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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Smad3

Z-value: 1.26

Motif logo

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Transcription factors associated with Smad3

Gene Symbol Gene ID Gene Info
Smad3
ENSMUSG00000032402.13 Smad3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad3mm39_v1_chr9_-_63665216_63665276-0.316.2e-02Click!

Activity profile of Smad3 motif

Sorted Z-values of Smad3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_-_60455331 3.93 ENSMUST00000135953.2
Mup1
major urinary protein 1
chr13_+_23940964 2.35 ENSMUST00000102965.4
H4c2
H4 clustered histone 2
chr13_+_22220000 2.17 ENSMUST00000110455.4
H2bc12
H2B clustered histone 12
chr7_+_123061535 2.05 ENSMUST00000098056.6
Aqp8
aquaporin 8
chr7_+_26534730 2.02 ENSMUST00000005685.15
Cyp2a5
cytochrome P450, family 2, subfamily a, polypeptide 5
chr13_+_22227359 1.95 ENSMUST00000110452.2
H2bc11
H2B clustered histone 11
chr7_+_26006594 1.83 ENSMUST00000098657.5
Cyp2a4
cytochrome P450, family 2, subfamily a, polypeptide 4
chr13_-_23735822 1.80 ENSMUST00000102971.2
H4c6
H4 clustered histone 6
chr13_+_23765546 1.64 ENSMUST00000102968.3
H4c4
H4 clustered histone 4
chr13_-_22227114 1.46 ENSMUST00000091741.6
H2ac11
H2A clustered histone 11
chr13_-_23755374 1.41 ENSMUST00000102969.6
H2ac8
H2A clustered histone 8
chr13_+_23715220 1.39 ENSMUST00000102972.6
H4c8
H4 clustered histone 8
chr13_+_23755551 1.34 ENSMUST00000079251.8
H2bc8
H2B clustered histone 8
chr13_-_22017677 1.30 ENSMUST00000081342.7
H2ac24
H2A clustered histone 24
chr13_+_23718038 1.28 ENSMUST00000073261.3
H2ac10
H2A clustered histone 10
chr13_-_21934675 1.27 ENSMUST00000102983.2
H4c12
H4 clustered histone 12
chr13_+_22017906 1.26 ENSMUST00000180288.2
H2bc24
H2B clustered histone 24
chr15_-_103161237 1.23 ENSMUST00000154510.8
Nfe2
nuclear factor, erythroid derived 2
chr2_-_152673032 1.23 ENSMUST00000128172.3
Bcl2l1
BCL2-like 1
chr2_-_152673585 1.22 ENSMUST00000156688.2
ENSMUST00000007803.12
Bcl2l1
BCL2-like 1
chr13_+_21971631 1.10 ENSMUST00000110473.3
ENSMUST00000102982.2
H2bc22
H2B clustered histone 22
chr2_+_29759495 1.10 ENSMUST00000047521.7
ENSMUST00000134152.2
Cercam
cerebral endothelial cell adhesion molecule
chr13_-_22016364 1.06 ENSMUST00000102979.2
H4c18
H4 clustered histone 18
chr13_-_22225527 1.06 ENSMUST00000102977.4
H4c9
H4 clustered histone 9
chr13_-_21900313 1.02 ENSMUST00000091756.2
H2bc13
H2B clustered histone 13
chr6_+_136785230 0.97 ENSMUST00000074556.7
ENSMUST00000203982.2
H2aj
H2J.A histone
chr7_-_99340830 0.95 ENSMUST00000208713.2
Slco2b1
solute carrier organic anion transporter family, member 2b1
chr13_+_23868175 0.90 ENSMUST00000018246.6
H2bc4
H2B clustered histone 4
chr3_-_96170627 0.89 ENSMUST00000171473.3
H4c14
H4 clustered histone 14
chr13_-_21971388 0.88 ENSMUST00000091751.3
H2ac22
H2A clustered histone 22
chr17_-_71575584 0.87 ENSMUST00000233148.2
Emilin2
elastin microfibril interfacer 2
chr13_-_96572460 0.78 ENSMUST00000181761.2
Ankdd1b
ankyrin repeat and death domain containing 1B
chr9_-_106533279 0.71 ENSMUST00000023959.13
ENSMUST00000201681.2
Grm2
glutamate receptor, metabotropic 2
chr12_+_58258558 0.71 ENSMUST00000110671.3
ENSMUST00000044299.3
Sstr1
somatostatin receptor 1
chr7_-_81104423 0.69 ENSMUST00000178892.3
ENSMUST00000098331.10
Cpeb1
cytoplasmic polyadenylation element binding protein 1
chr8_+_124532781 0.69 ENSMUST00000117702.2
Rab4a
RAB4A, member RAS oncogene family
chr13_-_23867924 0.67 ENSMUST00000171127.4
H2ac6
H2A clustered histone 6
chr11_+_73131136 0.59 ENSMUST00000138853.3
Trpv1
transient receptor potential cation channel, subfamily V, member 1
chr4_+_45018583 0.56 ENSMUST00000133157.8
ENSMUST00000029999.15
ENSMUST00000107814.10
Polr1e
polymerase (RNA) I polypeptide E
chr2_+_177834868 0.55 ENSMUST00000103065.2
Phactr3
phosphatase and actin regulator 3
chr11_+_73130872 0.54 ENSMUST00000108470.8
Trpv1
transient receptor potential cation channel, subfamily V, member 1
chr19_-_47907705 0.54 ENSMUST00000095998.7
Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr1_-_128256048 0.54 ENSMUST00000073490.7
Lct
lactase
chr19_-_47907628 0.52 ENSMUST00000237029.2
Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr2_-_119060366 0.51 ENSMUST00000076084.6
Ppp1r14d
protein phosphatase 1, regulatory inhibitor subunit 14D
chr8_-_85549452 0.51 ENSMUST00000065539.6
Dand5
DAN domain family member 5, BMP antagonist
chr17_-_43003135 0.50 ENSMUST00000170723.8
ENSMUST00000164524.2
ENSMUST00000024711.11
ENSMUST00000167993.8
Adgrf4
adhesion G protein-coupled receptor F4
chr7_+_51530060 0.50 ENSMUST00000145049.2
Gas2
growth arrest specific 2
chr7_-_30335277 0.49 ENSMUST00000108147.3
Etv2
ets variant 2
chr9_-_123778334 0.49 ENSMUST00000071404.5
Ccr1l1
chemokine (C-C motif) receptor 1-like 1
chr9_-_66421868 0.48 ENSMUST00000056890.10
Fbxl22
F-box and leucine-rich repeat protein 22
chr6_-_129252323 0.48 ENSMUST00000204411.2
Cd69
CD69 antigen
chr10_+_33780993 0.47 ENSMUST00000169670.8
Rsph4a
radial spoke head 4 homolog A (Chlamydomonas)
chr5_+_72360631 0.47 ENSMUST00000169617.3
Atp10d
ATPase, class V, type 10D
chr1_+_146373352 0.45 ENSMUST00000132847.8
ENSMUST00000166814.8
Brinp3
bone morphogenetic protein/retinoic acid inducible neural specific 3
chr9_+_53678801 0.44 ENSMUST00000048670.10
Slc35f2
solute carrier family 35, member F2
chr7_-_4550523 0.44 ENSMUST00000206023.2
Syt5
synaptotagmin V
chrX_+_72454702 0.42 ENSMUST00000033740.12
Zfp92
zinc finger protein 92
chr14_+_53775648 0.41 ENSMUST00000200115.2
ENSMUST00000103650.3
Trav12-1
T cell receptor alpha variable 12-1
chr11_-_87719115 0.39 ENSMUST00000136446.3
Lpo
lactoperoxidase
chr4_-_129015493 0.39 ENSMUST00000135763.2
ENSMUST00000149763.3
ENSMUST00000164649.8
Hpca
hippocalcin
chr7_-_119078330 0.38 ENSMUST00000207460.2
Umod
uromodulin
chr18_-_77134980 0.37 ENSMUST00000154665.2
ENSMUST00000026486.13
ENSMUST00000123650.2
ENSMUST00000126153.8
Katnal2
katanin p60 subunit A-like 2
chr7_-_43885522 0.37 ENSMUST00000206686.2
ENSMUST00000037220.5
1700028J19Rik
RIKEN cDNA 1700028J19 gene
chr13_-_23015518 0.37 ENSMUST00000226294.2
ENSMUST00000226180.2
Vmn1r210
vomeronasal 1 receptor 210
chr13_-_22289994 0.37 ENSMUST00000227357.2
ENSMUST00000228428.2
Vmn1r189
vomeronasal 1 receptor 189
chr18_-_77134939 0.36 ENSMUST00000137354.8
ENSMUST00000137498.8
Katnal2
katanin p60 subunit A-like 2
chr12_-_76842263 0.35 ENSMUST00000082431.6
Gpx2
glutathione peroxidase 2
chr2_-_30084124 0.35 ENSMUST00000113659.8
ENSMUST00000113660.2
Kyat1
kynurenine aminotransferase 1
chr1_+_60948149 0.34 ENSMUST00000027164.9
Ctla4
cytotoxic T-lymphocyte-associated protein 4
chr13_+_22268610 0.33 ENSMUST00000228243.2
ENSMUST00000226680.2
Vmn1r188
vomeronasal 1 receptor 188
chr15_+_81821112 0.33 ENSMUST00000135663.2
Csdc2
cold shock domain containing C2, RNA binding
chr14_+_64331130 0.33 ENSMUST00000224112.2
ENSMUST00000165710.2
ENSMUST00000170709.2
Prss51
protease, serine 51
chr12_+_114594300 0.33 ENSMUST00000095364.3
ENSMUSG00000090765.2

chrX_-_143471176 0.33 ENSMUST00000040184.4
Trpc5
transient receptor potential cation channel, subfamily C, member 5
chr11_-_82070629 0.32 ENSMUST00000108189.9
ENSMUST00000021043.5
Ccl1
chemokine (C-C motif) ligand 1
chr5_+_75735576 0.32 ENSMUST00000144270.8
ENSMUST00000005815.7
Kit
KIT proto-oncogene receptor tyrosine kinase
chr9_+_108368032 0.32 ENSMUST00000166103.9
ENSMUST00000085044.14
ENSMUST00000193678.6
ENSMUST00000178075.8
Usp19
ubiquitin specific peptidase 19
chr18_+_57666852 0.32 ENSMUST00000079738.10
ENSMUST00000135806.8
ENSMUST00000127130.9
Ccdc192
coiled-coil domain containing 192
chr9_+_43983493 0.32 ENSMUST00000176671.2
Usp2
ubiquitin specific peptidase 2
chr11_+_87457544 0.31 ENSMUST00000060360.7
Septin4
septin 4
chr15_-_76906832 0.31 ENSMUST00000019037.10
ENSMUST00000169226.9
Mb
myoglobin
chr12_-_81468705 0.31 ENSMUST00000085319.4
Adam4
a disintegrin and metallopeptidase domain 4
chr5_-_53864874 0.30 ENSMUST00000031093.5
Cckar
cholecystokinin A receptor
chr9_+_108367801 0.30 ENSMUST00000006854.13
Usp19
ubiquitin specific peptidase 19
chr3_-_79645101 0.30 ENSMUST00000078527.13
Rxfp1
relaxin/insulin-like family peptide receptor 1
chr7_+_3473178 0.30 ENSMUST00000108647.3
Cacng6
calcium channel, voltage-dependent, gamma subunit 6
chr3_+_107538638 0.29 ENSMUST00000106703.2
Gm10961
predicted gene 10961
chr7_-_104019046 0.29 ENSMUST00000106831.3
Trim30b
tripartite motif-containing 30B
chr2_-_173117936 0.29 ENSMUST00000139306.2
Pmepa1
prostate transmembrane protein, androgen induced 1
chr1_+_60948307 0.29 ENSMUST00000097720.4
Ctla4
cytotoxic T-lymphocyte-associated protein 4
chr14_+_53478202 0.28 ENSMUST00000179583.3
Trav12n-3
T cell receptor alpha variable 12N-3
chr14_-_62693735 0.28 ENSMUST00000165651.8
ENSMUST00000022501.10
Gucy1b2
guanylate cyclase 1, soluble, beta 2
chr7_-_104018989 0.27 ENSMUST00000164410.2
Trim30b
tripartite motif-containing 30B
chr12_-_115129697 0.27 ENSMUST00000103524.2
ENSMUST00000193145.2
Ighv8-6
immunoglobulin heavy variable V8-6
chr7_+_104506216 0.27 ENSMUST00000067695.8
Usp17la
ubiquitin specific peptidase 17-like A
chr2_-_17465410 0.27 ENSMUST00000145492.2
Nebl
nebulette
chr1_+_165312738 0.26 ENSMUST00000111440.8
ENSMUST00000027852.15
ENSMUST00000111439.8
Adcy10
adenylate cyclase 10
chr3_+_107008343 0.26 ENSMUST00000197470.5
Kcna2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr5_-_72661546 0.25 ENSMUST00000005352.10
Corin
corin, serine peptidase
chr14_-_50020788 0.25 ENSMUST00000118129.2
ENSMUST00000036972.14
Armh4
armadillo-like helical domain containing 4
chr12_+_119909692 0.24 ENSMUST00000058644.15
Tmem196
transmembrane protein 196
chr15_-_101471324 0.24 ENSMUST00000023714.5
Krt90
keratin 90
chr7_+_103065903 0.24 ENSMUST00000079348.4
Usp17lc
ubiquitin specific peptidase 17-like C
chr13_+_23398297 0.24 ENSMUST00000236177.2
Vmn1r221
vomeronasal 1 receptor 221
chrX_-_94070277 0.24 ENSMUST00000096367.5
Spin4
spindlin family, member 4
chr8_+_55053809 0.23 ENSMUST00000033917.7
Spata4
spermatogenesis associated 4
chr6_+_120070307 0.23 ENSMUST00000112711.9
Ninj2
ninjurin 2
chr10_+_79690452 0.23 ENSMUST00000165704.8
Ptbp1
polypyrimidine tract binding protein 1
chr1_+_180720666 0.23 ENSMUST00000085797.6
Lefty2
left-right determination factor 2
chr10_+_79690492 0.23 ENSMUST00000171599.8
ENSMUST00000095457.11
Ptbp1
polypyrimidine tract binding protein 1
chr12_+_100745314 0.22 ENSMUST00000069782.11
Dglucy
D-glutamate cyclase
chrX_+_142447286 0.22 ENSMUST00000112868.8
Pak3
p21 (RAC1) activated kinase 3
chr6_-_129252396 0.22 ENSMUST00000032259.6
Cd69
CD69 antigen
chr6_+_90105406 0.21 ENSMUST00000072859.6
Vmn1r51
vomeronasal 1 receptor 51
chr11_+_69047815 0.21 ENSMUST00000036424.3
Alox12b
arachidonate 12-lipoxygenase, 12R type
chr13_+_23343482 0.19 ENSMUST00000226845.2
ENSMUST00000228666.2
ENSMUST00000227388.2
Vmn1r219
vomeronasal 1 receptor 219
chr18_-_74340842 0.19 ENSMUST00000040188.16
Ska1
spindle and kinetochore associated complex subunit 1
chrX_+_142447361 0.18 ENSMUST00000126592.8
ENSMUST00000156449.8
ENSMUST00000155215.8
ENSMUST00000112865.8
Pak3
p21 (RAC1) activated kinase 3
chr11_-_94932158 0.18 ENSMUST00000038431.8
Pdk2
pyruvate dehydrogenase kinase, isoenzyme 2
chr16_+_34470290 0.17 ENSMUST00000148562.8
Ropn1
ropporin, rhophilin associated protein 1
chr12_+_100745333 0.16 ENSMUST00000110073.8
ENSMUST00000110069.8
Dglucy
D-glutamate cyclase
chr12_-_114370581 0.16 ENSMUST00000191918.2
Ighv6-4
immunoglobulin heavy variable V6-4
chr7_-_12770556 0.15 ENSMUST00000123541.2
Ube2m
ubiquitin-conjugating enzyme E2M
chr12_-_115031622 0.15 ENSMUST00000194257.2
Ighv8-5
immunoglobulin heavy variable V8-5
chr5_+_114912738 0.15 ENSMUST00000102578.11
Ankrd13a
ankyrin repeat domain 13a
chr13_+_23191826 0.15 ENSMUST00000228758.2
ENSMUST00000228031.2
ENSMUST00000227573.2
Vmn1r213
vomeronasal 1 receptor 213
chr19_+_55886708 0.15 ENSMUST00000148666.3
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr3_+_92281215 0.14 ENSMUST00000056590.6
Sprr2g
small proline-rich protein 2G
chr1_-_126420659 0.14 ENSMUST00000161954.8
Nckap5
NCK-associated protein 5
chr18_+_31767369 0.14 ENSMUST00000235017.2
ENSMUST00000178164.8
ENSMUST00000025109.8
Sap130
Sin3A associated protein
chr1_+_131616504 0.13 ENSMUST00000129905.2
Rab7b
RAB7B, member RAS oncogene family
chr14_+_31750946 0.13 ENSMUST00000022460.11
Galnt15
polypeptide N-acetylgalactosaminyltransferase 15
chr16_-_44978546 0.12 ENSMUST00000114600.2
Slc35a5
solute carrier family 35, member A5
chr1_+_171197660 0.12 ENSMUST00000111286.9
Nectin4
nectin cell adhesion molecule 4
chr7_-_127187767 0.12 ENSMUST00000072155.5
Ccdc189
coiled-coil domain containing 189
chr7_-_119078472 0.12 ENSMUST00000209095.2
ENSMUST00000033263.6
ENSMUST00000207261.2
Umod
uromodulin
chr11_+_49414548 0.11 ENSMUST00000077143.7
Olfr1383
olfactory receptor 1383
chr1_-_126420420 0.11 ENSMUST00000162877.8
Nckap5
NCK-associated protein 5
chr12_-_114217671 0.10 ENSMUST00000193408.2
Ighv3-4
immunoglobulin heavy variable V3-4
chr5_+_92540444 0.10 ENSMUST00000126281.8
Art3
ADP-ribosyltransferase 3
chr10_-_119075910 0.09 ENSMUST00000020315.13
Cand1
cullin associated and neddylation disassociated 1
chr7_+_24920840 0.09 ENSMUST00000055604.6
Zfp526
zinc finger protein 526
chr18_-_74340885 0.08 ENSMUST00000177604.2
Ska1
spindle and kinetochore associated complex subunit 1
chr6_+_41092970 0.08 ENSMUST00000103268.3
Trbv13-1
T cell receptor beta, variable 13-1
chr16_+_90017634 0.07 ENSMUST00000023707.11
Sod1
superoxide dismutase 1, soluble
chr7_-_24016020 0.05 ENSMUST00000108436.8
ENSMUST00000032673.15
Zfp94
zinc finger protein 94
chr3_+_107008867 0.05 ENSMUST00000038695.6
Kcna2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr2_-_164876690 0.04 ENSMUST00000122070.2
ENSMUST00000121377.8
ENSMUST00000153905.2
ENSMUST00000040381.15
Ncoa5
nuclear receptor coactivator 5
chr1_-_75187441 0.03 ENSMUST00000185448.2
Glb1l
galactosidase, beta 1-like
chr14_+_20398230 0.03 ENSMUST00000224930.2
ENSMUST00000224110.2
ENSMUST00000225942.2
ENSMUST00000051915.7
ENSMUST00000090499.13
ENSMUST00000224721.2
ENSMUST00000090503.12
ENSMUST00000225991.2
ENSMUST00000037698.13
Fam149b
family with sequence similarity 149, member B
chr6_+_41092928 0.02 ENSMUST00000194399.2
Trbv13-1
T cell receptor beta, variable 13-1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0046898 response to cycloheximide(GO:0046898)
