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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Runx1

Z-value: 1.95

Motif logo

Transcription factors associated with Runx1

Gene Symbol Gene ID Gene Info
ENSMUSG00000022952.18 Runx1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Runx1mm39_v1_chr16_-_92622972_926230370.892.2e-13Click!

Activity profile of Runx1 motif

Sorted Z-values of Runx1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr11_+_87684299 18.14 ENSMUST00000020779.11
myeloperoxidase
chr11_+_87684548 13.14 ENSMUST00000143021.9
myeloperoxidase
chr15_-_103163860 10.12 ENSMUST00000075192.13
nuclear factor, erythroid derived 2
chr15_+_80456775 9.90 ENSMUST00000229980.2
GRB2-related adaptor protein 2
chr4_-_46404224 9.84 ENSMUST00000107764.9
hemogen
chr2_-_27974889 9.29 ENSMUST00000028179.15
ENSMUST00000117486.8
ENSMUST00000135472.2
ficolin B
chr13_-_113237505 9.22 ENSMUST00000224282.2
ENSMUST00000023897.7
granzyme A
chr2_+_164790139 8.30 ENSMUST00000017881.3
matrix metallopeptidase 9
chr7_+_44221791 8.15 ENSMUST00000002274.10
napsin A aspartic peptidase
chr16_-_16681839 7.30 ENSMUST00000100136.4
immunoglobulin lambda-like polypeptide 1
chrX_-_7956682 7.27 ENSMUST00000033505.7
Wiskott-Aldrich syndrome
chr17_+_47906985 7.06 ENSMUST00000182539.8
cyclin D3
chr18_-_35782412 5.60 ENSMUST00000025211.6
marginal zone B and B1 cell-specific protein 1
chr17_+_12338161 5.60 ENSMUST00000024594.9
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr15_-_66673425 5.52 ENSMUST00000168589.8
src-like adaptor
chr17_+_29712008 5.18 ENSMUST00000234665.2
proviral integration site 1
chr7_-_126736979 5.15 ENSMUST00000049931.6
sialophorin
chr6_-_136918495 4.97 ENSMUST00000111892.8
Rho, GDP dissociation inhibitor (GDI) beta
chr4_-_133600308 4.88 ENSMUST00000137486.3
ribosomal protein S6 kinase polypeptide 1
chr2_-_25911691 4.54 ENSMUST00000036509.14
ubiquitin associated domain containing 1
chr6_-_136918671 4.44 ENSMUST00000032344.12
Rho, GDP dissociation inhibitor (GDI) beta
chr3_+_103767581 4.36 ENSMUST00000029433.9
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr2_-_25911544 4.32 ENSMUST00000136750.3
ubiquitin associated domain containing 1
chrX_-_56384089 4.28 ENSMUST00000033468.11
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr14_+_71011744 3.84 ENSMUST00000022698.8
docking protein 2
chr11_-_79421397 3.74 ENSMUST00000103236.4
ENSMUST00000170799.8
ENSMUST00000170422.4
ecotropic viral integration site 2a
ecotropic viral integration site 2
chr17_+_31427023 3.69 ENSMUST00000173776.2
ENSMUST00000048656.15
ubiquitin associated and SH3 domain containing, A
chr2_-_58050494 3.68 ENSMUST00000028175.7
cytohesin 1 interacting protein
chr17_+_33857030 3.38 ENSMUST00000052079.8
PML-RAR alpha-regulated adaptor molecule 1
chr11_-_69786324 3.29 ENSMUST00000001631.7
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr15_-_98505508 3.27 ENSMUST00000096224.6
adenylate cyclase 6
chr18_-_62313019 3.20 ENSMUST00000053640.5
adrenergic receptor, beta 2
chr12_+_85733415 3.18 ENSMUST00000040536.6
basic leucine zipper transcription factor, ATF-like
chr14_-_56499690 3.11 ENSMUST00000015581.6
granzyme B
chr10_-_35587888 2.97 ENSMUST00000080898.4
S-adenosylmethionine decarboxylase 2
chr8_-_11058458 2.93 ENSMUST00000040514.8
insulin receptor substrate 2
chr15_-_97742134 2.66 ENSMUST00000119670.8
ENSMUST00000116409.9
histone deacetylase 7
chr8_+_110432132 2.55 ENSMUST00000212964.2
ENSMUST00000034163.9
zinc finger protein 821
chr2_-_73316053 2.51 ENSMUST00000102680.8
WAS/WASL interacting protein family, member 1
chr11_-_100305654 2.39 ENSMUST00000066489.13
prolyl 3-hydroxylase family member 4 (non-enzymatic)
chr11_-_100986192 2.35 ENSMUST00000019447.15
proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
chr3_-_86049988 2.30 ENSMUST00000029722.7
ribosomal protein S3A1
chr1_+_40554513 2.28 ENSMUST00000027237.12
interleukin 18 receptor accessory protein
chr7_-_133310779 2.23 ENSMUST00000124759.2
ENSMUST00000106144.8
ENSMUST00000106145.10
uroporphyrinogen III synthase
chr9_+_113641615 2.23 ENSMUST00000111838.10
ENSMUST00000166734.10
ENSMUST00000214522.2
ENSMUST00000163895.3
CLIP associating protein 2
chr10_-_80382611 2.15 ENSMUST00000183233.9
ENSMUST00000182604.8
REX1, RNA exonuclease 1
chr7_+_45084257 2.14 ENSMUST00000003964.17
glycogen synthase 1, muscle
chr4_+_134847949 2.11 ENSMUST00000056977.14
runt related transcription factor 3
chr15_-_78377926 2.11 ENSMUST00000163494.3
interleukin 2 receptor, beta chain
chr10_-_40178182 2.08 ENSMUST00000099945.6
ENSMUST00000238953.2
ENSMUST00000238969.2
S-adenosylmethionine decarboxylase 1
chr9_+_108356935 2.03 ENSMUST00000194147.2
ENSMUST00000065014.10
ENSMUST00000195483.6
ENSMUST00000195058.2
laminin, beta 2
chr7_-_133310687 2.02 ENSMUST00000106146.8
uroporphyrinogen III synthase
chr15_+_97259060 2.00 ENSMUST00000228521.2
ENSMUST00000226495.2
PC-esterase domain containing 1B
chr1_+_171216480 1.98 ENSMUST00000056449.9
Rho GTPase activating protein 30
chr9_-_56151334 1.88 ENSMUST00000188142.7
pseudopodium-enriched atypical kinase 1
chr9_-_107648144 1.86 ENSMUST00000183248.3
ENSMUST00000182022.8
ENSMUST00000035199.13
ENSMUST00000182659.8
RNA binding motif protein 5
chr11_+_75422516 1.85 ENSMUST00000149727.8
ENSMUST00000108433.8
ENSMUST00000042561.14
ENSMUST00000143035.8
solute carrier family 43, member 2
chr2_+_172235702 1.82 ENSMUST00000099061.9
ENSMUST00000103073.9
Cas scaffolding protein family member 4
chr4_+_132903646 1.78 ENSMUST00000105912.2
WASP family, member 2
chr15_-_97742045 1.76 ENSMUST00000120683.8
histone deacetylase 7
chr4_-_70328659 1.76 ENSMUST00000144099.8
CDK5 regulatory subunit associated protein 2
chr16_-_95387444 1.75 ENSMUST00000233269.2
ETS transcription factor
chr7_-_43182595 1.69 ENSMUST00000205503.2
CD33 antigen
chr7_+_45084300 1.63 ENSMUST00000211150.2
glycogen synthase 1, muscle
chr7_-_115423934 1.63 ENSMUST00000169129.8
SRY (sex determining region Y)-box 6
chr7_-_45083688 1.62 ENSMUST00000210439.2
RuvB-like protein 2
chr2_+_172235820 1.60 ENSMUST00000109136.3
ENSMUST00000228775.2
Cas scaffolding protein family member 4
chr19_+_5618029 1.53 ENSMUST00000235575.2
ENSMUST00000235542.2
adaptor-related protein complex 5, beta 1 subunit
chr4_-_129467430 1.52 ENSMUST00000102596.8
lymphocyte protein tyrosine kinase
chr11_-_110058899 1.51 ENSMUST00000044850.4
ATP-binding cassette, sub-family A (ABC1), member 9
chr7_-_43182504 1.44 ENSMUST00000004728.12
CD33 antigen
chr7_+_126184108 1.43 ENSMUST00000039522.8
apolipoprotein B receptor
chr8_+_110432210 1.42 ENSMUST00000212192.2
zinc finger protein 821
chr14_-_56299764 1.36 ENSMUST00000043249.10
mast cell protease 4
chr13_+_76727787 1.33 ENSMUST00000126960.8
ENSMUST00000109583.9
multiple C2 domains, transmembrane 1
chr11_-_115426618 1.29 ENSMUST00000121185.8
ENSMUST00000117589.8
small ubiquitin-like modifier 2
chr5_-_107873883 1.28 ENSMUST00000159263.3
growth factor independent 1 transcription repressor
chr17_-_37269425 1.28 ENSMUST00000172518.8
RNA polymerase I subunit H
chr11_+_6511133 1.27 ENSMUST00000160633.8
ENSMUST00000109721.3
cerebral cavernous malformation 2
chr17_+_26882171 1.26 ENSMUST00000236346.2
ATPase, H+ transporting, lysosomal V0 subunit E
chr11_+_75422925 1.24 ENSMUST00000169547.9
solute carrier family 43, member 2
chr2_+_30331839 1.21 ENSMUST00000131476.8
protein phosphatase 2 protein activator
chr1_-_138103021 1.19 ENSMUST00000182755.8
ENSMUST00000193650.2
ENSMUST00000182283.8
protein tyrosine phosphatase, receptor type, C
chr3_-_96721829 1.19 ENSMUST00000047702.8
CD160 antigen
chr11_-_108234743 1.16 ENSMUST00000059595.11
protein kinase C, alpha
chr6_-_53045546 1.10 ENSMUST00000074541.6
JAZF zinc finger 1
chr5_+_139392142 1.06 ENSMUST00000052176.9
RIKEN cDNA C130050O18 gene
chr3_-_59009231 1.05 ENSMUST00000085040.5
G protein-coupled receptor 171
chr11_+_69857722 1.05 ENSMUST00000151515.2
claudin 7
chr16_+_91188609 1.04 ENSMUST00000160764.2
predicted gene 21970
chr17_+_75485791 1.04 ENSMUST00000135447.8
ENSMUST00000112516.8
latent transforming growth factor beta binding protein 1
chr15_+_9436114 1.00 ENSMUST00000042360.5
ENSMUST00000226688.2
calcyphosine-like
chr11_-_83540175 0.95 ENSMUST00000001008.6
chemokine (C-C motif) ligand 3
chrX_+_158410528 0.93 ENSMUST00000073094.10
SH3-domain kinase binding protein 1
chrX_+_55831887 0.92 ENSMUST00000144600.8
four and a half LIM domains 1
chr2_+_32611067 0.92 ENSMUST00000074248.11
SH2 domain containing 3C
chr19_+_5618096 0.92 ENSMUST00000096318.4
adaptor-related protein complex 5, beta 1 subunit
chr4_-_6990774 0.90 ENSMUST00000039987.4
thymocyte selection-associated high mobility group box
chr11_+_11414256 0.90 ENSMUST00000020410.11
spermatogenesis associated 48
chr17_-_37269330 0.87 ENSMUST00000113669.9
RNA polymerase I subunit H
chr3_-_107667499 0.87 ENSMUST00000153114.2
ENSMUST00000118593.8
ENSMUST00000120243.8
colony stimulating factor 1 (macrophage)
chr15_-_37459570 0.82 ENSMUST00000119730.8
ENSMUST00000120746.8
neurocalcin delta
chr11_+_116324913 0.81 ENSMUST00000057676.7
UBA-like domain containing 2
chr11_-_100098333 0.81 ENSMUST00000007272.8
keratin 14
chr11_-_3321307 0.79 ENSMUST00000101640.10
ENSMUST00000101642.10
LIM motif-containing protein kinase 2
chr15_+_80595486 0.76 ENSMUST00000067689.9
trinucleotide repeat containing 6b
chr3_+_102965601 0.75 ENSMUST00000029445.13
ENSMUST00000200069.5
neuroblastoma ras oncogene
chr5_-_140368482 0.75 ENSMUST00000196566.5
sorting nexin 8
chr1_-_138102972 0.75 ENSMUST00000195533.6
ENSMUST00000183301.8
protein tyrosine phosphatase, receptor type, C
chr7_-_24831892 0.71 ENSMUST00000108418.11
ENSMUST00000175774.9
ENSMUST00000108415.10
ENSMUST00000098679.10
ENSMUST00000108417.10
ENSMUST00000108416.10
ENSMUST00000108413.8
ENSMUST00000176408.8
POU domain, class 2, transcription factor 2
chrX_-_20816841 0.68 ENSMUST00000009550.14
ELK1, member of ETS oncogene family
chr11_-_95733235 0.67 ENSMUST00000059026.10
ABI family member 3
chrX_-_12026594 0.63 ENSMUST00000043441.13
BCL6 interacting corepressor
chr17_+_75485906 0.63 ENSMUST00000112514.2
latent transforming growth factor beta binding protein 1
chr6_+_136495784 0.60 ENSMUST00000032335.13
ENSMUST00000185724.7
activating transcription factor 7 interacting protein
chr2_-_71198091 0.59 ENSMUST00000151937.8
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr9_-_103569984 0.58 ENSMUST00000049452.15
transmembrane protein 108
chr7_-_105218472 0.58 ENSMUST00000187683.7
ENSMUST00000210079.2
ENSMUST00000187051.7
ENSMUST00000189265.7
ENSMUST00000190369.7
amyloid beta (A4) precursor protein-binding, family B, member 1
chr13_+_76727799 0.56 ENSMUST00000109589.3
multiple C2 domains, transmembrane 1
chr19_-_45619559 0.53 ENSMUST00000160718.9
F-box and WD-40 domain protein 4
chr1_+_36346824 0.52 ENSMUST00000142319.8
ENSMUST00000097778.9
ENSMUST00000115031.8
ENSMUST00000115032.8
ENSMUST00000137906.2
ENSMUST00000115029.2
AT rich interactive domain 5A (MRF1-like)
chr2_-_119590776 0.47 ENSMUST00000082130.13
ENSMUST00000028759.13
leukocyte tyrosine kinase
chr13_+_49761506 0.47 ENSMUST00000021822.7
osteoglycin
chr19_+_4264470 0.47 ENSMUST00000237171.2
predicted gene, 45928
chr11_-_52173391 0.47 ENSMUST00000086844.10
transcription factor 7, T cell specific
chrX_+_158480304 0.45 ENSMUST00000123433.8
SH3-domain kinase binding protein 1
chr12_-_114878652 0.44 ENSMUST00000103515.2
immunoglobulin heavy variable 1-39
chr12_-_112824506 0.43 ENSMUST00000021729.9
G protein-coupled receptor 132
chr1_+_83022653 0.41 ENSMUST00000222567.2
predicted gene, 47969
chr15_-_38519499 0.41 ENSMUST00000110329.8
ENSMUST00000065308.13
antizyme inhibitor 1
chr11_-_72106418 0.38 ENSMUST00000021157.9
mediator complex subunit 31
chr15_-_102630589 0.37 ENSMUST00000023818.11
calcium binding and coiled coil domain 1
chr15_-_102630496 0.31 ENSMUST00000171838.2
calcium binding and coiled coil domain 1
chr19_+_4264292 0.31 ENSMUST00000046506.7
cardiotrophin-like cytokine factor 1
chr2_-_73316809 0.27 ENSMUST00000141264.8
WAS/WASL interacting protein family, member 1
chr5_+_57879201 0.27 ENSMUST00000199310.2
protocadherin 7
chr15_-_98277078 0.26 ENSMUST00000057386.6
olfactory receptor 283
chr16_-_38253507 0.25 ENSMUST00000002926.8
phospholipase A1 member A
chr11_+_75422953 0.24 ENSMUST00000127226.3
solute carrier family 43, member 2
chr6_-_100648086 0.24 ENSMUST00000089245.7
ENSMUST00000113312.9
ENSMUST00000170667.8
SHQ1 homolog (S. cerevisiae)
chr7_-_105217851 0.24 ENSMUST00000188368.7
ENSMUST00000187057.7
amyloid beta (A4) precursor protein-binding, family B, member 1
chr6_+_21985902 0.23 ENSMUST00000115383.9
cadherin-like and PC-esterase domain containing 1
chr4_-_110149916 0.23 ENSMUST00000106601.8
ELAV like RNA binding protein 4
chr14_+_53994813 0.23 ENSMUST00000180380.3
T cell receptor alpha variable 13-4-DV7
chr17_-_37269153 0.23 ENSMUST00000172823.2
RNA polymerase I subunit H
chr6_+_17749169 0.22 ENSMUST00000053148.14
ENSMUST00000115417.4
suppression of tumorigenicity 7
chr3_+_96088467 0.22 ENSMUST00000035371.9
synaptic vesicle glycoprotein 2 a
chr3_+_64884839 0.21 ENSMUST00000239069.2
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr12_+_114594300 0.21 ENSMUST00000095364.3

chr10_-_14593935 0.19 ENSMUST00000020016.5
gap junction protein, epsilon 1
chr17_+_47604995 0.17 ENSMUST00000190020.4
transcriptional regulating factor 1
chr5_-_75205358 0.17 ENSMUST00000075452.7
cysteine-rich hydrophobic domain 2
chr14_-_20668406 0.16 ENSMUST00000035340.14
ubiquitin specific peptidase 54
chr1_-_168259839 0.16 ENSMUST00000188912.7
pre B cell leukemia homeobox 1
chr11_-_102109748 0.15 ENSMUST00000131254.2
histone deacetylase 5
chr5_+_104582978 0.15 ENSMUST00000086833.13
ENSMUST00000031243.15
ENSMUST00000112748.8
ENSMUST00000112746.8
ENSMUST00000145084.8
ENSMUST00000132457.8
secreted phosphoprotein 1
chr18_-_60781365 0.15 ENSMUST00000143275.3
synaptopodin
chr19_-_8816530 0.13 ENSMUST00000096259.6
guanine nucleotide binding protein (G protein), gamma 3
chr11_+_95733109 0.12 ENSMUST00000107714.9
ENSMUST00000107711.8
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chrX_-_100777806 0.10 ENSMUST00000056614.7
chemokine (C-X-C motif) receptor 3
chr12_-_115567853 0.09 ENSMUST00000103538.3
ENSMUST00000198646.2
immunoglobulin heavy variable V1-67
chr7_-_25374472 0.09 ENSMUST00000108404.8
ENSMUST00000108405.2
ENSMUST00000079439.10
transmembrane protein 91
chr6_+_136495818 0.08 ENSMUST00000186577.7
activating transcription factor 7 interacting protein
chr1_-_173945580 0.08 ENSMUST00000063030.4
olfactory receptor 231
chr10_+_127575407 0.07 ENSMUST00000054287.9
zinc finger and BTB domain containing 39
chr1_-_161616031 0.04 ENSMUST00000000834.4
Fas ligand (TNF superfamily, member 6)
chr11_-_100012384 0.04 ENSMUST00000007275.3
keratin 13
chr16_-_92622972 0.02 ENSMUST00000023673.14
runt related transcription factor 1
chr12_-_115706126 0.01 ENSMUST00000166645.2
ENSMUST00000196690.2
immunoglobulin heavy variable 1-71
chr1_-_164763091 0.00 ENSMUST00000027860.8
chemokine (C motif) ligand 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.4 31.3 GO:0002149 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
2.8 8.3 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
2.4 7.3 GO:0002625 regulation of T cell antigen processing and presentation(GO:0002625)
1.9 9.3 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
1.7 5.2 GO:0001807 regulation of type IV hypersensitivity(GO:0001807)
1.7 5.1 GO:0006597 spermine biosynthetic process(GO:0006597)
1.5 7.5 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
1.5 4.4 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
1.4 4.2 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780)
1.1 3.3 GO:1904117 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
1.0 9.4 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.9 9.2 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.8 3.2 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.7 2.0 GO:0072312 metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313)
0.7 10.1 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.6 3.1 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.5 4.9 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.4 0.9 GO:1902226 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.4 5.2 GO:0070561 vitamin D receptor signaling pathway(GO:0070561) regulation of hematopoietic stem cell proliferation(GO:1902033)
0.4 1.2 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.4 6.3 GO:0043129 surfactant homeostasis(GO:0043129)
0.3 1.3 GO:0070103 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.3 7.1 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.3 1.8 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.3 4.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.3 1.2 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.3 1.6 GO:0071899 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.3 3.4 GO:0043313 regulation of neutrophil degranulation(GO:0043313)
0.2 2.9 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.2 0.7 GO:0002380 immunoglobulin secretion involved in immune response(GO:0002380)
0.2 2.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 1.8 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.2 3.2 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.2 3.7 GO:0038065 collagen-activated signaling pathway(GO:0038065)
0.2 0.6 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.2 1.5 GO:0045588 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645)
0.1 1.6 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.8 GO:0050760 thymidylate synthase biosynthetic process(GO:0050757) regulation of thymidylate synthase biosynthetic process(GO:0050758) negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.1 0.2 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.1 0.6 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 0.8 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.1 1.3 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.1 1.4 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.1 10.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 0.4 GO:1902269 positive regulation of polyamine transmembrane transport(GO:1902269)
0.1 0.5 GO:0030538 embryonic genitalia morphogenesis(GO:0030538) embryonic hindgut morphogenesis(GO:0048619)
0.1 2.8 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 0.6 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 2.1 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 1.8 GO:0072673 lamellipodium morphogenesis(GO:0072673)
0.1 1.0 GO:0043615 astrocyte cell migration(GO:0043615)
0.1 0.8 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 0.7 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 3.8 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 1.0 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.1 1.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 7.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 0.2 GO:2000863 positive regulation of estrogen secretion(GO:2000863)
0.0 1.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.6 GO:0072600 establishment of protein localization to Golgi(GO:0072600)
0.0 2.3 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 1.3 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 5.6 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.0 0.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 1.4 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.7 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 5.6 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 1.9 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 1.7 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 1.2 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 2.1 GO:0030101 natural killer cell activation(GO:0030101)
0.0 1.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.5 GO:0010663 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.0 1.9 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.2 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.0 0.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 31.3 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.8 3.1 GO:0044194 cytolytic granule(GO:0044194)
0.7 2.2 GO:1904511 cortical microtubule plus-end(GO:1903754) cytoplasmic microtubule plus-end(GO:1904511)
0.7 8.2 GO:0097208 alveolar lamellar body(GO:0097208)
0.7 9.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.6 1.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.5 2.0 GO:0005608 laminin-3 complex(GO:0005608)
0.4 5.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.3 5.2 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.2 0.9 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.2 1.6 GO:0097255 R2TP complex(GO:0097255)
0.1 3.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.8 GO:0031209 SCAR complex(GO:0031209)
0.1 3.3 GO:0000242 pericentriolar material(GO:0000242)
0.1 6.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 1.3 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.8 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.1 7.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 1.2 GO:0042627 chylomicron(GO:0042627)
0.1 3.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.4 GO:0070847 core mediator complex(GO:0070847)
0.0 10.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 8.2 GO:0005884 actin filament(GO:0005884)
0.0 4.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.1 GO:0097444 spine apparatus(GO:0097444)
0.0 3.6 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 6.3 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 3.3 GO:0016234 inclusion body(GO:0016234)
0.0 5.0 GO:0030027 lamellipodium(GO:0030027)
0.0 5.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.4 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 4.5 GO:0005819 spindle(GO:0005819)
0.0 0.7 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.6 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 1.3 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
1.0 9.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.8 9.3 GO:0033691 sialic acid binding(GO:0033691)
0.8 3.2 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.7 5.1 GO:0019808 polyamine binding(GO:0019808)
0.7 4.2 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.7 2.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.5 3.3 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.4 31.3 GO:0004601 peroxidase activity(GO:0004601)
0.4 0.9 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.4 1.7 GO:0050436 microfibril binding(GO:0050436)
0.4 5.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.4 1.2 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.3 4.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.3 1.5 GO:0042610 CD8 receptor binding(GO:0042610)
0.3 1.2 GO:0008160 protein tyrosine phosphatase activator activity(GO:0008160)
0.3 8.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.2 2.3 GO:0050692 DBD domain binding(GO:0050692)
0.2 5.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 6.7 GO:0043274 phospholipase binding(GO:0043274)
0.2 2.3 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.2 1.6 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.2 6.9 GO:0001968 fibronectin binding(GO:0001968)
0.2 4.2 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 10.1 GO:0050699 WW domain binding(GO:0050699)
0.1 1.0 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 1.2 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1 12.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.8 GO:1990254 keratin filament binding(GO:1990254)
0.1 7.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 0.6 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 0.4 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.1 2.2 GO:0002162 dystroglycan binding(GO:0002162)
0.1 4.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 1.3 GO:0031386 protein tag(GO:0031386)
0.1 2.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 7.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 3.3 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 1.0 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 1.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 2.3 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 8.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.8 GO:0048156 tau protein binding(GO:0048156)
0.0 6.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 2.2 GO:0004527 exonuclease activity(GO:0004527)
0.0 0.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.1 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 2.1 GO:0046332 SMAD binding(GO:0046332)
0.0 2.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 9.9 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.4 26.8 PID IL23 PATHWAY IL23-mediated signaling events
0.4 6.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3 16.9 PID IL12 2PATHWAY IL12-mediated signaling events
0.2 5.2 PID IL5 PATHWAY IL5-mediated signaling events
0.2 1.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 5.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2 7.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.2 7.9 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.2 7.5 PID IL2 1PATHWAY IL2-mediated signaling events
0.1 3.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 2.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 5.9 PID ARF6 PATHWAY Arf6 signaling events
0.1 11.6 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 3.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 9.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 1.9 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 4.9 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 1.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 1.6 PID MYC PATHWAY C-MYC pathway
0.0 5.4 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 1.4 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.8 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.7 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 15.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.3 1.9 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2 6.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 3.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 2.9 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.2 4.2 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 4.6 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 4.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 5.6 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 5.6 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 7.1 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 5.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 2.1 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 3.2 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 3.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 0.8 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 10.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.5 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 3.1 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 4.2 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 4.4 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.6 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 9.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.0 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 2.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.9 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis