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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nr1h2

Z-value: 3.57

Motif logo

Transcription factors associated with Nr1h2

Gene Symbol Gene ID Gene Info
ENSMUSG00000060601.14 Nr1h2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr1h2mm39_v1_chr7_-_44203319_44203392-0.702.4e-06Click!

Activity profile of Nr1h2 motif

Sorted Z-values of Nr1h2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1h2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr7_-_97066937 49.03 ENSMUST00000043077.8
thyroid hormone responsive
chr2_+_102488985 14.26 ENSMUST00000080210.10
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr3_+_146302832 13.49 ENSMUST00000029837.14
ENSMUST00000147409.2
ENSMUST00000121133.2
urate oxidase
chr11_-_60101235 13.44 ENSMUST00000144942.2
sterol regulatory element binding transcription factor 1
chr17_-_84154173 12.66 ENSMUST00000000687.9
3-hydroxyanthranilate 3,4-dioxygenase
chr17_-_84154196 12.15 ENSMUST00000234214.2
3-hydroxyanthranilate 3,4-dioxygenase
chr11_-_120715351 11.44 ENSMUST00000055655.9
fatty acid synthase
chr6_-_119521243 10.88 ENSMUST00000119369.2
ENSMUST00000178696.8
wingless-type MMTV integration site family, member 5B
chr11_+_54988866 10.84 ENSMUST00000000608.8
GM2 ganglioside activator protein
chr12_+_112073261 10.29 ENSMUST00000223412.2
asparaginase
chr6_+_125297596 10.04 ENSMUST00000176655.8
ENSMUST00000176110.8
sodium channel, nonvoltage-gated 1 alpha
chr1_-_139487951 9.57 ENSMUST00000023965.8
complement factor H-related 1
chr3_-_90421557 9.21 ENSMUST00000107340.2
ENSMUST00000060738.9
S100 calcium binding protein A1
chr16_+_13758494 9.20 ENSMUST00000141971.8
ENSMUST00000124947.8
ENSMUST00000023360.14
ENSMUST00000143697.8
Mpv17 transgene, kidney disease mutant-like
chr7_-_12732067 8.60 ENSMUST00000032539.14
ENSMUST00000120903.8
solute carrier family 27 (fatty acid transporter), member 5
chr7_-_12731594 8.09 ENSMUST00000133977.3
solute carrier family 27 (fatty acid transporter), member 5
chr4_+_43641262 7.80 ENSMUST00000123351.8
ENSMUST00000128549.3
natriuretic peptide receptor 2
chr15_+_82439273 7.72 ENSMUST00000229103.2
ENSMUST00000068861.8
ENSMUST00000229904.2
cytochrome P450, family 2, subfamily d, polypeptide 12
chr3_-_146302343 7.22 ENSMUST00000029836.9
deoxyribonuclease II beta
chr6_+_90439596 6.96 ENSMUST00000203039.3
Kruppel-like factor 15
chr13_-_12476313 6.89 ENSMUST00000143693.8
ENSMUST00000144283.2
ENSMUST00000099820.10
ENSMUST00000135166.8
lectin, galactose binding, soluble 8
chr6_+_90439544 6.86 ENSMUST00000032174.12
Kruppel-like factor 15
chr17_+_25023263 6.71 ENSMUST00000234372.2
ENSMUST00000024972.7
meiosis specific with OB domains
chr11_-_120618052 6.44 ENSMUST00000106148.10
ENSMUST00000026144.5
dicarbonyl L-xylulose reductase
chr5_+_115604321 6.36 ENSMUST00000145785.8
ENSMUST00000031495.11
ENSMUST00000112071.8
ENSMUST00000125568.2
phospholipase A2, group IB, pancreas
chr2_+_155223728 6.17 ENSMUST00000043237.14
ENSMUST00000174685.8
transformation related protein 53 inducible nuclear protein 2
chr5_+_9163244 6.14 ENSMUST00000198935.2
transmembrane protein 243, mitochondrial
chr6_+_54016543 5.87 ENSMUST00000046856.14
chimerin 2
chr17_-_36207965 5.81 ENSMUST00000150056.2
ENSMUST00000156817.2
ENSMUST00000146451.8
ENSMUST00000148482.8
RIKEN cDNA 2310061I04 gene
chr2_+_30156733 5.41 ENSMUST00000113645.8
ENSMUST00000133877.8
ENSMUST00000139719.8
ENSMUST00000113643.8
ENSMUST00000150695.8
phytanoyl-CoA dioxygenase domain containing 1
chr7_-_4633186 5.38 ENSMUST00000205360.2
ENSMUST00000206610.2
transmembrane protein 86B
chr7_+_27879650 5.27 ENSMUST00000172467.8
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr8_-_71085097 4.82 ENSMUST00000110103.2
growth differentiation factor 15
chr7_+_28937859 4.59 ENSMUST00000108237.2
Yip1 interacting factor homolog B (S. cerevisiae)
chr1_-_131204651 4.57 ENSMUST00000161764.8
inhibitor of kappaB kinase epsilon
chr2_+_30156523 4.55 ENSMUST00000091132.13
phytanoyl-CoA dioxygenase domain containing 1
chr2_+_155224105 4.43 ENSMUST00000134218.2
transformation related protein 53 inducible nuclear protein 2
chr6_+_54406588 4.41 ENSMUST00000132855.8
ENSMUST00000126637.8
WAS/WASL interacting protein family, member 3
chr11_+_84070678 4.37 ENSMUST00000136463.9
acetyl-Coenzyme A carboxylase alpha
chr9_+_77848556 4.36 ENSMUST00000134072.2
ELOVL family member 5, elongation of long chain fatty acids (yeast)
chr1_+_57416752 4.35 ENSMUST00000042734.3
RIKEN cDNA 1700066M21 gene
chr4_-_115875055 4.17 ENSMUST00000049095.6
fatty acid amide hydrolase
chr1_+_24717968 4.16 ENSMUST00000095062.10
LMBR1 domain containing 1
chr11_-_101010715 4.11 ENSMUST00000017946.6
reticulophagy regulator family member 3
chr15_+_85716503 4.04 ENSMUST00000146088.8
tetratricopeptide repeat domain 38
chr1_+_78635591 4.03 ENSMUST00000134566.8
ENSMUST00000142704.8
ENSMUST00000053760.12
acyl-CoA synthetase long-chain family member 3
UTP14B small subunit processome component
chr11_-_101010640 4.00 ENSMUST00000107295.10
reticulophagy regulator family member 3
chr3_+_90421742 3.91 ENSMUST00000048138.8
S100 calcium binding protein A13
chr17_-_57023788 3.90 ENSMUST00000067931.7
vimentin-type intermediate filament associated coiled-coil protein
chr8_-_106863423 3.83 ENSMUST00000146940.2
epithelial splicing regulatory protein 2
chr8_-_106863521 3.77 ENSMUST00000115979.9
epithelial splicing regulatory protein 2
chr11_+_84070593 3.69 ENSMUST00000137500.9
ENSMUST00000130012.9
acetyl-Coenzyme A carboxylase alpha
chr2_-_65068917 3.61 ENSMUST00000090896.10
ENSMUST00000155082.2
Cobl-like 1
chr9_-_63306497 3.57 ENSMUST00000168665.3
RIKEN cDNA 2300009A05 gene
chr11_+_101010764 3.46 ENSMUST00000043680.9
tubulin, gamma 1
chr5_+_124466146 3.45 ENSMUST00000111477.2
ENSMUST00000077376.3
RIKEN cDNA 2810006K23 gene
chr7_-_118304930 3.38 ENSMUST00000207323.2
ENSMUST00000038791.15
glycerophosphodiester phosphodiesterase 1
chr4_-_63072367 3.36 ENSMUST00000030041.5
alpha 1 microglobulin/bikunin precursor
chr17_+_28491085 3.25 ENSMUST00000169040.3
peroxisome proliferator activator receptor delta
chr1_+_78635542 3.24 ENSMUST00000035779.15
acyl-CoA synthetase long-chain family member 3
chr7_+_28937898 3.16 ENSMUST00000138128.3
ENSMUST00000142519.3
Yip1 interacting factor homolog B (S. cerevisiae)
chr14_-_20133246 3.11 ENSMUST00000059666.6
SAYSVFN motif domain containing 1
chr2_-_65068960 3.07 ENSMUST00000112429.9
ENSMUST00000102726.8
ENSMUST00000112430.8
Cobl-like 1
chr3_+_62327089 3.04 ENSMUST00000161057.2
Rho guanine nucleotide exchange factor (GEF) 26
chr13_+_102830104 2.97 ENSMUST00000172138.2
CD180 antigen
chr7_-_133378468 2.96 ENSMUST00000033290.12
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr14_+_47069667 2.83 ENSMUST00000140114.3
ENSMUST00000133989.8
cell growth regulator with ring finger domain 1
chr6_+_124639990 2.80 ENSMUST00000004381.14
lysophosphatidylcholine acyltransferase 3
chr5_+_107479023 2.72 ENSMUST00000031215.15
ENSMUST00000112677.10
bromodomain, testis-specific
chr7_-_19556612 2.59 ENSMUST00000120537.8
B cell leukemia/lymphoma 3
chr7_+_28937746 2.57 ENSMUST00000108238.8
ENSMUST00000032809.10
Yip1 interacting factor homolog B (S. cerevisiae)
chr7_-_78432774 2.56 ENSMUST00000032841.7
mitochondrial ribosomal protein L46
chr10_-_67384898 2.54 ENSMUST00000075686.7
2-aminoethanethiol (cysteamine) dioxygenase
chrX_+_10583629 2.51 ENSMUST00000115524.8
ENSMUST00000008179.7
ENSMUST00000156321.2
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr4_-_119279551 2.47 ENSMUST00000106316.2
ENSMUST00000030385.13
phosphopantothenoylcysteine synthetase
chr18_-_9619460 2.43 ENSMUST00000234003.2
ENSMUST00000062769.7
centrin 1
chr5_-_21850539 2.41 ENSMUST00000115234.2
F-box and leucine-rich repeat protein 13
chr7_+_114367971 2.38 ENSMUST00000117543.3
ENSMUST00000151464.2
INSC spindle orientation adaptor protein
chr1_-_14374794 2.36 ENSMUST00000190337.7
EYA transcriptional coactivator and phosphatase 1
chr4_-_152122891 2.26 ENSMUST00000030792.2
taste receptor, type 1, member 1
chr5_-_21850579 2.25 ENSMUST00000051358.11
F-box and leucine-rich repeat protein 13
chr2_-_160714749 2.25 ENSMUST00000176141.8
zinc fingers and homeoboxes 3
chr1_-_14374842 2.22 ENSMUST00000188857.7
ENSMUST00000185453.7
EYA transcriptional coactivator and phosphatase 1
chr10_-_81436671 2.19 ENSMUST00000151858.8
ENSMUST00000142948.8
ENSMUST00000072020.9
transducin-like enhancer of split 6
chr1_-_131204422 2.19 ENSMUST00000159195.2
inhibitor of kappaB kinase epsilon
chr5_+_135038267 2.10 ENSMUST00000201890.2
ENSMUST00000154469.8
abhydrolase domain containing 11
chr17_+_49735386 2.07 ENSMUST00000165390.9
ENSMUST00000024797.16
molybdenum cofactor synthesis 1
chr7_+_141276575 2.07 ENSMUST00000185406.8
mucin 2
chrX_-_73689241 2.06 ENSMUST00000114119.2
PWWP domain containing 4C
chr7_+_141988714 1.96 ENSMUST00000118276.8
ENSMUST00000105976.8
ENSMUST00000097939.9
synaptotagmin VIII
chr17_-_56525879 1.95 ENSMUST00000038794.6
dipeptidylpeptidase 9
chr9_-_122673080 1.88 ENSMUST00000203176.3
ENSMUST00000203656.3
ENSMUST00000204619.2
predicted gene, 35549
chr11_+_93886906 1.84 ENSMUST00000041956.14
sperm associated antigen 9
chr5_+_27109679 1.84 ENSMUST00000120555.8
dipeptidylpeptidase 6
chr7_-_80020830 1.84 ENSMUST00000205436.2
ENSMUST00000098346.5
mannosidase 2, alpha 2
chr11_+_95915366 1.82 ENSMUST00000103157.10
gastric inhibitory polypeptide
chrX_+_73636285 1.81 ENSMUST00000216108.2
ENSMUST00000216007.2
olfactory receptor 1325
chr17_+_49735413 1.81 ENSMUST00000173033.8
molybdenum cofactor synthesis 1
chr15_+_65658874 1.80 ENSMUST00000015146.16
ENSMUST00000173858.8
ENSMUST00000172756.2
ENSMUST00000174856.7
EFR3 homolog A
chr7_+_49408847 1.77 ENSMUST00000085272.7
ENSMUST00000207895.2
HIV-1 Tat interactive protein 2
chr3_+_89153704 1.68 ENSMUST00000168900.3
keratinocyte associated protein 2
chr9_-_35111172 1.68 ENSMUST00000176021.8
ENSMUST00000176531.8
ENSMUST00000176685.8
ENSMUST00000177129.8
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
chr18_+_89215438 1.63 ENSMUST00000237110.2
CD226 antigen
chr6_+_116185077 1.63 ENSMUST00000204051.2
WASH complex subunit 2`
chr6_-_90201420 1.53 ENSMUST00000076086.3
vomeronasal 1 receptor 53
chr2_-_86940289 1.49 ENSMUST00000215828.3
olfactory receptor 259
chr8_+_14145848 1.46 ENSMUST00000152652.8
ENSMUST00000133298.8
DLG associated protein 2
chr18_+_39439778 1.45 ENSMUST00000235660.2
Rho GTPase activating protein 26
chr16_-_38370535 1.45 ENSMUST00000036210.7
protein O-glucosyltransferase 1
chr7_+_78432867 1.44 ENSMUST00000032840.5
mitochondrial ribosomal protein S11
chr3_+_89153258 1.43 ENSMUST00000040888.12
keratinocyte associated protein 2
chr9_+_65268304 1.42 ENSMUST00000147185.3
ubiquitin-associated protein 1-like
chr17_+_27152276 1.40 ENSMUST00000237412.2
PHD finger protein 1
chr17_-_80022480 1.36 ENSMUST00000234361.2
cytochrome P450, family 1, subfamily b, polypeptide 1
chr3_-_51316347 1.31 ENSMUST00000193279.2
ENSMUST00000038108.12
NADH:ubiquinone oxidoreductase subunit C1
chr16_-_17711950 1.30 ENSMUST00000155943.9
DiGeorge syndrome critical region gene 2
chr17_-_80022463 1.29 ENSMUST00000024894.2
cytochrome P450, family 1, subfamily b, polypeptide 1
chr1_+_6285082 1.22 ENSMUST00000160062.8
RB1-inducible coiled-coil 1
chr8_-_84963653 1.22 ENSMUST00000039480.7
zinc finger SWIM-type containing 4
chr15_+_78761360 1.20 ENSMUST00000041587.8
golgi associated, gamma adaptin ear containing, ARF binding protein 1
chr13_-_100688949 1.19 ENSMUST00000159515.2
ENSMUST00000160859.8
ENSMUST00000069756.11
occludin
chr16_-_37205302 1.19 ENSMUST00000114781.8
ENSMUST00000114780.8
syntaxin binding protein 5-like
chr1_+_192984278 1.18 ENSMUST00000016315.16
laminin, beta 3
chr9_+_106337849 1.17 ENSMUST00000189099.2
poly(rC) binding protein 4
chrX_-_52610946 1.16 ENSMUST00000123034.3
RIKEN cDNA 4933416I08 gene
chr2_-_157413189 1.15 ENSMUST00000173378.8
bladder cancer associated protein
chr2_-_155676765 1.14 ENSMUST00000029143.7
ENSMUST00000239423.2
family with sequence similarity 83, member C
chr15_+_88484484 1.14 ENSMUST00000066949.9
zinc finger, DHHC domain containing 25
chr16_+_17712061 1.09 ENSMUST00000046937.4
testis-specific serine kinase 1
chr2_-_32977182 1.01 ENSMUST00000102810.10
GTPase activating RANGAP domain-like 3
chr9_+_37119472 1.00 ENSMUST00000034632.10
transmembrane protein 218
chr1_-_164285914 0.99 ENSMUST00000027863.13
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr2_+_153760311 0.99 ENSMUST00000109760.2
BPI fold containing family B, member 3
chr3_-_137892434 0.98 ENSMUST00000012186.9
ENSMUST00000199293.2
RIKEN cDNA 4930579F01 gene
chr4_+_120389415 0.97 ENSMUST00000062990.4
schlafen like 1
chr7_-_102537358 0.96 ENSMUST00000078191.3
olfactory receptor 569
chr9_+_38278192 0.94 ENSMUST00000216168.2
olfactory receptor 250
chr6_+_116184991 0.93 ENSMUST00000036759.11
ENSMUST00000204476.3
WASH complex subunit 2`
chr3_+_55154486 0.93 ENSMUST00000200348.2
doublecortin-like kinase 1
chr3_-_89153135 0.91 ENSMUST00000041022.15
tripartite motif-containing 46
chr10_+_61253751 0.91 ENSMUST00000049339.7
nodal
chrX_-_134985958 0.90 ENSMUST00000138878.2
ENSMUST00000080929.13
nuclear RNA export factor 3
chr6_-_69969961 0.89 ENSMUST00000200160.5
ENSMUST00000103373.3
immunoglobulin kappa chain variable 18-36
chr15_+_76238632 0.89 ENSMUST00000208833.3
predicted gene, 35339
chr4_-_123217391 0.87 ENSMUST00000102640.2
3-oxoacid CoA transferase 2A
chr2_+_131052283 0.87 ENSMUST00000110210.8
ENSMUST00000089506.12
ENSMUST00000110208.8
adaptor-related protein 5 complex, sigma 1 subunit
chr7_-_44828962 0.84 ENSMUST00000211004.2
ENSMUST00000179443.3
golgi-associated olfactory signaling regulator
chr1_+_135980639 0.83 ENSMUST00000112064.8
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr7_-_140367737 0.81 ENSMUST00000211616.2
ENSMUST00000026553.6
synaptonemal complex central element protein 1
chr5_+_31652079 0.81 ENSMUST00000076949.13
ENSMUST00000202394.4
GPN-loop GTPase 1
chr14_-_101437750 0.80 ENSMUST00000187304.2
proline rich 30
chr13_+_23879775 0.79 ENSMUST00000041052.5
H1.6 linker histone, cluster member
chr1_+_58750647 0.79 ENSMUST00000097722.9
ENSMUST00000114313.8
CASP8 and FADD-like apoptosis regulator
chr7_+_37885660 0.78 ENSMUST00000179503.5
RIKEN cDNA 1600014C10 gene
chr5_-_146521629 0.76 ENSMUST00000200112.2
ENSMUST00000197431.2
ENSMUST00000197825.2
G-protein coupled receptor 12
chr14_+_53411782 0.74 ENSMUST00000197433.5
ENSMUST00000103590.4
T cell receptor alpha variable 15N-1
chr13_+_112454981 0.74 ENSMUST00000223871.2
ankyrin repeat domain 55
chr1_+_66214431 0.74 ENSMUST00000156636.9
microtubule-associated protein 2
chr1_+_135980508 0.73 ENSMUST00000112068.10
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr1_+_135980488 0.73 ENSMUST00000160641.8
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr1_+_131526977 0.72 ENSMUST00000027690.7
arginine vasopressin receptor 1B
chr3_-_151960992 0.68 ENSMUST00000198750.5
nexilin
chr7_+_139913930 0.66 ENSMUST00000214858.2
olfactory receptor 527
chr15_-_89294434 0.66 ENSMUST00000109314.9
synaptonemal complex central element protein 3
chr15_-_98215234 0.65 ENSMUST00000216901.2
olfactory receptor 285
chr5_-_146122114 0.65 ENSMUST00000073721.7
RIKEN cDNA 1700001J03 gene
chr3_-_116217579 0.64 ENSMUST00000106491.7
ENSMUST00000090464.7
CDC14 cell division cycle 14A
chr7_-_45375205 0.63 ENSMUST00000094424.7
sperm acrosome associated 4
chr16_+_96295011 0.63 ENSMUST00000233816.2
Purkinje cell protein 4
chr7_+_44984723 0.62 ENSMUST00000211327.2
histidine rich calcium binding protein
chr6_-_24956296 0.61 ENSMUST00000127247.4
transmembrane protein 229A
chr14_+_53279810 0.61 ENSMUST00000198439.5
ENSMUST00000103605.3
T cell receptor alpha variable 8D-2
chr11_+_73051228 0.59 ENSMUST00000006104.10
ENSMUST00000135202.8
ENSMUST00000136894.3
purinergic receptor P2X, ligand-gated ion channel, 5
chr3_-_95148909 0.58 ENSMUST00000090815.6
ENSMUST00000107197.2
predicted gene 128
chr17_-_56607286 0.58 ENSMUST00000097303.3
arrestin domain containing 5
chr2_+_131052421 0.57 ENSMUST00000110206.2
adaptor-related protein 5 complex, sigma 1 subunit
chr16_-_37205277 0.56 ENSMUST00000114787.8
ENSMUST00000114782.8
ENSMUST00000114775.8
syntaxin binding protein 5-like
chr16_+_96006919 0.55 ENSMUST00000129904.3
SH3-binding domain glutamic acid-rich protein
chr5_-_144969564 0.55 ENSMUST00000071421.6
predicted gene 4871
chr4_+_40472180 0.55 ENSMUST00000049655.3
transmembrane protein 215
chr16_+_16688692 0.55 ENSMUST00000232547.2
topoisomerase (DNA) III beta
chr17_-_34694911 0.55 ENSMUST00000065841.5
butyrophilin-like 4
chr6_-_42524521 0.54 ENSMUST00000217978.2
olfactory receptor 455
chr3_-_80820835 0.53 ENSMUST00000107743.8
ENSMUST00000029654.15
glycine receptor, beta subunit
chr2_+_131048998 0.52 ENSMUST00000153097.3
adaptor-related protein 5 complex, sigma 1 subunit
chr2_-_104679838 0.52 ENSMUST00000126824.2
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr14_+_54923655 0.50 ENSMUST00000038539.8
ENSMUST00000228027.2
RIKEN cDNA 1700123O20 gene
chr7_+_112553162 0.48 ENSMUST00000182858.2
Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
chr7_+_43600038 0.47 ENSMUST00000072204.5
kallikrein 1-related peptidase b8
chr3_-_151960948 0.46 ENSMUST00000199423.5
ENSMUST00000198460.5
nexilin
chr1_+_39026887 0.46 ENSMUST00000194552.2
phosducin-like 3
chr17_-_56607250 0.43 ENSMUST00000233911.2
arrestin domain containing 5
chr1_+_165123358 0.41 ENSMUST00000178700.8
G protein-coupled receptor 161
chr2_-_13798843 0.40 ENSMUST00000003509.10
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
chr10_-_128505096 0.40 ENSMUST00000238610.2
ENSMUST00000238712.2
IKAROS family zinc finger 4
chr1_+_153528689 0.37 ENSMUST00000041776.12
regulator of G-protein signaling 8
chr5_+_32390031 0.34 ENSMUST00000202220.4
phospholipase B1
chr9_-_119652926 0.33 ENSMUST00000215718.2
sodium channel, voltage-gated, type XI, alpha
chr2_+_154065657 0.32 ENSMUST00000045959.8
BPI fold containing family B, member 5
chr17_-_37594351 0.30 ENSMUST00000216328.2
olfactory receptor 99

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 16.7 GO:0046951 ketone body biosynthetic process(GO:0046951)
3.4 10.3 GO:0006530 asparagine catabolic process(GO:0006530)
2.8 24.8 GO:0046874 quinolinate metabolic process(GO:0046874)
2.1 6.4 GO:0042732 D-xylose metabolic process(GO:0042732)
2.1 6.4 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
2.0 14.3 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.8 7.3 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004) regulation of phosphatidylcholine biosynthetic process(GO:2001245)
1.6 8.1 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
1.5 9.2 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
1.5 13.4 GO:0003062 regulation of heart rate by chemical signal(GO:0003062)
1.4 11.4 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
1.4 10.8 GO:0009313 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
1.2 49.0 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
1.1 5.4 GO:0046485 ether lipid metabolic process(GO:0046485)
1.0 4.2 GO:0038016 insulin receptor internalization(GO:0038016)
1.0 6.9 GO:0002317 plasma cell differentiation(GO:0002317)
0.9 2.7 GO:0002930 trabecular meshwork development(GO:0002930) endothelial cell-cell adhesion(GO:0071603)
0.9 2.6 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.8 7.8 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.7 6.7 GO:0007144 female meiosis I(GO:0007144)
0.7 5.5 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.6 9.2 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.6 13.5 GO:0046415 urate metabolic process(GO:0046415)
0.6 1.8 GO:0046021 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.6 3.5 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.6 1.7 GO:0032618 interleukin-15 production(GO:0032618)
0.6 3.9 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.5 3.9 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.4 13.8 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.4 4.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.4 3.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.4 1.2 GO:0061723 glycophagy(GO:0061723)
0.4 2.3 GO:0050917 sensory perception of umami taste(GO:0050917)
0.4 4.4 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.3 1.0 GO:1903281 positive regulation of calcium:sodium antiporter activity(GO:1903281)
0.3 7.2 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.3 0.9 GO:0048320 axial mesoderm formation(GO:0048320)
0.3 1.8 GO:0070094 positive regulation of glucagon secretion(GO:0070094)
0.3 2.3 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.3 1.4 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.3 0.8 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.3 1.8 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.2 1.4 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.2 3.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.2 1.2 GO:1902163 negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902163)
0.2 1.8 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.2 2.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.2 0.8 GO:0014732 skeletal muscle atrophy(GO:0014732) negative regulation of myoblast fusion(GO:1901740) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.2 3.5 GO:0000212 meiotic spindle organization(GO:0000212)
0.2 0.7 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.2 4.7 GO:0051639 actin filament network formation(GO:0051639)
0.2 0.9 GO:0046950 cellular ketone body metabolic process(GO:0046950)
0.2 1.8 GO:0006013 mannose metabolic process(GO:0006013)
0.2 7.6 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.1 4.8 GO:1901739 regulation of myoblast fusion(GO:1901739) positive regulation of myoblast fusion(GO:1901741)
0.1 2.5 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 9.5 GO:0055078 sodium ion homeostasis(GO:0055078)
0.1 6.8 GO:0034340 response to type I interferon(GO:0034340)
0.1 3.0 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 2.7 GO:0007141 male meiosis I(GO:0007141)
0.1 2.1 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 2.5 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.1 10.9 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 3.1 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.1 7.7 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.1 3.7 GO:0034308 primary alcohol metabolic process(GO:0034308)
0.1 1.2 GO:0070673 response to interleukin-18(GO:0070673)
0.1 10.6 GO:0000045 autophagosome assembly(GO:0000045)
0.1 5.3 GO:0060612 adipose tissue development(GO:0060612)
0.1 9.9 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 0.5 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.1 0.5 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.1 1.2 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.1 1.4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 0.8 GO:0051324 meiotic prophase I(GO:0007128) prophase(GO:0051324)
0.1 0.6 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 1.1 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 0.6 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.0 1.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.6 GO:0016998 cell wall macromolecule catabolic process(GO:0016998) cell wall macromolecule metabolic process(GO:0044036) cell wall organization or biogenesis(GO:0071554)
0.0 0.9 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 2.0 GO:0007340 acrosome reaction(GO:0007340)
0.0 2.4 GO:0060487 lung epithelial cell differentiation(GO:0060487)
0.0 0.6 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.0 4.2 GO:0009062 fatty acid catabolic process(GO:0009062)
0.0 0.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.2 GO:0001575 globoside metabolic process(GO:0001575)
0.0 0.3 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.0 0.8 GO:0097499 protein localization to nonmotile primary cilium(GO:0097499)
0.0 0.7 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 1.8 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
0.0 0.4 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.4 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.9 GO:0099612 protein localization to axon(GO:0099612)
0.0 1.3 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 1.7 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.4 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 2.3 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.8 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 1.2 GO:1901998 toxin transport(GO:1901998)
0.0 0.9 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.2 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 2.0 GO:0000724 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.0 8.1 GO:0010976 positive regulation of neuron projection development(GO:0010976)
0.0 0.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 2.8 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 1.3 GO:0019236 response to pheromone(GO:0019236)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0019008 molybdopterin synthase complex(GO:0019008)
1.1 4.4 GO:0097447 dendritic tree(GO:0097447)
1.0 11.4 GO:0042587 glycogen granule(GO:0042587)
0.5 2.6 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.4 3.5 GO:0005827 polar microtubule(GO:0005827)
0.4 3.9 GO:0045098 type III intermediate filament(GO:0045098)
0.3 10.4 GO:0034706 sodium channel complex(GO:0034706)
0.3 7.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.3 0.9 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.3 3.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 14.3 GO:0030673 axolemma(GO:0030673)
0.2 0.9 GO:1990769 proximal neuron projection(GO:1990769)
0.2 9.9 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.2 9.2 GO:0031430 M band(GO:0031430)
0.2 1.2 GO:0005610 laminin-5 complex(GO:0005610)
0.2 16.7 GO:0009925 basal plasma membrane(GO:0009925)
0.1 31.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.5 GO:0000801 central element(GO:0000801)
0.1 1.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 4.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 10.1 GO:0005776 autophagosome(GO:0005776)
0.1 1.4 GO:0000813 ESCRT I complex(GO:0000813)
0.1 1.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 6.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.8 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 6.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 3.2 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 0.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 2.6 GO:0030904 retromer complex(GO:0030904)
0.1 0.6 GO:0005883 neurofilament(GO:0005883)
0.1 1.8 GO:0001533 cornified envelope(GO:0001533)
0.0 1.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 2.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 12.9 GO:0072562 blood microparticle(GO:0072562)
0.0 0.3 GO:0008091 spectrin(GO:0008091)
0.0 33.7 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 1.4 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 2.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 4.6 GO:0032993 protein-DNA complex(GO:0032993)
0.0 3.9 GO:0001650 fibrillar center(GO:0001650)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 7.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 14.8 GO:0005739 mitochondrion(GO:0005739)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.4 GO:0031177 [acyl-carrier-protein] S-malonyltransferase activity(GO:0004314) oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297) S-acetyltransferase activity(GO:0016418) S-malonyltransferase activity(GO:0016419) malonyltransferase activity(GO:0016420) phosphopantetheine binding(GO:0031177)
3.4 10.3 GO:0004067 asparaginase activity(GO:0004067)
2.4 14.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
2.2 13.4 GO:0032810 sterol response element binding(GO:0032810)
2.2 10.8 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
1.6 8.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
1.4 7.2 GO:0004531 deoxyribonuclease II activity(GO:0004531)
1.3 7.8 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
1.1 6.8 GO:0008384 IkappaB kinase activity(GO:0008384)
1.1 16.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.1 3.2 GO:0016501 prostacyclin receptor activity(GO:0016501)
1.1 24.3 GO:0019825 oxygen binding(GO:0019825)
1.0 13.5 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.8 3.4 GO:0019862 IgA binding(GO:0019862)
0.8 10.0 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.7 6.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.7 3.5 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.7 5.4 GO:0016803 ether hydrolase activity(GO:0016803)
0.7 6.7 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.6 1.8 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572)
0.6 7.3 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.5 1.4 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.4 3.9 GO:0050786 RAGE receptor binding(GO:0050786)
0.4 1.7 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.4 9.2 GO:0044548 S100 protein binding(GO:0044548)
0.4 2.8 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.4 4.2 GO:0031419 cobalamin binding(GO:0031419)
0.4 4.4 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.3 3.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.3 3.1 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.3 0.9 GO:0070698 type I activin receptor binding(GO:0070698)
0.3 2.4 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.3 2.7 GO:0070330 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) aromatase activity(GO:0070330)
0.3 4.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 2.3 GO:0008527 taste receptor activity(GO:0008527)
0.2 10.9 GO:0005109 frizzled binding(GO:0005109)
0.2 0.9 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.2 3.9 GO:0019215 intermediate filament binding(GO:0019215)
0.1 6.4 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.1 6.7 GO:0003785 actin monomer binding(GO:0003785)
0.1 2.6 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 1.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 1.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 0.3 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.1 7.7 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 12.5 GO:0051213 dioxygenase activity(GO:0051213)
0.1 1.8 GO:0048273 MAP-kinase scaffold activity(GO:0005078) mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 3.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 2.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 2.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 1.0 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.7 GO:0005000 vasopressin receptor activity(GO:0005000)
0.1 12.0 GO:0043130 ubiquitin binding(GO:0043130)
0.1 0.5 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 4.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 2.5 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.6 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.8 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 0.5 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1 0.8 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.6 GO:0003796 lysozyme activity(GO:0003796)
0.0 7.2 GO:0005178 integrin binding(GO:0005178)
0.0 59.1 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.2 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 1.1 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 2.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.9 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 1.8 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 9.7 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 1.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 5.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.8 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 1.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 2.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.2 GO:0032947 protein complex scaffold(GO:0032947)
0.0 1.8 GO:0005179 hormone activity(GO:0005179)
0.0 2.2 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.3 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.3 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 13.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2 11.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.8 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 3.2 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 1.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 10.9 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.6 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 4.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 5.9 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 5.7 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 1.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 9.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.3 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.5 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 7.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 3.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 24.8 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
1.5 16.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.8 13.9 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.5 9.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.5 19.7 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.4 6.8 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.3 13.4 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.2 10.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.2 3.5 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2 14.3 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.7 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.1 2.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.1 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 1.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 3.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.8 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.0 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 2.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.9 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.6 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 2.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 6.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.4 REACTOME PRE NOTCH EXPRESSION AND PROCESSING Genes involved in Pre-NOTCH Expression and Processing
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.5 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport