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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Mtf1

Z-value: 2.63

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Transcription factors associated with Mtf1

Gene Symbol Gene ID Gene Info
Mtf1
ENSMUSG00000028890.14 Mtf1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mtf1mm39_v1_chr4_+_124696336_1246963810.617.8e-05Click!

Activity profile of Mtf1 motif

Sorted Z-values of Mtf1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Mtf1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_+_94899292 82.90 ENSMUST00000034214.8
ENSMUST00000212806.2
Mt2
metallothionein 2
chr8_+_94905710 23.87 ENSMUST00000034215.8
ENSMUST00000212291.2
ENSMUST00000211807.2
Mt1
metallothionein 1
chr9_+_98372575 22.72 ENSMUST00000035029.3
Rbp2
retinol binding protein 2, cellular
chr6_+_90596123 9.63 ENSMUST00000032177.10
Slc41a3
solute carrier family 41, member 3
chr3_+_107803225 9.28 ENSMUST00000172247.8
ENSMUST00000167387.8
Gstm5
glutathione S-transferase, mu 5
chr3_+_107803137 8.95 ENSMUST00000004134.11
Gstm5
glutathione S-transferase, mu 5
chr4_-_43040278 8.70 ENSMUST00000107958.8
ENSMUST00000107959.8
ENSMUST00000152846.8
Fam214b
family with sequence similarity 214, member B
chr3_+_107803563 8.68 ENSMUST00000169365.2
Gstm5
glutathione S-transferase, mu 5
chr1_+_135656885 7.99 ENSMUST00000027677.8
Csrp1
cysteine and glycine-rich protein 1
chr5_-_34794451 7.97 ENSMUST00000124668.2
ENSMUST00000001109.11
ENSMUST00000155577.8
ENSMUST00000114329.8
Mfsd10
major facilitator superfamily domain containing 10
chr1_-_169358912 7.40 ENSMUST00000192248.2
ENSMUST00000028000.13
Nuf2
NUF2, NDC80 kinetochore complex component
chr2_+_118943274 6.42 ENSMUST00000140939.8
ENSMUST00000028795.10
Rad51
RAD51 recombinase
chr5_-_34794546 6.13 ENSMUST00000114331.10
Mfsd10
major facilitator superfamily domain containing 10
chr17_-_71833752 5.65 ENSMUST00000232863.2
ENSMUST00000024851.10
Ndc80
NDC80 kinetochore complex component
chr1_-_169359015 5.52 ENSMUST00000111368.8
Nuf2
NUF2, NDC80 kinetochore complex component
chr11_+_63023893 5.07 ENSMUST00000108700.2
Pmp22
peripheral myelin protein 22
chr12_-_36206780 4.64 ENSMUST00000223382.2
ENSMUST00000020856.6
Bzw2
basic leucine zipper and W2 domains 2
chr9_-_66032134 4.59 ENSMUST00000034946.15
Snx1
sorting nexin 1
chr3_-_121325887 4.40 ENSMUST00000039197.9
Slc44a3
solute carrier family 44, member 3
chr17_-_46513499 4.03 ENSMUST00000024749.9
Polh
polymerase (DNA directed), eta (RAD 30 related)
chr4_-_126057263 3.93 ENSMUST00000097891.4
Sh3d21
SH3 domain containing 21
chr6_-_56900917 3.91 ENSMUST00000031793.8
Nt5c3
5'-nucleotidase, cytosolic III
chr11_+_63023395 3.82 ENSMUST00000108701.8
Pmp22
peripheral myelin protein 22
chr10_+_20828446 3.72 ENSMUST00000105525.12
Ahi1
Abelson helper integration site 1
chr5_-_34794185 3.69 ENSMUST00000149657.5
Mfsd10
major facilitator superfamily domain containing 10
chr8_+_71358576 3.60 ENSMUST00000019405.4
ENSMUST00000212511.2
Map1s
microtubule-associated protein 1S
chr1_+_75376714 3.45 ENSMUST00000113589.8
Speg
SPEG complex locus
chr12_-_36206750 3.41 ENSMUST00000221388.2
Bzw2
basic leucine zipper and W2 domains 2
chr12_-_36206626 3.38 ENSMUST00000220828.2
Bzw2
basic leucine zipper and W2 domains 2
chr15_-_83033508 3.12 ENSMUST00000100375.11
Poldip3
polymerase (DNA-directed), delta interacting protein 3
chr6_+_18848570 2.74 ENSMUST00000056398.11
Lsm8
LSM8 homolog, U6 small nuclear RNA associated
chr12_+_111725282 2.74 ENSMUST00000239017.2
ENSMUST00000084941.12
Klc1
kinesin light chain 1
chr11_-_32172233 2.70 ENSMUST00000150381.2
ENSMUST00000144902.2
ENSMUST00000020524.15
Rhbdf1
rhomboid 5 homolog 1
chr15_-_83033559 2.67 ENSMUST00000058793.14
Poldip3
polymerase (DNA-directed), delta interacting protein 3
chr12_+_111725357 2.59 ENSMUST00000118471.8
ENSMUST00000122300.8
Klc1
kinesin light chain 1
chr14_-_8123295 2.41 ENSMUST00000225775.2
ENSMUST00000224877.2
ENSMUST00000090591.4
Il3ra
interleukin 3 receptor, alpha chain
chr19_-_4665668 2.38 ENSMUST00000113822.3
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr11_+_58845502 2.32 ENSMUST00000108817.5
ENSMUST00000047697.12
H2aw
Trim17
H2A.W histone
tripartite motif-containing 17
chr19_-_4665509 2.31 ENSMUST00000053597.3
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr9_-_14292269 2.29 ENSMUST00000214236.2
Endod1
endonuclease domain containing 1
chr5_-_100126707 2.21 ENSMUST00000170912.2
Hnrnpd
heterogeneous nuclear ribonucleoprotein D
chr15_-_83033471 1.99 ENSMUST00000129372.2
Poldip3
polymerase (DNA-directed), delta interacting protein 3
chr4_-_126056412 1.89 ENSMUST00000094760.9
Sh3d21
SH3 domain containing 21
chr8_+_93553901 1.67 ENSMUST00000034187.9
Mmp2
matrix metallopeptidase 2
chr2_-_119617985 1.62 ENSMUST00000110793.8
ENSMUST00000099529.9
ENSMUST00000048493.12
Rpap1
RNA polymerase II associated protein 1
chr10_+_17931459 1.61 ENSMUST00000154718.8
ENSMUST00000126390.8
ENSMUST00000164556.8
ENSMUST00000150029.8
Reps1
RalBP1 associated Eps domain containing protein
chr6_+_18848600 1.59 ENSMUST00000201141.3
Lsm8
LSM8 homolog, U6 small nuclear RNA associated
chr1_+_128031055 1.55 ENSMUST00000188381.7
ENSMUST00000187900.7
ENSMUST00000036288.11
R3hdm1
R3H domain containing 1
chr8_+_106937625 1.52 ENSMUST00000109297.8
Prmt7
protein arginine N-methyltransferase 7
chr7_-_119393182 1.50 ENSMUST00000106523.8
ENSMUST00000063902.14
ENSMUST00000150844.3
Eri2
exoribonuclease 2
chr15_-_93417380 1.47 ENSMUST00000109255.3
Prickle1
prickle planar cell polarity protein 1
chr16_+_38405718 1.36 ENSMUST00000165631.2
Tmem39a
transmembrane protein 39a
chr4_+_135933676 1.33 ENSMUST00000047526.8
Asap3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr3_-_27764571 1.23 ENSMUST00000046157.10
Fndc3b
fibronectin type III domain containing 3B
chr16_-_91394522 1.16 ENSMUST00000023686.15
Tmem50b
transmembrane protein 50B
chr8_+_106937568 1.15 ENSMUST00000071592.12
Prmt7
protein arginine N-methyltransferase 7
chr5_+_115644727 1.07 ENSMUST00000067268.15
ENSMUST00000086523.7
ENSMUST00000212819.3
Pxn
paxillin
chr9_+_19716202 1.05 ENSMUST00000212540.3
ENSMUST00000217280.2
Olfr859
olfactory receptor 859
chr7_-_42962640 0.94 ENSMUST00000012796.14
ENSMUST00000107986.9
Zfp715
zinc finger protein 715
chr2_+_144210881 0.88 ENSMUST00000028911.15
ENSMUST00000147747.8
ENSMUST00000183618.3
Kat14
Pet117
lysine acetyltransferase 14
PET117 homolog
chr11_-_5848771 0.85 ENSMUST00000102921.4
Myl7
myosin, light polypeptide 7, regulatory
chr10_-_7162196 0.80 ENSMUST00000015346.12
Cnksr3
Cnksr family member 3
chr11_+_4845328 0.80 ENSMUST00000038237.8
Thoc5
THO complex 5
chr7_+_119393210 0.80 ENSMUST00000033218.15
ENSMUST00000106520.9
Rexo5
RNA exonuclease 5
chr16_-_18165876 0.79 ENSMUST00000125287.9
Tango2
transport and golgi organization 2
chr11_+_4845314 0.78 ENSMUST00000101615.9
Thoc5
THO complex 5
chr1_+_66426127 0.76 ENSMUST00000145419.8
Map2
microtubule-associated protein 2
chr9_+_108368032 0.69 ENSMUST00000166103.9
ENSMUST00000085044.14
ENSMUST00000193678.6
ENSMUST00000178075.8
Usp19
ubiquitin specific peptidase 19
chr5_-_125418107 0.67 ENSMUST00000111390.8
ENSMUST00000086075.13
Scarb1
scavenger receptor class B, member 1
chr2_+_28082943 0.67 ENSMUST00000113920.8
Olfm1
olfactomedin 1
chr4_+_133302039 0.66 ENSMUST00000030662.3
Gpatch3
G patch domain containing 3
chr4_+_152171286 0.57 ENSMUST00000118648.8
Plekhg5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr15_+_81686622 0.51 ENSMUST00000109553.10
Tef
thyrotroph embryonic factor
chr10_-_80837173 0.47 ENSMUST00000099462.8
ENSMUST00000118233.8
Gng7
guanine nucleotide binding protein (G protein), gamma 7
chr7_+_119393312 0.43 ENSMUST00000084644.3
Rexo5
RNA exonuclease 5
chr15_+_27466732 0.36 ENSMUST00000022875.7
Ank
progressive ankylosis
chr14_+_59438658 0.34 ENSMUST00000173547.8
ENSMUST00000043227.13
ENSMUST00000022551.14
Rcbtb1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr9_+_108367801 0.23 ENSMUST00000006854.13
Usp19
ubiquitin specific peptidase 19
chr10_+_80972089 0.22 ENSMUST00000048128.15
Zbtb7a
zinc finger and BTB domain containing 7a
chr5_+_31026967 0.20 ENSMUST00000114716.4
Tmem214
transmembrane protein 214
chr5_-_140986312 0.18 ENSMUST00000085786.7
Card11
caspase recruitment domain family, member 11
chr8_-_71229293 0.15 ENSMUST00000034296.15
Pik3r2
phosphoinositide-3-kinase regulatory subunit 2
chr16_+_18166045 0.15 ENSMUST00000239533.1
ENSMUST00000239534.1
ARVCF
armadillo repeat deleted in velocardiofacial syndrome
chr4_+_138700195 0.10 ENSMUST00000123636.8
ENSMUST00000043042.10
ENSMUST00000050949.9
Tmco4
transmembrane and coiled-coil domains 4
chr10_-_117074501 0.03 ENSMUST00000159193.8
ENSMUST00000020392.5
9530003J23Rik
RIKEN cDNA 9530003J23 gene

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
13.3 106.8 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
4.5 26.9 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
4.4 17.8 GO:0015904 tetracycline transport(GO:0015904)
2.5 22.7 GO:0006776 vitamin A metabolic process(GO:0006776)
2.1 6.4 GO:1990426 homologous recombination-dependent replication fork processing(GO:1990426)
1.2 3.7 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
1.1 5.3 GO:0035617 stress granule disassembly(GO:0035617)
0.8 2.4 GO:0038156 interleukin-3-mediated signaling pathway(GO:0038156)
0.6 5.7 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.5 1.5 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.4 2.2 GO:1901355 response to rapamycin(GO:1901355)
0.4 4.0 GO:0071494 cellular response to UV-C(GO:0071494)
0.4 2.7 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.3 7.8 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.3 1.7 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.3 3.6 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.3 12.9 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.3 4.6 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.3 8.7 GO:0032060 bleb assembly(GO:0032060)
0.2 1.6 GO:0010793 regulation of mRNA export from nucleus(GO:0010793) negative regulation of DNA damage checkpoint(GO:2000002)
0.2 0.7 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.2 3.9 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 8.0 GO:0070527 platelet aggregation(GO:0070527)
0.1 1.2 GO:0060510 Type II pneumocyte differentiation(GO:0060510)
0.1 0.7 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.9 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.0 0.5 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 1.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.9 GO:1900037 regulation of cellular response to hypoxia(GO:1900037)
0.0 1.1 GO:0060396 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.8 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.4 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 2.7 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.0 3.4 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 0.2 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0 0.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.6 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 1.5 GO:0051492 regulation of stress fiber assembly(GO:0051492)
0.0 4.3 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 18.6 GO:0031262 Ndc80 complex(GO:0031262)
1.5 4.6 GO:0030905 retromer, tubulation complex(GO:0030905)
1.1 26.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.5 9.4 GO:0000346 transcription export complex(GO:0000346)
0.3 4.3 GO:0005688 U6 snRNP(GO:0005688)
0.3 8.9 GO:0043218 compact myelin(GO:0043218)
0.2 3.7 GO:0036038 MKS complex(GO:0036038)
0.1 17.8 GO:0031526 brush border membrane(GO:0031526)
0.1 6.4 GO:0035861 site of double-strand break(GO:0035861)
0.1 0.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 5.3 GO:0005871 kinesin complex(GO:0005871)
0.0 0.9 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.7 GO:0031528 microvillus membrane(GO:0031528)
0.0 13.5 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 1.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 10.5 GO:0005925 focal adhesion(GO:0005925)
0.0 6.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.7 GO:0001650 fibrillar center(GO:0001650)
0.0 0.9 GO:0031672 A band(GO:0031672)
0.0 0.7 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.6 GO:0030880 RNA polymerase complex(GO:0030880)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 17.8 GO:0008493 tetracycline transporter activity(GO:0008493)
1.3 22.7 GO:0019841 retinol binding(GO:0019841)
1.1 4.6 GO:1990460 leptin receptor binding(GO:1990460)
0.9 26.9 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.8 2.4 GO:0004912 interleukin-3 receptor activity(GO:0004912) interleukin-3 binding(GO:0019978)
0.7 6.4 GO:0000150 recombinase activity(GO:0000150)
0.5 2.7 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.3 1.1 GO:0051435 BH4 domain binding(GO:0051435)
0.2 17.9 GO:0005507 copper ion binding(GO:0005507)
0.2 0.7 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.2 3.9 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 2.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 4.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.8 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.9 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 76.5 GO:0008270 zinc ion binding(GO:0008270)
0.1 3.6 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 0.4 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 5.3 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.6 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 5.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 10.1 GO:0045296 cadherin binding(GO:0045296)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 2.3 GO:0004519 endonuclease activity(GO:0004519)
0.0 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 2.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 20.9 GO:0003723 RNA binding(GO:0003723)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 22.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 6.4 PID BARD1 PATHWAY BARD1 signaling events
0.1 5.7 PID AURORA B PATHWAY Aurora B signaling
0.1 8.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 5.3 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 4.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.0 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 1.7 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 2.4 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.8 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 26.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.5 22.7 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.3 6.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 3.9 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.2 5.3 REACTOME KINESINS Genes involved in Kinesins
0.2 18.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 4.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 1.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 2.6 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.7 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta