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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nfatc4

Z-value: 0.91

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Transcription factors associated with Nfatc4

Gene Symbol Gene ID Gene Info
Nfatc4
ENSMUSG00000023411.13 Nfatc4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfatc4mm39_v1_chr14_+_56062252_56062348-0.679.2e-06Click!

Activity profile of Nfatc4 motif

Sorted Z-values of Nfatc4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfatc4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_150341911 5.10 ENSMUST00000162367.8
ENSMUST00000161611.8
ENSMUST00000161320.8
ENSMUST00000159035.2
Prg4
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
chr12_-_84497718 4.37 ENSMUST00000085192.7
ENSMUST00000220491.2
Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr11_+_75358866 3.42 ENSMUST00000043598.14
ENSMUST00000108435.2
Tlcd2
TLC domain containing 2
chr8_+_129085719 2.33 ENSMUST00000026917.10
Nrp1
neuropilin 1
chr3_-_20329823 2.10 ENSMUST00000011607.6
Cpb1
carboxypeptidase B1 (tissue)
chr6_-_21851827 2.09 ENSMUST00000202353.2
ENSMUST00000134635.2
ENSMUST00000123116.8
ENSMUST00000120965.8
ENSMUST00000143531.2
Tspan12
tetraspanin 12
chr15_+_3300249 1.99 ENSMUST00000082424.12
ENSMUST00000159158.9
ENSMUST00000159216.10
ENSMUST00000160311.3
Selenop
selenoprotein P
chr14_-_25927674 1.92 ENSMUST00000100811.6
Tmem254a
transmembrane protein 254a
chr14_-_25928096 1.79 ENSMUST00000185006.9
Tmem254a
transmembrane protein 254a
chr10_-_53952686 1.77 ENSMUST00000220088.2
Man1a
mannosidase 1, alpha
chr13_-_53135064 1.59 ENSMUST00000071065.8
Nfil3
nuclear factor, interleukin 3, regulated
chr12_+_8027767 1.52 ENSMUST00000037520.14
Apob
apolipoprotein B
chr11_-_35871300 1.45 ENSMUST00000018993.7
Wwc1
WW, C2 and coiled-coil domain containing 1
chr19_-_4993060 1.33 ENSMUST00000133504.2
ENSMUST00000133254.2
ENSMUST00000120475.8
ENSMUST00000025834.15
Peli3
pellino 3
chr19_+_8816663 1.28 ENSMUST00000160556.8
Bscl2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr13_+_25127127 1.18 ENSMUST00000021773.13
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr14_+_53980561 1.07 ENSMUST00000103667.6
Trav16
T cell receptor alpha variable 16
chr10_+_4561974 0.90 ENSMUST00000105590.8
ENSMUST00000067086.14
Esr1
estrogen receptor 1 (alpha)
chr15_-_79816785 0.84 ENSMUST00000089293.11
ENSMUST00000109616.9
Cbx7
chromobox 7
chr14_-_65187287 0.81 ENSMUST00000067843.10
ENSMUST00000176489.8
ENSMUST00000175905.8
ENSMUST00000022544.14
ENSMUST00000175744.8
ENSMUST00000176128.8
Hmbox1
homeobox containing 1
chr4_-_148244299 0.78 ENSMUST00000151127.8
ENSMUST00000105705.9
Fbxo44
F-box protein 44
chr10_-_12689345 0.77 ENSMUST00000217899.2
Utrn
utrophin
chr15_-_79816717 0.71 ENSMUST00000177044.2
ENSMUST00000109615.8
Cbx7
chromobox 7
chr11_-_99412084 0.71 ENSMUST00000076948.2
Krt39
keratin 39
chrX_+_7504913 0.70 ENSMUST00000128890.2
Syp
synaptophysin
chr12_+_84498196 0.70 ENSMUST00000137170.3
Lin52
lin-52 homolog (C. elegans)
chr11_-_99412162 0.59 ENSMUST00000107445.8
Krt39
keratin 39
chr8_-_39128662 0.55 ENSMUST00000118896.2
Sgcz
sarcoglycan zeta
chr12_+_76580386 0.54 ENSMUST00000219063.2
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr1_+_174257996 0.53 ENSMUST00000053178.5
Olfr414
olfactory receptor 414
chr2_-_73490719 0.50 ENSMUST00000154258.8
Chn1
chimerin 1
chr2_+_124978518 0.50 ENSMUST00000238754.2
Ctxn2
cortexin 2
chr4_+_130001349 0.48 ENSMUST00000030563.6
Pef1
penta-EF hand domain containing 1
chr14_+_70793340 0.46 ENSMUST00000163060.2
Hr
lysine demethylase and nuclear receptor corepressor
chr17_+_48037758 0.45 ENSMUST00000024782.12
ENSMUST00000144955.2
Pgc
progastricsin (pepsinogen C)
chr4_-_3938352 0.44 ENSMUST00000003369.10
Plag1
pleiomorphic adenoma gene 1
chr14_+_49409659 0.41 ENSMUST00000153488.9
Naa30
N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr9_+_51959415 0.39 ENSMUST00000000590.16
ENSMUST00000238858.2
Rdx
radixin
chr9_+_51959534 0.38 ENSMUST00000061352.11
Rdx
radixin
chr16_+_43184507 0.36 ENSMUST00000148775.8
Zbtb20
zinc finger and BTB domain containing 20
chr12_+_52550775 0.35 ENSMUST00000219443.2
Arhgap5
Rho GTPase activating protein 5
chr2_+_124978612 0.34 ENSMUST00000099452.3
ENSMUST00000238377.2
Ctxn2
cortexin 2
chr19_+_8828132 0.33 ENSMUST00000235683.2
ENSMUST00000096257.3
Lrrn4cl
LRRN4 C-terminal like
chr8_-_68270936 0.33 ENSMUST00000120071.8
Psd3
pleckstrin and Sec7 domain containing 3
chr1_-_168259710 0.32 ENSMUST00000072863.6
Pbx1
pre B cell leukemia homeobox 1
chr2_+_55325931 0.31 ENSMUST00000067101.10
Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr9_-_64858878 0.30 ENSMUST00000037798.8
Slc24a1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr5_-_112542671 0.30 ENSMUST00000196256.2
Asphd2
aspartate beta-hydroxylase domain containing 2
chr8_-_41494890 0.30 ENSMUST00000051379.14
Mtus1
mitochondrial tumor suppressor 1
chr1_-_169938298 0.30 ENSMUST00000192312.6
Ddr2
discoidin domain receptor family, member 2
chr10_-_44334711 0.29 ENSMUST00000039174.11
Prdm1
PR domain containing 1, with ZNF domain
chr11_-_89587671 0.28 ENSMUST00000128717.9
Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr11_-_47270201 0.27 ENSMUST00000077221.6
Sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr12_+_103564479 0.27 ENSMUST00000190151.2
Ppp4r4
protein phosphatase 4, regulatory subunit 4
chr10_+_33071964 0.27 ENSMUST00000219211.2
Trdn
triadin
chr19_+_26600820 0.25 ENSMUST00000176584.2
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr8_-_68270870 0.23 ENSMUST00000059374.5
Psd3
pleckstrin and Sec7 domain containing 3
chr3_-_37180093 0.23 ENSMUST00000029275.6
Il2
interleukin 2
chr6_-_128599779 0.23 ENSMUST00000203275.3
Klrb1a
killer cell lectin-like receptor subfamily B member 1A
chrX_+_56144946 0.22 ENSMUST00000141936.2
Vgll1
vestigial like family member 1
chr10_+_23727325 0.20 ENSMUST00000020190.8
Vnn3
vanin 3
chr3_-_105908789 0.20 ENSMUST00000066319.8
Pifo
primary cilia formation
chr14_+_120513106 0.19 ENSMUST00000227012.2
ENSMUST00000167459.3
Mbnl2
muscleblind like splicing factor 2
chr10_-_44334683 0.19 ENSMUST00000105490.3
Prdm1
PR domain containing 1, with ZNF domain
chr3_+_94744844 0.19 ENSMUST00000107270.9
Pogz
pogo transposable element with ZNF domain
chr14_+_120513076 0.17 ENSMUST00000088419.13
Mbnl2
muscleblind like splicing factor 2
chr1_-_144052997 0.15 ENSMUST00000111941.2
ENSMUST00000052375.8
Rgs13
regulator of G-protein signaling 13
chr1_+_34044940 0.13 ENSMUST00000187486.7
ENSMUST00000182697.8
Dst
dystonin
chr1_+_82891043 0.13 ENSMUST00000220768.2
A030005L19Rik
RIKEN cDNA A030005L19 gene
chr10_-_89270527 0.13 ENSMUST00000218764.2
Gas2l3
growth arrest-specific 2 like 3
chr9_+_88838953 0.11 ENSMUST00000098485.4
Bcl2a1a
B cell leukemia/lymphoma 2 related protein A1a
chr9_-_13358049 0.11 ENSMUST00000167906.3
Gm17571
predicted gene, 17571
chr5_+_53747796 0.11 ENSMUST00000113865.5
Rbpj
recombination signal binding protein for immunoglobulin kappa J region
chr17_+_34129221 0.10 ENSMUST00000174541.9
Daxx
Fas death domain-associated protein
chr5_+_117501557 0.10 ENSMUST00000111959.2
Wsb2
WD repeat and SOCS box-containing 2
chr18_+_42186757 0.10 ENSMUST00000074679.4
Sh3rf2
SH3 domain containing ring finger 2
chr11_-_53509485 0.10 ENSMUST00000000889.7
Il4
interleukin 4
chr1_+_78794475 0.09 ENSMUST00000057262.8
ENSMUST00000187432.2
Kcne4
potassium voltage-gated channel, Isk-related subfamily, gene 4
chr18_+_42186713 0.09 ENSMUST00000072008.11
Sh3rf2
SH3 domain containing ring finger 2
chr6_+_21986445 0.08 ENSMUST00000115382.8
Cped1
cadherin-like and PC-esterase domain containing 1
chr3_-_86455575 0.08 ENSMUST00000077524.4
Mab21l2
mab-21-like 2
chr10_+_21869776 0.07 ENSMUST00000092673.11
Sgk1
serum/glucocorticoid regulated kinase 1
chr4_+_48049080 0.06 ENSMUST00000153369.2
Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr7_+_91321500 0.05 ENSMUST00000238619.2
ENSMUST00000238467.2
Dlg2
discs large MAGUK scaffold protein 2
chr9_+_77543776 0.05 ENSMUST00000057781.8
Klhl31
kelch-like 31
chr18_+_73996743 0.04 ENSMUST00000134847.2
Mro
maestro
chr1_-_169938060 0.04 ENSMUST00000027985.8
ENSMUST00000194690.6
Ddr2
discoidin domain receptor family, member 2
chr12_+_91367764 0.04 ENSMUST00000021346.14
ENSMUST00000021343.8
Tshr
thyroid stimulating hormone receptor
chr2_+_61876806 0.01 ENSMUST00000102735.10
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.4 GO:0019859 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.8 2.3 GO:0097374 cell migration involved in vasculogenesis(GO:0035441) neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) sensory neuron axon guidance(GO:0097374)
0.6 5.1 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.3 1.2 GO:0010982 GPI anchor release(GO:0006507) regulation of high-density lipoprotein particle clearance(GO:0010982)
0.2 2.0 GO:0001887 selenium compound metabolic process(GO:0001887)
0.2 0.7 GO:2000474 regulation of opioid receptor signaling pathway(GO:2000474)
0.2 0.5 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.2 0.5 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082)
0.2 0.5 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803)
0.1 0.9 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.1 1.4 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.7 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.1 0.8 GO:1902965 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.1 1.5 GO:0006642 triglyceride mobilization(GO:0006642)
0.1 0.8 GO:0007527 adult somatic muscle development(GO:0007527)
0.1 1.5 GO:0048733 sebaceous gland development(GO:0048733)
0.1 0.3 GO:0080163 regulation of protein serine/threonine phosphatase activity(GO:0080163)
0.1 1.8 GO:0006491 N-glycan processing(GO:0006491)
0.1 2.1 GO:0010842 retina layer formation(GO:0010842)
0.1 1.3 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.4 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.3 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.3 GO:2000320 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.0 1.6 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.0 GO:1904587 response to glycoprotein(GO:1904587)
0.0 0.8 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.3 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.5 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.3 GO:0050957 equilibrioception(GO:0050957)
0.0 0.4 GO:0060736 prostate gland growth(GO:0060736)
0.0 0.3 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.1 GO:1900625 positive regulation of mast cell cytokine production(GO:0032765) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.5 GO:0008045 motor neuron axon guidance(GO:0008045)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0034359 mature chylomicron(GO:0034359)
0.3 2.3 GO:0097443 sorting endosome(GO:0097443)
0.1 0.9 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.4 GO:0031417 NatC complex(GO:0031417)
0.1 0.8 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 1.6 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.8 GO:0051286 cell tip(GO:0051286)
0.0 0.8 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.7 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.1 GO:0031673 H zone(GO:0031673)
0.0 1.3 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.3 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.3 0.9 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.2 5.1 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 1.8 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 1.2 GO:0004630 phospholipase D activity(GO:0004630)
0.1 1.5 GO:0035473 lipase binding(GO:0035473)
0.1 2.0 GO:0008430 selenium binding(GO:0008430)
0.1 2.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.8 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 4.4 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.1 0.3 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 1.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.5 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.1 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.0 0.8 GO:0017166 vinculin binding(GO:0017166)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 1.3 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 5.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.8 PID RHOA PATHWAY RhoA signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 4.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.3 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 1.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.7 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.9 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4