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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Ppard

Z-value: 0.98

Motif logo

Transcription factors associated with Ppard

Gene Symbol Gene ID Gene Info
ENSMUSG00000002250.17 Ppard

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Ppardmm39_v1_chr17_+_28491085_28491135-0.144.1e-01Click!

Activity profile of Ppard motif

Sorted Z-values of Ppard motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Ppard

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr9_-_46146558 4.94 ENSMUST00000121916.8
ENSMUST00000034586.9
apolipoprotein C-III
chr3_-_79535966 3.77 ENSMUST00000120992.8
electron transferring flavoprotein, dehydrogenase
chr16_+_22769822 3.71 ENSMUST00000023590.9
histidine-rich glycoprotein
chr16_+_22769844 3.50 ENSMUST00000232422.2
histidine-rich glycoprotein
chr9_-_46146928 3.23 ENSMUST00000118649.8
apolipoprotein C-III
chr9_+_108539296 2.50 ENSMUST00000035222.6
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chr3_-_79536166 2.40 ENSMUST00000029386.14
electron transferring flavoprotein, dehydrogenase
chr3_+_98187743 2.33 ENSMUST00000120541.8
ENSMUST00000090746.3
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
chr15_-_89310060 1.90 ENSMUST00000109313.9
carnitine palmitoyltransferase 1b, muscle
chr2_+_92205651 1.84 ENSMUST00000028650.9
peroxisomal biogenesis factor 16
chr4_+_59581617 1.70 ENSMUST00000107528.8
hydroxysteroid dehydrogenase like 2
chr1_+_139429430 1.61 ENSMUST00000027615.7
coagulation factor XIII, beta subunit
chr15_-_102097466 1.48 ENSMUST00000023805.3
cysteine sulfinic acid decarboxylase
chr15_-_102097387 1.42 ENSMUST00000230288.2
cysteine sulfinic acid decarboxylase
chr11_-_69906171 1.30 ENSMUST00000018718.8
ENSMUST00000102574.10
acyl-Coenzyme A dehydrogenase, very long chain
chr17_-_46749370 1.28 ENSMUST00000087012.7
solute carrier family 22 (organic anion transporter), member 7
chr11_-_73217298 1.26 ENSMUST00000155630.9
aspartoacylase
chr11_-_83483807 1.18 ENSMUST00000019071.4
chemokine (C-C motif) ligand 6
chr10_-_125164399 1.16 ENSMUST00000063318.10
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr10_+_3490232 1.13 ENSMUST00000019896.5
iodotyrosine deiodinase
chr5_+_114284585 1.08 ENSMUST00000102582.8
acetyl-Coenzyme A carboxylase beta
chr3_-_137837117 1.06 ENSMUST00000029805.13
microsomal triglyceride transfer protein
chr7_+_43093507 1.04 ENSMUST00000004729.5
ENSMUST00000206286.2
ENSMUST00000206196.2
ENSMUST00000206411.2
electron transferring flavoprotein, beta polypeptide
chr10_-_125164826 1.02 ENSMUST00000211781.2
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr11_-_73217633 1.00 ENSMUST00000134079.2
aspartoacylase
chr1_-_120047868 0.88 ENSMUST00000112648.8
diazepam binding inhibitor
chr2_-_103315483 0.79 ENSMUST00000028610.10
catalase
chr2_-_103315418 0.76 ENSMUST00000111168.4
catalase
chr18_+_74912268 0.73 ENSMUST00000041053.11
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
chr19_-_6899173 0.69 ENSMUST00000025906.12
ENSMUST00000239322.2
estrogen related receptor, alpha
chr5_+_36622342 0.67 ENSMUST00000031099.4
GrpE-like 1, mitochondrial
chr17_-_46749320 0.66 ENSMUST00000233575.2
solute carrier family 22 (organic anion transporter), member 7
chr2_+_162829250 0.64 ENSMUST00000018012.14
serum/glucocorticoid regulated kinase 2
chr16_-_84632383 0.61 ENSMUST00000114191.8
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr16_-_23339329 0.60 ENSMUST00000230040.2
ENSMUST00000229619.2
mannan-binding lectin serine peptidase 1
chr2_+_162829422 0.58 ENSMUST00000117123.2
serum/glucocorticoid regulated kinase 2
chr1_+_171052623 0.58 ENSMUST00000111321.8
ENSMUST00000005824.12
ENSMUST00000111320.8
ENSMUST00000111319.2
apolipoprotein A-II
chr9_+_21914334 0.56 ENSMUST00000115331.10
protein kinase C substrate 80K-H
chr9_+_21914083 0.56 ENSMUST00000216344.2
protein kinase C substrate 80K-H
chr1_+_55127110 0.55 ENSMUST00000075242.7
heat shock protein 1 (chaperonin 10)
chr19_-_6899121 0.52 ENSMUST00000173635.2
estrogen related receptor, alpha
chr10_+_93983844 0.52 ENSMUST00000105290.9
nuclear receptor subfamily 2, group C, member 1
chr6_-_97436223 0.52 ENSMUST00000113359.8
FERM domain containing 4B
chr4_+_148686985 0.51 ENSMUST00000105701.9
ENSMUST00000052060.7
mannan-binding lectin serine peptidase 2
chr2_-_32594156 0.50 ENSMUST00000127812.3
folylpolyglutamyl synthetase
chrX_+_10118544 0.49 ENSMUST00000049910.13
ornithine transcarbamylase
chr16_-_84632439 0.48 ENSMUST00000138279.2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr9_+_21914296 0.48 ENSMUST00000003493.9
protein kinase C substrate 80K-H
chr9_+_45924105 0.46 ENSMUST00000126865.8
SIK family kinase 3
chr17_-_34247016 0.40 ENSMUST00000236627.2
ENSMUST00000237759.2
ENSMUST00000045467.14
ENSMUST00000114303.4
H2-K region expressed gene 6
chrX_+_10118600 0.39 ENSMUST00000115528.3
ornithine transcarbamylase
chr16_-_84632513 0.39 ENSMUST00000023608.14
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr19_+_5510636 0.39 ENSMUST00000225141.2
ENSMUST00000025847.7
fibroblast growth factor (acidic) intracellular binding protein
chr4_+_98434930 0.38 ENSMUST00000102792.10
PATJ, crumbs cell polarity complex component
chr17_+_34879431 0.38 ENSMUST00000238967.2
tenascin XB
chr3_+_96737385 0.32 ENSMUST00000058865.14
PDZ domain containing 1
chr1_-_55127183 0.31 ENSMUST00000027123.15
heat shock protein 1 (chaperonin)
chr1_-_55127312 0.31 ENSMUST00000127861.8
ENSMUST00000144077.3
heat shock protein 1 (chaperonin)
chr2_+_165834546 0.31 ENSMUST00000109252.8
ENSMUST00000088095.6
nuclear receptor coactivator 3
chr18_-_36859732 0.30 ENSMUST00000061829.8
CD14 antigen
chr2_-_73741664 0.29 ENSMUST00000111996.8
ENSMUST00000018914.3
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)
chr9_+_21914513 0.29 ENSMUST00000215795.2
protein kinase C substrate 80K-H
chr9_+_45924120 0.28 ENSMUST00000120463.9
ENSMUST00000120247.8
SIK family kinase 3
chr8_+_117822593 0.27 ENSMUST00000034308.16
ENSMUST00000176860.2
beta-carotene oxygenase 1
chr9_-_108888779 0.27 ENSMUST00000061973.5
three prime repair exonuclease 1
chr11_-_4654303 0.23 ENSMUST00000058407.6
ubiquinol-cytochrome c reductase, complex III subunit X
chr4_+_98435155 0.23 ENSMUST00000030290.8
PATJ, crumbs cell polarity complex component
chr11_-_94390788 0.21 ENSMUST00000127305.2
epsin 3
chr4_-_41048124 0.20 ENSMUST00000030136.13
aquaporin 7
chr15_-_50753792 0.17 ENSMUST00000185183.2
transcriptional repressor GATA binding 1
chr19_+_4644365 0.16 ENSMUST00000113825.4
pyruvate carboxylase
chr6_-_142418801 0.16 ENSMUST00000032371.8
glycogen synthase 2
chr15_-_89309998 0.15 ENSMUST00000168376.2
carnitine palmitoyltransferase 1b, muscle
chr3_+_89958940 0.15 ENSMUST00000159064.8
RIKEN cDNA 4933434E20 gene
chr2_+_84891281 0.14 ENSMUST00000238769.2
tankyrase 1 binding protein 1
chr14_+_14210932 0.14 ENSMUST00000022271.14
acyl-Coenzyme A oxidase 2, branched chain
chr2_+_160730019 0.13 ENSMUST00000109455.9
ENSMUST00000040872.13
lipin 3
chr2_-_32594043 0.13 ENSMUST00000143743.2
folylpolyglutamyl synthetase
chr9_-_21913833 0.12 ENSMUST00000115336.10
outer dynein arm docking complex subunit 3
chr1_+_180553569 0.11 ENSMUST00000027780.6
acyl-Coenzyme A binding domain containing 3
chr12_+_84498196 0.11 ENSMUST00000137170.3
lin-52 homolog (C. elegans)
chr16_-_91728162 0.10 ENSMUST00000139277.8
ENSMUST00000154661.8
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr9_+_107217786 0.10 ENSMUST00000042581.4
RIKEN cDNA 6430571L13 gene
chr15_+_101184488 0.09 ENSMUST00000229525.2
ENSMUST00000230525.2
autophagy related 101
chr1_-_133617824 0.08 ENSMUST00000189524.2
ENSMUST00000169295.8
lymphocyte transmembrane adaptor 1
chr1_+_171216480 0.07 ENSMUST00000056449.9
Rho GTPase activating protein 30
chr11_+_98337655 0.07 ENSMUST00000019456.5
growth factor receptor bound protein 7
chr2_+_90865958 0.06 ENSMUST00000111445.10
ENSMUST00000111446.10
ENSMUST00000050323.6
receptor-associated protein of the synapse
chr15_-_27630724 0.06 ENSMUST00000059662.8
OTU deubiquitinase with linear linkage specificity
chr9_-_21913896 0.05 ENSMUST00000044926.6
outer dynein arm docking complex subunit 3
chr12_-_40273173 0.03 ENSMUST00000001672.12
interferon-related developmental regulator 1
chr1_+_171386752 0.00 ENSMUST00000004829.13
CD244 molecule A
chr10_-_14581203 0.00 ENSMUST00000149485.2
ENSMUST00000154132.8
vesicle (multivesicular body) trafficking 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.2 GO:0097037 heme export(GO:0097037)
2.0 8.2 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)
0.6 2.9 GO:0042412 taurine biosynthetic process(GO:0042412)
0.4 8.7 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.4 1.1 GO:0046949 fatty-acyl-CoA biosynthetic process(GO:0046949) malonyl-CoA metabolic process(GO:2001293)
0.3 2.3 GO:0006083 acetate metabolic process(GO:0006083)
0.3 2.8 GO:0015879 carnitine transport(GO:0015879)
0.3 2.2 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.3 1.8 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.3 0.9 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450)
0.2 0.6 GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.2 0.6 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.2 0.7 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.2 0.9 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.1 0.6 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901) diacylglycerol catabolic process(GO:0046340)
0.1 1.1 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 1.5 GO:0009650 UV protection(GO:0009650)
0.1 0.3 GO:0071726 response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.1 1.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 1.9 GO:0035634 response to stilbenoid(GO:0035634)
0.1 1.9 GO:0006491 N-glycan processing(GO:0006491)
0.1 1.1 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 2.3 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.1 1.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.4 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.2 GO:0015793 glycerol transport(GO:0015793) renal water absorption(GO:0070295)
0.0 0.3 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.2 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.0 0.5 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 1.2 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 2.0 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.0 1.2 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.2 GO:0017062 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.0 0.3 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.7 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0 0.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.2 GO:0061474 phagolysosome membrane(GO:0061474)
1.8 7.2 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.7 8.2 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.4 1.9 GO:0017177 glucosidase II complex(GO:0017177)
0.1 1.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.9 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 1.8 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 0.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 1.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.4 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 6.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.7 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
1.2 6.2 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.8 2.3 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.8 2.3 GO:0019807 aspartoacylase activity(GO:0019807)
0.6 2.5 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.4 1.3 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.4 2.9 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.4 1.5 GO:0004096 catalase activity(GO:0004096)
0.3 2.0 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.3 2.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 0.9 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.2 0.9 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.2 1.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.2 0.6 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.1 0.6 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 6.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.4 GO:0070404 NADH binding(GO:0070404)
0.1 0.3 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 0.2 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.1 1.9 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 1.1 GO:0010181 FMN binding(GO:0010181)
0.1 1.1 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.7 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.0 1.2 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.3 GO:0071723 lipopeptide binding(GO:0071723)
0.0 0.2 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.3 GO:0005124 scavenger receptor binding(GO:0005124)
0.0 0.2 GO:0004736 pyruvate carboxylase activity(GO:0004736)
0.0 1.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.5 GO:0001846 opsonin binding(GO:0001846)
0.0 0.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.7 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 1.9 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 1.7 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 1.5 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.4 GO:0017134 fibroblast growth factor binding(GO:0017134)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 7.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 2.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.5 PID FOXO PATHWAY FoxO family signaling
0.0 0.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.7 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 5.6 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 1.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.9 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 2.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.9 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 6.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 2.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 1.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.6 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 7.2 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.1 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.3 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 2.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins