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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nkx2-5

Z-value: 1.16

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Transcription factors associated with Nkx2-5

Gene Symbol Gene ID Gene Info
Nkx2-5
ENSMUSG00000015579.6 Nkx2-5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-5mm39_v1_chr17_-_27060539_270605650.231.8e-01Click!

Activity profile of Nkx2-5 motif

Sorted Z-values of Nkx2-5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-5

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_30639217 21.20 ENSMUST00000031806.10
Cpa1
carboxypeptidase A1, pancreatic
chr6_+_41279199 18.05 ENSMUST00000031913.5
Try4
trypsin 4
chr6_+_30541581 11.44 ENSMUST00000096066.5
Cpa2
carboxypeptidase A2, pancreatic
chr4_-_137137088 10.23 ENSMUST00000024200.7
Cela3a
chymotrypsin-like elastase family, member 3A
chr6_-_136899167 5.90 ENSMUST00000032343.7
Erp27
endoplasmic reticulum protein 27
chr1_+_74752710 4.77 ENSMUST00000027356.7
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
chr6_-_5193816 4.06 ENSMUST00000002663.12
Pon1
paraoxonase 1
chr11_-_5900019 3.00 ENSMUST00000102920.4
Gck
glucokinase
chr3_-_107145968 2.05 ENSMUST00000197758.5
Prok1
prokineticin 1
chr8_+_107877252 1.98 ENSMUST00000034400.5
Cyb5b
cytochrome b5 type B
chr5_+_90708962 1.90 ENSMUST00000094615.8
ENSMUST00000200765.2
Albfm1
albumin superfamily member 1
chr9_+_54824547 1.88 ENSMUST00000039742.8
Hykk
hydroxylysine kinase 1
chr7_-_48493388 1.87 ENSMUST00000167786.4
Csrp3
cysteine and glycine-rich protein 3
chr15_-_54783357 1.62 ENSMUST00000167541.3
ENSMUST00000171545.9
ENSMUST00000041591.16
ENSMUST00000173516.8
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr14_-_45767575 1.57 ENSMUST00000045905.15
Fermt2
fermitin family member 2
chr9_+_106324952 1.46 ENSMUST00000215475.2
ENSMUST00000187106.7
ENSMUST00000190167.7
Abhd14b
abhydrolase domain containing 14b
chr2_+_22959223 1.17 ENSMUST00000114523.10
Acbd5
acyl-Coenzyme A binding domain containing 5
chr11_-_96807192 1.15 ENSMUST00000144731.8
ENSMUST00000127048.8
Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr7_-_126496534 1.05 ENSMUST00000120007.8
Tmem219
transmembrane protein 219
chr12_+_8062331 0.98 ENSMUST00000171239.2
Apob
apolipoprotein B
chr11_+_68858942 0.97 ENSMUST00000102606.10
ENSMUST00000018884.6
Slc25a35
solute carrier family 25, member 35
chrX_-_154123743 0.96 ENSMUST00000130349.3
Prdx4
peroxiredoxin 4
chr9_-_50657800 0.95 ENSMUST00000239417.2
ENSMUST00000034564.4
2310030G06Rik
RIKEN cDNA 2310030G06 gene
chr1_-_66856695 0.94 ENSMUST00000068168.10
ENSMUST00000113987.2
Kansl1l
KAT8 regulatory NSL complex subunit 1-like
chr5_+_28370687 0.85 ENSMUST00000036177.9
En2
engrailed 2
chr2_+_127112127 0.81 ENSMUST00000110375.9
Stard7
START domain containing 7
chr9_-_53447908 0.81 ENSMUST00000150244.2
Atm
ataxia telangiectasia mutated
chr9_+_53212871 0.79 ENSMUST00000051014.2
Exph5
exophilin 5
chr9_+_44684248 0.78 ENSMUST00000128150.8
Ift46
intraflagellar transport 46
chr5_-_31448370 0.78 ENSMUST00000041565.11
ENSMUST00000201809.2
Ift172
intraflagellar transport 172
chr9_+_44684285 0.72 ENSMUST00000239014.2
Ift46
intraflagellar transport 46
chr3_-_57483330 0.70 ENSMUST00000120977.2
Wwtr1
WW domain containing transcription regulator 1
chr17_-_56916771 0.69 ENSMUST00000052832.6
Micos13
mitochondrial contact site and cristae organizing system subunit 13
chrX_+_41149264 0.68 ENSMUST00000224454.2
Xiap
X-linked inhibitor of apoptosis
chr9_+_44684450 0.60 ENSMUST00000238800.2
ENSMUST00000147559.8
Ift46
intraflagellar transport 46
chr16_+_43993599 0.59 ENSMUST00000119746.8
ENSMUST00000088356.10
ENSMUST00000169582.3
Usf3
upstream transcription factor family member 3
chr9_+_44684324 0.58 ENSMUST00000214854.3
ENSMUST00000125877.8
Ift46
intraflagellar transport 46
chr7_+_28869770 0.56 ENSMUST00000033886.8
ENSMUST00000209019.2
ENSMUST00000208330.2
Ggn
gametogenetin
chr9_+_44684206 0.54 ENSMUST00000002099.11
Ift46
intraflagellar transport 46
chr6_+_115830431 0.52 ENSMUST00000112925.8
ENSMUST00000038234.13
ENSMUST00000112923.7
Ift122
intraflagellar transport 122
chr3_-_49711765 0.51 ENSMUST00000035931.13
Pcdh18
protocadherin 18
chr14_+_21550921 0.51 ENSMUST00000182964.3
Kat6b
K(lysine) acetyltransferase 6B
chr14_+_53743184 0.50 ENSMUST00000103583.5
Trav10
T cell receptor alpha variable 10
chr2_-_173117936 0.49 ENSMUST00000139306.2
Pmepa1
prostate transmembrane protein, androgen induced 1
chr2_+_32498716 0.48 ENSMUST00000129165.2
St6galnac6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr2_-_121287174 0.47 ENSMUST00000110613.9
ENSMUST00000056312.10
Serinc4
serine incorporator 4
chrX_-_110372800 0.47 ENSMUST00000137712.9
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr6_-_29380423 0.43 ENSMUST00000147483.3
Opn1sw
opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)
chr17_+_48037758 0.41 ENSMUST00000024782.12
ENSMUST00000144955.2
Pgc
progastricsin (pepsinogen C)
chr11_+_115865535 0.41 ENSMUST00000021107.14
ENSMUST00000169928.8
ENSMUST00000106461.8
Itgb4
integrin beta 4
chr7_+_28869629 0.41 ENSMUST00000098609.4
Ggn
gametogenetin
chr8_-_95839963 0.38 ENSMUST00000213004.2
Kifc3
kinesin family member C3
chr11_-_78441584 0.37 ENSMUST00000103242.5
Tmem97
transmembrane protein 97
chr9_-_119852624 0.36 ENSMUST00000111635.4
Xirp1
xin actin-binding repeat containing 1
chr9_+_121245036 0.35 ENSMUST00000211187.2
Trak1
trafficking protein, kinesin binding 1
chr11_+_64326141 0.35 ENSMUST00000058652.6
Hs3st3a1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr14_-_63509131 0.35 ENSMUST00000132122.2
Gata4
GATA binding protein 4
chr5_-_71815318 0.34 ENSMUST00000199357.2
Gabra4
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
chr6_-_29380467 0.33 ENSMUST00000080428.13
Opn1sw
opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)
chr3_-_57483175 0.32 ENSMUST00000029380.14
Wwtr1
WW domain containing transcription regulator 1
chr4_+_137321451 0.31 ENSMUST00000105840.8
ENSMUST00000105839.8
ENSMUST00000055131.13
ENSMUST00000105838.8
Usp48
ubiquitin specific peptidase 48
chr2_-_73722874 0.31 ENSMUST00000136958.8
ENSMUST00000112010.9
ENSMUST00000128531.8
ENSMUST00000112017.8
Atf2
activating transcription factor 2
chr1_-_170755109 0.30 ENSMUST00000162136.2
ENSMUST00000162887.2
Fcrla
Fc receptor-like A
chr2_-_73722932 0.29 ENSMUST00000154456.8
ENSMUST00000090802.11
ENSMUST00000055833.12
ENSMUST00000112007.8
ENSMUST00000112016.9
Atf2
activating transcription factor 2
chr12_+_84363876 0.29 ENSMUST00000222258.2
ENSMUST00000222832.2
ENSMUST00000220931.2
Zfp410
zinc finger protein 410
chr2_+_173918089 0.29 ENSMUST00000155000.8
ENSMUST00000134876.8
ENSMUST00000147038.8
Stx16
syntaxin 16
chrM_+_8603 0.29 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr5_+_71815382 0.27 ENSMUST00000199967.5
Gabrb1
gamma-aminobutyric acid (GABA) A receptor, subunit beta 1
chr6_+_14901343 0.27 ENSMUST00000115477.8
Foxp2
forkhead box P2
chr1_+_174257996 0.27 ENSMUST00000053178.5
Olfr414
olfactory receptor 414
chr5_-_8417982 0.26 ENSMUST00000088761.11
ENSMUST00000115386.8
ENSMUST00000050166.14
ENSMUST00000046838.14
ENSMUST00000115388.9
ENSMUST00000088744.12
ENSMUST00000115385.2
Adam22
a disintegrin and metallopeptidase domain 22
chr10_-_60667161 0.26 ENSMUST00000218637.2
Unc5b
unc-5 netrin receptor B
chrX_+_113384297 0.24 ENSMUST00000133447.2
Klhl4
kelch-like 4
chr6_+_14901439 0.23 ENSMUST00000128567.8
Foxp2
forkhead box P2
chr17_+_27152276 0.22 ENSMUST00000237412.2
Phf1
PHD finger protein 1
chr8_-_84301386 0.21 ENSMUST00000238861.2
Tecr
trans-2,3-enoyl-CoA reductase
chr15_-_79212400 0.21 ENSMUST00000173163.8
ENSMUST00000047816.15
ENSMUST00000172403.9
ENSMUST00000173632.8
Pla2g6
phospholipase A2, group VI
chr8_-_84301457 0.20 ENSMUST00000238997.2
Tecr
trans-2,3-enoyl-CoA reductase
chr11_-_97909134 0.20 ENSMUST00000107561.9
Cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr12_-_115611981 0.17 ENSMUST00000103540.3
ENSMUST00000199266.2
Ighv8-12
immunoglobulin heavy variable V8-12
chr11_-_99907030 0.17 ENSMUST00000018399.3
Krt33a
keratin 33A
chrX_-_110372733 0.17 ENSMUST00000065976.12
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr6_-_41535322 0.17 ENSMUST00000193003.2
Trbv31
T cell receptor beta, variable 31
chr6_-_41535292 0.15 ENSMUST00000103300.3
Trbv31
T cell receptor beta, variable 31
chr1_-_133589020 0.15 ENSMUST00000193504.6
ENSMUST00000195067.2
ENSMUST00000191896.6
ENSMUST00000194668.6
ENSMUST00000195424.6
ENSMUST00000179598.4
ENSMUST00000027736.13
Zc3h11a
Gm38394
Zc3h11a
zinc finger CCCH type containing 11A
predicted gene, 38394
zinc finger CCCH type containing 11A
chrX_-_140508177 0.14 ENSMUST00000067841.8
Irs4
insulin receptor substrate 4
chr9_-_10904714 0.14 ENSMUST00000162484.8
ENSMUST00000160216.8
Cntn5
contactin 5
chr11_+_67061908 0.14 ENSMUST00000018641.8
Myh2
myosin, heavy polypeptide 2, skeletal muscle, adult
chr4_+_85123654 0.13 ENSMUST00000030212.15
ENSMUST00000107189.8
ENSMUST00000107184.8
Sh3gl2
SH3-domain GRB2-like 2
chr8_+_114369838 0.13 ENSMUST00000095173.3
ENSMUST00000034219.12
ENSMUST00000212269.2
Syce1l
synaptonemal complex central element protein 1 like
chr5_+_124466146 0.13 ENSMUST00000111477.2
ENSMUST00000077376.3
2810006K23Rik
RIKEN cDNA 2810006K23 gene
chr11_+_87457479 0.13 ENSMUST00000239011.2
Septin4
septin 4
chr8_-_107775204 0.12 ENSMUST00000055316.10
Pdf
peptide deformylase (mitochondrial)
chr15_-_79212323 0.12 ENSMUST00000166977.9
Pla2g6
phospholipase A2, group VI
chr3_-_63806794 0.12 ENSMUST00000161052.3
ENSMUST00000159188.2
ENSMUST00000177143.8
Plch1
phospholipase C, eta 1
chr14_-_4506874 0.12 ENSMUST00000224934.2
Thrb
thyroid hormone receptor beta
chr7_-_79381911 0.10 ENSMUST00000178257.3
Plin1
perilipin 1
chr12_-_114186874 0.10 ENSMUST00000103477.4
ENSMUST00000192499.3
Ighv7-4
immunoglobulin heavy variable 7-4
chr11_+_67061837 0.10 ENSMUST00000170159.8
Myh2
myosin, heavy polypeptide 2, skeletal muscle, adult
chr15_-_5273645 0.10 ENSMUST00000120563.2
Ptger4
prostaglandin E receptor 4 (subtype EP4)
chr3_-_129597679 0.09 ENSMUST00000185462.7
ENSMUST00000179187.2
Lrit3
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
chr14_+_20724378 0.09 ENSMUST00000224492.2
ENSMUST00000223751.2
ENSMUST00000225108.2
ENSMUST00000224754.2
Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr15_-_5273659 0.09 ENSMUST00000047379.15
Ptger4
prostaglandin E receptor 4 (subtype EP4)
chr10_+_60235628 0.09 ENSMUST00000218974.2
Gm17455
predicted gene, 17455
chr10_-_114638202 0.07 ENSMUST00000239411.2
Trhde
TRH-degrading enzyme
chr12_+_103281188 0.07 ENSMUST00000189885.2
ENSMUST00000179363.2
Fam181a
family with sequence similarity 181, member A
chr7_-_4909515 0.07 ENSMUST00000210663.2
Gm36210
predicted gene, 36210
chr12_+_37930661 0.07 ENSMUST00000040500.9
Dgkb
diacylglycerol kinase, beta
chr7_+_114318746 0.06 ENSMUST00000182044.2
Calcb
calcitonin-related polypeptide, beta
chr6_-_52222776 0.06 ENSMUST00000048026.10
Hoxa11
homeobox A11
chr6_-_90013823 0.04 ENSMUST00000073415.2
Vmn1r48
vomeronasal 1 receptor 48
chr11_-_101877832 0.04 ENSMUST00000107173.9
ENSMUST00000107172.8
Dusp3
dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
chr12_-_115531211 0.04 ENSMUST00000103536.4
Ighv8-11
immunoglobulin heavy variable V8-11
chr15_-_99355593 0.03 ENSMUST00000161948.2
Nckap5l
NCK-associated protein 5-like
chr6_-_28421678 0.03 ENSMUST00000090511.4
Gcc1
golgi coiled coil 1
chr11_+_87457544 0.03 ENSMUST00000060360.7
Septin4
septin 4
chr11_+_73125118 0.03 ENSMUST00000102526.9
Trpv1
transient receptor potential cation channel, subfamily V, member 1
chrX_-_164110372 0.03 ENSMUST00000058787.9
Glra2
glycine receptor, alpha 2 subunit
chr12_-_114286421 0.02 ENSMUST00000103483.3
Ighv3-8
immunoglobulin heavy variable V3-8
chr10_+_60236532 0.02 ENSMUST00000218360.2
Gm17455
predicted gene, 17455
chr10_-_116732813 0.02 ENSMUST00000048229.9
Myrfl
myelin regulatory factor-like
chr14_+_47238772 0.02 ENSMUST00000125113.9
Samd4
sterile alpha motif domain containing 4
chr8_+_63404395 0.01 ENSMUST00000119068.8
Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr14_-_78326435 0.01 ENSMUST00000118785.3
ENSMUST00000066437.5
Fam216b
family with sequence similarity 216, member B
chr3_-_89067462 0.01 ENSMUST00000029686.4
Hcn3
hyperpolarization-activated, cyclic nucleotide-gated K+ 3
chr14_+_52131067 0.01 ENSMUST00000047726.12
Slc39a2
solute carrier family 39 (zinc transporter), member 2
chr16_+_33504908 0.00 ENSMUST00000126532.2
Heg1
heart development protein with EGF-like domains 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:1902617 response to fluoride(GO:1902617)
0.6 1.9 GO:1903920 positive regulation of actin filament severing(GO:1903920)
0.6 3.0 GO:0009730 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.3 0.8 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.2 1.6 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.2 1.0 GO:0022417 protein maturation by protein folding(GO:0022417)
0.2 0.5 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.2 0.7 GO:1902530 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.1 0.6 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 1.2 GO:0071569 protein ufmylation(GO:0071569)
0.1 0.4 GO:0002225 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803)
0.1 1.0 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.1 0.3 GO:0060464 lung lobe formation(GO:0060464) diaphragm morphogenesis(GO:0060540)
0.1 0.8 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 3.2 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.1 1.2 GO:0030242 pexophagy(GO:0030242)
0.1 18.1 GO:0007586 digestion(GO:0007586)
0.1 1.0 GO:0072307 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1 15.1 GO:0008203 cholesterol metabolic process(GO:0008203)
0.1 0.2 GO:1904348 negative regulation of gastro-intestinal system smooth muscle contraction(GO:1904305) negative regulation of small intestine smooth muscle contraction(GO:1904348)
0.1 0.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.3 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.1 0.3 GO:2001023 regulation of response to drug(GO:2001023)
0.1 0.3 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.1 0.8 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 0.4 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.8 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.2 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 1.6 GO:0033622 integrin activation(GO:0033622)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.4 GO:0035878 nail development(GO:0035878)
0.0 0.8 GO:0061525 hindgut development(GO:0061525) left/right axis specification(GO:0070986)
0.0 0.5 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.4 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.6 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 0.4 GO:0030497 fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 2.0 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 0.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 29.9 GO:0006508 proteolysis(GO:0006508)
0.0 0.8 GO:0007566 embryo implantation(GO:0007566)
0.0 0.3 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.1 GO:0051324 M phase(GO:0000279) meiotic prophase I(GO:0007128) prophase(GO:0051324) meiotic cell cycle phase(GO:0098762) meiosis I cell cycle phase(GO:0098764)
0.0 0.8 GO:1903955 positive regulation of establishment of protein localization to mitochondrion(GO:1903749) positive regulation of protein targeting to mitochondrion(GO:1903955)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0034359 mature chylomicron(GO:0034359)
0.3 4.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.2 0.8 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.2 2.9 GO:0045180 basal cortex(GO:0045180)
0.1 3.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.5 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.4 GO:0005915 zonula adherens(GO:0005915)
0.0 1.9 GO:0031941 filamentous actin(GO:0031941)
0.0 54.6 GO:0005615 extracellular space(GO:0005615)
0.0 0.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.8 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.5 GO:0000786 nucleosome(GO:0000786)
0.0 0.8 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.3 GO:1904115 axon cytoplasm(GO:1904115)
0.0 7.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 32.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.0 4.1 GO:0004063 aryldialkylphosphatase activity(GO:0004063)
0.3 1.6 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.3 3.0 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.3 0.8 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.3 1.9 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 28.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.8 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 1.0 GO:0035473 lipase binding(GO:0035473)
0.1 4.8 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 1.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.6 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.4 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 1.0 GO:0051920 peroxiredoxin activity(GO:0051920)
0.0 0.3 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.5 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.3 GO:0005042 netrin receptor activity(GO:0005042)
0.0 1.2 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.3 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.3 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.2 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.1 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 1.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 2.0 GO:0020037 heme binding(GO:0020037)
0.0 0.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.4 GO:0031005 filamin binding(GO:0031005)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.0 GO:0008083 growth factor activity(GO:0008083)
0.0 0.3 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.6 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 10.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.2 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.7 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.8 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 2.8 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 0.8 REACTOME OPSINS Genes involved in Opsins
0.1 0.8 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.5 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.7 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.6 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE