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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nfkb2

Z-value: 0.62

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Transcription factors associated with Nfkb2

Gene Symbol Gene ID Gene Info
Nfkb2
ENSMUSG00000025225.16 Nfkb2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfkb2mm39_v1_chr19_+_46292759_462928450.492.6e-03Click!

Activity profile of Nfkb2 motif

Sorted Z-values of Nfkb2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfkb2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr14_+_80237691 3.84 ENSMUST00000228749.2
ENSMUST00000088735.4
Olfm4
olfactomedin 4
chr17_+_56259617 2.10 ENSMUST00000003274.8
Ebi3
Epstein-Barr virus induced gene 3
chr7_-_44181477 2.00 ENSMUST00000098483.9
ENSMUST00000035323.6
Spib
Spi-B transcription factor (Spi-1/PU.1 related)
chrX_-_7537580 1.99 ENSMUST00000033486.6
Plp2
proteolipid protein 2
chr7_+_44866635 1.96 ENSMUST00000097216.5
ENSMUST00000209343.2
ENSMUST00000209678.2
Tead2
TEA domain family member 2
chr1_+_153616090 1.44 ENSMUST00000027748.8
Rgs16
regulator of G-protein signaling 16
chr8_+_79755194 1.29 ENSMUST00000119254.8
ENSMUST00000238669.2
Zfp827
zinc finger protein 827
chr19_-_46327024 1.22 ENSMUST00000236046.2
ENSMUST00000236980.2
ENSMUST00000235485.2
ENSMUST00000236061.2
ENSMUST00000236236.2
ENSMUST00000236768.2
ENSMUST00000236651.2
Cuedc2
CUE domain containing 2
chr19_-_46327071 1.16 ENSMUST00000235977.2
ENSMUST00000167861.8
ENSMUST00000051234.9
ENSMUST00000236066.2
Cuedc2
CUE domain containing 2
chr11_+_70548022 1.15 ENSMUST00000157027.8
ENSMUST00000072841.12
ENSMUST00000108548.8
ENSMUST00000126241.8
Eno3
enolase 3, beta muscle
chr8_+_79754980 1.04 ENSMUST00000087927.11
ENSMUST00000098614.9
Zfp827
zinc finger protein 827
chr19_+_46292759 0.83 ENSMUST00000237330.2
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr8_+_120729459 0.80 ENSMUST00000108972.4
Crispld2
cysteine-rich secretory protein LCCL domain containing 2
chr11_+_70548622 0.79 ENSMUST00000170716.8
Eno3
enolase 3, beta muscle
chr14_-_30348153 0.77 ENSMUST00000112211.9
ENSMUST00000112210.11
Prkcd
protein kinase C, delta
chr19_+_6391148 0.75 ENSMUST00000025897.13
ENSMUST00000130382.8
Map4k2
mitogen-activated protein kinase kinase kinase kinase 2
chr2_+_102380357 0.71 ENSMUST00000028612.8
Pamr1
peptidase domain containing associated with muscle regeneration 1
chr7_+_3339059 0.69 ENSMUST00000096744.8
Myadm
myeloid-associated differentiation marker
chr11_-_54853729 0.68 ENSMUST00000108885.8
ENSMUST00000102730.9
ENSMUST00000018482.13
ENSMUST00000108886.8
ENSMUST00000102731.8
Tnip1
TNFAIP3 interacting protein 1
chr19_+_46293210 0.65 ENSMUST00000236591.2
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr7_-_44702269 0.62 ENSMUST00000057293.8
Prr12
proline rich 12
chr14_-_30329765 0.60 ENSMUST00000112207.8
ENSMUST00000112206.8
ENSMUST00000112202.8
ENSMUST00000112203.2
Prkcd
protein kinase C, delta
chr5_-_137529251 0.58 ENSMUST00000132525.8
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr19_+_46293160 0.55 ENSMUST00000073116.13
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr5_-_137529465 0.54 ENSMUST00000150063.9
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr11_+_70548513 0.50 ENSMUST00000134087.8
Eno3
enolase 3, beta muscle
chr13_+_43938251 0.42 ENSMUST00000015540.4
Cd83
CD83 antigen
chr7_-_125799644 0.39 ENSMUST00000168189.8
Xpo6
exportin 6
chr15_-_102154874 0.37 ENSMUST00000063339.14
Rarg
retinoic acid receptor, gamma
chr2_-_93292257 0.35 ENSMUST00000150508.8
Cd82
CD82 antigen
chr3_+_97565528 0.35 ENSMUST00000045743.13
Prkab2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr7_-_19363280 0.34 ENSMUST00000094762.10
ENSMUST00000049912.15
ENSMUST00000098754.5
Relb
avian reticuloendotheliosis viral (v-rel) oncogene related B
chr7_-_125799570 0.34 ENSMUST00000009344.16
Xpo6
exportin 6
chr9_+_5308828 0.33 ENSMUST00000162846.8
ENSMUST00000027012.14
Casp4
caspase 4, apoptosis-related cysteine peptidase
chr7_+_28988724 0.31 ENSMUST00000207714.2
ENSMUST00000048187.6
Ppp1r14a
protein phosphatase 1, regulatory inhibitor subunit 14A
chr4_+_129878890 0.31 ENSMUST00000106017.8
ENSMUST00000121049.8
Adgrb2
adhesion G protein-coupled receptor B2
chr2_-_37312881 0.30 ENSMUST00000112936.4
ENSMUST00000112934.8
Rc3h2
ring finger and CCCH-type zinc finger domains 2
chr19_+_53517528 0.30 ENSMUST00000038287.7
Dusp5
dual specificity phosphatase 5
chr17_-_36291087 0.28 ENSMUST00000055454.14
Prr3
proline-rich polypeptide 3
chr9_-_106762818 0.28 ENSMUST00000185707.2
Rbm15b
RNA binding motif protein 15B
chr3_-_107667499 0.28 ENSMUST00000153114.2
ENSMUST00000118593.8
ENSMUST00000120243.8
Csf1
colony stimulating factor 1 (macrophage)
chr7_+_30121776 0.26 ENSMUST00000108175.8
Nfkbid
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
chr4_+_124880223 0.25 ENSMUST00000030687.8
Rspo1
R-spondin 1
chr8_+_124138163 0.21 ENSMUST00000071134.4
ENSMUST00000212743.2
Tubb3
tubulin, beta 3 class III
chr4_-_125021610 0.20 ENSMUST00000036188.8
Zc3h12a
zinc finger CCCH type containing 12A
chr17_+_36290743 0.19 ENSMUST00000087200.4
Gnl1
guanine nucleotide binding protein-like 1
chr11_+_101066867 0.18 ENSMUST00000103109.4
Cntnap1
contactin associated protein-like 1
chr3_+_31149201 0.16 ENSMUST00000118470.8
ENSMUST00000029194.12
ENSMUST00000123532.2
Skil
SKI-like
chr8_-_105357941 0.13 ENSMUST00000034351.8
Rrad
Ras-related associated with diabetes
chr11_-_71928300 0.12 ENSMUST00000048207.10
Aipl1
aryl hydrocarbon receptor-interacting protein-like 1
chr1_+_149975782 0.11 ENSMUST00000035065.9
Ptgs2
prostaglandin-endoperoxide synthase 2
chr9_-_44646487 0.11 ENSMUST00000034611.15
Phldb1
pleckstrin homology like domain, family B, member 1
chr9_-_107486381 0.09 ENSMUST00000102531.7
ENSMUST00000102530.8
ENSMUST00000195057.2
ENSMUST00000102532.10
Sema3b
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr1_-_63153675 0.06 ENSMUST00000097718.9
Ino80d
INO80 complex subunit D
chr14_+_55829165 0.06 ENSMUST00000019443.15
Rnf31
ring finger protein 31
chr3_+_31149247 0.06 ENSMUST00000117728.8
Skil
SKI-like
chr11_+_77576981 0.05 ENSMUST00000100802.11
ENSMUST00000181023.2
Nufip2
nuclear fragile X mental retardation protein interacting protein 2
chr5_+_90907207 0.04 ENSMUST00000031318.6
Cxcl5
chemokine (C-X-C motif) ligand 5
chr17_-_88372315 0.03 ENSMUST00000235056.2
ENSMUST00000130379.9
Fbxo11
F-box protein 11
chr7_-_125799585 0.02 ENSMUST00000163959.2
Xpo6
exportin 6
chr7_+_18910340 0.02 ENSMUST00000117338.8
Eml2
echinoderm microtubule associated protein like 2
chr4_+_129878627 0.02 ENSMUST00000120204.8
Adgrb2
adhesion G protein-coupled receptor B2
chr11_+_69920542 0.01 ENSMUST00000232266.2
ENSMUST00000132597.5
Dlg4
discs large MAGUK scaffold protein 4
chr6_+_68547717 0.00 ENSMUST00000196839.5
ENSMUST00000103327.3
Igkv12-98
immunoglobulin kappa variable 12-98
chr7_+_16043502 0.00 ENSMUST00000002152.13
Bbc3
BCL2 binding component 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0002268 follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268)
0.3 1.4 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
0.3 2.4 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.1 0.9 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.1 0.3 GO:1903969 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.1 0.7 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.1 2.0 GO:0048368 lateral mesoderm development(GO:0048368)
0.1 0.4 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 3.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.3 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.4 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 2.0 GO:0030225 macrophage differentiation(GO:0030225)
0.0 0.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.3 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.2 GO:0033085 negative regulation of T cell differentiation in thymus(GO:0033085)
0.0 0.1 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.3 GO:2000254 regulation of male germ cell proliferation(GO:2000254)
0.0 0.7 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 2.4 GO:0006096 glycolytic process(GO:0006096)
0.0 0.1 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.2 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.3 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.2 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.8 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.1 GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.4 2.0 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.2 2.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 3.8 GO:0042581 specific granule(GO:0042581)
0.1 0.3 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 0.3 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.2 2.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.3 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 2.0 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 2.0 GO:0019956 chemokine binding(GO:0019956)
0.0 0.7 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.0 1.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 2.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.8 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.7 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID IL27 PATHWAY IL27-mediated signaling events
0.0 2.0 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID TNF PATHWAY TNF receptor signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 2.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 2.0 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.3 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway