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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Ptf1a

Z-value: 2.67

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Transcription factors associated with Ptf1a

Gene Symbol Gene ID Gene Info
Ptf1a
ENSMUSG00000026735.3 Ptf1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Ptf1amm39_v1_chr2_+_19450443_194504740.761.0e-07Click!

Activity profile of Ptf1a motif

Sorted Z-values of Ptf1a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Ptf1a

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_-_41291634 53.08 ENSMUST00000064324.12
Try5
trypsin 5
chr8_-_112417633 43.83 ENSMUST00000034435.7
Ctrb1
chymotrypsinogen B1
chr6_+_41369290 33.13 ENSMUST00000049079.9
Gm5771
predicted gene 5771
chr6_+_41435846 32.96 ENSMUST00000031910.8
Prss1
protease, serine 1 (trypsin 1)
chr6_+_41279199 29.76 ENSMUST00000031913.5
Try4
trypsin 4
chr7_+_28240262 26.76 ENSMUST00000119180.4
Sycn
syncollin
chr6_+_41331039 24.89 ENSMUST00000072103.7
Try10
trypsin 10
chr7_-_130924021 13.70 ENSMUST00000046611.9
Cuzd1
CUB and zona pellucida-like domains 1
chr2_+_164790139 8.78 ENSMUST00000017881.3
Mmp9
matrix metallopeptidase 9
chr14_-_63654478 7.67 ENSMUST00000014597.5
Blk
B lymphoid kinase
chrX_-_161747552 7.60 ENSMUST00000038769.3
S100g
S100 calcium binding protein G
chr2_+_172994841 6.93 ENSMUST00000029017.6
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
chr2_+_164611812 6.41 ENSMUST00000088248.13
ENSMUST00000001439.7
Ube2c
ubiquitin-conjugating enzyme E2C
chr17_-_26420300 6.35 ENSMUST00000025019.9
Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr14_-_32907023 5.18 ENSMUST00000130509.10
ENSMUST00000061753.15
Wdfy4
WD repeat and FYVE domain containing 4
chr12_-_114104740 4.69 ENSMUST00000103473.2
Ighv9-3
immunoglobulin heavy variable V9-3
chr17_-_26420332 4.38 ENSMUST00000121959.3
Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr9_+_59563872 4.28 ENSMUST00000215623.2
ENSMUST00000215660.2
ENSMUST00000217353.2
Pkm
pyruvate kinase, muscle
chr4_-_63965161 4.18 ENSMUST00000107377.10
Tnc
tenascin C
chr9_+_59563838 4.13 ENSMUST00000163694.4
Pkm
pyruvate kinase, muscle
chr16_-_21980200 4.12 ENSMUST00000115379.2
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr19_-_9876745 3.87 ENSMUST00000237725.2
Incenp
inner centromere protein
chr17_-_28736483 3.81 ENSMUST00000114792.8
ENSMUST00000177939.8
Fkbp5
FK506 binding protein 5
chr4_-_133615075 3.45 ENSMUST00000003741.16
ENSMUST00000105894.11
Rps6ka1
ribosomal protein S6 kinase polypeptide 1
chr10_+_60182630 3.42 ENSMUST00000020301.14
ENSMUST00000105460.8
ENSMUST00000170507.8
Vsir
V-set immunoregulatory receptor
chr6_-_115785695 3.32 ENSMUST00000081840.6
Rpl32
ribosomal protein L32
chr6_+_68233361 2.90 ENSMUST00000103320.3
Igkv14-111
immunoglobulin kappa variable 14-111
chrX_+_159173680 2.89 ENSMUST00000112408.9
ENSMUST00000112402.8
ENSMUST00000112401.8
ENSMUST00000112400.8
ENSMUST00000112405.9
ENSMUST00000112404.9
ENSMUST00000146805.8
Adgrg2
adhesion G protein-coupled receptor G2
chr6_-_136758716 2.88 ENSMUST00000078095.11
ENSMUST00000032338.10
Gucy2c
guanylate cyclase 2c
chr8_-_106022676 2.82 ENSMUST00000057855.4
Exoc3l
exocyst complex component 3-like
chr11_+_120653613 2.73 ENSMUST00000105046.4
Hmga1b
high mobility group AT-hook 1B
chr10_-_75768302 2.64 ENSMUST00000120281.8
ENSMUST00000000924.13
Mmp11
matrix metallopeptidase 11
chr5_-_99400698 2.41 ENSMUST00000031276.15
ENSMUST00000168092.8
Rasgef1b
RasGEF domain family, member 1B
chr11_-_74480870 2.36 ENSMUST00000145524.2
ENSMUST00000102521.9
Rap1gap2
RAP1 GTPase activating protein 2
chr17_+_8144822 2.36 ENSMUST00000036370.8
Tagap
T cell activation Rho GTPase activating protein
chr19_+_40648182 2.24 ENSMUST00000112231.9
ENSMUST00000127828.8
Entpd1
ectonucleoside triphosphate diphosphohydrolase 1
chr11_+_101221431 2.20 ENSMUST00000103105.10
Aoc3
amine oxidase, copper containing 3
chr5_-_121025645 2.09 ENSMUST00000086368.12
Oas1g
2'-5' oligoadenylate synthetase 1G
chr14_-_70445086 2.06 ENSMUST00000022682.6
Sorbs3
sorbin and SH3 domain containing 3
chr14_-_32907446 2.02 ENSMUST00000159606.2
Wdfy4
WD repeat and FYVE domain containing 4
chr14_-_56181993 2.02 ENSMUST00000022834.7
ENSMUST00000226280.2
Cma1
chymase 1, mast cell
chr19_-_7218363 1.97 ENSMUST00000236769.2
Naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit
chr14_-_51295099 1.96 ENSMUST00000227764.2
Rnase12
ribonuclease, RNase A family, 12 (non-active)
chr19_-_7218512 1.92 ENSMUST00000025675.11
Naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit
chr11_+_48691175 1.83 ENSMUST00000020640.8
Rack1
receptor for activated C kinase 1
chr12_+_83572774 1.75 ENSMUST00000223291.2
Dcaf4
DDB1 and CUL4 associated factor 4
chr4_+_114945905 1.69 ENSMUST00000171877.8
ENSMUST00000177647.8
ENSMUST00000106548.9
ENSMUST00000030488.3
Pdzk1ip1
PDZK1 interacting protein 1
chr12_+_112727089 1.68 ENSMUST00000063888.5
Pld4
phospholipase D family, member 4
chr11_+_72332167 1.61 ENSMUST00000045633.6
Mybbp1a
MYB binding protein (P160) 1a
chr14_-_8123295 1.58 ENSMUST00000225775.2
ENSMUST00000224877.2
ENSMUST00000090591.4
Il3ra
interleukin 3 receptor, alpha chain
chr11_-_118246332 1.57 ENSMUST00000017610.10
Timp2
tissue inhibitor of metalloproteinase 2
chr18_-_80484066 1.57 ENSMUST00000161003.2
Ctdp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr2_-_167852538 1.55 ENSMUST00000099073.3
Ripor3
RIPOR family member 3
chr12_+_29988035 1.53 ENSMUST00000122328.8
ENSMUST00000118321.3
Pxdn
peroxidasin
chr11_-_99045894 1.51 ENSMUST00000103134.4
Ccr7
chemokine (C-C motif) receptor 7
chr9_+_20927271 1.44 ENSMUST00000086399.6
Icam1
intercellular adhesion molecule 1
chr10_+_75047897 1.42 ENSMUST00000218766.2
Specc1l
sperm antigen with calponin homology and coiled-coil domains 1-like
chr11_-_118246566 1.37 ENSMUST00000155707.3
Timp2
tissue inhibitor of metalloproteinase 2
chr18_-_80484003 1.36 ENSMUST00000160434.3
Ctdp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr11_+_49138278 1.32 ENSMUST00000109194.2
Mgat1
mannoside acetylglucosaminyltransferase 1
chr1_-_171434882 1.27 ENSMUST00000111277.2
ENSMUST00000004827.14
Ly9
lymphocyte antigen 9
chr6_-_69626340 1.24 ENSMUST00000198328.2
Igkv4-53
immunoglobulin kappa variable 4-53
chr11_-_6394352 1.23 ENSMUST00000093346.6
H2az2
H2A.Z histone variant 2
chr15_+_79982033 1.19 ENSMUST00000143928.2
Syngr1
synaptogyrin 1
chr8_+_123920682 1.18 ENSMUST00000212409.2
Dpep1
dipeptidase 1
chr11_-_6394385 1.16 ENSMUST00000109737.9
H2az2
H2A.Z histone variant 2
chr12_-_114263874 0.98 ENSMUST00000103482.2
ENSMUST00000194159.2
Ighv9-4
immunoglobulin heavy variable 9-4
chr19_+_32463151 0.98 ENSMUST00000025827.10
Minpp1
multiple inositol polyphosphate histidine phosphatase 1
chr7_-_30643444 0.96 ENSMUST00000062620.9
Hamp
hepcidin antimicrobial peptide
chr2_+_26863428 0.88 ENSMUST00000014996.14
Adamts13
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13
chr11_+_82802079 0.84 ENSMUST00000018989.14
ENSMUST00000164945.3
Unc45b
unc-45 myosin chaperone B
chr6_-_69584812 0.83 ENSMUST00000103359.3
Igkv4-55
immunoglobulin kappa variable 4-55
chr17_+_29899420 0.80 ENSMUST00000130052.9
Cmtr1
cap methyltransferase 1
chr9_-_44646487 0.80 ENSMUST00000034611.15
Phldb1
pleckstrin homology like domain, family B, member 1
chr1_-_171434944 0.78 ENSMUST00000068878.14
Ly9
lymphocyte antigen 9
chr3_-_83749036 0.76 ENSMUST00000029623.11
Tlr2
toll-like receptor 2
chr7_-_25418401 0.74 ENSMUST00000125699.3
ENSMUST00000002683.3
Ccdc97
coiled-coil domain containing 97
chr9_+_106354463 0.72 ENSMUST00000047721.10
Rrp9
ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
chr4_-_88357112 0.70 ENSMUST00000132493.8
ENSMUST00000030221.3
ENSMUST00000151280.8
Hacd4
3-hydroxyacyl-CoA dehydratase 4
chr2_-_91780731 0.68 ENSMUST00000111303.2
Dgkz
diacylglycerol kinase zeta
chr10_+_94350687 0.67 ENSMUST00000065060.12
Tmcc3
transmembrane and coiled coil domains 3
chr11_+_101215889 0.62 ENSMUST00000041095.14
ENSMUST00000107264.2
Aoc2
amine oxidase, copper containing 2 (retina-specific)
chr8_+_123920233 0.56 ENSMUST00000212773.2
Dpep1
dipeptidase 1
chrX_-_162859429 0.49 ENSMUST00000134272.2
Siah1b
siah E3 ubiquitin protein ligase 1B
chr2_-_93787383 0.48 ENSMUST00000148314.3
Gm13889
predicted gene 13889
chr13_+_19528728 0.47 ENSMUST00000179181.3
Trgc4
T cell receptor gamma, constant 4
chr11_+_78356523 0.46 ENSMUST00000001126.4
Slc46a1
solute carrier family 46, member 1
chr15_+_99568208 0.39 ENSMUST00000023758.9
Asic1
acid-sensing (proton-gated) ion channel 1
chr18_+_32055339 0.39 ENSMUST00000233994.2
Lims2
LIM and senescent cell antigen like domains 2
chr12_+_71062733 0.39 ENSMUST00000046305.12
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr10_+_85857726 0.35 ENSMUST00000130320.8
Fbxo7
F-box protein 7
chr10_+_85858050 0.31 ENSMUST00000120344.8
ENSMUST00000117597.2
Fbxo7
F-box protein 7
chr2_+_25390762 0.30 ENSMUST00000015239.10
Fbxw5
F-box and WD-40 domain protein 5
chr16_-_63684477 0.29 ENSMUST00000232654.2
ENSMUST00000064405.8
Epha3
Eph receptor A3
chr6_-_69261303 0.28 ENSMUST00000103349.2
Igkv4-69
immunoglobulin kappa variable 4-69
chr1_+_21021889 0.25 ENSMUST00000038447.6
Efhc1
EF-hand domain (C-terminal) containing 1
chr10_+_75768964 0.23 ENSMUST00000219839.2
Chchd10
coiled-coil-helix-coiled-coil-helix domain containing 10
chr7_+_18865610 0.20 ENSMUST00000165913.2
Fbxo46
F-box protein 46
chr9_-_108474757 0.11 ENSMUST00000193621.2
ENSMUST00000006853.11
P4htm
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr6_-_69162381 0.10 ENSMUST00000103344.3
Igkv4-74
immunoglobulin kappa variable 4-74
chr10_-_95253042 0.10 ENSMUST00000135822.8
Socs2
suppressor of cytokine signaling 2
chr9_-_21763898 0.09 ENSMUST00000217336.2
ENSMUST00000034728.9
Dock6
dedicator of cytokinesis 6
chr12_-_114073050 0.05 ENSMUST00000103472.4
Ighv9-2
immunoglobulin heavy variable V9-2
chr11_-_90281721 0.03 ENSMUST00000004051.8
Hlf
hepatic leukemia factor
chr8_+_95584146 0.02 ENSMUST00000211939.2
ENSMUST00000212124.2
Polr2c
polymerase (RNA) II (DNA directed) polypeptide C
chr6_-_69394425 0.02 ENSMUST00000199160.2
Igkv4-61
immunoglobulin kappa chain variable 4-61

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.8 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
1.7 6.9 GO:0061402 glycerol biosynthetic process(GO:0006114) positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
1.4 4.2 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
1.2 213.0 GO:0007586 digestion(GO:0007586)
0.9 6.4 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.8 8.4 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.7 2.9 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.7 2.0 GO:0042222 interleukin-1 biosynthetic process(GO:0042222)
0.6 3.4 GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.5 1.6 GO:0038156 interleukin-3-mediated signaling pathway(GO:0038156)
0.5 1.5 GO:0002649 regulation of tolerance induction to self antigen(GO:0002649) lymphocyte migration into lymphoid organs(GO:0097021) positive regulation of thymocyte migration(GO:2000412) regulation of dendritic cell dendrite assembly(GO:2000547)
0.5 3.5 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.5 1.8 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.4 1.7 GO:0016999 antibiotic metabolic process(GO:0016999)
0.4 0.8 GO:0032741 positive regulation of interleukin-18 production(GO:0032741)
0.4 2.2 GO:2001170 negative regulation of ATP biosynthetic process(GO:2001170)
0.3 1.3 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.3 2.2 GO:0035902 response to immobilization stress(GO:0035902)
0.3 1.6 GO:2000210 positive regulation of anoikis(GO:2000210)
0.3 2.9 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.2 1.4 GO:0046813 receptor-mediated virion attachment to host cell(GO:0046813)
0.2 1.0 GO:0034757 negative regulation of iron ion transport(GO:0034757) negative regulation of iron ion transmembrane transport(GO:0034760)
0.2 2.8 GO:0051601 exocyst localization(GO:0051601)
0.2 0.8 GO:0097309 cap1 mRNA methylation(GO:0097309)
0.1 3.9 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474) histone H2A acetylation(GO:0043968)
0.1 2.0 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.1 2.6 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.1 3.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.2 GO:2000983 regulation of ATP citrate synthase activity(GO:2000983) negative regulation of ATP citrate synthase activity(GO:2000984)
0.1 13.3 GO:0031638 zymogen activation(GO:0031638)
0.1 0.7 GO:1903599 positive regulation of mitophagy(GO:1903599)
0.1 7.7 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.1 0.5 GO:0015886 heme transport(GO:0015886) methotrexate transport(GO:0051958)
0.1 0.4 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 0.4 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 2.9 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.1 0.8 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 1.5 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.4 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 1.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 22.2 GO:0006887 exocytosis(GO:0006887)
0.0 0.7 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 2.1 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 4.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.4 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.7 GO:0042761 fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 4.1 GO:0051028 mRNA transport(GO:0051028)
0.0 3.2 GO:0000910 cytokinesis(GO:0000910)
0.0 1.7 GO:0006909 phagocytosis(GO:0006909)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.4 GO:1902912 pyruvate kinase complex(GO:1902912)
0.6 1.8 GO:1990630 IRE1-RACK1-PP2A complex(GO:1990630)
0.6 13.7 GO:0042589 zymogen granule membrane(GO:0042589)
0.5 1.6 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.3 3.9 GO:0000801 central element(GO:0000801)
0.3 26.8 GO:0030667 secretory granule membrane(GO:0030667)
0.3 0.8 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.2 6.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 0.7 GO:1990037 Lewy body core(GO:1990037)
0.1 4.2 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.8 GO:0000145 exocyst(GO:0000145)
0.1 2.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 24.6 GO:0072562 blood microparticle(GO:0072562)
0.1 2.2 GO:0005605 basal lamina(GO:0005605)
0.1 154.7 GO:0005615 extracellular space(GO:0005615)
0.1 0.7 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 2.9 GO:0051233 spindle midzone(GO:0051233)
0.1 1.7 GO:0005682 U5 snRNP(GO:0005682)
0.1 30.2 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 0.7 GO:0005686 U2 snRNP(GO:0005686)
0.0 1.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.8 GO:0045180 basal cortex(GO:0045180)
0.0 3.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 5.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.7 GO:0005819 spindle(GO:0005819)
0.0 3.2 GO:0031012 extracellular matrix(GO:0031012)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.9 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
1.7 8.4 GO:0004743 pyruvate kinase activity(GO:0004743)
1.2 10.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.0 228.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.0 2.9 GO:0001096 TFIIF-class transcription factor binding(GO:0001096)
1.0 7.6 GO:0005499 vitamin D binding(GO:0005499)
0.9 2.8 GO:0052595 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.5 1.6 GO:0019978 interleukin-3 receptor activity(GO:0004912) interleukin-3 binding(GO:0019978)
0.4 3.9 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.4 4.2 GO:0045545 syndecan binding(GO:0045545)
0.3 1.3 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.3 0.8 GO:0042497 triacyl lipopeptide binding(GO:0042497)
0.2 1.7 GO:0070573 metallodipeptidase activity(GO:0070573)
0.2 2.2 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.2 1.0 GO:0052743 inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.2 1.7 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.2 3.8 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 2.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.7 GO:0102345 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.1 0.8 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.1 2.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.8 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1 4.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 6.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 2.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 1.5 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 7.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.7 GO:0034511 U3 snoRNA binding(GO:0034511)
0.1 0.5 GO:0015232 heme transporter activity(GO:0015232)
0.1 3.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 2.1 GO:0017166 vinculin binding(GO:0017166)
0.0 1.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.7 GO:0001727 lipid kinase activity(GO:0001727)
0.0 4.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.4 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 1.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 3.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.8 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 2.8 GO:0000149 SNARE binding(GO:0000149)
0.0 2.0 GO:0004540 ribonuclease activity(GO:0004540)
0.0 1.0 GO:0005507 copper ion binding(GO:0005507)
0.0 1.4 GO:0005178 integrin binding(GO:0005178)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 13.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.2 7.7 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 36.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 10.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 3.5 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 6.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.9 PID AURORA B PATHWAY Aurora B signaling
0.1 1.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.6 PID IL3 PATHWAY IL3-mediated signaling events
0.0 3.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 4.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 93.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.4 6.9 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.3 6.4 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.1 7.7 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 2.9 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.1 2.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 0.8 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 3.5 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 11.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.6 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 3.9 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 3.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.3 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 1.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.8 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 1.7 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis