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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Nkx6-3_Dbx2_Barx2
Z-value: 1.19
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Transcription factors associated with Nkx6-3_Dbx2_Barx2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
Nkx6-3
|
ENSMUSG00000063672.8 | Nkx6-3 |
|
Dbx2
|
ENSMUSG00000045608.8 | Dbx2 |
|
Barx2
|
ENSMUSG00000032033.12 | Barx2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Dbx2 | mm39_v1_chr15_-_95553841_95553841 | 0.26 | 1.3e-01 | Click! |
| Nkx6-3 | mm39_v1_chr8_+_23643279_23643292 | 0.10 | 5.8e-01 | Click! |
| Barx2 | mm39_v1_chr9_-_31824758_31824779 | 0.01 | 9.4e-01 | Click! |
Activity profile of Nkx6-3_Dbx2_Barx2 motif
Sorted Z-values of Nkx6-3_Dbx2_Barx2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of Nkx6-3_Dbx2_Barx2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.8 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.8 | 2.4 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
| 0.7 | 6.6 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.6 | 4.3 | GO:0035633 | cyclooxygenase pathway(GO:0019371) maintenance of blood-brain barrier(GO:0035633) |
| 0.6 | 0.6 | GO:0009441 | glycolate metabolic process(GO:0009441) |
| 0.5 | 1.5 | GO:0060305 | regulation of inositol-polyphosphate 5-phosphatase activity(GO:0010924) positive regulation of inositol-polyphosphate 5-phosphatase activity(GO:0010925) phospholipase C-inhibiting G-protein coupled receptor signaling pathway(GO:0030845) regulation of cell diameter(GO:0060305) |
| 0.3 | 1.0 | GO:0097037 | heme export(GO:0097037) |
| 0.3 | 1.3 | GO:0046351 | disaccharide biosynthetic process(GO:0046351) |
| 0.3 | 0.9 | GO:0006780 | uroporphyrinogen III biosynthetic process(GO:0006780) |
| 0.3 | 1.1 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.2 | 1.5 | GO:0060160 | negative regulation of dopamine receptor signaling pathway(GO:0060160) |
| 0.2 | 1.8 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 0.2 | 2.2 | GO:0045719 | negative regulation of glycogen biosynthetic process(GO:0045719) |
| 0.2 | 2.7 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.2 | 0.8 | GO:2000473 | regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473) |
| 0.2 | 0.6 | GO:0001966 | thigmotaxis(GO:0001966) |
| 0.2 | 5.8 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.2 | 0.5 | GO:0060448 | dichotomous subdivision of terminal units involved in lung branching(GO:0060448) |
| 0.1 | 1.6 | GO:0030916 | otic vesicle formation(GO:0030916) |
| 0.1 | 0.9 | GO:0060690 | epithelial cell differentiation involved in salivary gland development(GO:0060690) |
| 0.1 | 0.4 | GO:0002476 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476) positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566) |
| 0.1 | 1.9 | GO:0046884 | follicle-stimulating hormone secretion(GO:0046884) |
| 0.1 | 0.6 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
| 0.1 | 0.3 | GO:1901074 | regulation of engulfment of apoptotic cell(GO:1901074) |
| 0.1 | 0.3 | GO:1904116 | response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117) |
| 0.1 | 0.7 | GO:2001205 | negative regulation of osteoclast development(GO:2001205) |
| 0.1 | 2.1 | GO:0032570 | response to progesterone(GO:0032570) |
| 0.1 | 0.6 | GO:1902962 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.1 | 1.0 | GO:0035878 | nail development(GO:0035878) |
| 0.1 | 2.7 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.1 | 0.2 | GO:0045360 | nitric oxide production involved in inflammatory response(GO:0002537) regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.1 | 0.3 | GO:0002856 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859) |
| 0.1 | 0.2 | GO:1990859 | cellular response to endothelin(GO:1990859) |
| 0.1 | 0.4 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.1 | 0.4 | GO:0090306 | regulation of asymmetric cell division(GO:0009786) spindle assembly involved in meiosis(GO:0090306) |
| 0.1 | 0.4 | GO:2001268 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268) |
| 0.1 | 2.8 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 3.8 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 0.3 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.0 | 0.2 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.0 | 0.4 | GO:0002826 | negative regulation of T-helper 1 type immune response(GO:0002826) |
| 0.0 | 0.3 | GO:0006083 | acetate metabolic process(GO:0006083) |
| 0.0 | 0.7 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.0 | 0.3 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 0.0 | 2.1 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.0 | 0.7 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.0 | 0.7 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.0 | 0.9 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.0 | 0.4 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.0 | 0.6 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.0 | 0.3 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.0 | 0.7 | GO:0021860 | pyramidal neuron development(GO:0021860) |
| 0.0 | 0.5 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 0.0 | 0.2 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.0 | 0.4 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 0.0 | 0.1 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.0 | 3.1 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.0 | 0.3 | GO:0007042 | lysosomal lumen acidification(GO:0007042) |
| 0.0 | 0.9 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 0.2 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.0 | 0.0 | GO:1902256 | apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
| 0.0 | 0.2 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.0 | 0.4 | GO:0051156 | glucose 6-phosphate metabolic process(GO:0051156) |
| 0.0 | 0.1 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.0 | 0.2 | GO:0006851 | mitochondrial calcium ion transport(GO:0006851) |
| 0.0 | 0.1 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.7 | GO:0042585 | germinal vesicle(GO:0042585) |
| 0.3 | 2.0 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.3 | 1.0 | GO:0061474 | phagolysosome membrane(GO:0061474) |
| 0.2 | 0.5 | GO:0060187 | cell pole(GO:0060187) |
| 0.2 | 2.1 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.1 | 0.7 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 0.1 | 0.5 | GO:0097636 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
| 0.1 | 1.5 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.1 | 0.6 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.1 | 0.3 | GO:0070992 | translation initiation complex(GO:0070992) |
| 0.1 | 0.3 | GO:1903754 | cortical microtubule plus-end(GO:1903754) cytoplasmic microtubule plus-end(GO:1904511) |
| 0.1 | 2.1 | GO:0042581 | specific granule(GO:0042581) |
| 0.1 | 0.6 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.1 | 0.9 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.0 | 0.1 | GO:0071007 | U2-type catalytic step 2 spliceosome(GO:0071007) |
| 0.0 | 0.3 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.0 | 0.4 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 3.9 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 0.6 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 0.1 | GO:0008623 | CHRAC(GO:0008623) |
| 0.0 | 0.9 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.4 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.0 | 0.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.1 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 0.0 | 3.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 0.2 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 0.3 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.0 | 0.2 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 0.1 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.0 | 0.7 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 0.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 1.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.3 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.2 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.0 | 0.4 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.0 | 0.2 | GO:0000974 | Prp19 complex(GO:0000974) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 6.6 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.3 | 2.9 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.2 | 1.5 | GO:0031750 | D3 dopamine receptor binding(GO:0031750) |
| 0.2 | 0.6 | GO:0047192 | 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192) |
| 0.2 | 5.8 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.2 | 0.6 | GO:0016899 | oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899) |
| 0.1 | 0.4 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.1 | 0.9 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.1 | 2.1 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 2.0 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 1.7 | GO:0050308 | sugar-phosphatase activity(GO:0050308) |
| 0.1 | 0.3 | GO:0034188 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 0.1 | 0.3 | GO:0019807 | aspartoacylase activity(GO:0019807) |
| 0.1 | 0.2 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
| 0.1 | 4.3 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.1 | 0.5 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
| 0.1 | 2.4 | GO:0016645 | oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645) |
| 0.0 | 1.0 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.3 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.0 | 1.1 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.9 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.0 | 0.7 | GO:0005452 | inorganic anion exchanger activity(GO:0005452) |
| 0.0 | 0.7 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 0.6 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.0 | 4.1 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 2.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.7 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.0 | 0.4 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.0 | 0.4 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.0 | 0.2 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.0 | 0.5 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.0 | 0.8 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 0.2 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.0 | 0.3 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.0 | 3.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 0.1 | GO:0030519 | snoRNP binding(GO:0030519) |
| 0.0 | 0.2 | GO:0015288 | porin activity(GO:0015288) |
| 0.0 | 3.6 | GO:0005506 | iron ion binding(GO:0005506) |
| 0.0 | 0.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.2 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.0 | 0.3 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 1.4 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.0 | 6.6 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.1 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.0 | 1.7 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.1 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 0.7 | GO:0043022 | ribosome binding(GO:0043022) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 2.5 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 2.5 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.9 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 1.8 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 0.8 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 1.9 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 0.3 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 1.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.6 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.0 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.2 | 2.7 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.2 | 1.9 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.1 | 2.2 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 1.0 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.1 | 4.1 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 0.8 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 0.6 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 2.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.9 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.6 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.7 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 7.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.7 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.7 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 2.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.6 | REACTOME ACYL CHAIN REMODELLING OF PC | Genes involved in Acyl chain remodelling of PC |
| 0.0 | 0.3 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 0.2 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 0.2 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.0 | 0.3 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |