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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nr4a2

Z-value: 1.10

Motif logo

Transcription factors associated with Nr4a2

Gene Symbol Gene ID Gene Info
ENSMUSG00000026826.14 Nr4a2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr4a2mm39_v1_chr2_-_57003064_57003084-0.281.0e-01Click!

Activity profile of Nr4a2 motif

Sorted Z-values of Nr4a2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr4a2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr15_+_76579960 3.14 ENSMUST00000229679.2
glutamic pyruvic transaminase, soluble
chr7_-_14172434 2.50 ENSMUST00000210396.2
ENSMUST00000168252.9
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
chr9_-_21900724 1.99 ENSMUST00000045726.8
ral guanine nucleotide dissociation stimulator-like 3
chr15_+_25940781 1.67 ENSMUST00000227275.2
reticulophagy regulator 1
chr15_+_25940912 1.67 ENSMUST00000226438.2
reticulophagy regulator 1
chr15_+_25940931 1.60 ENSMUST00000110438.3
reticulophagy regulator 1
chr5_+_30437579 1.57 ENSMUST00000145167.9
selenoprotein I
chr7_+_51537645 1.54 ENSMUST00000208711.2
growth arrest specific 2
chr16_+_43960183 1.51 ENSMUST00000159514.8
ENSMUST00000161326.8
ENSMUST00000063520.15
ENSMUST00000063542.8
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr16_-_43959993 1.38 ENSMUST00000137557.8
ATPase, H+ transporting, lysosomal V1 subunit A
chr2_-_73722932 1.29 ENSMUST00000154456.8
ENSMUST00000090802.11
ENSMUST00000055833.12
ENSMUST00000112007.8
ENSMUST00000112016.9
activating transcription factor 2
chr1_+_167445815 1.27 ENSMUST00000111380.2
retinoid X receptor gamma
chr2_+_61423469 1.21 ENSMUST00000112494.2
TRAF family member-associated Nf-kappa B activator
chr2_+_61423421 1.19 ENSMUST00000112495.8
ENSMUST00000112501.9
TRAF family member-associated Nf-kappa B activator
chr2_-_73722874 1.12 ENSMUST00000136958.8
ENSMUST00000112010.9
ENSMUST00000128531.8
ENSMUST00000112017.8
activating transcription factor 2
chr8_-_65186565 1.10 ENSMUST00000141021.2
methylsterol monoxygenase 1
chr5_-_66308421 1.10 ENSMUST00000200775.4
ENSMUST00000094756.11
RNA binding motif protein 47
chr9_-_21913833 1.05 ENSMUST00000115336.10
outer dynein arm docking complex subunit 3
chr1_-_63215952 1.05 ENSMUST00000185412.7
ENSMUST00000027111.15
ENSMUST00000189664.2
NADH:ubiquinone oxidoreductase core subunit S1
chr16_-_43959559 1.02 ENSMUST00000063661.13
ENSMUST00000114666.9
ATPase, H+ transporting, lysosomal V1 subunit A
chr8_+_105573693 1.01 ENSMUST00000055052.6
carboxylesterase 2C
chr9_-_21913896 0.99 ENSMUST00000044926.6
outer dynein arm docking complex subunit 3
chr16_-_43960045 0.97 ENSMUST00000147025.2
ATPase, H+ transporting, lysosomal V1 subunit A
chr8_-_71315902 0.94 ENSMUST00000212611.2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr1_-_63215812 0.93 ENSMUST00000185847.2
ENSMUST00000185732.7
ENSMUST00000188370.7
ENSMUST00000168099.9
NADH:ubiquinone oxidoreductase core subunit S1
chr18_-_57108405 0.85 ENSMUST00000139243.9
ENSMUST00000025488.15
RIKEN cDNA C330018D20 gene
chr11_+_4207557 0.84 ENSMUST00000066283.12
leukemia inhibitory factor
chrX_-_47602395 0.83 ENSMUST00000114945.9
ENSMUST00000037349.8
apoptosis-inducing factor, mitochondrion-associated 1
chr10_-_42354276 0.83 ENSMUST00000151747.8
AFG1 like ATPase
chr19_+_3817396 0.77 ENSMUST00000052699.13
ENSMUST00000113974.11
ENSMUST00000113972.9
ENSMUST00000113973.8
ENSMUST00000113977.9
ENSMUST00000113968.9
lysine methyltransferase 5B
chr9_-_21996693 0.76 ENSMUST00000179422.8
ENSMUST00000098937.10
ENSMUST00000177967.2
ENSMUST00000180180.8
ECSIT signalling integrator
chr5_-_66309244 0.73 ENSMUST00000167950.8
RNA binding motif protein 47
chr10_-_42354482 0.72 ENSMUST00000041024.15
AFG1 like ATPase
chr4_+_102617495 0.71 ENSMUST00000072481.12
ENSMUST00000156596.8
ENSMUST00000080728.13
ENSMUST00000106882.9
SH3-domain GRB2-like (endophilin) interacting protein 1
chr4_+_97665843 0.70 ENSMUST00000075448.13
ENSMUST00000092532.13
nuclear factor I/A
chr13_+_93440265 0.63 ENSMUST00000109494.8
homer scaffolding protein 1
chr10_+_67021509 0.63 ENSMUST00000173689.8
jumonji domain containing 1C
chr9_+_108269992 0.59 ENSMUST00000192995.6
RIKEN cDNA 1700102P08 gene
chrX_-_141173330 0.57 ENSMUST00000112907.8
acyl-CoA synthetase long-chain family member 4
chr4_+_97665992 0.57 ENSMUST00000107062.9
ENSMUST00000052018.12
ENSMUST00000107057.8
nuclear factor I/A
chr10_+_27950809 0.56 ENSMUST00000166468.2
ENSMUST00000218359.2
ENSMUST00000218276.2
protein tyrosine phosphatase, receptor type, K
chr1_-_123972900 0.55 ENSMUST00000112603.4
dipeptidylpeptidase 10
chr5_-_66308666 0.55 ENSMUST00000201561.4
RNA binding motif protein 47
chr5_-_88823049 0.55 ENSMUST00000133532.8
ENSMUST00000150438.2
G-rich RNA sequence binding factor 1
chr5_-_121665249 0.55 ENSMUST00000152270.8
MAP kinase-activated protein kinase 5
chr13_+_93440572 0.54 ENSMUST00000109493.9
homer scaffolding protein 1
chrX_-_139501246 0.54 ENSMUST00000112996.9
TSC22 domain family, member 3
chr16_+_8647959 0.53 ENSMUST00000023150.7
RIKEN cDNA 1810013L24 gene
chr6_+_15727798 0.53 ENSMUST00000128849.3
MyoD family inhibitor domain containing
chr10_+_98943999 0.51 ENSMUST00000161240.4
polypeptide N-acetylgalactosaminyltransferase 4
chr2_+_127180559 0.51 ENSMUST00000059839.9
astacin-like metalloendopeptidase (M12 family)
chr4_+_102617332 0.50 ENSMUST00000066824.14
SH3-domain GRB2-like (endophilin) interacting protein 1
chr9_-_114393406 0.50 ENSMUST00000111816.3
tripartite motif-containing 71
chr15_+_25940859 0.49 ENSMUST00000226750.2
reticulophagy regulator 1
chr1_+_83094481 0.48 ENSMUST00000027351.13
ENSMUST00000113437.9
ENSMUST00000186832.2
chemokine (C-C motif) ligand 20
chr19_+_3818112 0.48 ENSMUST00000005518.16
ENSMUST00000237440.2
ENSMUST00000152935.8
ENSMUST00000176262.8
ENSMUST00000176407.8
ENSMUST00000176926.8
ENSMUST00000176512.8
lysine methyltransferase 5B
chr15_-_76113692 0.47 ENSMUST00000074834.12
plectin
chr9_+_108270020 0.47 ENSMUST00000035234.6
RIKEN cDNA 1700102P08 gene
chr11_-_94568228 0.46 ENSMUST00000116349.9
xylosyltransferase II
chr19_+_36532061 0.45 ENSMUST00000169036.9
ENSMUST00000047247.12
HECT domain E3 ubiquitin protein ligase 2
chr5_-_88823472 0.45 ENSMUST00000113234.8
ENSMUST00000153565.8
G-rich RNA sequence binding factor 1
chr2_+_105499280 0.44 ENSMUST00000142772.8
paired box 6
chrX_-_16683578 0.43 ENSMUST00000040820.13
monoamine oxidase B
chr2_+_105499233 0.43 ENSMUST00000111086.11
ENSMUST00000111087.10
paired box 6
chr15_+_25774070 0.43 ENSMUST00000125667.3
myosin X
chr1_+_131838220 0.43 ENSMUST00000189946.7
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr9_+_55056648 0.42 ENSMUST00000121677.8
ubiquitin-conjugating enzyme E2Q family member 2
chr2_+_4980986 0.41 ENSMUST00000027978.7
ENSMUST00000195688.2
upper zone of growth plate and cartilage matrix associated
chr10_-_41179167 0.41 ENSMUST00000043814.5
FIG4 phosphoinositide 5-phosphatase
chr17_-_36220518 0.41 ENSMUST00000141132.2
alpha tubulin acetyltransferase 1
chr9_-_42372710 0.38 ENSMUST00000066179.14
tubulin folding cofactor E-like
chr9_+_118335294 0.37 ENSMUST00000084820.6
golgi autoantigen, golgin subfamily a, 4
chr19_-_40371242 0.36 ENSMUST00000224583.2
sorbin and SH3 domain containing 1
chr7_+_24310171 0.36 ENSMUST00000206422.2
pleckstrin homology like domain, family B, member 3
chr2_-_26127360 0.35 ENSMUST00000036187.9
quiescin Q6 sulfhydryl oxidase 2
chr4_+_150999019 0.35 ENSMUST00000135169.8
tumor necrosis factor receptor superfamily, member 9
chr15_-_50753792 0.34 ENSMUST00000185183.2
transcriptional repressor GATA binding 1
chr2_+_4980923 0.34 ENSMUST00000167607.8
ENSMUST00000115010.9
upper zone of growth plate and cartilage matrix associated
chr2_-_129541753 0.34 ENSMUST00000028883.12
prodynorphin
chr9_-_106533279 0.34 ENSMUST00000023959.13
ENSMUST00000201681.2
glutamate receptor, metabotropic 2
chr10_-_23226684 0.34 ENSMUST00000220299.2
EYA transcriptional coactivator and phosphatase 4
chr13_+_74269554 0.33 ENSMUST00000036208.7
ENSMUST00000225423.2
ENSMUST00000221703.2
solute carrier family 9 (sodium/hydrogen exchanger), member 3
chr2_+_79538124 0.33 ENSMUST00000090760.9
ENSMUST00000040863.11
ENSMUST00000111780.3
protein phosphatase 1, regulatory inhibitor subunit 1C
chr12_+_56742413 0.33 ENSMUST00000001538.10
paired box 9
chr6_-_124791259 0.32 ENSMUST00000172132.10
ENSMUST00000239432.2
triosephosphate isomerase 1
chr11_-_97242842 0.32 ENSMUST00000093942.5
G protein-coupled receptor 179
chr2_+_30485048 0.32 ENSMUST00000102853.4
CSA-conditional, T cell activation-dependent protein
chr17_-_36220924 0.31 ENSMUST00000141662.8
ENSMUST00000056034.13
ENSMUST00000077494.13
ENSMUST00000149277.8
ENSMUST00000061052.12
alpha tubulin acetyltransferase 1
chr10_-_12745109 0.30 ENSMUST00000218635.2
utrophin
chr19_+_3817953 0.30 ENSMUST00000113970.8
lysine methyltransferase 5B
chr5_+_63806451 0.30 ENSMUST00000159584.3
NACHT and WD repeat domain containing 2
chr2_+_58991182 0.29 ENSMUST00000168631.8
ENSMUST00000102754.11
ENSMUST00000123908.8
plakophilin 4
chr4_+_33081505 0.29 ENSMUST00000147889.2
gamma-aminobutyric acid (GABA) C receptor, subunit rho 2
chr4_-_150998857 0.29 ENSMUST00000105675.8
Parkinson disease (autosomal recessive, early onset) 7
chr2_-_120394288 0.29 ENSMUST00000055241.13
ENSMUST00000135625.8
zinc finger protein 106
chr3_-_87934772 0.28 ENSMUST00000005014.9
hyaluronan and proteoglycan link protein 2
chr2_+_143874979 0.28 ENSMUST00000037722.9
ENSMUST00000110032.2
BANF family member 2
chr7_-_141009346 0.27 ENSMUST00000124444.2
cell cycle exit and neuronal differentiation 1
chr12_+_31488208 0.26 ENSMUST00000001254.6
solute carrier family 26, member 3
chr19_+_46140942 0.26 ENSMUST00000026254.14
golgi-specific brefeldin A-resistance factor 1
chr7_-_134100659 0.26 ENSMUST00000238294.2
DNA segment, Chr 7, ERATO Doi 443, expressed
chr4_-_141351110 0.25 ENSMUST00000038661.8
solute carrier family 25, member 34
chr7_-_133203838 0.25 ENSMUST00000033275.4
testis expressed 36
chr2_-_24809583 0.24 ENSMUST00000046227.12
ENSMUST00000114432.9
ENSMUST00000091348.11
ENSMUST00000102938.10
ENSMUST00000150379.2
ENSMUST00000152161.8
ENSMUST00000147147.8
euchromatic histone methyltransferase 1
chr4_-_42853888 0.24 ENSMUST00000107979.2
family with sequence similarity 205, member A1
chr3_+_84832783 0.24 ENSMUST00000107675.8
F-box and WD-40 domain protein 7
chr5_-_90487583 0.23 ENSMUST00000197021.2
ankyrin repeat domain 17
chr19_-_32038838 0.23 ENSMUST00000096119.5
N-acylsphingosine amidohydrolase 2
chr4_+_41966058 0.22 ENSMUST00000108026.3
family with sequence similarity 205, member A4
chr13_-_17979675 0.22 ENSMUST00000223490.2
cyclin-dependent kinase 13
chr9_+_98746796 0.22 ENSMUST00000167951.3
proline rich 23A, member 3
chr2_-_58990967 0.21 ENSMUST00000226455.2
ENSMUST00000077687.6
coiled-coil domain containing 148
chr5_+_16758538 0.21 ENSMUST00000199581.5
hepatocyte growth factor
chr6_+_3993774 0.21 ENSMUST00000031673.7
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr1_+_87501721 0.21 ENSMUST00000166259.8
ENSMUST00000172222.8
ENSMUST00000163606.8
neuraminidase 2
chr6_-_99073156 0.21 ENSMUST00000175886.8
forkhead box P1
chr7_-_141009264 0.21 ENSMUST00000164387.2
ENSMUST00000137488.2
ENSMUST00000084436.10
cell cycle exit and neuronal differentiation 1
chr9_-_18585826 0.20 ENSMUST00000208663.2
mucin 16
chr18_+_86729184 0.19 ENSMUST00000068423.10
cerebellin 2 precursor protein
chr7_+_4122555 0.18 ENSMUST00000079415.12
tweety family member 1
chr2_+_75662511 0.18 ENSMUST00000047232.14
ENSMUST00000111952.9
alkylglycerone phosphate synthase
chr2_-_155787197 0.18 ENSMUST00000040162.3
growth differentiation factor 5
chr4_+_42318272 0.17 ENSMUST00000178192.3
family with sequence similarity 205, member A3
chr10_-_20600442 0.17 ENSMUST00000170265.8
phosphodiesterase 7B
chr6_+_34897904 0.17 ENSMUST00000185102.2
ENSMUST00000114997.3
stimulated by retinoic acid gene 8
chr17_+_69746321 0.17 ENSMUST00000169935.2
A kinase (PRKA) anchor inhibitor 1
chr6_+_113674011 0.17 ENSMUST00000089018.11
TatD DNase domain containing 2
chr19_+_11724913 0.16 ENSMUST00000025585.4
cobalamin binding intrinsic factor
chr10_-_20600797 0.16 ENSMUST00000020165.14
phosphodiesterase 7B
chr3_-_92407800 0.15 ENSMUST00000062129.2
small proline-rich protein 4
chr2_+_75662806 0.15 ENSMUST00000175646.2
alkylglycerone phosphate synthase
chr11_-_100713348 0.15 ENSMUST00000107358.9
signal transducer and activator of transcription 5B
chr14_-_78326435 0.15 ENSMUST00000118785.3
ENSMUST00000066437.5
family with sequence similarity 216, member B
chrX_-_166638057 0.15 ENSMUST00000238211.2
FERM and PDZ domain containing 4
chr6_-_3487369 0.14 ENSMUST00000201607.4
HEPACAM family member 2
chr12_-_75596441 0.14 ENSMUST00000218716.2
protein phosphatase 2, regulatory subunit B', epsilon
chr10_+_93983844 0.14 ENSMUST00000105290.9
nuclear receptor subfamily 2, group C, member 1
chr10_+_110756031 0.14 ENSMUST00000220409.2
ENSMUST00000219502.2
cysteine and glycine-rich protein 2
chr7_-_89176294 0.13 ENSMUST00000207932.2
protease, serine 23
chr2_-_101451383 0.12 ENSMUST00000090513.11
intraflagellar transport associated protein
chr11_-_59029996 0.12 ENSMUST00000219084.3
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr12_-_76842263 0.12 ENSMUST00000082431.6
glutathione peroxidase 2
chr7_+_120234399 0.12 ENSMUST00000033176.7
ENSMUST00000208400.2
ubiquinol cytochrome c reductase core protein 2
chr6_+_34897874 0.12 ENSMUST00000114999.8
stimulated by retinoic acid gene 8
chr9_-_13358049 0.11 ENSMUST00000167906.3
predicted gene, 17571
chr9_-_32255533 0.11 ENSMUST00000216033.2
potassium inwardly-rectifying channel, subfamily J, member 5
chr11_+_70548513 0.11 ENSMUST00000134087.8
enolase 3, beta muscle
chr4_-_82939330 0.11 ENSMUST00000071708.12
Fras1 related extracellular matrix protein 1
chr10_+_42378193 0.10 ENSMUST00000105499.2
sorting nexin 3
chr10_+_90665639 0.10 ENSMUST00000179337.9
ankyrin repeat and sterile alpha motif domain containing 1B
chrX_+_48552803 0.10 ENSMUST00000130558.8
Rho GTPase activating protein 36
chr2_+_121125918 0.09 ENSMUST00000110639.8
microtubule-associated protein 1 A
chr7_-_65177444 0.09 ENSMUST00000206228.2
tight junction protein 1
chr16_+_21644692 0.09 ENSMUST00000232240.2
mitogen-activated protein kinase kinase kinase 13
chrX_+_159551009 0.09 ENSMUST00000033650.14
retinoschisis (X-linked, juvenile) 1 (human)
chr8_-_13544478 0.08 ENSMUST00000033828.7
growth arrest specific 6
chr17_+_70828649 0.07 ENSMUST00000233283.2
DLG associated protein 1
chr6_+_92068361 0.07 ENSMUST00000113460.8
nuclear receptor subfamily 2, group C, member 2
chr7_-_102566717 0.07 ENSMUST00000214160.2
ENSMUST00000215773.2
olfactory receptor 571
chr18_+_57275854 0.06 ENSMUST00000139892.2
multiple EGF-like-domains 10
chr9_-_32255556 0.06 ENSMUST00000214223.2
potassium inwardly-rectifying channel, subfamily J, member 5
chrX_+_6327790 0.05 ENSMUST00000143641.4
shroom family member 4
chr10_-_40178182 0.05 ENSMUST00000099945.6
ENSMUST00000238953.2
ENSMUST00000238969.2
S-adenosylmethionine decarboxylase 1
chr13_+_118851214 0.05 ENSMUST00000022246.9
fibroblast growth factor 10
chrX_+_159551171 0.04 ENSMUST00000112368.3
retinoschisis (X-linked, juvenile) 1 (human)
chrX_+_7445806 0.04 ENSMUST00000234363.2
ENSMUST00000235116.2
ENSMUST00000115739.9
ENSMUST00000234574.2
ENSMUST00000115740.9
forkhead box P3
chr19_-_40371016 0.04 ENSMUST00000225766.3
sorbin and SH3 domain containing 1
chr5_+_16758777 0.04 ENSMUST00000030683.8
hepatocyte growth factor
chr3_+_95041399 0.03 ENSMUST00000066386.6
LysM, putative peptidoglycan-binding, domain containing 1
chr7_+_4122523 0.03 ENSMUST00000119661.8
ENSMUST00000129423.8
tweety family member 1
chr19_+_43770619 0.03 ENSMUST00000026208.6
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr14_+_27598021 0.01 ENSMUST00000211684.2
ENSMUST00000210924.2
ELKS/RAB6-interacting/CAST family member 2
chr2_+_128907854 0.01 ENSMUST00000035812.14
tubulin tyrosine ligase
chr6_+_96090127 0.01 ENSMUST00000122120.8
TAFA chemokine like family member 1
chr13_+_95012107 0.00 ENSMUST00000022195.13
orthopedia homeobox

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.4 GO:0061709 reticulophagy(GO:0061709)
0.6 2.4 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.6 2.4 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.3 1.5 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.2 0.7 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.2 0.9 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.2 2.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 0.5 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.2 1.6 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.8 GO:1901674 histone H3-K27 acetylation(GO:0043974) spongiotrophoblast differentiation(GO:0060708) regulation of histone H3-K27 acetylation(GO:1901674)
0.1 3.4 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 1.6 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.1 0.5 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933) negative regulation of cerebellar granule cell precursor proliferation(GO:0021941)
0.1 1.5 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.1 0.6 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.1 0.4 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.1 0.3 GO:0046166 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 0.5 GO:2000360 negative regulation of binding of sperm to zona pellucida(GO:2000360)
0.1 0.4 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.1 0.3 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 1.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.3 GO:1903198 enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.1 0.3 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 0.8 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.1 1.2 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 1.3 GO:0072189 ureter development(GO:0072189)
0.1 0.6 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 0.4 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180)
0.0 0.5 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.5 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.2 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.4 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 0.3 GO:0007527 adult somatic muscle development(GO:0007527)
0.0 0.2 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.3 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.0 0.6 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.2 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0 0.1 GO:0070676 intralumenal vesicle formation(GO:0070676) negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.1 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.0 0.3 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.5 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.1 GO:0009608 response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609)
0.0 0.3 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 2.0 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 1.3 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.2 GO:0006689 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
0.0 0.0 GO:0050787 detoxification of mercury ion(GO:0050787)
0.0 0.2 GO:0060591 chondroblast differentiation(GO:0060591)
0.0 0.2 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.3 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.3 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.1 GO:0046544 development of secondary male sexual characteristics(GO:0046544)
0.0 0.1 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.3 GO:0051454 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0 0.5 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.0 GO:0002851 positive regulation of tolerance induction dependent upon immune response(GO:0002654) regulation of peripheral tolerance induction(GO:0002658) positive regulation of peripheral tolerance induction(GO:0002660) regulation of peripheral T cell tolerance induction(GO:0002849) positive regulation of peripheral T cell tolerance induction(GO:0002851)
0.0 1.1 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.8 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 1.0 GO:1903078 positive regulation of protein localization to plasma membrane(GO:1903078)
0.0 0.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.8 GO:0001707 mesoderm formation(GO:0001707)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 0.5 GO:0032156 septin cytoskeleton(GO:0032156)
0.2 0.5 GO:0060473 cortical granule(GO:0060473)
0.1 1.0 GO:0031415 NatA complex(GO:0031415)
0.1 0.2 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.1 5.2 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.4 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 1.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.7 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.2 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 2.4 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 1.6 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 2.3 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.1 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 1.2 GO:0043034 costamere(GO:0043034)
0.0 1.0 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.5 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.8 GO:0016235 aggresome(GO:0016235)
0.0 0.3 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) contractile ring(GO:0070938) glycoprotein complex(GO:0090665)
0.0 0.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0047635 L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635)
0.6 2.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.4 1.6 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.3 2.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 2.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 1.6 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.2 0.8 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.2 0.5 GO:0070002 glutamic-type peptidase activity(GO:0070002)
0.2 0.8 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.2 0.5 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 1.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.9 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 3.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 1.2 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.4 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 0.6 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.3 GO:0036478 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478) cupric ion binding(GO:1903135)
0.1 0.4 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 0.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 2.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.5 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.1 0.5 GO:0043426 MRF binding(GO:0043426)
0.1 0.2 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.4 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.2 GO:0052795 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.6 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.3 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.9 GO:0070410 AT DNA binding(GO:0003680) co-SMAD binding(GO:0070410)
0.0 0.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.2 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.6 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.5 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.5 GO:0035198 miRNA binding(GO:0035198)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.2 GO:0036122 BMP binding(GO:0036122)
0.0 0.1 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.6 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.3 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.8 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.1 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.8 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.6 ST P38 MAPK PATHWAY p38 MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 3.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 3.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 2.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 2.0 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.9 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.2 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 2.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 1.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway