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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Msx3

Z-value: 0.78

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Transcription factors associated with Msx3

Gene Symbol Gene ID Gene Info
Msx3
ENSMUSG00000025469.11 Msx3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Msx3mm39_v1_chr7_-_139628991_1396290070.298.2e-02Click!

Activity profile of Msx3 motif

Sorted Z-values of Msx3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Msx3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr9_+_96140781 3.30 ENSMUST00000190104.7
ENSMUST00000179416.8
ENSMUST00000189606.7
Tfdp2
transcription factor Dp 2
chr8_+_57964921 2.49 ENSMUST00000067925.8
Hmgb2
high mobility group box 2
chr17_-_24746911 1.91 ENSMUST00000176652.8
Traf7
TNF receptor-associated factor 7
chr8_+_57964956 1.88 ENSMUST00000210871.2
Hmgb2
high mobility group box 2
chr17_-_24746804 1.87 ENSMUST00000176353.8
ENSMUST00000176237.8
Traf7
TNF receptor-associated factor 7
chr9_+_96140750 1.67 ENSMUST00000186609.7
Tfdp2
transcription factor Dp 2
chr17_+_56920389 1.62 ENSMUST00000080492.7
Rpl36
ribosomal protein L36
chr2_-_168609110 1.56 ENSMUST00000029061.12
ENSMUST00000103074.2
Sall4
spalt like transcription factor 4
chr14_+_26722319 1.34 ENSMUST00000035433.10
Hesx1
homeobox gene expressed in ES cells
chr12_-_114443071 1.33 ENSMUST00000103492.2
Ighv10-1
immunoglobulin heavy variable 10-1
chr19_+_13208692 1.24 ENSMUST00000207246.4
Olfr1463
olfactory receptor 1463
chr2_-_168608949 1.23 ENSMUST00000075044.10
Sall4
spalt like transcription factor 4
chr3_-_88317601 1.22 ENSMUST00000193338.6
ENSMUST00000056370.13
Pmf1
polyamine-modulated factor 1
chr19_-_39875192 1.20 ENSMUST00000168838.3
Cyp2c69
cytochrome P450, family 2, subfamily c, polypeptide 69
chr1_-_52230062 1.14 ENSMUST00000156887.8
ENSMUST00000129107.2
Gls
glutaminase
chr2_+_163500290 1.07 ENSMUST00000164399.8
ENSMUST00000064703.13
ENSMUST00000099105.9
ENSMUST00000152418.8
ENSMUST00000126182.8
ENSMUST00000131228.8
Pkig
protein kinase inhibitor, gamma
chr12_-_114487525 0.98 ENSMUST00000103495.3
Ighv10-3
immunoglobulin heavy variable V10-3
chr7_+_101545547 0.94 ENSMUST00000035395.14
ENSMUST00000106973.8
ENSMUST00000144207.9
Anapc15
anaphase promoting complex C subunit 15
chrX_+_152506577 0.87 ENSMUST00000140575.8
ENSMUST00000208373.2
ENSMUST00000185492.7
ENSMUST00000149514.8
Nbdy
negative regulator of P-body association
chr8_+_107757847 0.85 ENSMUST00000034388.10
Vps4a
vacuolar protein sorting 4A
chr10_+_81093110 0.82 ENSMUST00000117488.8
ENSMUST00000105328.10
ENSMUST00000121205.8
Matk
megakaryocyte-associated tyrosine kinase
chr10_-_75946790 0.80 ENSMUST00000120757.2
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr7_+_89814713 0.78 ENSMUST00000207084.2
Picalm
phosphatidylinositol binding clathrin assembly protein
chr16_+_49519561 0.76 ENSMUST00000046777.11
ENSMUST00000142682.9
Ift57
intraflagellar transport 57
chr7_+_101546059 0.76 ENSMUST00000143835.8
Anapc15
anaphase promoting complex C subunit 15
chr6_+_68279392 0.75 ENSMUST00000103322.3
Igkv2-109
immunoglobulin kappa variable 2-109
chr3_-_129834788 0.68 ENSMUST00000168644.3
Sec24b
Sec24 related gene family, member B (S. cerevisiae)
chr4_+_134658209 0.67 ENSMUST00000030622.3
Syf2
SYF2 homolog, RNA splicing factor (S. cerevisiae)
chr12_-_113649535 0.64 ENSMUST00000103449.4
ENSMUST00000195707.3
Ighv2-5
immunoglobulin heavy variable 2-5
chr2_-_174188505 0.63 ENSMUST00000168292.2
Gm20721
predicted gene, 20721
chr3_+_57332735 0.57 ENSMUST00000029377.8
Tm4sf4
transmembrane 4 superfamily member 4
chr17_-_37523969 0.55 ENSMUST00000060728.7
ENSMUST00000216318.2
Olfr95
olfactory receptor 95
chr2_+_87696836 0.55 ENSMUST00000213308.3
Olfr1152
olfactory receptor 1152
chr9_+_44309727 0.54 ENSMUST00000213268.2
Slc37a4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr4_+_94627513 0.52 ENSMUST00000073939.13
ENSMUST00000102798.8
Tek
TEK receptor tyrosine kinase
chrX_+_132751729 0.48 ENSMUST00000033602.9
Tnmd
tenomodulin
chr15_+_82136598 0.48 ENSMUST00000136948.3
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr9_+_35334878 0.47 ENSMUST00000154652.8
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr4_-_43710231 0.46 ENSMUST00000217544.2
ENSMUST00000107862.3
Olfr71
olfactory receptor 71
chr1_-_34478753 0.46 ENSMUST00000042493.10
Ccdc115
coiled-coil domain containing 115
chr19_-_24178000 0.43 ENSMUST00000233658.3
Tjp2
tight junction protein 2
chrX_+_9751861 0.43 ENSMUST00000067529.9
ENSMUST00000086165.4
Sytl5
synaptotagmin-like 5
chr3_+_82962823 0.39 ENSMUST00000150268.8
ENSMUST00000122128.2
Plrg1
pleiotropic regulator 1
chrX_+_100492684 0.38 ENSMUST00000033674.6
Itgb1bp2
integrin beta 1 binding protein 2
chr11_+_6366259 0.37 ENSMUST00000213200.2
Ppia
peptidylprolyl isomerase A
chr11_-_73382303 0.37 ENSMUST00000119863.2
ENSMUST00000215358.2
ENSMUST00000214623.2
Olfr381
olfactory receptor 381
chr2_-_111843053 0.37 ENSMUST00000213559.3
Olfr1310
olfactory receptor 1310
chr7_+_45271229 0.36 ENSMUST00000033100.5
Izumo1
izumo sperm-egg fusion 1
chr11_+_69909245 0.36 ENSMUST00000231415.2
ENSMUST00000108588.9
Dlg4
discs large MAGUK scaffold protein 4
chr5_-_105198913 0.36 ENSMUST00000112718.5
Gbp8
guanylate-binding protein 8
chr19_+_12257218 0.35 ENSMUST00000207186.4
ENSMUST00000207915.2
Olfr1434
olfactory receptor 1434
chr2_-_87504008 0.34 ENSMUST00000213835.2
Olfr1135
olfactory receptor 1135
chr13_-_22289994 0.33 ENSMUST00000227357.2
ENSMUST00000228428.2
Vmn1r189
vomeronasal 1 receptor 189
chr1_-_4430481 0.33 ENSMUST00000027032.6
Rp1
retinitis pigmentosa 1 (human)
chr11_-_99134885 0.32 ENSMUST00000103132.10
ENSMUST00000038214.7
Krt222
keratin 222
chr2_+_85648823 0.32 ENSMUST00000214416.2
Olfr1018
olfactory receptor 1018
chr1_+_34478932 0.30 ENSMUST00000027303.14
Imp4
IMP4, U3 small nucleolar ribonucleoprotein
chr2_-_45007407 0.30 ENSMUST00000176438.9
Zeb2
zinc finger E-box binding homeobox 2
chr13_-_78344492 0.29 ENSMUST00000125176.3
Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr2_-_87570322 0.27 ENSMUST00000214573.2
Olfr1138
olfactory receptor 1138
chr17_+_34457868 0.27 ENSMUST00000095342.11
ENSMUST00000167280.8
ENSMUST00000236838.2
H2-Ob
histocompatibility 2, O region beta locus
chr14_+_60615128 0.26 ENSMUST00000022561.9
Amer2
APC membrane recruitment 2
chr2_-_85632888 0.24 ENSMUST00000217410.3
ENSMUST00000216425.3
Olfr1016
olfactory receptor 1016
chr11_-_99265721 0.22 ENSMUST00000006963.3
Krt28
keratin 28
chr3_+_94745009 0.21 ENSMUST00000107266.8
ENSMUST00000042402.12
ENSMUST00000107269.2
Pogz
pogo transposable element with ZNF domain
chr14_+_65612788 0.21 ENSMUST00000224687.2
Zfp395
zinc finger protein 395
chr8_+_66964401 0.18 ENSMUST00000002025.5
ENSMUST00000183187.2
Tktl2
transketolase-like 2
chr7_+_84562283 0.18 ENSMUST00000216367.2
ENSMUST00000214501.3
Olfr290
olfactory receptor 290
chr7_-_106341650 0.17 ENSMUST00000217734.2
Olfr697
olfactory receptor 697
chr9_+_43222104 0.15 ENSMUST00000034511.7
Trim29
tripartite motif-containing 29
chrX_-_74621828 0.15 ENSMUST00000033545.6
Rab39b
RAB39B, member RAS oncogene family
chrX_-_48980360 0.14 ENSMUST00000217355.3
Olfr1322
olfactory receptor 1322
chr7_-_107633196 0.14 ENSMUST00000210173.3
Olfr478
olfactory receptor 478
chr13_+_22268610 0.14 ENSMUST00000228243.2
ENSMUST00000226680.2
Vmn1r188
vomeronasal 1 receptor 188
chr9_+_38516398 0.14 ENSMUST00000217057.2
Olfr914
olfactory receptor 914
chr13_+_19394484 0.12 ENSMUST00000200495.2
Trgj1
T cell receptor gamma joining 1
chr1_-_171854818 0.11 ENSMUST00000138714.2
ENSMUST00000027837.13
ENSMUST00000111264.8
Vangl2
VANGL planar cell polarity 2
chr10_+_32959472 0.11 ENSMUST00000095762.5
ENSMUST00000218281.2
ENSMUST00000217779.2
ENSMUST00000219665.2
ENSMUST00000219931.2
Trdn
triadin
chr15_-_101422054 0.10 ENSMUST00000230067.3
Gm49425
predicted gene, 49425
chr3_+_66892979 0.10 ENSMUST00000162362.8
ENSMUST00000065074.14
ENSMUST00000065047.13
Rsrc1
arginine/serine-rich coiled-coil 1
chr19_-_11261177 0.09 ENSMUST00000186937.7
ENSMUST00000067673.13
Ms4a5
membrane-spanning 4-domains, subfamily A, member 5
chr13_-_118523760 0.09 ENSMUST00000022245.10
Mrps30
mitochondrial ribosomal protein S30
chr9_-_53882530 0.09 ENSMUST00000048409.14
Elmod1
ELMO/CED-12 domain containing 1
chr4_+_102111936 0.08 ENSMUST00000106907.9
Pde4b
phosphodiesterase 4B, cAMP specific
chr7_+_3648264 0.07 ENSMUST00000206287.2
ENSMUST00000038913.16
Cnot3
CCR4-NOT transcription complex, subunit 3
chr18_+_37827413 0.06 ENSMUST00000193414.2
Pcdhga5
protocadherin gamma subfamily A, 5
chr13_+_68011442 0.06 ENSMUST00000078471.7
BC048507
cDNA sequence BC048507
chr12_+_102094977 0.06 ENSMUST00000159329.8
Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr19_+_29929208 0.05 ENSMUST00000136850.2
Il33
interleukin 33
chr9_-_40895756 0.03 ENSMUST00000180872.9
Crtam
cytotoxic and regulatory T cell molecule
chr11_+_53324126 0.03 ENSMUST00000018382.7
Gdf9
growth differentiation factor 9
chr12_-_11258973 0.03 ENSMUST00000049877.3
Msgn1
mesogenin 1
chr3_-_41696906 0.03 ENSMUST00000026866.15
Sclt1
sodium channel and clathrin linker 1
chr6_-_145379805 0.02 ENSMUST00000149666.2
Lmntd1
lamin tail domain containing 1
chr13_+_23191826 0.01 ENSMUST00000228758.2
ENSMUST00000228031.2
ENSMUST00000227573.2
Vmn1r213
vomeronasal 1 receptor 213
chr6_-_41749300 0.01 ENSMUST00000050412.5
Olfr459
olfactory receptor 459
chr2_-_150097511 0.01 ENSMUST00000063463.6
Gm21994
predicted gene 21994
chr2_-_111820618 0.01 ENSMUST00000216948.2
ENSMUST00000214935.2
ENSMUST00000217452.2
ENSMUST00000215045.2
Olfr1309
olfactory receptor 1309

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.4 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.3 0.8 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.3 3.8 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 1.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 0.7 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 0.8 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1 1.3 GO:0030916 otic vesicle formation(GO:0030916)
0.1 2.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.5 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.3 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.1 1.7 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.4 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.1 0.5 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.1 0.8 GO:1904659 glucose transmembrane transport(GO:1904659)
0.1 0.5 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 1.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.5 GO:1905146 lysosomal protein catabolic process(GO:1905146)
0.0 0.3 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.1 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0 0.8 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.4 GO:0098953 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.3 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.7 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.4 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 3.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.1 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.3 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.0 GO:0002355 detection of tumor cell(GO:0002355)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 0.8 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.3 GO:0034457 Mpp10 complex(GO:0034457)
0.1 0.8 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.5 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 1.1 GO:0000974 Prp19 complex(GO:0000974)
0.1 1.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.7 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.3 GO:0097542 ciliary tip(GO:0097542)
0.0 0.8 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 3.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 4.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 2.8 GO:0000792 heterochromatin(GO:0000792)
0.0 4.4 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.4 GO:0002080 acrosomal membrane(GO:0002080)
0.0 3.8 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.4 GO:0005921 gap junction(GO:0005921)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.2 1.1 GO:0004359 glutaminase activity(GO:0004359)
0.2 0.5 GO:0015152 glucose-6-phosphate transmembrane transporter activity(GO:0015152)
0.1 0.3 GO:0030519 snoRNP binding(GO:0030519)
0.1 1.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.8 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.1 0.2 GO:0004802 transketolase activity(GO:0004802)
0.1 0.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.4 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 1.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 3.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 3.2 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 5.0 PID E2F PATHWAY E2F transcription factor network
0.0 2.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 0.4 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 1.1 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.8 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.8 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.0 0.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation