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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nr0b1

Z-value: 1.01

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Transcription factors associated with Nr0b1

Gene Symbol Gene ID Gene Info
Nr0b1
ENSMUSG00000025056.5 Nr0b1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr0b1mm39_v1_chrX_+_85235370_85235388-0.382.4e-02Click!

Activity profile of Nr0b1 motif

Sorted Z-values of Nr0b1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr0b1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_+_88015524 5.01 ENSMUST00000113139.2
Ugt1a8
UDP glucuronosyltransferase 1 family, polypeptide A8
chr6_-_72212547 3.54 ENSMUST00000042646.8
Atoh8
atonal bHLH transcription factor 8
chr12_-_104831335 3.36 ENSMUST00000109936.3
Clmn
calmin
chr16_-_20440005 2.70 ENSMUST00000052939.4
Camk2n2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr2_+_27567213 2.18 ENSMUST00000077257.12
Rxra
retinoid X receptor alpha
chr4_+_148215339 2.17 ENSMUST00000084129.9
Mad2l2
MAD2 mitotic arrest deficient-like 2
chr11_-_69260203 2.15 ENSMUST00000092971.13
ENSMUST00000108661.8
Chd3
chromodomain helicase DNA binding protein 3
chr15_-_85918378 2.12 ENSMUST00000016172.10
Celsr1
cadherin, EGF LAG seven-pass G-type receptor 1
chr19_+_37423198 1.92 ENSMUST00000025944.9
Hhex
hematopoietically expressed homeobox
chr4_+_53826013 1.79 ENSMUST00000030127.13
Tmem38b
transmembrane protein 38B
chr10_-_128425519 1.61 ENSMUST00000082059.7
Erbb3
erb-b2 receptor tyrosine kinase 3
chr8_-_71834543 1.60 ENSMUST00000002466.9
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr2_+_157120946 1.57 ENSMUST00000116380.9
ENSMUST00000029171.6
Rpn2
ribophorin II
chr5_+_30972067 1.57 ENSMUST00000200692.4
Mapre3
microtubule-associated protein, RP/EB family, member 3
chr2_+_4722956 1.56 ENSMUST00000056914.7
Bend7
BEN domain containing 7
chr10_-_127504416 1.36 ENSMUST00000129252.2
Nab2
Ngfi-A binding protein 2
chr9_-_110571645 1.35 ENSMUST00000006005.12
Pth1r
parathyroid hormone 1 receptor
chr2_-_144173615 1.27 ENSMUST00000103171.10
Ovol2
ovo like zinc finger 2
chr10_-_81186025 1.20 ENSMUST00000122993.8
Hmg20b
high mobility group 20B
chr10_-_81186137 1.18 ENSMUST00000167481.8
Hmg20b
high mobility group 20B
chr10_-_81186222 1.11 ENSMUST00000020454.11
ENSMUST00000105324.9
ENSMUST00000154609.3
ENSMUST00000105323.8
Hmg20b
high mobility group 20B
chr8_-_71308040 1.10 ENSMUST00000212509.3
Kcnn1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr6_+_85164420 1.06 ENSMUST00000045942.9
Emx1
empty spiracles homeobox 1
chr8_-_71308229 1.05 ENSMUST00000212086.2
Kcnn1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr11_-_115503704 1.04 ENSMUST00000106506.8
Mif4gd
MIF4G domain containing
chr1_+_140173787 1.03 ENSMUST00000239229.2
ENSMUST00000120709.8
ENSMUST00000120796.8
ENSMUST00000119786.8
Kcnt2
potassium channel, subfamily T, member 2
chr15_+_35371644 1.02 ENSMUST00000227455.2
Vps13b
vacuolar protein sorting 13B
chr19_+_23736205 1.01 ENSMUST00000025830.9
Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr4_+_116078874 0.99 ENSMUST00000106490.3
Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
chr4_+_116078787 0.88 ENSMUST00000147292.8
Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
chr18_+_35963353 0.79 ENSMUST00000235169.2
Cxxc5
CXXC finger 5
chr11_-_115503316 0.76 ENSMUST00000106507.9
Mif4gd
MIF4G domain containing
chr8_+_85807369 0.72 ENSMUST00000079764.14
Wdr83os
WD repeat domain 83 opposite strand
chr11_-_69871320 0.71 ENSMUST00000143175.2
Elp5
elongator acetyltransferase complex subunit 5
chr16_+_56942050 0.68 ENSMUST00000166897.3
Tomm70a
translocase of outer mitochondrial membrane 70A
chr8_+_106434901 0.67 ENSMUST00000013302.7
ENSMUST00000211852.2
4933405L10Rik
RIKEN cDNA 4933405L10 gene
chr19_-_23425757 0.66 ENSMUST00000036069.8
Mamdc2
MAM domain containing 2
chr7_+_45434755 0.65 ENSMUST00000233503.2
ENSMUST00000120005.10
ENSMUST00000211609.2
Lmtk3
lemur tyrosine kinase 3
chr17_+_88837540 0.65 ENSMUST00000038551.8
Ppp1r21
protein phosphatase 1, regulatory subunit 21
chr7_-_80020830 0.64 ENSMUST00000205436.2
ENSMUST00000098346.5
Man2a2
mannosidase 2, alpha 2
chr17_-_23964807 0.63 ENSMUST00000046525.10
Kremen2
kringle containing transmembrane protein 2
chr5_-_108134869 0.63 ENSMUST00000145239.2
ENSMUST00000031198.11
Dipk1a
divergent protein kinase domain 1A
chr2_-_17735847 0.62 ENSMUST00000028080.12
Nebl
nebulette
chr2_+_81883566 0.58 ENSMUST00000047527.8
Zfp804a
zinc finger protein 804A
chr14_-_61677258 0.56 ENSMUST00000022496.9
Kpna3
karyopherin (importin) alpha 3
chr4_+_116078830 0.56 ENSMUST00000030464.14
Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
chr11_-_88608958 0.52 ENSMUST00000107908.2
Msi2
musashi RNA-binding protein 2
chr7_-_30560989 0.50 ENSMUST00000052700.6
Ffar1
free fatty acid receptor 1
chr8_-_85807281 0.50 ENSMUST00000152785.8
Wdr83
WD repeat domain containing 83
chr9_-_119812042 0.49 ENSMUST00000214058.2
Csrnp1
cysteine-serine-rich nuclear protein 1
chr5_-_31350352 0.49 ENSMUST00000202758.4
ENSMUST00000114603.8
Eif2b4
eukaryotic translation initiation factor 2B, subunit 4 delta
chr8_-_85807308 0.48 ENSMUST00000093357.12
Wdr83
WD repeat domain containing 83
chr15_+_81695615 0.46 ENSMUST00000023024.8
Tef
thyrotroph embryonic factor
chrX_-_37653396 0.46 ENSMUST00000016681.15
Cul4b
cullin 4B
chr8_+_56393488 0.43 ENSMUST00000000275.10
Glra3
glycine receptor, alpha 3 subunit
chr7_-_80020590 0.43 ENSMUST00000206212.2
Man2a2
mannosidase 2, alpha 2
chr15_-_73295074 0.42 ENSMUST00000226893.2
Ptk2
PTK2 protein tyrosine kinase 2
chr10_+_36383008 0.40 ENSMUST00000168572.8
Hs3st5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr2_-_144174066 0.38 ENSMUST00000037423.4
Ovol2
ovo like zinc finger 2
chr3_+_105359641 0.33 ENSMUST00000098761.10
Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
chr17_-_81035453 0.32 ENSMUST00000234133.2
ENSMUST00000112389.9
ENSMUST00000025089.9
Map4k3
mitogen-activated protein kinase kinase kinase kinase 3
chr11_-_62348599 0.30 ENSMUST00000127471.9
Ncor1
nuclear receptor co-repressor 1
chr17_-_25652750 0.28 ENSMUST00000159610.8
ENSMUST00000159048.8
ENSMUST00000078496.12
Cacna1h
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr2_-_52314837 0.28 ENSMUST00000036541.8
Arl5a
ADP-ribosylation factor-like 5A
chr8_+_13485451 0.27 ENSMUST00000167505.3
ENSMUST00000167071.9
Tmem255b
transmembrane protein 255B
chr2_-_157121440 0.27 ENSMUST00000143663.2
Mroh8
maestro heat-like repeat family member 8
chr6_+_134012916 0.26 ENSMUST00000164648.2
Etv6
ets variant 6
chr2_+_153684901 0.25 ENSMUST00000175856.3
Efcab8
EF-hand calcium binding domain 8
chr16_+_8647959 0.24 ENSMUST00000023150.7
1810013L24Rik
RIKEN cDNA 1810013L24 gene
chrX_+_13147209 0.24 ENSMUST00000000804.7
Ddx3x
DEAD box helicase 3, X-linked
chr7_+_19093665 0.24 ENSMUST00000140836.8
Ppp1r13l
protein phosphatase 1, regulatory subunit 13 like
chr5_-_99184894 0.22 ENSMUST00000031277.7
Prkg2
protein kinase, cGMP-dependent, type II
chr11_-_62348115 0.22 ENSMUST00000069456.11
ENSMUST00000018645.13
Ncor1
nuclear receptor co-repressor 1
chr2_-_57014015 0.21 ENSMUST00000112629.8
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr5_-_31350449 0.21 ENSMUST00000166769.8
Eif2b4
eukaryotic translation initiation factor 2B, subunit 4 delta
chrX_-_47123719 0.20 ENSMUST00000039026.8
Apln
apelin
chr4_+_127062924 0.17 ENSMUST00000046659.14
Dlgap3
DLG associated protein 3
chr15_-_73294923 0.17 ENSMUST00000226848.2
ENSMUST00000226466.2
ENSMUST00000226988.3
Ptk2
PTK2 protein tyrosine kinase 2
chr4_-_148215135 0.14 ENSMUST00000030862.5
Draxin
dorsal inhibitory axon guidance protein
chr5_-_135518098 0.14 ENSMUST00000201998.2
Hip1
huntingtin interacting protein 1
chr5_-_99185201 0.12 ENSMUST00000161490.8
Prkg2
protein kinase, cGMP-dependent, type II
chr13_+_94495457 0.12 ENSMUST00000022196.5
Ap3b1
adaptor-related protein complex 3, beta 1 subunit
chr2_-_131194754 0.11 ENSMUST00000059372.11
Rnf24
ring finger protein 24
chr3_+_86131970 0.05 ENSMUST00000192145.6
ENSMUST00000194759.6
ENSMUST00000107635.7
Lrba
LPS-responsive beige-like anchor
chr18_+_7869066 0.03 ENSMUST00000171486.8
ENSMUST00000170932.8
ENSMUST00000167020.8
Wac
WW domain containing adaptor with coiled-coil
chr11_+_19874354 0.02 ENSMUST00000093299.13
Spred2
sprouty-related EVH1 domain containing 2
chr15_-_73295029 0.01 ENSMUST00000239146.2
ENSMUST00000110036.11
ENSMUST00000228180.3
Ptk2
PTK2 protein tyrosine kinase 2
chr11_+_19874403 0.01 ENSMUST00000093298.12
Spred2
sprouty-related EVH1 domain containing 2
chr11_-_88609048 0.00 ENSMUST00000107909.8
Msi2
musashi RNA-binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.4 2.2 GO:0045994 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.4 2.2 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.4 5.0 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.4 1.6 GO:1903033 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.3 1.9 GO:0061017 hepatoblast differentiation(GO:0061017)
0.2 1.7 GO:0060214 endocardium formation(GO:0060214)
0.2 3.5 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.2 1.4 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.1 3.5 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 0.5 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)
0.1 0.6 GO:0007172 signal complex assembly(GO:0007172)
0.1 1.1 GO:0006013 mannose metabolic process(GO:0006013)
0.1 0.3 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.1 0.2 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 1.3 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.1 0.2 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 0.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 1.6 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 1.6 GO:0050961 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 1.1 GO:0070444 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.1 0.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.7 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 0.3 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.4 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 1.0 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.0 0.1 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.5 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.2 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.1 GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588)
0.0 0.3 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
0.0 1.4 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.3 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.0 0.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 5.0 GO:0006813 potassium ion transport(GO:0006813)
0.0 1.9 GO:0006333 chromatin assembly or disassembly(GO:0006333)
0.0 1.6 GO:0006487 protein N-linked glycosylation(GO:0006487)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.5 2.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 1.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.7 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.7 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 2.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 2.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.5 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 1.6 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.5 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0098890 extrinsic component of postsynaptic membrane(GO:0098890)
0.0 0.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.9 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.3 GO:0031526 brush border membrane(GO:0031526)
0.0 2.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.4 1.1 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572)
0.3 2.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.2 2.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 2.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 1.3 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.2 1.6 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.2 1.6 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 3.5 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 2.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 2.8 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 5.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 2.8 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.3 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.4 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 0.3 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 0.5 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 3.5 GO:0070888 E-box binding(GO:0070888)
0.0 0.5 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 1.8 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.7 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 1.2 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0032051 clathrin light chain binding(GO:0032051)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 2.4 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 2.2 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 2.7 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.6 PID EPHA2 FWD PATHWAY EPHA2 forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 2.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.6 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 3.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 1.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.2 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 1.6 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 0.4 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import