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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Obox3

Z-value: 1.01

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Transcription factors associated with Obox3

Gene Symbol Gene ID Gene Info
Obox3
ENSMUSG00000066772.13 Obox3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Obox3mm39_v1_chr7_-_15361801_153618010.372.6e-02Click!

Activity profile of Obox3 motif

Sorted Z-values of Obox3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Obox3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_+_76579885 3.27 ENSMUST00000231028.2
Gpt
glutamic pyruvic transaminase, soluble
chr15_+_76579960 3.08 ENSMUST00000229679.2
Gpt
glutamic pyruvic transaminase, soluble
chr10_-_75617245 2.45 ENSMUST00000001715.10
Gstt3
glutathione S-transferase, theta 3
chr11_+_3981769 1.45 ENSMUST00000019512.8
Sec14l4
SEC14-like lipid binding 4
chr2_-_23939401 1.36 ENSMUST00000051416.12
Hnmt
histamine N-methyltransferase
chr3_-_63872189 0.84 ENSMUST00000029402.15
Slc33a1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr4_-_137137088 0.80 ENSMUST00000024200.7
Cela3a
chymotrypsin-like elastase family, member 3A
chr7_-_103492361 0.72 ENSMUST00000063957.6
Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr3_-_63872079 0.71 ENSMUST00000161659.8
Slc33a1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr11_-_68864666 0.70 ENSMUST00000038644.5
Rangrf
RAN guanine nucleotide release factor
chr10_+_111808569 0.65 ENSMUST00000163048.8
ENSMUST00000174653.2
Krr1
KRR1, small subunit (SSU) processome component, homolog (yeast)
chr2_+_144435974 0.62 ENSMUST00000136628.2
Smim26
small integral membrane protein 26
chr6_-_122317156 0.58 ENSMUST00000159384.8
Phc1
polyhomeotic 1
chrX_+_73468140 0.57 ENSMUST00000135165.8
ENSMUST00000114128.8
ENSMUST00000004330.10
ENSMUST00000114133.9
ENSMUST00000114129.9
ENSMUST00000132749.2
Ikbkg
inhibitor of kappaB kinase gamma
chr9_+_62249341 0.55 ENSMUST00000135395.8
Anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr7_+_43361930 0.49 ENSMUST00000066834.8
Klk13
kallikrein related-peptidase 13
chr3_-_73615732 0.45 ENSMUST00000029367.6
Bche
butyrylcholinesterase
chr9_+_62249730 0.44 ENSMUST00000156461.2
Anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chrX_+_141010919 0.39 ENSMUST00000042329.12
Nxt2
nuclear transport factor 2-like export factor 2
chr1_+_140173787 0.37 ENSMUST00000239229.2
ENSMUST00000120709.8
ENSMUST00000120796.8
ENSMUST00000119786.8
Kcnt2
potassium channel, subfamily T, member 2
chr2_-_164455520 0.35 ENSMUST00000094351.11
ENSMUST00000109338.2
Wfdc8
WAP four-disulfide core domain 8
chr2_+_152804405 0.35 ENSMUST00000099197.9
ENSMUST00000103155.10
Ttll9
tubulin tyrosine ligase-like family, member 9
chr2_+_69553141 0.34 ENSMUST00000090858.10
Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chrX_+_139565319 0.30 ENSMUST00000128809.2
Mid2
midline 2
chr6_-_91784299 0.30 ENSMUST00000159684.8
Grip2
glutamate receptor interacting protein 2
chr19_-_46314945 0.30 ENSMUST00000225781.2
ENSMUST00000223903.2
Psd
pleckstrin and Sec7 domain containing
chr18_-_78100610 0.29 ENSMUST00000170760.3
Siglec15
sialic acid binding Ig-like lectin 15
chr18_+_42644552 0.28 ENSMUST00000237602.2
ENSMUST00000236088.2
ENSMUST00000025375.15
Tcerg1
transcription elongation regulator 1 (CA150)
chr3_-_19682833 0.28 ENSMUST00000119133.2
1700064H15Rik
RIKEN cDNA 1700064H15 gene
chr6_-_91784405 0.28 ENSMUST00000162300.8
Grip2
glutamate receptor interacting protein 2
chr17_+_9207165 0.27 ENSMUST00000024650.12
1700010I14Rik
RIKEN cDNA 1700010I14 gene
chr11_+_70350963 0.27 ENSMUST00000126105.2
Zmynd15
zinc finger, MYND-type containing 15
chr10_+_76284907 0.26 ENSMUST00000092406.12
2610028H24Rik
RIKEN cDNA 2610028H24 gene
chr11_+_70350725 0.26 ENSMUST00000147289.2
Zmynd15
zinc finger, MYND-type containing 15
chr1_+_17797257 0.25 ENSMUST00000159958.8
ENSMUST00000160305.8
ENSMUST00000095075.5
Crispld1
cysteine-rich secretory protein LCCL domain containing 1
chr7_+_48438751 0.25 ENSMUST00000118927.8
ENSMUST00000125280.8
Zdhhc13
zinc finger, DHHC domain containing 13
chr16_-_20135500 0.24 ENSMUST00000182741.2
Cyp2ab1
cytochrome P450, family 2, subfamily ab, polypeptide 1
chr7_+_114318746 0.24 ENSMUST00000182044.2
Calcb
calcitonin-related polypeptide, beta
chr4_-_129015493 0.23 ENSMUST00000135763.2
ENSMUST00000149763.3
ENSMUST00000164649.8
Hpca
hippocalcin
chr11_+_60956624 0.23 ENSMUST00000041944.9
ENSMUST00000108717.3
Kcnj12
potassium inwardly-rectifying channel, subfamily J, member 12
chr19_+_3817396 0.23 ENSMUST00000052699.13
ENSMUST00000113974.11
ENSMUST00000113972.9
ENSMUST00000113973.8
ENSMUST00000113977.9
ENSMUST00000113968.9
Kmt5b
lysine methyltransferase 5B
chr14_-_118289557 0.22 ENSMUST00000022725.4
Dct
dopachrome tautomerase
chr12_-_109019507 0.22 ENSMUST00000185745.2
ENSMUST00000239108.2
Begain
brain-enriched guanylate kinase-associated
chr4_+_73931679 0.22 ENSMUST00000098006.9
ENSMUST00000084474.6
Frmd3
FERM domain containing 3
chr11_-_95405368 0.21 ENSMUST00000058866.8
Nxph3
neurexophilin 3
chr14_+_61375893 0.21 ENSMUST00000089394.10
Sacs
sacsin
chr17_+_9207180 0.20 ENSMUST00000151609.2
ENSMUST00000232775.2
ENSMUST00000136954.3
1700010I14Rik
RIKEN cDNA 1700010I14 gene
chr9_+_73020708 0.20 ENSMUST00000169399.8
ENSMUST00000034738.14
Rsl24d1
ribosomal L24 domain containing 1
chr17_+_26005538 0.20 ENSMUST00000095500.5
Ccdc78
coiled-coil domain containing 78
chr11_-_69127848 0.18 ENSMUST00000021259.9
ENSMUST00000108665.8
ENSMUST00000108664.2
Gucy2e
guanylate cyclase 2e
chr8_-_65440483 0.18 ENSMUST00000210982.2
Trim75
tripartite motif-containing 75
chr13_-_23553327 0.18 ENSMUST00000125328.2
ENSMUST00000145451.8
ENSMUST00000050101.9
Zfp322a
zinc finger protein 322A
chr11_+_51895166 0.17 ENSMUST00000109076.2
Cdkl3
cyclin-dependent kinase-like 3
chr1_-_52271455 0.17 ENSMUST00000114512.8
Gls
glutaminase
chr1_+_60948149 0.17 ENSMUST00000027164.9
Ctla4
cytotoxic T-lymphocyte-associated protein 4
chr10_-_107330580 0.17 ENSMUST00000044210.5
Myf6
myogenic factor 6
chr5_-_93688059 0.16 ENSMUST00000200745.2
Pramel33
PRAME like 33
chr16_+_34511073 0.16 ENSMUST00000231609.2
Ccdc14
coiled-coil domain containing 14
chr4_-_34050076 0.16 ENSMUST00000029927.6
Spaca1
sperm acrosome associated 1
chr19_+_3817953 0.16 ENSMUST00000113970.8
Kmt5b
lysine methyltransferase 5B
chr4_-_34050038 0.16 ENSMUST00000084734.11
Spaca1
sperm acrosome associated 1
chr1_+_60948307 0.15 ENSMUST00000097720.4
Ctla4
cytotoxic T-lymphocyte-associated protein 4
chr18_+_37630044 0.15 ENSMUST00000059571.7
Pcdhb19
protocadherin beta 19
chr8_+_20078070 0.15 ENSMUST00000084046.6
Gm15319
predicted gene 15319
chr8_+_21154935 0.15 ENSMUST00000178438.3
Gm21119
predicted gene, 21119
chr8_+_19779592 0.15 ENSMUST00000098909.5
4930467E23Rik
RIKEN cDNA 4930467E23 gene
chr3_-_73615535 0.14 ENSMUST00000138216.8
Bche
butyrylcholinesterase
chr14_+_14210932 0.14 ENSMUST00000022271.14
Acox2
acyl-Coenzyme A oxidase 2, branched chain
chr16_+_32066037 0.14 ENSMUST00000141820.8
ENSMUST00000178573.8
ENSMUST00000023474.4
ENSMUST00000135289.2
Wdr53
WD repeat domain 53
chr8_-_65440298 0.13 ENSMUST00000095295.3
Trim75
tripartite motif-containing 75
chr13_+_41154478 0.13 ENSMUST00000046951.10
Pak1ip1
PAK1 interacting protein 1
chr19_+_3818112 0.12 ENSMUST00000005518.16
ENSMUST00000237440.2
ENSMUST00000152935.8
ENSMUST00000176262.8
ENSMUST00000176407.8
ENSMUST00000176926.8
ENSMUST00000176512.8
Kmt5b
lysine methyltransferase 5B
chr7_-_11414074 0.12 ENSMUST00000227010.2
ENSMUST00000209638.3
Vmn1r72
vomeronasal 1 receptor 72
chr14_-_31362835 0.11 ENSMUST00000167066.8
ENSMUST00000127204.9
Hacl1
2-hydroxyacyl-CoA lyase 1
chr6_+_90246088 0.11 ENSMUST00000058039.3
Vmn1r54
vomeronasal 1 receptor 54
chr16_-_17732923 0.10 ENSMUST00000012279.6
ENSMUST00000232493.2
Gsc2
goosecoid homebox 2
chr12_-_101943134 0.10 ENSMUST00000221227.2
Ndufb1
NADH:ubiquinone oxidoreductase subunit B1
chr1_-_119765343 0.09 ENSMUST00000064091.12
Ptpn4
protein tyrosine phosphatase, non-receptor type 4
chr3_+_55023594 0.09 ENSMUST00000146109.2
Spg20
spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)
chr4_+_33062999 0.09 ENSMUST00000108162.8
ENSMUST00000024035.9
Gabrr2
gamma-aminobutyric acid (GABA) C receptor, subunit rho 2
chr9_-_40025502 0.08 ENSMUST00000217536.3
Olfr984
olfactory receptor 984
chr12_+_21366386 0.08 ENSMUST00000076813.8
ENSMUST00000221693.2
ENSMUST00000223345.2
ENSMUST00000222344.2
Iah1
isoamyl acetate-hydrolyzing esterase 1 homolog
chr4_+_114857370 0.08 ENSMUST00000129957.8
Stil
Scl/Tal1 interrupting locus
chr1_-_119765068 0.07 ENSMUST00000163435.8
Ptpn4
protein tyrosine phosphatase, non-receptor type 4
chr9_+_38630317 0.06 ENSMUST00000129598.2
Vwa5a
von Willebrand factor A domain containing 5A
chr1_-_119764729 0.05 ENSMUST00000163621.2
ENSMUST00000168303.8
Ptpn4
protein tyrosine phosphatase, non-receptor type 4
chr18_-_3281752 0.05 ENSMUST00000140332.8
ENSMUST00000147138.8
Crem
cAMP responsive element modulator
chr9_-_21223631 0.03 ENSMUST00000115433.11
Ap1m2
adaptor protein complex AP-1, mu 2 subunit
chr18_-_43526411 0.03 ENSMUST00000025379.14
Dpysl3
dihydropyrimidinase-like 3
chr19_+_8595369 0.03 ENSMUST00000010250.4
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr7_-_110581376 0.02 ENSMUST00000154466.2
Irag1
inositol 1,4,5-triphosphate receptor associated 1
chr16_-_19341016 0.02 ENSMUST00000214315.2
Olfr167
olfactory receptor 167
chr15_+_81548090 0.02 ENSMUST00000023029.15
ENSMUST00000174229.8
ENSMUST00000172748.8
L3mbtl2
L3MBTL2 polycomb repressive complex 1 subunit
chr16_+_33614378 0.02 ENSMUST00000115044.8
Muc13
mucin 13, epithelial transmembrane
chr9_+_50528608 0.00 ENSMUST00000000171.15
ENSMUST00000151197.8
Pih1d2
PIH1 domain containing 2
chr19_+_44980565 0.00 ENSMUST00000179305.2
Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0001692 histamine metabolic process(GO:0001692)
0.1 0.6 GO:0014016 neuroblast differentiation(GO:0014016)
0.1 0.7 GO:0015671 oxygen transport(GO:0015671)
0.1 0.2 GO:0030824 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.1 0.7 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.1 0.2 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.3 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.0 0.1 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.0 0.6 GO:0014824 artery smooth muscle contraction(GO:0014824)
0.0 0.5 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.2 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.1 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.0 2.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.6 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.2 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.2 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.3 GO:2001204 regulation of osteoclast development(GO:2001204)
0.0 1.5 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.1 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0098536 deuterosome(GO:0098536)
0.0 0.6 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.2 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.5 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 1.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.4 GO:0047635 L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635)
0.3 1.5 GO:0051185 coenzyme transporter activity(GO:0051185)
0.2 0.6 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.2 0.7 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 0.5 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 2.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.2 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.6 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 1.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.6 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.6 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors