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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Pax4

Z-value: 1.27

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Transcription factors associated with Pax4

Gene Symbol Gene ID Gene Info
Pax4
ENSMUSG00000029706.16 Pax4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax4mm39_v1_chr6_-_28447179_284471790.261.3e-01Click!

Activity profile of Pax4 motif

Sorted Z-values of Pax4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr9_+_59563872 5.31 ENSMUST00000215623.2
ENSMUST00000215660.2
ENSMUST00000217353.2
Pkm
pyruvate kinase, muscle
chr9_+_59564482 5.14 ENSMUST00000216620.2
ENSMUST00000217038.2
Pkm
pyruvate kinase, muscle
chr9_+_59563838 5.03 ENSMUST00000163694.4
Pkm
pyruvate kinase, muscle
chr7_+_78563150 4.39 ENSMUST00000118867.8
Isg20
interferon-stimulated protein
chr7_+_78563513 4.35 ENSMUST00000038142.15
Isg20
interferon-stimulated protein
chr7_+_78563184 4.11 ENSMUST00000121645.8
Isg20
interferon-stimulated protein
chr11_+_98798627 4.00 ENSMUST00000092706.13
Cdc6
cell division cycle 6
chr17_+_35278011 3.91 ENSMUST00000007255.13
ENSMUST00000174493.8
Ddah2
dimethylarginine dimethylaminohydrolase 2
chr11_+_62465304 3.30 ENSMUST00000018651.14
Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr16_-_36486429 3.30 ENSMUST00000089620.11
Cd86
CD86 antigen
chr7_+_24561616 2.63 ENSMUST00000170837.3
Gm9844
predicted pseudogene 9844
chr13_-_55676334 2.57 ENSMUST00000047877.5
Dok3
docking protein 3
chr5_+_66833434 2.21 ENSMUST00000031131.11
Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr11_+_106916430 2.07 ENSMUST00000140447.4
1810010H24Rik
RIKEN cDNA 1810010H24 gene
chr9_+_32607301 2.05 ENSMUST00000034534.13
ENSMUST00000050797.14
ENSMUST00000184887.2
Ets1
E26 avian leukemia oncogene 1, 5' domain
chr5_+_135703426 2.00 ENSMUST00000153515.8
Por
P450 (cytochrome) oxidoreductase
chr17_-_23864237 1.94 ENSMUST00000024696.9
Mmp25
matrix metallopeptidase 25
chr2_-_125348305 1.86 ENSMUST00000028633.13
Fbn1
fibrillin 1
chr4_-_87951565 1.84 ENSMUST00000078090.12
Mllt3
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
chr15_+_78481247 1.83 ENSMUST00000043069.6
ENSMUST00000231180.2
ENSMUST00000229796.2
ENSMUST00000229295.2
Cyth4
cytohesin 4
chr9_+_96141317 1.80 ENSMUST00000165768.4
Tfdp2
transcription factor Dp 2
chr9_+_96141299 1.77 ENSMUST00000179065.8
Tfdp2
transcription factor Dp 2
chr4_-_58987094 1.64 ENSMUST00000030069.7
Ptgr1
prostaglandin reductase 1
chr1_+_153628598 1.61 ENSMUST00000182538.3
Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr6_+_47854138 1.60 ENSMUST00000061890.8
Zfp282
zinc finger protein 282
chr4_+_6365694 1.54 ENSMUST00000175769.8
ENSMUST00000140830.8
ENSMUST00000108374.8
Sdcbp
syndecan binding protein
chr19_-_4240984 1.50 ENSMUST00000045864.4
Tbc1d10c
TBC1 domain family, member 10c
chr16_-_14109219 1.46 ENSMUST00000230397.2
ENSMUST00000231567.2
ENSMUST00000090287.5
Myh11
myosin, heavy polypeptide 11, smooth muscle
chr19_+_53128861 1.40 ENSMUST00000111741.10
Add3
adducin 3 (gamma)
chr9_-_58066484 1.34 ENSMUST00000041477.15
Islr
immunoglobulin superfamily containing leucine-rich repeat
chr4_+_6365650 1.30 ENSMUST00000029912.11
ENSMUST00000103008.12
Sdcbp
syndecan binding protein
chr12_-_84265609 1.24 ENSMUST00000046266.13
ENSMUST00000220974.2
Mideas
mitotic deacetylase associated SANT domain protein
chr2_+_22785534 1.20 ENSMUST00000053729.14
Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr1_-_79838897 1.18 ENSMUST00000190724.2
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr7_+_43057611 1.17 ENSMUST00000005592.7
Siglecg
sialic acid binding Ig-like lectin G
chr2_+_22785593 0.96 ENSMUST00000152170.8
Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr19_-_4241034 0.92 ENSMUST00000237495.2
Tbc1d10c
TBC1 domain family, member 10c
chr8_-_83129134 0.87 ENSMUST00000209363.2
Il15
interleukin 15
chr4_+_150366028 0.87 ENSMUST00000105682.9
Rere
arginine glutamic acid dipeptide (RE) repeats
chr13_+_23922783 0.82 ENSMUST00000040914.3
H1f2
H1.2 linker histone, cluster member
chr2_-_160155536 0.77 ENSMUST00000109475.3
Gm826
predicted gene 826
chr4_+_124960465 0.76 ENSMUST00000052183.7
Snip1
Smad nuclear interacting protein 1
chr3_+_95532282 0.74 ENSMUST00000058230.13
ENSMUST00000037983.6
Ensa
endosulfine alpha
chr7_+_80764564 0.69 ENSMUST00000119083.2
Slc28a1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chrX_+_72235828 0.69 ENSMUST00000101486.5
Xlr3b
X-linked lymphocyte-regulated 3B
chr13_+_21901791 0.66 ENSMUST00000188775.2
H3c10
H3 clustered histone 10
chr11_+_87017878 0.66 ENSMUST00000041282.13
Trim37
tripartite motif-containing 37
chr11_-_18968955 0.66 ENSMUST00000068264.14
ENSMUST00000185131.8
Meis1
Meis homeobox 1
chr19_+_4022322 0.63 ENSMUST00000143380.3
Aldh3b2
aldehyde dehydrogenase 3 family, member B2
chr2_-_114485421 0.62 ENSMUST00000028640.14
ENSMUST00000102542.10
Dph6
diphthamine biosynthesis 6
chr7_+_80764547 0.61 ENSMUST00000026820.11
Slc28a1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr4_+_147216495 0.54 ENSMUST00000084149.10
Zfp991
zinc finger protein 991
chr8_-_83128992 0.53 ENSMUST00000210094.2
Il15
interleukin 15
chr10_+_119655294 0.53 ENSMUST00000105262.9
ENSMUST00000147454.8
ENSMUST00000138410.8
ENSMUST00000144825.8
ENSMUST00000148954.8
ENSMUST00000144959.8
Grip1
glutamate receptor interacting protein 1
chr2_+_181322077 0.52 ENSMUST00000103042.10
Tcea2
transcription elongation factor A (SII), 2
chr6_+_136495784 0.49 ENSMUST00000032335.13
ENSMUST00000185724.7
Atf7ip
activating transcription factor 7 interacting protein
chr13_-_101904662 0.43 ENSMUST00000055518.13
Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
chr10_+_129153986 0.43 ENSMUST00000215503.2
Olfr780
olfactory receptor 780
chr2_-_114485342 0.43 ENSMUST00000055144.8
Dph6
diphthamine biosynthesis 6
chr15_-_59245998 0.42 ENSMUST00000022976.6
Washc5
WASH complex subunit 5
chr10_+_127257077 0.37 ENSMUST00000168780.8
R3hdm2
R3H domain containing 2
chr2_-_131170902 0.35 ENSMUST00000110194.8
Rnf24
ring finger protein 24
chr9_+_14411907 0.34 ENSMUST00000004200.9
Cwc15
CWC15 spliceosome-associated protein
chr5_-_121641461 0.33 ENSMUST00000079368.5
Adam1b
a disintegrin and metallopeptidase domain 1b
chr12_+_71095112 0.32 ENSMUST00000135709.2
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr10_-_129509659 0.32 ENSMUST00000213294.2
ENSMUST00000216067.3
ENSMUST00000203424.2
Olfr801
olfactory receptor 801
chr9_+_88209250 0.31 ENSMUST00000034992.8
Nt5e
5' nucleotidase, ecto
chr9_+_20209828 0.29 ENSMUST00000215540.2
ENSMUST00000075717.7
Olfr873
olfactory receptor 873
chr10_+_89906956 0.28 ENSMUST00000183109.2
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr4_+_136011969 0.27 ENSMUST00000144217.8
Zfp46
zinc finger protein 46
chr17_+_69690314 0.26 ENSMUST00000062369.14
Zbtb14
zinc finger and BTB domain containing 14
chr5_+_124690908 0.26 ENSMUST00000071057.14
ENSMUST00000111438.2
Ddx55
DEAD box helicase 55
chr10_+_127256993 0.25 ENSMUST00000170336.8
R3hdm2
R3H domain containing 2
chrM_+_11735 0.23 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr19_+_55169148 0.22 ENSMUST00000154886.8
ENSMUST00000120936.8
ENSMUST00000025936.12
Tectb
tectorin beta
chr17_+_47604995 0.21 ENSMUST00000190020.4
Trerf1
transcriptional regulating factor 1
chr6_+_136495818 0.21 ENSMUST00000186577.7
Atf7ip
activating transcription factor 7 interacting protein
chr7_+_43090206 0.20 ENSMUST00000040227.3
Cldnd2
claudin domain containing 2
chr10_+_21870565 0.15 ENSMUST00000020145.12
Sgk1
serum/glucocorticoid regulated kinase 1
chr9_-_101076198 0.14 ENSMUST00000066773.9
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr9_+_36743980 0.09 ENSMUST00000034630.15
Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chrX_-_153911405 0.09 ENSMUST00000076671.4
Cldn34b2
claudin 34B2
chr17_+_69690018 0.08 ENSMUST00000112674.8
Zbtb14
zinc finger and BTB domain containing 14
chr4_+_146695418 0.05 ENSMUST00000130825.8
Zfp993
zinc finger protein 993
chr17_+_17622934 0.03 ENSMUST00000115576.3
Lix1
limb and CNS expressed 1
chr3_+_99147677 0.03 ENSMUST00000151606.8
Tbx15
T-box 15
chr17_+_34457868 0.01 ENSMUST00000095342.11
ENSMUST00000167280.8
ENSMUST00000236838.2
H2-Ob
histocompatibility 2, O region beta locus
chr16_-_13548307 0.01 ENSMUST00000115807.9
Pla2g10
phospholipase A2, group X
chrX_-_52298601 0.01 ENSMUST00000174390.2
Plac1
placental specific protein 1
chr16_-_45664591 0.00 ENSMUST00000076333.12
Phldb2
pleckstrin homology like domain, family B, member 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 12.8 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
1.5 15.5 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.5 2.0 GO:0090345 nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346)
0.5 2.8 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.5 1.9 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.4 1.2 GO:0042628 mating plug formation(GO:0042628) single-organism reproductive behavior(GO:0044704) post-mating behavior(GO:0045297) seminal vesicle development(GO:0061107)
0.4 2.2 GO:0007412 axon target recognition(GO:0007412)
0.3 1.3 GO:0015855 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.3 3.9 GO:0006527 arginine catabolic process(GO:0006527)
0.3 2.4 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.2 1.9 GO:0060022 hard palate development(GO:0060022)
0.2 1.4 GO:0045062 interleukin-15-mediated signaling pathway(GO:0035723) extrathymic T cell selection(GO:0045062) cellular response to interleukin-15(GO:0071350)
0.2 3.3 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.2 0.9 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.2 2.1 GO:0030578 PML body organization(GO:0030578) positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.1 1.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 4.0 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
0.1 0.7 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 1.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 2.2 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.1 0.3 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.1 1.6 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.1 0.4 GO:0090306 polar body extrusion after meiotic divisions(GO:0040038) spindle assembly involved in meiosis(GO:0090306)
0.0 1.8 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 3.3 GO:0090280 positive regulation of calcium ion import(GO:0090280)
0.0 0.3 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.4 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.7 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.6 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 0.1 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.0 0.8 GO:0035196 production of miRNAs involved in gene silencing by miRNA(GO:0035196)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.5 GO:1902912 pyruvate kinase complex(GO:1902912)
0.3 3.3 GO:0032584 growth cone membrane(GO:0032584)
0.2 12.8 GO:0015030 Cajal body(GO:0015030)
0.2 1.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 1.9 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 4.0 GO:0051233 spindle midzone(GO:0051233)
0.1 2.4 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.6 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 1.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.4 GO:0071203 WASH complex(GO:0071203)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 3.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 2.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.1 GO:0000118 histone deacetylase complex(GO:0000118)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 15.5 GO:0004743 pyruvate kinase activity(GO:0004743)
2.6 12.8 GO:0008859 exoribonuclease II activity(GO:0008859)
0.9 2.8 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.6 2.2 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.5 2.2 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.5 2.0 GO:0016708 nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726)
0.4 1.3 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.4 1.6 GO:0047522 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.4 3.9 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.6 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.4 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 1.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 2.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.6 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.7 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 1.9 GO:0016504 peptidase activator activity(GO:0016504)
0.0 2.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 3.3 GO:0005262 calcium channel activity(GO:0005262)
0.0 1.6 GO:0019843 rRNA binding(GO:0019843)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 1.2 GO:0005080 protein kinase C binding(GO:0005080)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 PID IL5 PATHWAY IL5-mediated signaling events
0.1 4.0 PID ATR PATHWAY ATR signaling pathway
0.1 3.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 2.1 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 2.2 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 3.6 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.0 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 14.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 3.3 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 1.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.3 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 2.8 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism