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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxd10

Z-value: 0.96

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Transcription factors associated with Hoxd10

Gene Symbol Gene ID Gene Info
Hoxd10
ENSMUSG00000050368.5 Hoxd10

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxd10mm39_v1_chr2_+_74522258_74522284-0.173.1e-01Click!

Activity profile of Hoxd10 motif

Sorted Z-values of Hoxd10 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxd10

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_+_110717062 15.38 ENSMUST00000001720.14
ENSMUST00000143741.2
Tat
tyrosine aminotransferase
chr19_+_20470056 7.20 ENSMUST00000225337.3
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr19_+_20470114 5.75 ENSMUST00000225313.2
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr1_-_130589321 4.47 ENSMUST00000137276.3
C4bp
complement component 4 binding protein
chr1_-_130589349 4.46 ENSMUST00000027657.14
C4bp
complement component 4 binding protein
chr3_+_137983250 4.26 ENSMUST00000004232.10
Adh1
alcohol dehydrogenase 1 (class I)
chr13_-_24098951 2.96 ENSMUST00000021769.16
Slc17a4
solute carrier family 17 (sodium phosphate), member 4
chr7_+_51530060 2.41 ENSMUST00000145049.2
Gas2
growth arrest specific 2
chr16_-_22847808 1.78 ENSMUST00000115349.9
Kng2
kininogen 2
chr16_-_22847760 1.73 ENSMUST00000039338.13
Kng2
kininogen 2
chr16_-_22847829 1.68 ENSMUST00000100046.9
Kng2
kininogen 2
chr6_-_146403410 1.65 ENSMUST00000053273.15
Itpr2
inositol 1,4,5-triphosphate receptor 2
chr16_-_37681508 1.62 ENSMUST00000205931.2
Gm36028
predicted gene, 36028
chr10_+_23727325 1.38 ENSMUST00000020190.8
Vnn3
vanin 3
chr16_+_22877000 1.36 ENSMUST00000039492.14
ENSMUST00000023589.15
ENSMUST00000089902.8
Kng1
kininogen 1
chr13_+_38529062 1.30 ENSMUST00000171970.3
Bmp6
bone morphogenetic protein 6
chr4_+_100336003 1.30 ENSMUST00000133493.9
ENSMUST00000092730.5
Ube2u
ubiquitin-conjugating enzyme E2U (putative)
chr10_-_30494333 1.30 ENSMUST00000019925.7
Hint3
histidine triad nucleotide binding protein 3
chr16_-_22848153 1.18 ENSMUST00000232459.2
Kng2
kininogen 2
chr1_+_139429430 1.14 ENSMUST00000027615.7
F13b
coagulation factor XIII, beta subunit
chr10_-_30494431 0.99 ENSMUST00000161074.8
Hint3
histidine triad nucleotide binding protein 3
chr7_+_44545501 0.94 ENSMUST00000071207.14
ENSMUST00000209132.2
ENSMUST00000207069.2
ENSMUST00000209039.2
ENSMUST00000207939.3
ENSMUST00000207485.2
ENSMUST00000208179.2
Fuz
fuzzy planar cell polarity protein
chr4_+_102112189 0.70 ENSMUST00000106908.9
Pde4b
phosphodiesterase 4B, cAMP specific
chrX_+_7628891 0.64 ENSMUST00000077680.10
ENSMUST00000079542.13
ENSMUST00000115679.8
ENSMUST00000137467.8
Tfe3
transcription factor E3
chr3_+_60380243 0.57 ENSMUST00000195724.6
Mbnl1
muscleblind like splicing factor 1
chr12_+_117652526 0.57 ENSMUST00000222185.2
Rapgef5
Rap guanine nucleotide exchange factor (GEF) 5
chr1_+_66361252 0.50 ENSMUST00000123647.8
Map2
microtubule-associated protein 2
chr16_-_18880821 0.49 ENSMUST00000200568.2
Iglc1
immunoglobulin lambda constant 1
chr3_+_55369149 0.39 ENSMUST00000199585.5
ENSMUST00000070418.9
Dclk1
doublecortin-like kinase 1
chr9_-_54381409 0.38 ENSMUST00000127880.8
Dmxl2
Dmx-like 2
chr2_+_21372338 0.37 ENSMUST00000055946.8
Gpr158
G protein-coupled receptor 158
chr4_+_43401232 0.34 ENSMUST00000125399.2
Rusc2
RUN and SH3 domain containing 2
chr13_-_72111832 0.33 ENSMUST00000077337.9
Irx1
Iroquois homeobox 1
chr2_+_120235239 0.32 ENSMUST00000135074.2
Ganc
glucosidase, alpha; neutral C
chr5_-_73787646 0.31 ENSMUST00000152215.3
Lrrc66
leucine rich repeat containing 66
chr10_+_116013256 0.27 ENSMUST00000155606.8
ENSMUST00000128399.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr3_-_75177378 0.26 ENSMUST00000039047.5
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr14_+_103750763 0.25 ENSMUST00000227322.2
Scel
sciellin
chr3_-_122828592 0.24 ENSMUST00000029761.14
Myoz2
myozenin 2
chr9_+_27702243 0.23 ENSMUST00000115243.9
Opcml
opioid binding protein/cell adhesion molecule-like
chrX_-_142716085 0.22 ENSMUST00000087313.10
Dcx
doublecortin
chr10_+_128626772 0.21 ENSMUST00000219404.2
ENSMUST00000026411.8
Mmp19
matrix metallopeptidase 19
chr6_-_92458324 0.21 ENSMUST00000113445.2
Prickle2
prickle planar cell polarity protein 2
chr18_+_52748978 0.20 ENSMUST00000072666.4
ENSMUST00000209270.2
Zfp474
zinc finger protein 474
chr2_-_76045696 0.20 ENSMUST00000144892.2
Pde11a
phosphodiesterase 11A
chr3_+_106393348 0.20 ENSMUST00000183271.2
Dennd2d
DENN/MADD domain containing 2D
chrX_+_65696608 0.19 ENSMUST00000036043.5
Slitrk2
SLIT and NTRK-like family, member 2
chr10_-_12490424 0.19 ENSMUST00000217994.2
Utrn
utrophin
chr14_+_103750814 0.18 ENSMUST00000095576.5
Scel
sciellin
chr19_-_24202344 0.17 ENSMUST00000099558.5
ENSMUST00000232956.2
Tjp2
tight junction protein 2
chr4_-_108690805 0.14 ENSMUST00000102742.11
Btf3l4
basic transcription factor 3-like 4
chr19_-_11838430 0.11 ENSMUST00000214796.2
Olfr1418
olfactory receptor 1418
chr11_+_54261452 0.10 ENSMUST00000094193.3
Meikin
meiotic kinetochore factor
chr16_+_25620652 0.10 ENSMUST00000115304.8
ENSMUST00000115305.2
ENSMUST00000040231.13
ENSMUST00000115306.8
Trp63
transformation related protein 63
chr19_+_12972378 0.09 ENSMUST00000207997.3
Olfr1451
olfactory receptor 1451
chr10_-_107747995 0.07 ENSMUST00000165341.5
Otogl
otogelin-like
chr14_-_48904958 0.07 ENSMUST00000144465.8
ENSMUST00000133479.8
ENSMUST00000119070.8
ENSMUST00000226501.2
Otx2
orthodenticle homeobox 2
chrX_-_142716200 0.07 ENSMUST00000112851.8
ENSMUST00000112856.3
ENSMUST00000033642.10
Dcx
doublecortin
chr9_+_55448432 0.07 ENSMUST00000034869.11
Isl2
insulin related protein 2 (islet 2)
chr6_+_70663930 0.06 ENSMUST00000103402.2
Igkv3-3
immunoglobulin kappa variable 3-3
chr7_+_43339842 0.05 ENSMUST00000056329.7
Klk14
kallikrein related-peptidase 14
chr2_+_111327525 0.04 ENSMUST00000121345.4
Olfr1291-ps1
olfactory receptor 1291, pseudogene 1
chr15_-_12493574 0.04 ENSMUST00000186113.2
Pdzd2
PDZ domain containing 2
chr9_-_58277734 0.02 ENSMUST00000040217.6
Tbc1d21
TBC1 domain family, member 21
chr17_+_71511642 0.02 ENSMUST00000126681.8
Lpin2
lipin 2
chrX_-_49517375 0.01 ENSMUST00000215270.2
Olfr1324
olfactory receptor 1324

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 15.4 GO:0006572 tyrosine catabolic process(GO:0006572)
1.4 13.0 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
1.1 4.3 GO:0006069 ethanol oxidation(GO:0006069)
0.3 0.9 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.2 1.3 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.1 7.7 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 1.6 GO:0071361 cellular response to ethanol(GO:0071361)
0.1 0.3 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.1 9.4 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.2 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.0 0.1 GO:0010481 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482) cloacal septation(GO:0060197)
0.0 1.4 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.0 0.4 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.2 GO:0007527 adult somatic muscle development(GO:0007527)
0.0 0.2 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.0 0.1 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.0 0.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 1.3 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.7 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 2.0 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 0.1 GO:0042706 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 2.4 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0033503 HULC complex(GO:0033503)
0.1 0.4 GO:0043291 RAVE complex(GO:0043291)
0.1 0.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.5 GO:0019815 B cell receptor complex(GO:0019815)
0.0 7.7 GO:0072562 blood microparticle(GO:0072562)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.4 GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
2.6 13.0 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
1.4 4.3 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.3 1.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.2 3.0 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 1.3 GO:0070700 BMP receptor binding(GO:0070700)
0.1 7.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.3 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.2 GO:0051373 FATZ binding(GO:0051373)
0.0 0.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.2 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.7 GO:0030552 cAMP binding(GO:0030552)
0.0 1.4 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 15.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 2.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.3 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 13.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 1.6 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 1.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 1.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 2.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 15.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events