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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Pax3

Z-value: 1.55

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Transcription factors associated with Pax3

Gene Symbol Gene ID Gene Info
Pax3
ENSMUSG00000004872.16 Pax3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax3mm39_v1_chr1_-_78173468_781734820.019.4e-01Click!

Activity profile of Pax3 motif

Sorted Z-values of Pax3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_-_84058292 10.90 ENSMUST00000050771.8
Gm11437
predicted gene 11437
chr5_-_87240405 10.61 ENSMUST00000132667.2
ENSMUST00000145617.8
ENSMUST00000094649.11
Ugt2b36
UDP glucuronosyltransferase 2 family, polypeptide B36
chr13_+_4484305 10.55 ENSMUST00000021630.15
Akr1c6
aldo-keto reductase family 1, member C6
chr2_+_102489558 6.41 ENSMUST00000111213.8
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr19_-_46136765 2.87 ENSMUST00000026259.16
Pitx3
paired-like homeodomain transcription factor 3
chr10_-_115197775 2.87 ENSMUST00000217848.2
Tmem19
transmembrane protein 19
chr7_-_133384449 2.28 ENSMUST00000063669.8
Dhx32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr19_-_36714053 2.12 ENSMUST00000087321.4
Ppp1r3c
protein phosphatase 1, regulatory subunit 3C
chr11_-_88742285 2.02 ENSMUST00000107903.8
Akap1
A kinase (PRKA) anchor protein 1
chr10_-_128759331 1.64 ENSMUST00000153731.8
ENSMUST00000026405.10
Bloc1s1
biogenesis of lysosomal organelles complex-1, subunit 1
chr10_-_128759817 1.63 ENSMUST00000131271.2
Bloc1s1
biogenesis of lysosomal organelles complex-1, subunit 1
chr1_+_176642226 1.41 ENSMUST00000056773.15
ENSMUST00000027785.15
Sdccag8
serologically defined colon cancer antigen 8
chr4_-_25281750 1.31 ENSMUST00000038705.8
ENSMUST00000102994.10
Ufl1
UFM1 specific ligase 1
chr3_+_108093645 1.07 ENSMUST00000050909.7
ENSMUST00000106659.3
ENSMUST00000106656.2
Amigo1
adhesion molecule with Ig like domain 1
chr16_+_20367327 0.98 ENSMUST00000003319.6
ENSMUST00000232680.2
ENSMUST00000232490.2
Abcf3
ATP-binding cassette, sub-family F (GCN20), member 3
chr4_+_126971167 0.85 ENSMUST00000046751.13
ENSMUST00000094713.4
Zmym6
zinc finger, MYM-type 6
chr8_+_111345209 0.84 ENSMUST00000034190.11
Vac14
Vac14 homolog (S. cerevisiae)
chr10_-_80374916 0.83 ENSMUST00000219648.2
Atp8b3
ATPase, class I, type 8B, member 3
chr14_+_52131067 0.83 ENSMUST00000047726.12
Slc39a2
solute carrier family 39 (zinc transporter), member 2
chr2_+_133394079 0.79 ENSMUST00000028836.7
Bmp2
bone morphogenetic protein 2
chr3_-_59170245 0.66 ENSMUST00000050360.14
ENSMUST00000199609.2
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr4_+_106954794 0.65 ENSMUST00000221740.2
Cdcp2
CUB domain containing protein 2
chr6_+_34897904 0.61 ENSMUST00000185102.2
ENSMUST00000114997.3
Stra8
stimulated by retinoic acid gene 8
chr13_-_21900313 0.58 ENSMUST00000091756.2
H2bc13
H2B clustered histone 13
chr13_-_74538899 0.54 ENSMUST00000223163.3
Zfp72
zinc finger protein 72
chr2_+_168072519 0.54 ENSMUST00000099071.5
Mocs3
molybdenum cofactor synthesis 3
chr10_+_36382810 0.52 ENSMUST00000167191.8
ENSMUST00000058738.11
Hs3st5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr16_+_4964849 0.49 ENSMUST00000165810.2
ENSMUST00000230616.2
Sec14l5
SEC14-like lipid binding 5
chr12_-_72231802 0.45 ENSMUST00000021494.6
Ccdc175
coiled-coil domain containing 175
chr7_-_139941566 0.43 ENSMUST00000215023.2
ENSMUST00000216027.2
ENSMUST00000210932.3
ENSMUST00000211031.3
Olfr60
olfactory receptor 60
chr2_-_136229849 0.41 ENSMUST00000035264.9
ENSMUST00000077200.4
Pak5
p21 (RAC1) activated kinase 5
chr17_-_23990512 0.40 ENSMUST00000226460.2
Flywch1
FLYWCH-type zinc finger 1
chrX_+_113384008 0.40 ENSMUST00000113371.8
ENSMUST00000040504.12
Klhl4
kelch-like 4
chr16_-_32698091 0.38 ENSMUST00000119810.2
Rubcn
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
chr10_+_103987773 0.37 ENSMUST00000180692.3
Gm6763
predicted gene 6763
chr10_+_103996282 0.37 ENSMUST00000181166.3
Gm8764
predicted gene 8764
chr10_+_104030318 0.37 ENSMUST00000181036.2
Gm4340
predicted gene 4340
chr10_+_103979263 0.37 ENSMUST00000180664.2
Gm21293
predicted gene, 21293
chr10_+_104004791 0.37 ENSMUST00000180568.2
Gm21304
predicted gene, 21304
chr10_+_104013300 0.37 ENSMUST00000181239.2
Gm21312
predicted gene, 21312
chr10_+_104021809 0.37 ENSMUST00000181707.2
Gm20765
predicted gene, 20765
chr6_-_87312681 0.36 ENSMUST00000204805.3
Antxr1
anthrax toxin receptor 1
chr11_+_3599183 0.34 ENSMUST00000096441.5
Morc2a
microrchidia 2A
chr3_-_75359125 0.31 ENSMUST00000204341.3
Wdr49
WD repeat domain 49
chr3_+_79791798 0.29 ENSMUST00000118853.8
ENSMUST00000145992.2
Gask1b
golgi associated kinase 1B
chr19_+_33985684 0.29 ENSMUST00000225505.2
Lipk
lipase, family member K
chr6_+_34897874 0.28 ENSMUST00000114999.8
Stra8
stimulated by retinoic acid gene 8
chr1_-_130815144 0.28 ENSMUST00000121040.8
Il24
interleukin 24
chr19_+_33985701 0.28 ENSMUST00000054260.8
Lipk
lipase, family member K
chr11_-_3599673 0.28 ENSMUST00000193809.2
Tug1
taurine upregulated gene 1
chr10_-_70428611 0.27 ENSMUST00000162251.8
Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr17_-_23990479 0.27 ENSMUST00000086325.13
Flywch1
FLYWCH-type zinc finger 1
chr10_-_107747995 0.27 ENSMUST00000165341.5
Otogl
otogelin-like
chr3_-_33136153 0.26 ENSMUST00000108225.10
Pex5l
peroxisomal biogenesis factor 5-like
chr9_-_40015750 0.26 ENSMUST00000213858.2
Olfr984
olfactory receptor 984
chr4_+_109092829 0.24 ENSMUST00000030285.8
Calr4
calreticulin 4
chr4_-_63663344 0.23 ENSMUST00000239480.2
ENSMUST00000062246.8
Tnfsf15
tumor necrosis factor (ligand) superfamily, member 15
chrX_+_156485570 0.22 ENSMUST00000112520.2
Smpx
small muscle protein, X-linked
chr10_+_104029903 0.21 ENSMUST00000181615.8
Gm4340
predicted gene 4340
chr10_+_103978848 0.21 ENSMUST00000181634.8
Gm21293
predicted gene, 21293
chr10_+_103987358 0.21 ENSMUST00000181287.5
Gm6763
predicted gene 6763
chr10_+_103995867 0.21 ENSMUST00000181179.5
Gm8764
predicted gene 8764
chr10_+_104004376 0.21 ENSMUST00000181059.8
Gm21304
predicted gene, 21304
chr10_+_104012885 0.21 ENSMUST00000180889.8
Gm21312
predicted gene, 21312
chr10_+_104021394 0.21 ENSMUST00000181703.8
Gm20765
predicted gene, 20765
chr12_+_38830812 0.20 ENSMUST00000160856.8
Etv1
ets variant 1
chr4_+_115099237 0.17 ENSMUST00000118278.2
Cyp4a29
cytochrome P450, family 4, subfamily a, polypeptide 29
chr6_+_43083303 0.16 ENSMUST00000213649.2
Olfr441
olfactory receptor 441
chr13_+_14804739 0.14 ENSMUST00000178289.3
ENSMUST00000038690.6
ENSMUST00000222052.2
AW209491
expressed sequence AW209491
chr11_-_52165682 0.13 ENSMUST00000238914.2
Tcf7
transcription factor 7, T cell specific
chr12_+_38830283 0.11 ENSMUST00000162563.8
ENSMUST00000161164.8
ENSMUST00000160996.8
Etv1
ets variant 1
chr18_+_35695199 0.10 ENSMUST00000236860.2
ENSMUST00000166793.10
ENSMUST00000237780.2
ENSMUST00000236507.2
ENSMUST00000235960.2
ENSMUST00000237061.2
Matr3
matrin 3
chr12_+_38831093 0.07 ENSMUST00000161513.9
Etv1
ets variant 1
chr9_-_35559489 0.03 ENSMUST00000178236.3
Pate3
prostate and testis expressed 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.6 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
1.0 2.9 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.9 6.4 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.3 1.3 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.2 2.0 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.2 0.8 GO:0003134 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134)
0.2 0.7 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.5 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.1 3.3 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.9 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 0.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.5 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0 0.4 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.0 1.1 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.8 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.3 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.0 2.1 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.4 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.3 GO:0019321 pentose metabolic process(GO:0019321)
0.0 0.8 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.8 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.1 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0042587 glycogen granule(GO:0042587)
0.1 3.3 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 6.4 GO:0030673 axolemma(GO:0030673)
0.1 2.0 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.8 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 1.4 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.3 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.2 GO:0005927 muscle tendon junction(GO:0005927)
0.0 1.1 GO:0032809 neuronal cell body membrane(GO:0032809)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.6 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
1.1 6.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 10.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 2.0 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 0.5 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.1 0.8 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 0.5 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.3 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 2.3 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.1 GO:0015459 potassium channel regulator activity(GO:0015459)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.8 PID BMP PATHWAY BMP receptor signaling
0.0 0.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 6.4 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.7 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.4 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis