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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nkx2-1

Z-value: 0.80

Motif logo

Transcription factors associated with Nkx2-1

Gene Symbol Gene ID Gene Info
ENSMUSG00000001496.16 Nkx2-1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-1mm39_v1_chr12_-_56583582_565836930.067.3e-01Click!

Activity profile of Nkx2-1 motif

Sorted Z-values of Nkx2-1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr9_+_98372575 5.28 ENSMUST00000035029.3
retinol binding protein 2, cellular
chr7_-_4755971 3.61 ENSMUST00000183971.8
ENSMUST00000182173.2
ENSMUST00000182738.8
ENSMUST00000182111.8
ENSMUST00000184143.8
ENSMUST00000182048.2
ENSMUST00000063324.14
cytochrome c oxidase subunit 6B2
chr11_+_117740077 3.26 ENSMUST00000081387.11
baculoviral IAP repeat-containing 5
chr10_+_75404482 2.96 ENSMUST00000134503.8
ENSMUST00000125770.8
ENSMUST00000128886.8
ENSMUST00000151212.8
gamma-glutamyltransferase 1
chr9_+_56344700 2.95 ENSMUST00000239472.2
ubiquitin-conjugating enzyme E2S (Ube2s) retrogene
chr11_+_117740111 2.36 ENSMUST00000093906.5
baculoviral IAP repeat-containing 5
chr9_-_44253630 2.30 ENSMUST00000097558.5
hydroxymethylbilane synthase
chr10_+_75404464 2.18 ENSMUST00000145928.8
ENSMUST00000131565.8
gamma-glutamyltransferase 1
chr9_+_55997246 2.03 ENSMUST00000059206.8
proline-serine-threonine phosphatase-interacting protein 1
chr10_+_81012465 2.00 ENSMUST00000047864.11
eukaryotic translation elongation factor 2
chr18_-_68562385 1.76 ENSMUST00000052347.8
melanocortin 2 receptor
chr1_-_181669891 1.69 ENSMUST00000193028.2
ENSMUST00000191878.6
ENSMUST00000005003.12
lamin B receptor
chrX_-_74174524 1.56 ENSMUST00000114091.8
membrane protein, palmitoylated
chr11_+_68989763 1.42 ENSMUST00000021271.14
period circadian clock 1
chr1_+_74193138 1.40 ENSMUST00000027372.8
ENSMUST00000106899.4
chemokine (C-X-C motif) receptor 2
chr2_-_156848923 1.33 ENSMUST00000146413.8
ENSMUST00000103129.9
ENSMUST00000103130.8
DSN1 homolog, MIS12 kinetochore complex component
chr16_-_4340920 1.29 ENSMUST00000090500.10
ENSMUST00000023161.8
sarcalumenin
chr5_-_148988110 1.27 ENSMUST00000110505.8
high mobility group box 1
chr11_+_70323452 1.27 ENSMUST00000084954.13
ENSMUST00000108568.10
ENSMUST00000079056.9
ENSMUST00000102564.11
ENSMUST00000124943.8
ENSMUST00000150076.8
ENSMUST00000102563.2
arrestin, beta 2
chr1_-_120432669 1.27 ENSMUST00000027639.8
macrophage receptor with collagenous structure
chr19_-_32443978 1.27 ENSMUST00000078034.5
ribosomal protein L9, pseudogene 6
chr11_-_96868483 1.18 ENSMUST00000107624.8
Sp2 transcription factor
chr2_+_121337226 1.17 ENSMUST00000099473.10
ENSMUST00000110602.9
WD repeat domain 76
chr9_-_45923908 1.14 ENSMUST00000217514.2
platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
chr13_+_23922783 1.11 ENSMUST00000040914.3
H1.2 linker histone, cluster member
chr12_+_30961650 1.06 ENSMUST00000020997.15
ENSMUST00000110880.3
Sh3 domain YSC-like 1
chr17_+_47983587 1.01 ENSMUST00000152724.2
ubiquitin specific peptidase 49
chr11_+_32483290 0.97 ENSMUST00000102821.4
serine/threonine kinase 10
chr7_+_127845984 0.92 ENSMUST00000164710.8
ENSMUST00000070656.12
transforming growth factor beta 1 induced transcript 1
chr12_-_30961570 0.92 ENSMUST00000062740.15
ENSMUST00000074038.7
acid phosphatase 1, soluble
chr2_-_170248421 0.90 ENSMUST00000154650.8
breast carcinoma amplified sequence 1
chr1_+_12788720 0.90 ENSMUST00000088585.10
sulfatase 1
chr15_-_64254754 0.86 ENSMUST00000177374.8
ENSMUST00000110114.10
ENSMUST00000110115.9
ENSMUST00000023008.16
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
chr15_+_66542598 0.84 ENSMUST00000065916.14
thyroglobulin
chr5_-_110927803 0.79 ENSMUST00000112426.8
pseudouridine synthase 1
chr10_+_22520910 0.77 ENSMUST00000042261.5
solute carrier family 2 (facilitated glucose transporter), member 12
chr8_+_55024446 0.75 ENSMUST00000239166.2
ENSMUST00000239106.2
ENSMUST00000239152.2
ankyrin repeat and SOCs box-containing 5
chr2_+_121337195 0.68 ENSMUST00000028676.12
WD repeat domain 76
chr11_-_86148344 0.65 ENSMUST00000136469.2
ENSMUST00000018212.13
integrator complex subunit 2
chr3_+_37474422 0.62 ENSMUST00000029277.13
ENSMUST00000198968.2
spermatogenesis associated 5
chr4_-_109522502 0.60 ENSMUST00000063531.5
cyclin dependent kinase inhibitor 2C
chr2_-_121337120 0.60 ENSMUST00000089926.6
microfibrillar-associated protein 1A
chr9_-_71803354 0.59 ENSMUST00000184448.8
transcription factor 12
chr15_-_64254585 0.57 ENSMUST00000176384.8
ENSMUST00000175799.8
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
chr1_-_120432477 0.56 ENSMUST00000186432.3
macrophage receptor with collagenous structure
chr7_-_118091135 0.54 ENSMUST00000178344.3
inositol 1,4,5-triphosphate receptor interacting protein-like 2
chr9_-_121621544 0.53 ENSMUST00000035110.11
hedgehog acyltransferase-like
chrX_-_73009933 0.53 ENSMUST00000114372.3
ENSMUST00000033761.13
host cell factor C1
chr6_+_72281587 0.53 ENSMUST00000183018.8
ENSMUST00000182014.10
surfactant associated protein B
chr2_-_121304521 0.51 ENSMUST00000056732.4
microfibrillar-associated protein 1B
chr13_+_55782814 0.51 ENSMUST00000172272.8
ENSMUST00000099479.4
ENSMUST00000223736.2
DEAD box helicase 46
chr6_-_38276157 0.48 ENSMUST00000058524.3
zinc finger CCCH-type, antiviral 1-like
chr4_-_141602190 0.48 ENSMUST00000036854.4
EF hand domain containing 2
chr6_-_41613322 0.48 ENSMUST00000031902.7
transient receptor potential cation channel, subfamily V, member 6
chr3_+_159545309 0.47 ENSMUST00000068952.10
ENSMUST00000198878.2
wntless WNT ligand secretion mediator
chr3_-_108108113 0.44 ENSMUST00000106655.2
ENSMUST00000065664.7
cytochrome b-561 domain containing 1
chr19_-_5452521 0.43 ENSMUST00000235569.2
testis specific 10 interacting protein
chr6_-_113411489 0.42 ENSMUST00000133348.2
cell death-inducing DFFA-like effector c
chr11_-_83353787 0.41 ENSMUST00000021020.13
ENSMUST00000119346.2
ENSMUST00000103209.10
ENSMUST00000108137.9
matrix metallopeptidase 28 (epilysin)
chr5_+_145020640 0.41 ENSMUST00000031625.15
actin related protein 2/3 complex, subunit 1A
chr12_-_111638722 0.41 ENSMUST00000001304.9
creatine kinase, brain
chr10_+_87926932 0.39 ENSMUST00000048621.8
pro-melanin-concentrating hormone
chr14_+_51351880 0.39 ENSMUST00000100645.5
epididymal protein 3B
chr9_+_110595224 0.39 ENSMUST00000136695.3
myosin, light polypeptide 3
chr6_+_127554931 0.38 ENSMUST00000071563.5
calcium release activated channel regulator 2A
chr4_+_129948803 0.38 ENSMUST00000123617.8
collagen, type XVI, alpha 1
chr6_-_148847854 0.35 ENSMUST00000139355.8
ENSMUST00000146457.2
ENSMUST00000054080.15
SIN3-HDAC complex associated factor
chrX_+_72935708 0.34 ENSMUST00000033765.8
ENSMUST00000101470.3
ENSMUST00000114395.2
arginine vasopressin receptor 2
chrX_+_143471903 0.32 ENSMUST00000112843.2
retrotransposon Gag like 4
chr17_-_26080429 0.30 ENSMUST00000079461.15
ENSMUST00000176923.9
WD repeat domain 90
chr11_+_100513747 0.30 ENSMUST00000142993.2
NFKB inhibitor interacting Ras-like protein 2
chrX_+_161543384 0.30 ENSMUST00000033720.12
ENSMUST00000112327.8
retinoblastoma binding protein 7, chromatin remodeling factor
chr11_-_86148379 0.28 ENSMUST00000132024.8
ENSMUST00000139285.8
integrator complex subunit 2
chr18_+_49965689 0.28 ENSMUST00000180611.8
Dmx-like 1
chr3_+_68491487 0.27 ENSMUST00000182997.3
schwannomin interacting protein 1
chr11_+_69920849 0.27 ENSMUST00000143920.4
discs large MAGUK scaffold protein 4
chr1_-_136273811 0.26 ENSMUST00000048309.12
calmodulin regulated spectrin-associated protein family, member 2
chr17_+_34062059 0.26 ENSMUST00000002379.15
CD320 antigen
chr15_-_10470575 0.25 ENSMUST00000136591.8
DnaJ heat shock protein family (Hsp40) member C21
chr13_+_93441447 0.25 ENSMUST00000109497.8
ENSMUST00000109498.8
ENSMUST00000060490.11
ENSMUST00000109492.9
ENSMUST00000109496.8
ENSMUST00000109495.8
homer scaffolding protein 1
chr15_+_76594810 0.25 ENSMUST00000136840.8
ENSMUST00000127208.8
ENSMUST00000036423.15
ENSMUST00000137649.8
ENSMUST00000155225.2
ENSMUST00000155735.2
leucine rich repeat containing 14
chr15_-_76419131 0.24 ENSMUST00000230604.2
transmembrane protein 249
chrX_-_100463810 0.23 ENSMUST00000118092.8
ENSMUST00000119699.8
zinc finger, MYM-type 3
chr1_+_85945790 0.23 ENSMUST00000149469.3
spermatogenesis associated 3
chrX_+_161543423 0.22 ENSMUST00000112326.8
retinoblastoma binding protein 7, chromatin remodeling factor
chr11_+_69920956 0.21 ENSMUST00000232115.2
discs large MAGUK scaffold protein 4
chrX_-_110372843 0.21 ENSMUST00000096348.10
ENSMUST00000113428.9
ribosomal protein S6 kinase polypeptide 6
chr19_-_8816530 0.21 ENSMUST00000096259.6
guanine nucleotide binding protein (G protein), gamma 3
chr4_-_9643636 0.19 ENSMUST00000108333.8
ENSMUST00000108334.8
ENSMUST00000108335.8
ENSMUST00000152526.8
ENSMUST00000103004.10
aspartate-beta-hydroxylase
chr6_-_98319684 0.18 ENSMUST00000164491.3
MyoD family inhibitor domain containing 2
chr12_+_91367764 0.18 ENSMUST00000021346.14
ENSMUST00000021343.8
thyroid stimulating hormone receptor
chr1_-_173363523 0.17 ENSMUST00000139092.8
interferon activated gene 214
chr3_+_88439616 0.17 ENSMUST00000172699.2
mex3 RNA binding family member A
chr2_-_89779008 0.16 ENSMUST00000214846.2
olfactory receptor 1259
chr12_-_11200306 0.16 ENSMUST00000055673.2
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr11_+_69920542 0.16 ENSMUST00000232266.2
ENSMUST00000132597.5
discs large MAGUK scaffold protein 4
chr1_-_54233207 0.16 ENSMUST00000120904.8
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chrX_+_56008685 0.16 ENSMUST00000096431.10
adhesion G protein-coupled receptor G4
chr7_-_28824440 0.15 ENSMUST00000214374.2
ENSMUST00000179893.9
ENSMUST00000032813.10
ryanodine receptor 1, skeletal muscle
chr13_+_110039620 0.15 ENSMUST00000120664.8
phosphodiesterase 4D, cAMP specific
chr17_+_69071546 0.14 ENSMUST00000233625.2
L3MBTL4 histone methyl-lysine binding protein
chr2_-_157988303 0.14 ENSMUST00000103122.10
transglutaminase 2, C polypeptide
chr15_+_98532624 0.14 ENSMUST00000003442.9
calcium channel, voltage-dependent, beta 3 subunit
chr2_-_120916316 0.14 ENSMUST00000028721.8
transglutaminase 5
chr12_-_84745388 0.13 ENSMUST00000221905.2
ENSMUST00000222422.2
ENSMUST00000095550.4
synapse differentiation inducing 1 like
chr14_+_53007210 0.13 ENSMUST00000178768.4
T cell receptor alpha variable 7D-4
chr17_-_26204621 0.13 ENSMUST00000041641.9
ENSMUST00000212520.2
calpain 15
chrX_-_101950075 0.13 ENSMUST00000120808.8
ENSMUST00000121197.8
DMRT-like family C1a
chrX_-_100463395 0.12 ENSMUST00000117901.8
ENSMUST00000120201.8
ENSMUST00000117637.8
ENSMUST00000134005.2
ENSMUST00000121520.8
zinc finger, MYM-type 3
chr2_+_67276338 0.11 ENSMUST00000239060.2
ENSMUST00000028410.4
ENSMUST00000112347.8
ENSMUST00000238878.2
xin actin-binding repeat containing 2
chr15_+_80118269 0.10 ENSMUST00000229138.2
ENSMUST00000166030.2
mitochondrial elongation factor 1
chr6_-_41749300 0.09 ENSMUST00000050412.5
olfactory receptor 459
chr6_-_40864428 0.09 ENSMUST00000031937.4
monooxygenase, DBH-like 2
chr9_-_119812042 0.09 ENSMUST00000214058.2
cysteine-serine-rich nuclear protein 1
chr3_-_37180093 0.08 ENSMUST00000029275.6
interleukin 2
chr7_+_28392456 0.08 ENSMUST00000151227.2
ENSMUST00000108281.8
F-box protein 27
chr16_+_17716480 0.07 ENSMUST00000055374.8
testis-specific serine kinase 2
chr2_-_88937158 0.06 ENSMUST00000099806.3
ENSMUST00000213288.2
olfactory receptor 1220
chr7_-_30443106 0.05 ENSMUST00000182634.8
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr13_-_34529157 0.04 ENSMUST00000040336.12
solute carrier family 22, member 23
chr6_-_52222776 0.04 ENSMUST00000048026.10
homeobox A11
chr4_+_45203914 0.03 ENSMUST00000107804.2
FERM and PDZ domain containing 1
chr2_-_57004933 0.03 ENSMUST00000028166.9
nuclear receptor subfamily 4, group A, member 2
chr14_-_70761507 0.03 ENSMUST00000022692.5
surfactant associated protein C
chr7_-_45463701 0.03 ENSMUST00000210898.2
ENSMUST00000107729.10
ENSMUST00000056820.13
cytohesin 2
chr3_+_90201388 0.03 ENSMUST00000199607.5
GATA zinc finger domain containing 2B
chr6_-_125142539 0.02 ENSMUST00000183272.2
ENSMUST00000182052.8
ENSMUST00000182277.2
glyceraldehyde-3-phosphate dehydrogenase
chr4_+_9269285 0.02 ENSMUST00000038841.14
clavesin 1
chr14_+_40853734 0.01 ENSMUST00000022314.10
ENSMUST00000170719.2
surfactant associated protein A1
chr2_-_88963396 0.01 ENSMUST00000214027.2
ENSMUST00000215816.3
olfactory receptor 1222
chr6_+_113303929 0.00 ENSMUST00000032406.15
8-oxoguanine DNA-glycosylase 1
chr7_+_34885782 0.00 ENSMUST00000135452.8
ENSMUST00000001854.12
solute carrier family 7 (cationic amino acid transporter, y+ system), member 10

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.6 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.8 2.3 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.6 5.1 GO:1901748 peptide modification(GO:0031179) leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.6 5.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.4 1.3 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270)
0.3 1.3 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
0.3 1.3 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.3 2.0 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.2 1.4 GO:0097167 circadian regulation of translation(GO:0097167)
0.2 1.4 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.2 1.4 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.2 1.0 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.2 0.5 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.2 1.3 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.2 0.5 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.9 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.5 GO:0019046 release from viral latency(GO:0019046)
0.1 0.4 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.1 0.8 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.1 0.5 GO:0010286 heat acclimation(GO:0010286)
0.1 0.9 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 1.8 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.3 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.1 0.4 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.1 0.8 GO:0015705 iodide transport(GO:0015705)
0.1 0.6 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
0.1 0.9 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 1.8 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.6 GO:0098970 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.1 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.0 0.3 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.8 GO:0035428 hexose transmembrane transport(GO:0035428)
0.0 1.6 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 0.5 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.1 GO:0046333 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.0 0.2 GO:1904587 response to glycoprotein(GO:1904587)
0.0 1.1 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.0 0.4 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.3 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.1 GO:0071415 cellular response to caffeine(GO:0071313) cellular response to purine-containing compound(GO:0071415)
0.0 1.0 GO:2000401 regulation of lymphocyte migration(GO:2000401)
0.0 0.1 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.6 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 1.1 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.0 0.3 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.1 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 2.0 GO:0000910 cytokinesis(GO:0000910)
0.0 0.0 GO:0051866 general adaptation syndrome(GO:0051866)
0.0 0.4 GO:0033622 integrin activation(GO:0033622)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.6 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.4 1.3 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.3 2.0 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 3.5 GO:0030061 mitochondrial crista(GO:0030061)
0.1 2.0 GO:0042788 polysomal ribosome(GO:0042788)
0.1 1.4 GO:0042629 mast cell granule(GO:0042629)
0.1 0.3 GO:0043291 RAVE complex(GO:0043291)
0.1 1.7 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 1.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.4 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.9 GO:0032039 integrator complex(GO:0032039)
0.0 0.6 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.1 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 1.4 GO:0002102 podosome(GO:0002102)
0.0 0.3 GO:0036449 microtubule minus-end(GO:0036449)
0.0 2.2 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.5 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.3 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 1.3 GO:0005905 clathrin-coated pit(GO:0005905)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.5 1.4 GO:0019959 interleukin-8 binding(GO:0019959)
0.4 5.1 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.4 1.3 GO:0000401 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.4 1.3 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.3 5.3 GO:0019841 retinol binding(GO:0019841)
0.3 1.8 GO:0004977 melanocortin receptor activity(GO:0004977)
0.2 1.1 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.2 1.7 GO:0070087 chromo shadow domain binding(GO:0070087)
0.2 0.9 GO:0048495 Roundabout binding(GO:0048495)
0.1 2.0 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 5.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.6 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.4 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.5 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.8 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.3 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 1.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.1 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.8 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 2.0 GO:0070888 E-box binding(GO:0070888)
0.0 1.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.1 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.3 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.2 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.6 PID AURORA A PATHWAY Aurora A signaling
0.1 1.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 1.5 PID ARF 3PATHWAY Arf1 pathway
0.1 2.7 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 4.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.1 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.6 ST GA12 PATHWAY G alpha 12 Pathway
0.0 2.0 PID MTOR 4PATHWAY mTOR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 5.3 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 5.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 7.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.8 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.5 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.5 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 1.2 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 2.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.6 REACTOME G1 PHASE Genes involved in G1 Phase