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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nr5a2

Z-value: 2.62

Motif logo

Transcription factors associated with Nr5a2

Gene Symbol Gene ID Gene Info
ENSMUSG00000026398.15 Nr5a2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr5a2mm39_v1_chr1_-_136888118_136888234-0.693.2e-06Click!

Activity profile of Nr5a2 motif

Sorted Z-values of Nr5a2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr5a2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr5_+_90638580 36.93 ENSMUST00000042755.7
ENSMUST00000200693.2
alpha fetoprotein
chrX_-_7834057 19.63 ENSMUST00000033502.14
GATA binding protein 1
chr3_+_14951264 19.03 ENSMUST00000192609.6
carbonic anhydrase 2
chr16_+_32427738 18.12 ENSMUST00000023486.15
transferrin receptor
chr16_+_32427789 16.95 ENSMUST00000120680.2
transferrin receptor
chr11_+_74510413 14.72 ENSMUST00000100866.3
coiled-coil domain containing 92B
chr2_-_131001916 14.64 ENSMUST00000103188.10
ENSMUST00000133602.8
ENSMUST00000028800.12
RIKEN cDNA 1700037H04 gene
chr15_+_89218601 14.46 ENSMUST00000023282.9
myo-inositol oxygenase
chr6_-_115739284 13.97 ENSMUST00000166254.7
ENSMUST00000170625.8
transmembrane protein 40
chr2_-_28453374 13.43 ENSMUST00000028161.6
carboxyl ester lipase
chr2_+_131028861 13.00 ENSMUST00000028804.15
ENSMUST00000079857.9
cell division cycle 25B
chr4_-_137157824 12.28 ENSMUST00000102522.5
chymotrypsin-like elastase family, member 3B
chr3_+_14951478 12.26 ENSMUST00000029078.9
carbonic anhydrase 2
chr1_-_167221344 11.57 ENSMUST00000028005.3
microsomal glutathione S-transferase 3
chr7_+_100143250 11.32 ENSMUST00000153287.8
uncoupling protein 2 (mitochondrial, proton carrier)
chr2_-_25911691 11.02 ENSMUST00000036509.14
ubiquitin associated domain containing 1
chr2_-_25911544 10.68 ENSMUST00000136750.3
ubiquitin associated domain containing 1
chr7_+_110368037 10.61 ENSMUST00000213373.2
adenosine monophosphate deaminase 3
chr15_-_103161237 10.17 ENSMUST00000154510.8
nuclear factor, erythroid derived 2
chr8_+_95722289 10.17 ENSMUST00000211984.2
adhesion G protein-coupled receptor G1
chr9_+_65008735 10.14 ENSMUST00000213533.2
ENSMUST00000035499.5
ENSMUST00000077696.13
ENSMUST00000166273.2
immunoglobulin superfamily, DCC subclass, member 4
chrX_+_74425990 9.87 ENSMUST00000033541.5
FUN14 domain containing 2
chr19_-_11618165 9.79 ENSMUST00000186023.7
membrane-spanning 4-domains, subfamily A, member 3
chr8_+_85696695 9.68 ENSMUST00000164807.2
peroxiredoxin 2
chr19_-_11618192 8.99 ENSMUST00000112984.4
membrane-spanning 4-domains, subfamily A, member 3
chr8_+_85696453 8.91 ENSMUST00000125893.8
peroxiredoxin 2
chr8_+_85696396 8.72 ENSMUST00000109733.8
peroxiredoxin 2
chr6_-_41012435 8.10 ENSMUST00000031931.6
RIKEN cDNA 2210010C04 gene
chr19_+_6450553 7.99 ENSMUST00000146831.8
ENSMUST00000035716.15
ENSMUST00000138555.8
ENSMUST00000167240.8
RAS, guanyl releasing protein 2
chr12_-_110945415 7.32 ENSMUST00000135131.2
ENSMUST00000043459.13
ENSMUST00000128353.8
ankyrin repeat domain 9
chr6_+_90596123 7.29 ENSMUST00000032177.10
solute carrier family 41, member 3
chr17_+_29042640 7.06 ENSMUST00000233088.2
ENSMUST00000233182.2
ENSMUST00000233520.2
bromodomain and PHD finger containing, 3
chr10_-_80691009 6.92 ENSMUST00000220225.2
ENSMUST00000035775.9
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
chr2_+_103788321 6.87 ENSMUST00000156813.8
ENSMUST00000170926.8
LIM domain only 2
chr2_+_32477069 6.21 ENSMUST00000102818.11
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
chr5_+_118165808 6.06 ENSMUST00000031304.14
tescalcin
chr6_+_30541581 6.03 ENSMUST00000096066.5
carboxypeptidase A2, pancreatic
chr11_-_3454766 5.98 ENSMUST00000044507.12
inositol polyphosphate 5-phosphatase J
chr19_+_6449887 5.96 ENSMUST00000146601.8
ENSMUST00000150713.8
RAS, guanyl releasing protein 2
chr15_-_63932288 5.92 ENSMUST00000063838.11
ENSMUST00000228908.2
CYFIP related Rac1 interactor B
chr9_+_44245981 5.85 ENSMUST00000052686.4
H2A.X variant histone
chr10_-_62363217 5.82 ENSMUST00000160987.8
serglycin
chr15_-_79976016 5.75 ENSMUST00000185306.3
ribosomal protein L3
chr17_+_29042544 5.71 ENSMUST00000140587.9
bromodomain and PHD finger containing, 3
chr7_+_4743114 5.62 ENSMUST00000098853.9
ENSMUST00000130215.8
ENSMUST00000108582.10
ENSMUST00000108583.9
lysine methyltransferase 5C
chr6_+_113508636 5.58 ENSMUST00000036340.12
ENSMUST00000204827.3
Fanconi anemia, complementation group D2
chr2_+_129435448 5.45 ENSMUST00000049262.14
ENSMUST00000163034.8
ENSMUST00000160276.2
signal-regulatory protein alpha
chr11_+_58839716 5.45 ENSMUST00000078267.5
H2B.U histone 2
chr4_-_116228921 5.42 ENSMUST00000239239.2
ENSMUST00000239177.2
microtubule associated serine/threonine kinase 2
chr7_-_126398165 5.40 ENSMUST00000205890.2
ENSMUST00000205336.2
ENSMUST00000087566.11
aldolase A, fructose-bisphosphate
chr15_-_79169671 5.31 ENSMUST00000170955.2
ENSMUST00000165408.8
BAI1-associated protein 2-like 2
chr13_+_21906214 5.13 ENSMUST00000224651.2
H2B clustered histone 14
chr13_+_21994588 5.10 ENSMUST00000091745.6
H2A clustered histone 23
chrX_-_73293425 4.82 ENSMUST00000114299.8
filamin, alpha
chr11_+_96941637 4.80 ENSMUST00000168565.2
oxysterol binding protein-like 7
chr11_+_96941420 4.74 ENSMUST00000090020.13
oxysterol binding protein-like 7
chr10_+_80100812 4.64 ENSMUST00000105362.8
ENSMUST00000105361.10
DAZ associated protein 1
chr19_+_6450641 4.51 ENSMUST00000113467.2
RAS, guanyl releasing protein 2
chr12_-_110945052 4.47 ENSMUST00000140788.8
ankyrin repeat domain 9
chr2_+_25152600 4.41 ENSMUST00000114336.4
taperin
chr6_-_76474767 4.40 ENSMUST00000097218.7
predicted pseudogene 9008
chr4_-_131802606 4.33 ENSMUST00000146021.8
erythrocyte membrane protein band 4.1
chr15_-_98626002 4.30 ENSMUST00000003445.8
FK506 binding protein 11
chr19_-_7218363 4.30 ENSMUST00000236769.2
N(alpha)-acetyltransferase 40, NatD catalytic subunit
chr12_+_102521225 4.27 ENSMUST00000021610.7
chromogranin A
chr4_+_131600918 4.22 ENSMUST00000053819.6
serine and arginine-rich splicing factor 4
chr3_-_107992662 4.21 ENSMUST00000078912.7
adenosine monophosphate deaminase 2
chr1_+_136059101 4.21 ENSMUST00000075164.11
kinesin family member 21B
chr12_-_110945376 4.18 ENSMUST00000142012.2
ankyrin repeat domain 9
chr19_+_8568618 4.04 ENSMUST00000170817.2
ENSMUST00000010251.11
solute carrier family 22 (organic anion transporter), member 8
chr3_-_54823287 4.02 ENSMUST00000070342.4
serine rich and transmembrane domain containing 1
chr4_+_63477018 3.88 ENSMUST00000077709.11
transmembrane protein 268
chr9_+_107879700 3.85 ENSMUST00000035214.11
ENSMUST00000176854.7
ENSMUST00000175874.2
inositol hexaphosphate kinase 1
chr13_-_22227114 3.80 ENSMUST00000091741.6
H2A clustered histone 11
chr7_-_33929667 3.77 ENSMUST00000206415.2
glucose-6-phosphate isomerase 1
chr1_+_75377616 3.76 ENSMUST00000122266.3
SPEG complex locus
chr7_+_46496506 3.76 ENSMUST00000209984.2
lactate dehydrogenase A
chrX_+_70600481 3.76 ENSMUST00000123100.2
high mobility group box 3
chr3_-_83947416 3.75 ENSMUST00000192095.6
ENSMUST00000191758.6
ENSMUST00000052342.9
transmembrane 131 like
chr7_+_130467564 3.72 ENSMUST00000075181.11
ENSMUST00000151119.9
ENSMUST00000048180.12
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr19_+_6449776 3.69 ENSMUST00000113468.8
RAS, guanyl releasing protein 2
chr15_-_63932176 3.67 ENSMUST00000226675.2
ENSMUST00000228226.2
ENSMUST00000227024.2
CYFIP related Rac1 interactor B
chr7_+_46496929 3.66 ENSMUST00000132157.2
ENSMUST00000210631.2
lactate dehydrogenase A
chr15_-_64254754 3.63 ENSMUST00000177374.8
ENSMUST00000110114.10
ENSMUST00000110115.9
ENSMUST00000023008.16
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
chr2_+_26518456 3.63 ENSMUST00000074240.4
divergent protein kinase domain 1B
chr7_-_33929708 3.62 ENSMUST00000038027.6
glucose-6-phosphate isomerase 1
chr15_+_78783867 3.60 ENSMUST00000134703.8
ENSMUST00000061239.14
ENSMUST00000109698.9
predicted gene, 49510
SH3-domain binding protein 1
chr5_+_33493529 3.55 ENSMUST00000202113.2
macrophage erythroblast attacher
chr2_-_167334746 3.55 ENSMUST00000109211.9
ENSMUST00000057627.16
spermatogenesis associated 2
chrX_+_141608694 3.51 ENSMUST00000112888.2
transmembrane protein 164
chr5_+_137628377 3.49 ENSMUST00000175968.8
leucine-rich repeats and calponin homology (CH) domain containing 4
chr4_+_34893772 3.48 ENSMUST00000029975.10
ENSMUST00000135871.8
ENSMUST00000108130.2
glycoprotein hormones, alpha subunit
chr8_-_106198112 3.48 ENSMUST00000014990.13
tubulin polymerization-promoting protein family member 3
chr7_+_46496552 3.48 ENSMUST00000005051.6
lactate dehydrogenase A
chr16_+_35590745 3.38 ENSMUST00000231579.2
Hspb associated protein 1
chr13_-_21937997 3.35 ENSMUST00000074752.4
H2A clustered histone 15
chr13_+_22227359 3.34 ENSMUST00000110452.2
H2B clustered histone 11
chr15_-_102425241 3.12 ENSMUST00000169162.8
ENSMUST00000023812.10
ENSMUST00000165174.8
ENSMUST00000169367.8
ENSMUST00000169377.8
mitogen-activated protein kinase kinase kinase 12
chr10_-_80184238 3.08 ENSMUST00000095446.10
ENSMUST00000105352.2
ADAMTS-like 5
chr7_-_105131407 3.05 ENSMUST00000047040.4
caveolae associated 3
chr19_+_47079187 3.02 ENSMUST00000072141.4
programmed cell death 11
chr9_+_107468146 3.01 ENSMUST00000195746.2
interferon-related developmental regulator 2
chr12_+_104998895 2.99 ENSMUST00000223244.2
ENSMUST00000021522.5
glutaredoxin 5
chr1_-_79838897 2.94 ENSMUST00000190724.2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr17_+_29251602 2.90 ENSMUST00000130216.3
serine and arginine-rich splicing factor 3
chr12_-_111638722 2.79 ENSMUST00000001304.9
creatine kinase, brain
chr7_-_35096133 2.78 ENSMUST00000154597.2
ENSMUST00000032704.12
Fanconi anemia core complex associated protein 24
chr13_+_21900554 2.75 ENSMUST00000070124.5
H2A clustered histone 13
chr16_-_20245071 2.71 ENSMUST00000115547.9
ENSMUST00000096199.5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr16_-_20245138 2.70 ENSMUST00000079158.13
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr1_+_135727571 2.69 ENSMUST00000148201.8
troponin I, skeletal, slow 1
chr16_-_8455525 2.66 ENSMUST00000052505.10
transmembrane protein 186
chr4_-_126096376 2.59 ENSMUST00000106142.8
ENSMUST00000169403.8
ENSMUST00000130334.2
thyroid hormone receptor associated protein 3
chr8_-_106022676 2.58 ENSMUST00000057855.4
exocyst complex component 3-like
chr3_-_86828140 2.53 ENSMUST00000029719.14
doublecortin-like kinase 2
chr17_-_24360516 2.52 ENSMUST00000115411.8
ENSMUST00000115409.9
ENSMUST00000115407.9
ENSMUST00000102927.10
3-phosphoinositide dependent protein kinase 1
chr8_-_106553822 2.50 ENSMUST00000239468.2
ENSMUST00000041400.6
RAN binding protein 10
chr2_+_155453103 2.46 ENSMUST00000092995.6
myosin, heavy chain 7B, cardiac muscle, beta
chr2_-_93283024 2.46 ENSMUST00000111257.8
ENSMUST00000145553.8
CD82 antigen
chr11_+_5008110 2.44 ENSMUST00000037218.2
RAS-like, family 10, member A
chr1_-_133537953 2.39 ENSMUST00000164574.2
ENSMUST00000166291.8
ENSMUST00000164096.2
ENSMUST00000166915.8
small nuclear ribonucleoprotein E
chr7_-_79115915 2.32 ENSMUST00000073889.14
polymerase (DNA directed), gamma
chr17_-_27247581 2.30 ENSMUST00000143158.3
BCL2-antagonist/killer 1
chr5_-_137609634 2.30 ENSMUST00000054564.13
procollagen C-endopeptidase enhancer protein
chr8_-_105350898 2.29 ENSMUST00000212882.2
ENSMUST00000163783.4
cadherin 16
chr15_-_77653979 2.28 ENSMUST00000229259.2
myosin, heavy polypeptide 9, non-muscle
chr8_-_70975813 2.27 ENSMUST00000121623.8
ENSMUST00000093456.12
ENSMUST00000118850.8
KxDL motif containing 1
chr5_-_5744024 2.26 ENSMUST00000115425.9
ENSMUST00000115427.8
ENSMUST00000115424.9
ENSMUST00000015797.11
six transmembrane epithelial antigen of prostate 2
chr11_+_98632631 2.23 ENSMUST00000064187.12
thyroid hormone receptor alpha
chr5_+_34527230 2.22 ENSMUST00000180376.8
family with sequence homology 193, member A
chr11_+_96820091 2.20 ENSMUST00000054311.6
ENSMUST00000107636.4
proline rich 15-like
chr5_-_5744559 2.17 ENSMUST00000115426.9
six transmembrane epithelial antigen of prostate 2
chr15_-_64254585 2.16 ENSMUST00000176384.8
ENSMUST00000175799.8
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
chr13_-_115068626 2.15 ENSMUST00000056117.10
integrin alpha 2
chr15_+_98006346 2.15 ENSMUST00000051226.8
phosphofructokinase, muscle
chrX_+_156482116 2.14 ENSMUST00000112521.8
small muscle protein, X-linked
chr11_+_121593582 2.14 ENSMUST00000125580.2
meteorin, glial cell differentiation regulator-like
chr11_+_96820220 2.13 ENSMUST00000062172.6
proline rich 15-like
chr5_-_137609691 2.11 ENSMUST00000031731.14
procollagen C-endopeptidase enhancer protein
chr15_+_84553801 2.10 ENSMUST00000171460.8
proline rich 5 (renal)
chr1_-_52230062 2.09 ENSMUST00000156887.8
ENSMUST00000129107.2
glutaminase
chr11_+_31822211 2.09 ENSMUST00000020543.13
ENSMUST00000109412.9
cytoplasmic polyadenylation element binding protein 4
chr4_-_137137088 2.08 ENSMUST00000024200.7
chymotrypsin-like elastase family, member 3A
chr7_-_100232276 2.04 ENSMUST00000152876.3
ENSMUST00000150042.8
ENSMUST00000132888.9
mitochondrial ribosomal protein L48
chr5_+_129802127 2.03 ENSMUST00000086046.10
ENSMUST00000186265.6
nipsnap homolog 2
chr19_-_46315543 2.02 ENSMUST00000223917.2
ENSMUST00000224447.2
ENSMUST00000041391.5
ENSMUST00000096029.12
pleckstrin and Sec7 domain containing
chr11_+_3939924 1.98 ENSMUST00000109981.2
galactose-3-O-sulfotransferase 1
chr2_-_30305472 1.96 ENSMUST00000134120.2
ENSMUST00000102854.10
carnitine acetyltransferase
chr9_+_57921954 1.95 ENSMUST00000034874.14
cytochrome P450, family 11, subfamily a, polypeptide 1
chr4_+_132857816 1.92 ENSMUST00000084241.12
ENSMUST00000138831.2
WASP family, member 2
chr17_-_27842237 1.91 ENSMUST00000062397.13
ENSMUST00000176876.8
ENSMUST00000146321.3
nudix (nucleotide diphosphate linked moiety X)-type motif 3
chr19_-_5416339 1.91 ENSMUST00000170010.3
BAF nuclear assembly factor 1
chr4_-_45108038 1.91 ENSMUST00000107809.9
ENSMUST00000107808.3
ENSMUST00000107807.2
ENSMUST00000107810.3
translocase of outer mitochondrial membrane 5
chr14_+_20979466 1.88 ENSMUST00000022369.9
vinculin
chr2_-_60793536 1.87 ENSMUST00000028347.13
RNA binding motif, single stranded interacting protein 1
chr19_-_60862964 1.86 ENSMUST00000025961.7
peroxiredoxin 3
chr1_-_75196496 1.83 ENSMUST00000186758.7
tubulin, alpha 4A
chr5_-_5744326 1.77 ENSMUST00000148333.8
six transmembrane epithelial antigen of prostate 2
chr7_-_97794679 1.73 ENSMUST00000098281.4
olfactory marker protein
chr7_+_127078371 1.71 ENSMUST00000205432.3
fibrosin
chr19_+_4203603 1.70 ENSMUST00000236632.2
protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
chr8_-_105350881 1.63 ENSMUST00000211903.2
cadherin 16
chr15_-_99355623 1.62 ENSMUST00000023747.14
NCK-associated protein 5-like
chr2_-_174314672 1.61 ENSMUST00000117442.8
ENSMUST00000141100.2
ENSMUST00000120822.2
PRELI domain containing 3B
chr7_-_4448631 1.58 ENSMUST00000008579.14
retinol dehydrogenase 13 (all-trans and 9-cis)
chr7_-_108774367 1.57 ENSMUST00000207178.2
LIM domain only 1
chr15_-_98729333 1.56 ENSMUST00000168846.3
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
chr10_-_59277570 1.56 ENSMUST00000009798.5
oncoprotein induced transcript 3
chr16_+_4704103 1.56 ENSMUST00000023159.10
ENSMUST00000070658.16
ENSMUST00000229038.2
mahogunin, ring finger 1
chr7_-_79115760 1.48 ENSMUST00000125562.2
polymerase (DNA directed), gamma
chr12_-_84240781 1.48 ENSMUST00000110294.2
mitotic deacetylase associated SANT domain protein
chr4_-_138858340 1.48 ENSMUST00000143971.2
mitochondrial contact site and cristae organizing system subunit 10
chr16_-_4607848 1.47 ENSMUST00000004173.12
cell death inducing Trp53 target 1
chr13_+_23930717 1.45 ENSMUST00000099703.5
H2B clustered histone 3
chr3_+_63883527 1.45 ENSMUST00000029405.8
guanine monophosphate synthetase
chr8_-_105350533 1.44 ENSMUST00000212662.2
cadherin 16
chr6_+_87864796 1.44 ENSMUST00000113607.10
ENSMUST00000049966.6
coatomer protein complex, subunit gamma 1
chr19_-_4665668 1.44 ENSMUST00000113822.3
leucine rich repeat and fibronectin type III domain containing 4
chrX_+_20529137 1.43 ENSMUST00000001989.9
ubiquitin-like modifier activating enzyme 1
chr19_-_4665509 1.42 ENSMUST00000053597.3
leucine rich repeat and fibronectin type III domain containing 4
chr7_-_130148984 1.42 ENSMUST00000160289.9
NSE4 homolog A, SMC5-SMC6 complex component
chr16_-_43800109 1.40 ENSMUST00000231700.2
zinc finger, DHHC domain containing 23
chr16_+_4704166 1.37 ENSMUST00000230990.2
mahogunin, ring finger 1
chr19_-_5733371 1.37 ENSMUST00000127876.8
pecanex homolog 3
chr4_-_126096551 1.36 ENSMUST00000080919.12
thyroid hormone receptor associated protein 3
chr9_+_45311000 1.35 ENSMUST00000216289.2
FXYD domain-containing ion transport regulator 2
chr2_+_172187485 1.33 ENSMUST00000028995.5
family with sequence similarity 210, member B
chr11_+_68979308 1.30 ENSMUST00000021273.13
vesicle-associated membrane protein 2
chr11_-_82761954 1.29 ENSMUST00000108173.10
ENSMUST00000071152.14
ring finger and FYVE like domain containing protein
chr5_-_137608886 1.29 ENSMUST00000142675.8
procollagen C-endopeptidase enhancer protein
chr4_+_133097013 1.27 ENSMUST00000030669.8
solute carrier family 9 (sodium/hydrogen exchanger), member 1
chr8_-_86281946 1.26 ENSMUST00000034138.7
DnaJ heat shock protein family (Hsp40) member A2
chr16_-_4607751 1.24 ENSMUST00000117713.8
cell death inducing Trp53 target 1
chr3_+_104545974 1.24 ENSMUST00000046212.2
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr19_-_5416626 1.22 ENSMUST00000237167.2
BAF nuclear assembly factor 1
chr2_-_30305779 1.21 ENSMUST00000102855.8
ENSMUST00000028207.13
carnitine acetyltransferase
chr5_+_24569802 1.21 ENSMUST00000115090.6
ENSMUST00000030834.7
nitric oxide synthase 3, endothelial cell
chr18_-_43610829 1.21 ENSMUST00000057110.11
eukaryotic translation initiation factor 3, subunit J2
chr3_+_96128427 1.20 ENSMUST00000090781.8
H2B clustered histone 21
chr11_-_58213939 1.19 ENSMUST00000108829.8
zinc finger protein 672

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.8 31.3 GO:0090089 positive regulation of cellular pH reduction(GO:0032849) dipeptide transmembrane transport(GO:0035442) regulation of oligopeptide transport(GO:0090088) regulation of dipeptide transport(GO:0090089) positive regulation of oligopeptide transport(GO:2000878) positive regulation of dipeptide transport(GO:2000880) regulation of dipeptide transmembrane transport(GO:2001148) positive regulation of dipeptide transmembrane transport(GO:2001150)
6.5 19.6 GO:0030221 basophil differentiation(GO:0030221)
2.3 27.3 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536)
2.2 38.1 GO:0001542 ovulation from ovarian follicle(GO:0001542)
2.2 35.1 GO:0033572 transferrin transport(GO:0033572)
1.6 6.4 GO:0033366 protein localization to secretory granule(GO:0033366) protein localization to mast cell secretory granule(GO:0033367) protease localization to mast cell secretory granule(GO:0033368) maintenance of protein location in mast cell secretory granule(GO:0033370) T cell secretory granule organization(GO:0033371) maintenance of protease location in mast cell secretory granule(GO:0033373) protein localization to T cell secretory granule(GO:0033374) protease localization to T cell secretory granule(GO:0033375) maintenance of protein location in T cell secretory granule(GO:0033377) maintenance of protease location in T cell secretory granule(GO:0033379) granzyme B localization to T cell secretory granule(GO:0033380) maintenance of granzyme B location in T cell secretory granule(GO:0033382)
1.6 4.8 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
1.5 6.1 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417)
1.5 14.8 GO:0032264 IMP salvage(GO:0032264)
1.4 13.0 GO:0007144 female meiosis I(GO:0007144)
1.4 18.3 GO:0006020 inositol metabolic process(GO:0006020)
1.3 13.9 GO:0006113 fermentation(GO:0006113)
1.2 7.2 GO:0061110 dense core granule biogenesis(GO:0061110)
1.2 9.5 GO:0061621 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
1.2 3.6 GO:0048822 enucleate erythrocyte development(GO:0048822)
1.0 3.1 GO:0019043 establishment of viral latency(GO:0019043)
1.0 4.0 GO:0042939 glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
0.8 5.8 GO:1903525 regulation of membrane tubulation(GO:1903525) positive regulation of membrane tubulation(GO:1903527)
0.8 6.2 GO:0097461 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.8 3.1 GO:0071544 diphosphoinositol polyphosphate catabolic process(GO:0071544)
0.7 10.2 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.6 3.8 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.6 13.4 GO:0046514 ceramide catabolic process(GO:0046514)
0.6 2.3 GO:0010046 response to mycotoxin(GO:0010046)
0.6 2.3 GO:1903923 protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
0.6 11.4 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.6 5.6 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.6 2.2 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.5 3.7 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.5 6.9 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.5 2.0 GO:2000984 regulation of ATP citrate synthase activity(GO:2000983) negative regulation of ATP citrate synthase activity(GO:2000984)
0.5 5.6 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.5 3.2 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.4 1.3 GO:1903281 positive regulation of calcium:sodium antiporter activity(GO:1903281)
0.4 5.4 GO:0061615 glycolytic process through fructose-6-phosphate(GO:0061615)
0.4 9.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.4 5.4 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.3 3.0 GO:0009249 protein lipoylation(GO:0009249)
0.3 1.3 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.3 3.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.3 2.2 GO:0043308 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
0.3 3.5 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.3 1.2 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.3 3.2 GO:0071397 cellular response to cholesterol(GO:0071397)
0.3 2.9 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.3 1.9 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.2 6.0 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.2 0.7 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.2 4.3 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.2 2.1 GO:0051971 positive regulation of transmission of nerve impulse(GO:0051971)
0.2 2.1 GO:0038203 TORC2 signaling(GO:0038203)
0.2 8.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.2 1.6 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.2 2.0 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 20.2 GO:0071277 cellular response to calcium ion(GO:0071277)
0.2 1.7 GO:0009644 response to high light intensity(GO:0009644)
0.2 1.5 GO:0006177 GMP biosynthetic process(GO:0006177)
0.2 3.5 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.2 0.6 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.2 7.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 5.3 GO:2000251 actin crosslink formation(GO:0051764) positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.2 1.0 GO:0060903 positive regulation of meiosis I(GO:0060903)
0.2 3.0 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.2 2.1 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.2 3.4 GO:0033327 Leydig cell differentiation(GO:0033327)
0.2 3.0 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466)
0.2 5.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.2 4.3 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474) histone H2A acetylation(GO:0043968)
0.2 2.6 GO:0051601 exocyst localization(GO:0051601)
0.1 0.9 GO:0048840 otolith development(GO:0048840)
0.1 1.3 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 12.8 GO:0043966 histone H3 acetylation(GO:0043966)
0.1 1.0 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.1 1.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 2.5 GO:0006972 hyperosmotic response(GO:0006972)
0.1 1.4 GO:0051683 establishment of Golgi localization(GO:0051683)
0.1 2.7 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.1 0.5 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 0.7 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 1.6 GO:0006642 triglyceride mobilization(GO:0006642)
0.1 1.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 4.2 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 0.6 GO:0034436 glycoprotein transport(GO:0034436) response to high density lipoprotein particle(GO:0055099)
0.1 6.2 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 1.8 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.1 1.0 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.3 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.1 0.8 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.1 0.3 GO:2000657 regulation of apolipoprotein binding(GO:2000656) negative regulation of apolipoprotein binding(GO:2000657)
0.1 0.5 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1 0.2 GO:0001698 gastrin-induced gastric acid secretion(GO:0001698)
0.1 1.7 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.1 2.1 GO:0001967 suckling behavior(GO:0001967)
0.1 0.8 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 0.9 GO:1901070 guanosine-containing compound biosynthetic process(GO:1901070)
0.1 1.9 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.1 0.5 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.1 1.6 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.1 2.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 0.5 GO:0044351 macropinocytosis(GO:0044351)
0.1 1.0 GO:1901626 regulation of postsynaptic membrane organization(GO:1901626)
0.1 1.0 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.1 0.6 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 1.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.0 0.7 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.2 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 1.1 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.0 0.9 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 1.2 GO:0042026 protein refolding(GO:0042026)
0.0 0.3 GO:0016198 axon choice point recognition(GO:0016198)
0.0 5.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.3 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.4 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 0.2 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.0 0.2 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.0 2.5 GO:0046785 microtubule polymerization(GO:0046785)
0.0 0.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.3 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 5.1 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.2 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.1 GO:0033058 directional locomotion(GO:0033058)
0.0 1.6 GO:0032418 lysosome localization(GO:0032418)
0.0 0.8 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 1.0 GO:0042073 intraciliary transport(GO:0042073)
0.0 0.8 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.5 GO:0060008 Sertoli cell differentiation(GO:0060008)
0.0 0.1 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 1.4 GO:2001022 positive regulation of response to DNA damage stimulus(GO:2001022)
0.0 0.7 GO:0050798 activated T cell proliferation(GO:0050798)
0.0 0.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 1.5 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 0.1 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 7.0 GO:0007017 microtubule-based process(GO:0007017)
0.0 12.9 GO:0051726 regulation of cell cycle(GO:0051726)
0.0 0.4 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.2 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 35.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
1.4 12.8 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
1.3 3.8 GO:0005760 gamma DNA polymerase complex(GO:0005760)
0.9 10.2 GO:0097451 glial limiting end-foot(GO:0097451)
0.8 4.8 GO:0031523 Myb complex(GO:0031523)
0.8 6.9 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.7 5.8 GO:0005826 actomyosin contractile ring(GO:0005826)
0.7 4.3 GO:0042583 chromaffin granule(GO:0042583)
0.7 16.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.6 6.4 GO:0042629 mast cell granule(GO:0042629)
0.5 2.7 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.5 2.1 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.4 15.6 GO:0042588 zymogen granule(GO:0042588)
0.4 5.3 GO:0071439 clathrin complex(GO:0071439)
0.4 2.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.4 2.9 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.3 9.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.3 2.1 GO:0005927 muscle tendon junction(GO:0005927)
0.3 3.5 GO:0097427 microtubule bundle(GO:0097427)
0.3 8.9 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.2 6.2 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.2 0.8 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.2 1.1 GO:0098890 extrinsic component of postsynaptic membrane(GO:0098890)
0.2 2.4 GO:0005687 U4 snRNP(GO:0005687)
0.2 29.0 GO:0005902 microvillus(GO:0005902)
0.2 3.1 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.2 1.3 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.2 5.6 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.2 29.8 GO:0032993 protein-DNA complex(GO:0032993)
0.2 0.6 GO:0032021 NELF complex(GO:0032021)
0.1 0.7 GO:1990130 Iml1 complex(GO:1990130)
0.1 2.8 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 7.7 GO:0002102 podosome(GO:0002102)
0.1 1.4 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 2.1 GO:0031932 TORC2 complex(GO:0031932)
0.1 5.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 1.0 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 1.9 GO:0031209 SCAR complex(GO:0031209)
0.1 0.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 2.0 GO:0030061 mitochondrial crista(GO:0030061)
0.1 2.6 GO:0000145 exocyst(GO:0000145)
0.1 2.5 GO:0032982 myosin filament(GO:0032982)
0.1 30.5 GO:0043209 myelin sheath(GO:0043209)
0.1 1.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.8 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 0.3 GO:0005745 m-AAA complex(GO:0005745)
0.1 13.0 GO:0000922 spindle pole(GO:0000922)
0.1 1.6 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 3.0 GO:0032040 small-subunit processome(GO:0032040)
0.1 5.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 1.3 GO:0035371 microtubule plus-end(GO:0035371)
0.1 4.6 GO:0005844 polysome(GO:0005844)
0.1 14.4 GO:0001726 ruffle(GO:0001726)
0.1 0.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 4.2 GO:0005871 kinesin complex(GO:0005871)
0.1 0.2 GO:0005757 mitochondrial permeability transition pore complex(GO:0005757)
0.1 1.4 GO:0030057 desmosome(GO:0030057)
0.1 1.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 2.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.1 GO:0099634 postsynaptic specialization membrane(GO:0099634)
0.0 0.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 8.7 GO:0000793 condensed chromosome(GO:0000793)
0.0 1.0 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 1.0 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.1 GO:0001652 granular component(GO:0001652)
0.0 3.4 GO:0016605 PML body(GO:0016605)
0.0 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0097444 spine apparatus(GO:0097444)
0.0 1.0 GO:0008305 integrin complex(GO:0008305)
0.0 3.6 GO:0005901 caveola(GO:0005901)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 10.7 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.1 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 3.2 GO:0001650 fibrillar center(GO:0001650)
0.0 1.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 4.7 GO:0016607 nuclear speck(GO:0016607)
0.0 2.9 GO:0005769 early endosome(GO:0005769)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.2 36.9 GO:0004566 beta-glucuronidase activity(GO:0004566)
7.0 35.1 GO:0004998 transferrin receptor activity(GO:0004998)
4.5 13.4 GO:0050253 sterol esterase activity(GO:0004771) retinyl-palmitate esterase activity(GO:0050253)
3.1 31.3 GO:0004064 arylesterase activity(GO:0004064)
2.0 6.0 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
1.9 29.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
1.9 11.3 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
1.5 14.8 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
1.1 14.5 GO:0008199 ferric iron binding(GO:0008199)
1.1 19.6 GO:0008301 DNA binding, bending(GO:0008301)
1.0 10.9 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.8 4.8 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.8 5.6 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.8 3.2 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.8 6.2 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.8 5.3 GO:0004111 creatine kinase activity(GO:0004111)
0.7 7.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.7 7.5 GO:0070061 fructose binding(GO:0070061)
0.6 3.9 GO:0052724 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.6 6.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.6 2.2 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.5 7.1 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.5 2.0 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.5 2.0 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386)
0.5 4.3 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.4 4.0 GO:0015651 quaternary ammonium group transmembrane transporter activity(GO:0015651)
0.4 3.1 GO:0034432 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.4 1.2 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.4 2.4 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.4 5.7 GO:0008097 5S rRNA binding(GO:0008097)
0.4 2.1 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.4 2.5 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.3 1.4 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.3 11.6 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.3 1.4 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.2 1.0 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.2 20.5 GO:0005518 collagen binding(GO:0005518)
0.2 6.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 2.4 GO:1990446 U1 snRNP binding(GO:1990446)
0.2 3.3 GO:0043495 protein anchor(GO:0043495)
0.2 0.5 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.2 3.8 GO:0035613 RNA stem-loop binding(GO:0035613)
0.2 1.2 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.2 5.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 0.6 GO:0034437 glycoprotein transporter activity(GO:0034437)
0.1 2.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 8.5 GO:0050699 WW domain binding(GO:0050699)
0.1 0.4 GO:0001847 opsonin receptor activity(GO:0001847)
0.1 1.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 4.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.7 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 0.9 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.1 1.9 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 3.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.5 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 4.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 6.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 4.0 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 2.3 GO:0051400 BH domain binding(GO:0051400)
0.1 1.1 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 3.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 2.5 GO:0043274 phospholipase binding(GO:0043274)
0.1 0.5 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 1.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 13.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 1.6 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 2.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.8 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 2.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 5.8 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.1 0.3 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 0.2 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 3.9 GO:0015485 cholesterol binding(GO:0015485)
0.0 6.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 10.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 16.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.3 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 1.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 4.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.8 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 2.4 GO:0003774 motor activity(GO:0003774)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 2.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.0 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 1.0 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 4.5 GO:0005179 hormone activity(GO:0005179)
0.0 0.7 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 1.3 GO:0001671 ATPase activator activity(GO:0001671)
0.0 2.1 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.2 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 2.8 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.9 GO:0002039 p53 binding(GO:0002039)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 3.7 GO:0003924 GTPase activity(GO:0003924)
0.0 0.2 GO:0017081 chloride channel regulator activity(GO:0017081)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 13.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.0 80.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 23.4 PID RAS PATHWAY Regulation of Ras family activation
0.2 19.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.2 16.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 4.3 PID ARF 3PATHWAY Arf1 pathway
0.2 5.6 PID ATM PATHWAY ATM pathway
0.1 6.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 5.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 3.7 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.1 4.8 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 2.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 3.1 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 0.7 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 4.0 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.9 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.0 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 8.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.5 PID ENDOTHELIN PATHWAY Endothelins
0.0 2.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 5.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.3 PID TNF PATHWAY TNF receptor signaling pathway
0.0 1.2 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 1.1 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.3 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 35.1 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.6 13.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.6 14.8 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.6 22.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.4 3.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.4 5.6 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.4 6.7 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.3 3.5 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.3 8.4 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.3 4.0 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.3 6.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 11.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 2.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 11.7 REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION Genes involved in Cleavage of Growing Transcript in the Termination Region
0.2 28.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 5.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 7.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 2.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.6 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 6.0 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 1.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 2.5 REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.1 1.2 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 3.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 8.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 5.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 2.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 0.9 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 5.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 2.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.3 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.8 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 1.1 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.5 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.8 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.7 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis