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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nr2e1

Z-value: 5.90

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Transcription factors associated with Nr2e1

Gene Symbol Gene ID Gene Info
Nr2e1
ENSMUSG00000019803.12 Nr2e1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr2e1mm39_v1_chr10_-_42459624_424596350.009.8e-01Click!

Activity profile of Nr2e1 motif

Sorted Z-values of Nr2e1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr2e1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_-_62005498 109.86 ENSMUST00000107488.4
ENSMUST00000107472.8
ENSMUST00000084531.11
Mup3
major urinary protein 3
chr4_-_60457902 107.44 ENSMUST00000084548.11
ENSMUST00000103012.10
ENSMUST00000107499.4
Mup1
major urinary protein 1
chr4_-_60777462 91.90 ENSMUST00000211875.2
Mup22
major urinary protein 22
chr4_-_61437704 87.64 ENSMUST00000095051.6
ENSMUST00000107483.8
Mup16
major urinary protein 16
chr4_-_60697274 77.33 ENSMUST00000117932.2
Mup12
major urinary protein 12
chr4_-_61259997 65.08 ENSMUST00000071005.9
ENSMUST00000075206.12
Mup14
major urinary protein 14
chr4_-_61259801 59.68 ENSMUST00000125461.8
Mup14
major urinary protein 14
chr4_-_62069046 48.36 ENSMUST00000077719.4
Mup21
major urinary protein 21
chr6_-_141892517 39.25 ENSMUST00000168119.8
Slco1a1
solute carrier organic anion transporter family, member 1a1
chr5_-_87288177 17.05 ENSMUST00000067790.7
Ugt2b5
UDP glucuronosyltransferase 2 family, polypeptide B5
chr3_+_130411294 15.11 ENSMUST00000163620.8
Etnppl
ethanolamine phosphate phospholyase
chr13_+_24023428 13.98 ENSMUST00000091698.12
ENSMUST00000110422.3
ENSMUST00000166467.9
Slc17a3
solute carrier family 17 (sodium phosphate), member 3
chr4_+_60003438 12.71 ENSMUST00000107517.8
ENSMUST00000107520.2
Mup6
major urinary protein 6
chr13_+_24023386 10.81 ENSMUST00000039721.14
Slc17a3
solute carrier family 17 (sodium phosphate), member 3
chr4_-_59960659 10.79 ENSMUST00000075973.3
Mup4
major urinary protein 4
chr5_-_87054796 10.11 ENSMUST00000031181.16
ENSMUST00000113333.2
Ugt2b34
UDP glucuronosyltransferase 2 family, polypeptide B34
chr17_+_32904629 10.03 ENSMUST00000008801.7
Cyp4f15
cytochrome P450, family 4, subfamily f, polypeptide 15
chr17_+_32904601 9.77 ENSMUST00000168171.8
Cyp4f15
cytochrome P450, family 4, subfamily f, polypeptide 15
chr14_+_28740162 9.11 ENSMUST00000055662.4
Lrtm1
leucine-rich repeats and transmembrane domains 1
chr8_+_36956345 8.84 ENSMUST00000171777.2
Trmt9b
tRNA methyltransferase 9B
chr11_+_68858942 8.26 ENSMUST00000102606.10
ENSMUST00000018884.6
Slc25a35
solute carrier family 25, member 35
chr18_-_60881405 7.59 ENSMUST00000237070.2
Ndst1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr3_+_96432479 7.01 ENSMUST00000049208.11
Hjv
hemojuvelin BMP co-receptor
chr18_-_60881679 6.23 ENSMUST00000237783.2
Ndst1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr7_-_80055168 6.08 ENSMUST00000107362.10
ENSMUST00000135306.3
Furin
furin (paired basic amino acid cleaving enzyme)
chr12_+_111132847 5.61 ENSMUST00000021706.11
Traf3
TNF receptor-associated factor 3
chr12_+_111132779 5.09 ENSMUST00000117269.8
Traf3
TNF receptor-associated factor 3
chr14_+_31750946 4.83 ENSMUST00000022460.11
Galnt15
polypeptide N-acetylgalactosaminyltransferase 15
chr7_+_114367971 4.40 ENSMUST00000117543.3
ENSMUST00000151464.2
Insc
INSC spindle orientation adaptor protein
chr9_-_71070506 4.11 ENSMUST00000074465.9
Aqp9
aquaporin 9
chr17_+_48037758 3.99 ENSMUST00000024782.12
ENSMUST00000144955.2
Pgc
progastricsin (pepsinogen C)
chr15_+_41694317 3.39 ENSMUST00000166917.3
ENSMUST00000230127.2
ENSMUST00000230131.2
Oxr1
oxidation resistance 1
chr12_+_111132908 3.06 ENSMUST00000139162.8
ENSMUST00000060274.7
Traf3
TNF receptor-associated factor 3
chr4_-_119272690 2.44 ENSMUST00000238287.2
ENSMUST00000238759.2
ENSMUST00000063642.10
Ccdc30
coiled-coil domain containing 30
chrM_+_7006 2.31 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr7_+_131144596 2.26 ENSMUST00000046093.6
Hmx3
H6 homeobox 3
chr12_+_86781141 2.14 ENSMUST00000223308.2
Lrrc74a
leucine rich repeat containing 74A
chr6_+_65567373 2.10 ENSMUST00000114236.2
Tnip3
TNFAIP3 interacting protein 3
chr2_-_22930149 2.08 ENSMUST00000091394.13
ENSMUST00000093171.13
Abi1
abl interactor 1
chr6_+_42377172 2.08 ENSMUST00000057398.4
Tas2r143
taste receptor, type 2, member 143
chr12_+_86781154 1.97 ENSMUST00000095527.6
Lrrc74a
leucine rich repeat containing 74A
chr8_+_71156071 1.93 ENSMUST00000212436.2
Iqcn
IQ motif containing N
chr3_+_14643669 1.84 ENSMUST00000029069.13
ENSMUST00000165922.3
E2f5
E2F transcription factor 5
chr8_-_62355690 1.83 ENSMUST00000121785.9
ENSMUST00000034057.14
Palld
palladin, cytoskeletal associated protein
chr14_+_26414422 1.82 ENSMUST00000022433.12
Dnah12
dynein, axonemal, heavy chain 12
chr4_-_119272640 1.78 ENSMUST00000238293.2
Ccdc30
coiled-coil domain containing 30
chr4_-_119272667 1.64 ENSMUST00000238609.2
Ccdc30
coiled-coil domain containing 30
chr4_+_33924632 1.62 ENSMUST00000057188.7
Cnr1
cannabinoid receptor 1 (brain)
chrX_-_105528503 1.31 ENSMUST00000138724.8
ENSMUST00000149331.2
Fndc3c1
fibronectin type III domain containing 3C1
chr6_+_120070307 1.31 ENSMUST00000112711.9
Ninj2
ninjurin 2
chrY_+_24411927 1.28 ENSMUST00000179663.2
Gm20809
predicted gene, 20809
chrY_+_68550741 1.28 ENSMUST00000177765.2
Gm20816
predicted gene, 20816
chrY_-_65214536 1.28 ENSMUST00000177663.2
Gm20924
predicted gene, 20924
chrY_-_77972959 1.25 ENSMUST00000178900.2
Gm20867
predicted gene, 20867
chr9_-_42368880 1.23 ENSMUST00000125995.8
Tbcel
tubulin folding cofactor E-like
chr2_-_22930188 1.19 ENSMUST00000114544.10
ENSMUST00000139038.8
ENSMUST00000126112.8
ENSMUST00000178908.2
ENSMUST00000078977.14
ENSMUST00000140164.8
ENSMUST00000149719.8
Abi1
abl interactor 1
chr2_-_22930104 1.17 ENSMUST00000153931.8
ENSMUST00000123948.8
Abi1
abl interactor 1
chr3_-_146487102 1.08 ENSMUST00000005164.12
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chrY_-_9132561 1.07 ENSMUST00000171947.3
Gm21292
predicted gene, 21292
chrY_+_21166083 1.00 ENSMUST00000178234.2
Gm20909
predicted gene, 20909
chrY_-_53413354 1.00 ENSMUST00000179137.2
Gm20747
predicted gene, 20747
chr5_-_123185073 0.94 ENSMUST00000031437.14
Morn3
MORN repeat containing 3
chr7_+_104713682 0.94 ENSMUST00000213622.2
Olfr678
olfactory receptor 678
chrY_-_79161056 0.92 ENSMUST00000179922.2
Gm20917
predicted gene, 20917
chr9_+_8544143 0.81 ENSMUST00000050433.8
ENSMUST00000217462.2
Trpc6
transient receptor potential cation channel, subfamily C, member 6
chr3_-_24837772 0.78 ENSMUST00000203414.2
Naaladl2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr2_-_111820618 0.69 ENSMUST00000216948.2
ENSMUST00000214935.2
ENSMUST00000217452.2
ENSMUST00000215045.2
Olfr1309
olfactory receptor 1309
chr10_+_18345706 0.67 ENSMUST00000162891.8
ENSMUST00000100054.4
Nhsl1
NHS-like 1
chrY_+_21242966 0.56 ENSMUST00000179095.2
Gm20865
predicted gene, 20865
chr5_-_123185029 0.56 ENSMUST00000045843.15
Morn3
MORN repeat containing 3
chrX_-_133012457 0.54 ENSMUST00000159259.3
ENSMUST00000113275.10
Nox1
NADPH oxidase 1
chr11_-_58521327 0.40 ENSMUST00000214132.2
Olfr323
olfactory receptor 323
chr19_-_11261177 0.28 ENSMUST00000186937.7
ENSMUST00000067673.13
Ms4a5
membrane-spanning 4-domains, subfamily A, member 5
chr4_+_28813152 0.16 ENSMUST00000108194.9
ENSMUST00000108191.2
Epha7
Eph receptor A7
chr2_-_120916316 0.15 ENSMUST00000028721.8
Tgm5
transglutaminase 5
chr2_+_14828903 0.10 ENSMUST00000193800.6
Cacnb2
calcium channel, voltage-dependent, beta 2 subunit

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.0 107.4 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
4.8 149.1 GO:0035634 response to stilbenoid(GO:0035634)
1.7 24.8 GO:0015747 urate transport(GO:0015747)
1.5 13.8 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
1.5 6.1 GO:0090472 dibasic protein processing(GO:0090472)
1.3 4.0 GO:0002225 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803)
1.3 13.8 GO:0008063 Toll signaling pathway(GO:0008063)
1.0 4.1 GO:0015855 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.5 1.6 GO:0099553 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.2 3.4 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.1 0.5 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.1 4.4 GO:0072673 lamellipodium morphogenesis(GO:0072673)
0.1 2.1 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.1 2.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 1.8 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 9.1 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 4.4 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.1 1.1 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 1.8 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.7 GO:0097475 motor neuron migration(GO:0097475)
0.0 2.3 GO:0060135 maternal process involved in female pregnancy(GO:0060135)
0.0 2.3 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 8.3 GO:0006839 mitochondrial transport(GO:0006839)
0.0 1.3 GO:0042246 tissue regeneration(GO:0042246)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 13.8 GO:0035631 CD40 receptor complex(GO:0035631)
0.3 6.1 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.3 4.4 GO:0031209 SCAR complex(GO:0031209)
0.1 1.8 GO:0036156 inner dynein arm(GO:0036156)
0.1 2.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.5 GO:0071438 invadopodium membrane(GO:0071438)
0.1 226.8 GO:0005615 extracellular space(GO:0005615)
0.1 43.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 24.8 GO:0016324 apical plasma membrane(GO:0016324)
0.1 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 25.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.8 GO:0002102 podosome(GO:0002102)
0.0 4.4 GO:0045177 apical part of cell(GO:0045177)
0.0 0.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.8 GO:0016528 sarcoplasm(GO:0016528)
0.0 1.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 4.8 GO:0030133 transport vesicle(GO:0030133)
0.0 18.5 GO:0005739 mitochondrion(GO:0005739)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
35.8 107.4 GO:0005009 insulin-activated receptor activity(GO:0005009)
5.0 15.1 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
2.5 24.8 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
2.0 13.8 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
1.4 118.1 GO:0005550 pheromone binding(GO:0005550)
0.9 13.8 GO:0031996 thioesterase binding(GO:0031996)
0.8 35.5 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.8 4.1 GO:0005345 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.7 2.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.7 27.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.4 1.6 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.3 6.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.2 4.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 4.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 19.8 GO:0020037 heme binding(GO:0020037)
0.1 4.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 1.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.5 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 2.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 9.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 1.8 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 2.1 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 3.2 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 13.8 PID CD40 PATHWAY CD40/CD40L signaling
0.1 5.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 6.1 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.6 PID NCADHERIN PATHWAY N-cadherin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 13.8 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.4 6.1 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.3 13.8 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 4.1 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 1.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.1 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline