSMUST00000174286.3
ENSMUST00000045986.8
sepiapterin reductase
chr9_-_55419442 10.64 ENSMUST00000034866.9
electron transferring flavoprotein, alpha polypeptide
chr15_-_89064936 10.61 ENSMUST00000109331.9
plexin B2
chr12_+_59178072 10.44 ENSMUST00000176464.8
ENSMUST00000170992.9
ENSMUST00000176322.8
MIA SH3 domain ER export factor 2
chr5_-_24652775 10.41 ENSMUST00000123167.2
ENSMUST00000030799.15
transmembrane and ubiquitin-like domain containing 1
chr12_+_59177780 10.39 ENSMUST00000177460.8
MIA SH3 domain ER export factor 2
chr1_-_24044688 10.32 ENSMUST00000027338.4
succinate dehydrogenase complex assembly factor 4
chr9_+_21914083 10.10 ENSMUST00000216344.2
protein kinase C substrate 80K-H
chr1_-_90897329 9.89 ENSMUST00000130042.2
ENSMUST00000027529.12
RAB17, member RAS oncogene family
chr19_+_39499288 9.89 ENSMUST00000025968.5
cytochrome P450, family 2, subfamily c, polypeptide 39
chr4_-_83242490 9.80 ENSMUST00000102823.10
tetratricopeptide repeat domain 39B
chr19_-_8196196 9.76 ENSMUST00000113298.9
solute carrier family 22. member 29
chr12_+_59178258 9.45 ENSMUST00000177162.8
MIA SH3 domain ER export factor 2
chr11_+_74540284 9.29 ENSMUST00000117818.2
ENSMUST00000092915.12
clustered mitochondria (cluA/CLU1) homolog
chr4_-_138053603 9.19 ENSMUST00000030536.13
PTEN induced putative kinase 1
chr4_-_138053545 9.08 ENSMUST00000105817.4
PTEN induced putative kinase 1
chr4_+_118384426 9.01 ENSMUST00000030261.6
RIKEN cDNA 2610528J11 gene
chr9_+_21914334 8.90 ENSMUST00000115331.10
protein kinase C substrate 80K-H
chr4_+_97665843 8.74 ENSMUST00000075448.13
ENSMUST00000092532.13
nuclear factor I/A
chr10_+_81395242 8.58 ENSMUST00000002518.9
TLE family member 5, transcriptional modulator
chr11_-_12362136 8.36 ENSMUST00000174874.8
cordon-bleu WH2 repeat
chr5_+_8943943 8.20 ENSMUST00000196067.2
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr19_-_39875192 8.17 ENSMUST00000168838.3
cytochrome P450, family 2, subfamily c, polypeptide 69
chr2_-_130480014 7.85 ENSMUST00000089561.10
ENSMUST00000110260.8
leucine zipper, putative tumor suppressor family member 3
chr4_+_126503611 7.79 ENSMUST00000097886.4
ENSMUST00000164362.2
RIKEN cDNA 5730409E04Rik gene
chr9_+_21914296 7.77 ENSMUST00000003493.9
protein kinase C substrate 80K-H
chr2_-_90748331 7.61 ENSMUST00000111461.13
protein tyrosine phosphatase, mitochondrial 1
chr10_-_25412010 7.57 ENSMUST00000179685.3
small leucine-rich protein 1
chr19_+_46140942 7.45 ENSMUST00000026254.14
golgi-specific brefeldin A-resistance factor 1
chr12_+_59177552 7.05 ENSMUST00000175877.8
MIA SH3 domain ER export factor 2
chr15_-_90934021 6.75 ENSMUST00000109287.4
ENSMUST00000067205.16
ENSMUST00000088614.13
kinesin family member 21A
chr12_-_80159768 6.66 ENSMUST00000219642.2
ENSMUST00000165114.2
ENSMUST00000218835.2
ENSMUST00000021552.3
zinc finger protein 36, C3H type-like 1
chr19_-_10581622 6.52 ENSMUST00000037678.7
triokinase, FMN cyclase
chr5_+_8943677 6.51 ENSMUST00000003717.13
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr11_+_58090382 6.24 ENSMUST00000035266.11
ENSMUST00000094169.11
ENSMUST00000168280.2
ENSMUST00000058704.9
interferon gamma induced GTPase
immunity-related GTPase family M member 2
chr15_-_90934059 6.22 ENSMUST00000109288.9
ENSMUST00000100304.11
kinesin family member 21A
chr5_+_31454787 6.03 ENSMUST00000201166.4
ENSMUST00000072228.9
glucokinase regulatory protein
chr2_-_119060330 5.97 ENSMUST00000110820.3
protein phosphatase 1, regulatory inhibitor subunit 14D
chr4_-_83242366 5.96 ENSMUST00000030205.14
ENSMUST00000048274.11
tetratricopeptide repeat domain 39B
chr2_-_77000936 5.58 ENSMUST00000164114.9
ENSMUST00000049544.14
coiled-coil domain containing 141
chr3_-_79535966 5.53 ENSMUST00000120992.8
electron transferring flavoprotein, dehydrogenase
chr19_+_5138562 5.51 ENSMUST00000238093.2
ENSMUST00000025811.6
ENSMUST00000237025.2
Yip1 interacting factor homolog A (S. cerevisiae)
chr8_+_3637785 5.49 ENSMUST00000171962.3
ENSMUST00000207712.2
ENSMUST00000207970.2
ENSMUST00000207533.2
ENSMUST00000208240.2
ENSMUST00000207432.2
ENSMUST00000207077.2
calmodulin regulated spectrin-associated protein family, member 3
chr2_-_17465410 5.43 ENSMUST00000145492.2
nebulette
chr2_+_58991182 5.38 ENSMUST00000168631.8
ENSMUST00000102754.11
ENSMUST00000123908.8
plakophilin 4
chr15_-_27630724 5.35 ENSMUST00000059662.8
OTU deubiquitinase with linear linkage specificity
chr7_+_119773070 5.31 ENSMUST00000033201.7
ankyrin repeat and sterile alpha motif domain containing 4B
chr5_-_115109118 5.14 ENSMUST00000031535.12
HNF1 homeobox A
chr5_+_92285748 5.09 ENSMUST00000031355.10
ENSMUST00000202155.2
USO1 vesicle docking factor
chr4_-_119395966 5.04 ENSMUST00000079611.13
FSHD region gene 2 family member 1
chr2_+_3705824 5.04 ENSMUST00000115054.9
family with sequence similarity 107, member B
chr1_+_165958036 4.89 ENSMUST00000166860.2
glycoprotein A33 (transmembrane)
chr5_-_125371162 4.84 ENSMUST00000127148.2
scavenger receptor class B, member 1
chr9_-_107482462 4.68 ENSMUST00000194433.6
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr1_+_165957784 4.67 ENSMUST00000060833.14
glycoprotein A33 (transmembrane)
chrX_-_104972844 4.59 ENSMUST00000198441.5
ENSMUST00000137453.8
ATRX, chromatin remodeler
chr4_+_118266582 4.57 ENSMUST00000144577.2
mediator complex subunit 8
chr10_-_13428855 4.56 ENSMUST00000105539.2
peroxisomal biogenesis factor 3
chr1_+_165957909 4.44 ENSMUST00000166159.2
glycoprotein A33 (transmembrane)
chr1_+_185187000 4.38 ENSMUST00000061093.7
solute carrier family 30, member 10
chr9_-_35030479 4.37 ENSMUST00000213526.2
ENSMUST00000215089.2
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr9_+_21914513 4.37 ENSMUST00000215795.2
protein kinase C substrate 80K-H
chr2_+_157870653 4.35 ENSMUST00000152452.8
regulation of nuclear pre-mRNA domain containing 1B
chr14_-_52257113 4.32 ENSMUST00000166169.4
ENSMUST00000226605.2
zinc finger protein 219
chr7_+_66339637 4.27 ENSMUST00000153007.2
ENSMUST00000121777.9
ENSMUST00000150071.8
ENSMUST00000077967.13
lines homolog 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
32.8 98.4 GO:1903699 tarsal gland development(GO:1903699)
28.5 142.7 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
28.0 83.9 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450)
22.3 89.2 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
21.1 63.4 GO:0019860 uracil catabolic process(GO:0006212) uracil metabolic process(GO:0019860)
20.2 80.6 GO:0061402 glycerol biosynthetic process(GO:0006114) positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
14.4 57.4 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)
14.2 469.5 GO:0019373 epoxygenase P450 pathway(GO:0019373)
13.3 40.0 GO:0042853 glycine biosynthetic process, by transamination of glyoxylate(GO:0019265) L-alanine catabolic process(GO:0042853)
12.1 36.2 GO:0034442 regulation of lipoprotein oxidation(GO:0034442) negative regulation of lipoprotein oxidation(GO:0034443) multicellular organism lipid catabolic process(GO:0044240)
11.4 68.6 GO:0006742 NADP catabolic process(GO:0006742)
9.5 274.2 GO:0035634 response to stilbenoid(GO:0035634)
9.1 18.3 GO:1903383 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
9.1 27.2 GO:1901053 sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053)
8.2 139.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
8.2 40.9 GO:0009115 xanthine catabolic process(GO:0009115)
7.2 43.0 GO:0019805 quinolinate biosynthetic process(GO:0019805)
7.1 63.5 GO:0006572 tyrosine catabolic process(GO:0006572)
6.8 102.2 GO:0015747 urate transport(GO:0015747)
6.8 20.3 GO:0046949 fatty-acyl-CoA biosynthetic process(GO:0046949) malonyl-CoA metabolic process(GO:2001293)
6.3 19.0 GO:0035963 response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)
6.3 18.8 GO:0006553 lysine metabolic process(GO:0006553)
6.1 42.5 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
5.9 29.4 GO:0009441 glycolate metabolic process(GO:0009441)
5.4 16.2 GO:0046340 diacylglycerol catabolic process(GO:0046340)
5.3 16.0 GO:0006714 sesquiterpenoid metabolic process(GO:0006714) phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173)
5.2 222.5 GO:0019369 arachidonic acid metabolic process(GO:0019369)
5.0 50.1 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
4.9 14.7 GO:1903412 response to bile acid(GO:1903412) cellular response to bile acid(GO:1903413)
4.6 18.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
4.5 27.1 GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway(GO:0010641)
3.8 30.7 GO:0001887 selenium compound metabolic process(GO:0001887)
3.8 22.7 GO:0008295 spermidine biosynthetic process(GO:0008295)
3.8 22.6 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
3.3 9.9 GO:0002414 immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells(GO:0002414)
3.2 19.1 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
3.0 15.2 GO:0046618 drug export(GO:0046618)
2.9 37.9 GO:0046485 ether lipid metabolic process(GO:0046485)
2.8 28.1 GO:0061727 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
2.8 33.7 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
2.6 13.2 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
2.6 13.0 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
2.5 7.4 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
2.5 12.3 GO:0015746 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
2.4 26.3 GO:1903278 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
2.3 7.0 GO:0071929 alpha-tubulin acetylation(GO:0071929)
2.3 94.5 GO:0050892 intestinal absorption(GO:0050892)
2.3 24.9 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
2.2 6.7 GO:1904582 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
1.9 11.6 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
1.9 9.5 GO:0005984 disaccharide metabolic process(GO:0005984)
1.8 10.7 GO:0006558 L-phenylalanine metabolic process(GO:0006558) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221)
1.5 4.4 GO:0071579 regulation of zinc ion transport(GO:0071579)
1.4 27.3 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
1.4 17.1 GO:0061113 pancreas morphogenesis(GO:0061113)
1.4 13.7 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
1.4 4.1 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
1.3 16.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.3 11.7 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
1.2 13.5 GO:0097460 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
1.2 18.2 GO:0019321 pentose metabolic process(GO:0019321)
1.2 6.0 GO:0009750 response to fructose(GO:0009750)
1.2 8.4 GO:0001757 somite specification(GO:0001757)
1.2 9.3 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
1.1 6.5 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
1.1 38.9 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
1.0 31.1 GO:0006491 N-glycan processing(GO:0006491)
1.0 15.4 GO:0002934 desmosome organization(GO:0002934)
1.0 6.7 GO:0045218 zonula adherens maintenance(GO:0045218)
0.9 19.8 GO:0072189 ureter development(GO:0072189)
0.9 4.5 GO:1904970 brush border assembly(GO:1904970)
0.8 5.1 GO:0014826 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826)
0.8 3.3 GO:1900535 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) fatty-acyl-CoA catabolic process(GO:0036115) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.8 4.1 GO:0090366 DNA cytosine deamination(GO:0070383) positive regulation of mRNA modification(GO:0090366)
0.8 17.8 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.8 2.4 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.8 4.6 GO:1901580 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.8 2.3 GO:0060464 lung lobe formation(GO:0060464) diaphragm morphogenesis(GO:0060540)
0.7 27.7 GO:0015893 drug transport(GO:0015893)
0.7 7.6 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.7 26.8 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.7 4.7 GO:0015862 uridine transport(GO:0015862)
0.6 5.0 GO:0007403 glial cell fate determination(GO:0007403)
0.6 16.0 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.6 2.3 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.6 5.1 GO:0043691 reverse cholesterol transport(GO:0043691)
0.6 3.9 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.5 97.6 GO:0009636 response to toxic substance(GO:0009636)
0.5 4.2 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313) negative regulation of neutrophil activation(GO:1902564)
0.5 6.2 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.5 9.3 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.5 25.9 GO:0006730 one-carbon metabolic process(GO:0006730)
0.5 1.9 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.4 27.8 GO:0050919 negative chemotaxis(GO:0050919)
0.4 18.4 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.4 5.4 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431)
0.4 60.5 GO:0009166 nucleotide catabolic process(GO:0009166)
0.4 59.9 GO:0006956 complement activation(GO:0006956)
0.4 5.1 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.3 2.3 GO:0060406 positive regulation of penile erection(GO:0060406)
0.3 22.4 GO:0021799 cerebral cortex radially oriented cell migration(GO:0021799)
0.3 21.5 GO:0007566 embryo implantation(GO:0007566)
0.3 11.2 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.3 0.8 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.3 4.0 GO:0070932 histone H3 deacetylation(GO:0070932)
0.3 1.5 GO:0090168 Golgi reassembly(GO:0090168)
0.2 29.2 GO:0000045 autophagosome assembly(GO:0000045)
0.2 1.0 GO:0061215 regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
0.2 0.7 GO:1904954 negative regulation of axon extension involved in axon guidance(GO:0048843) Spemann organizer formation(GO:0060061) negative regulation of axon guidance(GO:1902668) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
0.2 2.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816) positive regulation of myoblast proliferation(GO:2000288)
0.2 5.0 GO:0030497 fatty acid elongation(GO:0030497)
0.2 1.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.2 2.2 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.2 1.0 GO:0070162 adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163) negative regulation of adiponectin secretion(GO:0070164)
0.2 2.2 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.2 80.7 GO:0032259 methylation(GO:0032259)
0.2 16.8 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.2 1.2 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.2 48.6 GO:0016042 lipid catabolic process(GO:0016042)
0.2 3.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.2 0.5 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 11.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 10.6 GO:0007405 neuroblast proliferation(GO:0007405)
0.1 5.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 10.4 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.1 2.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 28.0 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.1 1.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 9.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 4.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.6 GO:0060137 maternal process involved in parturition(GO:0060137)
0.1 15.6 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 2.6 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.1 4.0 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 2.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 1.3 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.1 0.7 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.1 1.1 GO:0008272 sulfate transport(GO:0008272)
0.1 10.7 GO:0031668 cellular response to extracellular stimulus(GO:0031668)
0.1 1.5 GO:0030325 adrenal gland development(GO:0030325)
0.1 4.4 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 9.6 GO:0035304 regulation of protein dephosphorylation(GO:0035304)
0.0 15.5 GO:0043434 response to peptide hormone(GO:0043434)
0.0 2.0 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 2.6 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.7 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 1.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 8.9 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.3 GO:0015074 DNA integration(GO:0015074)
0.0 0.7 GO:0022011 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.4 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 3.6 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.9 GO:0010761 fibroblast migration(GO:0010761)
0.0 1.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 2.1 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.1 GO:0046838 phosphorylated carbohydrate dephosphorylation(GO:0046838)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
8.2 74.1 GO:0005579 membrane attack complex(GO:0005579)
8.2 89.7 GO:0045179 apical cortex(GO:0045179)
6.2 31.1 GO:0017177 glucosidase II complex(GO:0017177)
5.5 60.5 GO:0045098 type III intermediate filament(GO:0045098)
5.2 41.7 GO:0008091 spectrin(GO:0008091)
4.0 16.2 GO:0017133 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
3.9 90.8 GO:0042627 chylomicron(GO:0042627)
3.8 111.5 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
2.3 16.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
2.3 16.0 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
2.2 73.1 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
1.7 13.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
1.7 29.9 GO:0046581 intercellular canaliculus(GO:0046581)
1.5 18.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
1.5 139.6 GO:0009925 basal plasma membrane(GO:0009925)
1.2 8.4 GO:1990357 terminal web(GO:1990357)
1.1 37.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
1.1 5.4 GO:0071797 LUBAC complex(GO:0071797)
1.0 17.6 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.9 24.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.9 157.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.8 4.1 GO:1990130 Iml1 complex(GO:1990130)
0.8 22.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.8 4.6 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.7 9.6 GO:0097427 microtubule bundle(GO:0097427)
0.7 4.0 GO:0005610 laminin-5 complex(GO:0005610)
0.6 63.3 GO:0005811 lipid particle(GO:0005811)
0.6 29.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.6 5.5 GO:0036449 microtubule minus-end(GO:0036449)
0.5 89.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 2.6 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.4 9.9 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.4 7.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.4 103.2 GO:0072562 blood microparticle(GO:0072562)
0.4 27.6 GO:0034707 chloride channel complex(GO:0034707)
0.3 27.3 GO:0005871 kinesin complex(GO:0005871)
0.3 634.9 GO:0005783 endoplasmic reticulum(GO:0005783)
0.3 44.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.2 5.4 GO:0030057 desmosome(GO:0030057)
0.2 7.6 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.2 14.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 9.2 GO:0016592 mediator complex(GO:0016592)
0.2 5.1 GO:0045120 pronucleus(GO:0045120)
0.1 282.6 GO:0005739 mitochondrion(GO:0005739)
0.1 4.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 20.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 0.7 GO:0070695 FHF complex(GO:0070695)
0.1 2.6 GO:0048786 presynaptic active zone(GO:0048786)
0.1 135.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 3.5 GO:0001772 immunological synapse(GO:0001772)
0.1 2.1 GO:0016460 myosin II complex(GO:0016460)
0.1 1.2 GO:0031011 Ino80 complex(GO:0031011)
0.1 11.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 2.3 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.1 2.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 5.4 GO:0055037 recycling endosome(GO:0055037)
0.0 3.9 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.0 4.6 GO:0000139 Golgi membrane(GO:0000139)
0.0 1.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 2.1 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
36.7 146.8 GO:0071614 linoleic acid epoxygenase activity(GO:0071614)
33.3 133.1 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
32.2 193.0 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
26.9 80.6 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
21.1 63.4 GO:0002061 uracil binding(GO:0002058) pyrimidine nucleobase binding(GO:0002061)
21.0 83.9 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
19.9 178.9 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
18.4 73.6 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
16.4 98.4 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
12.6 37.9 GO:0050479 glyceryl-ether monooxygenase activity(GO:0050479)
12.5 50.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
11.3 45.3 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
10.1 60.5 GO:0004850 uridine phosphorylase activity(GO:0004850)
9.3 390.3 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
9.1 27.2 GO:0008480 sarcosine dehydrogenase activity(GO:0008480)
8.4 66.9 GO:0001849 complement component C1q binding(GO:0001849)
8.2 24.6 GO:0019150 D-ribulokinase activity(GO:0019150)
8.2 40.9 GO:0043546 xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726) molybdenum ion binding(GO:0030151) molybdopterin cofactor binding(GO:0043546)
7.0 188.2 GO:0070330 aromatase activity(GO:0070330)
6.7 40.0 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
6.1 36.3 GO:0015232 heme transporter activity(GO:0015232)
6.0 36.2 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
5.3 21.3 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
4.5 199.0 GO:0008395 steroid hydroxylase activity(GO:0008395)
4.1 74.1 GO:0019841 retinol binding(GO:0019841)
4.1 20.3 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
3.9 43.0 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
3.9 27.3 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
3.8 49.0 GO:0004887 thyroid hormone receptor activity(GO:0004887)
3.5 28.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
3.1 18.8 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
2.9 11.7 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
2.8 81.7 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
2.7 13.5 GO:0004998 transferrin receptor activity(GO:0004998)
2.5 29.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
2.5 12.3 GO:0015137 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
2.5 14.7 GO:0090554 xenobiotic-transporting ATPase activity(GO:0008559) phosphatidylcholine-translocating ATPase activity(GO:0090554)
2.4 33.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
2.2 6.5 GO:0034012 glycerone kinase activity(GO:0004371) FAD-AMP lyase (cyclizing) activity(GO:0034012) triokinase activity(GO:0050354)
2.1 22.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
2.0 18.3 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
2.0 8.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
1.9 37.1 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
1.7 30.7 GO:0008430 selenium binding(GO:0008430)
1.7 21.5 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
1.5 50.8 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
1.5 128.8 GO:0005550 pheromone binding(GO:0005550)
1.4 25.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
1.4 5.5 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
1.3 5.1 GO:0031708 endothelin B receptor binding(GO:0031708)
1.2 4.8 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
1.2 27.7 GO:0015238 drug transmembrane transporter activity(GO:0015238)
1.0 17.6 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.8 33.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.8 10.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.8 4.1 GO:0004131 cytosine deaminase activity(GO:0004131)
0.8 2.3 GO:0045030 A1 adenosine receptor binding(GO:0031686) UTP-activated nucleotide receptor activity(GO:0045030)
0.7 151.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.7 61.3 GO:0038024 cargo receptor activity(GO:0038024)
0.7 4.6 GO:0015616 DNA translocase activity(GO:0015616)
0.6 7.0 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.6 6.2 GO:0051434 BH3 domain binding(GO:0051434)
0.6 4.4 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.6 5.0 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.6 6.0 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.6 4.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.6 7.6 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.6 11.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.6 24.9 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.5 8.7 GO:0038191 neuropilin binding(GO:0038191)
0.4 17.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.4 6.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.4 0.8 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.4 26.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 91.7 GO:0008168 methyltransferase activity(GO:0008168)
0.3 2.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.3 2.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 5.5 GO:0051011 microtubule minus-end binding(GO:0051011)
0.3 6.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.3 18.3 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.3 1.8 GO:0031849 olfactory receptor binding(GO:0031849)
0.2 3.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 27.3 GO:0003777 microtubule motor activity(GO:0003777)
0.2 2.5 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.2 7.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2 17.1 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.2 3.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.2 10.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 10.6 GO:0009055 electron carrier activity(GO:0009055)
0.2 8.4 GO:0003785 actin monomer binding(GO:0003785)
0.2 12.1 GO:0019003 GDP binding(GO:0019003)
0.2 25.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.6 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 1.3 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 12.6 GO:0005080 protein kinase C binding(GO:0005080)
0.1 23.1 GO:0002020 protease binding(GO:0002020)
0.1 1.9 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.1 1.7 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.1 5.1 GO:0001221 transcription cofactor binding(GO:0001221)
0.1 2.3 GO:0070410 co-SMAD binding(GO:0070410)
0.1 2.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 1.6 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 9.5 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1 1.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 2.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 2.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 7.1 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 14.4 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 4.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.7 GO:0048018 receptor agonist activity(GO:0048018)
0.0 1.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 2.0 GO:0019208 phosphatase regulator activity(GO:0019208)
0.0 4.4 GO:0008201 heparin binding(GO:0008201)
0.0 1.2 GO:0003678 DNA helicase activity(GO:0003678)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 7.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.6 GO:0044325 ion channel binding(GO:0044325)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 65.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
1.0 35.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
1.0 79.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.7 16.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.4 12.5 PID ARF 3PATHWAY Arf1 pathway
0.3 39.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.2 15.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 4.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 24.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 2.4 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 5.1 PID ENDOTHELIN PATHWAY Endothelins
0.1 5.0 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 1.6 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 6.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 4.0 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 6.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 0.8 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 12.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.6 PID LKB1 PATHWAY LKB1 signaling events
0.0 2.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.9 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 2.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
12.4 173.0 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
11.0 142.7 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
8.2 163.8 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
6.2 80.6 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
6.0 84.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
5.2 67.0 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
4.4 74.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
4.1 40.9 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
3.1 43.0 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
2.8 11.4 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
2.3 35.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
1.9 31.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
1.9 15.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
1.9 54.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
1.7 40.0 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
1.6 19.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
1.3 22.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
1.2 24.9 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.8 48.4 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.8 41.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.8 182.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.7 14.2 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.7 20.3 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.7 7.4 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.6 66.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.5 10.7 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.5 17.2 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.5 12.9 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.5 24.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.4 13.1 REACTOME KINESINS Genes involved in Kinesins
0.4 6.7 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.3 43.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.3 13.0 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.2 18.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 28.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 3.5 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 0.9 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 2.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 5.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 4.2 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 1.6 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 8.4 REACTOME BIOLOGICAL OXIDATIONS Genes involved in Biological oxidations
0.1 3.7 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 2.7 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 2.1 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 4.0 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 5.7 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 2.4 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events