0.3 3.9 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.3 1.1 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.3 2.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.2 0.9 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
0.2 0.6 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.1 0.4 GO:0031283 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.1 0.5 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.1 3.8 GO:0035634 response to stilbenoid(GO:0035634)
0.1 0.5 GO:0072233 ascending thin limb development(GO:0072021) thick ascending limb development(GO:0072023) metanephric ascending thin limb development(GO:0072218) metanephric thick ascending limb development(GO:0072233)
0.1 0.3 GO:0097052 L-kynurenine metabolic process(GO:0097052)
0.1 0.3 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.1 0.5 GO:0010040 response to iron(II) ion(GO:0010040)
0.1 0.6 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.3 GO:0060618 nipple development(GO:0060618)
0.1 0.5 GO:0060796 regulation of transcription involved in primary germ layer cell fate commitment(GO:0060796)
0.1 0.4 GO:0009609 response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609)
0.1 1.2 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1 0.3 GO:1904349 positive regulation of small intestine smooth muscle contraction(GO:1904349)
0.1 0.3 GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050)
0.1 0.7 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 0.7 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 0.3 GO:0021633 optic nerve structural organization(GO:0021633)
0.0 0.3 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023) positive regulation of somatostatin secretion(GO:0090274)
0.0 0.2 GO:0050812 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0 0.2 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.9 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 0.8 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.7 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 1.1 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.0 0.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.5 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 1.6 GO:0019236 response to pheromone(GO:0019236)
0.0 0.1 GO:0048625 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625)
0.0 0.3 GO:0003351 epithelial cilium movement(GO:0003351)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0046691 intracellular canaliculus(GO:0046691)
0.2 2.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.4 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.7 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 0.2 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.7 GO:0072687 meiotic spindle(GO:0072687)
0.0 3.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.0 0.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.4 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.6 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.9 GO:0009925 basal plasma membrane(GO:0009925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0005009 insulin-activated receptor activity(GO:0005009)
0.2 2.5 GO:0051434 BH3 domain binding(GO:0051434)
0.2 0.5 GO:0016015 morphogen activity(GO:0016015)
0.2 1.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.1 0.7 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.7 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.3 GO:0047312 L-phenylalanine:pyruvate aminotransferase activity(GO:0047312) glutamine-phenylpyruvate transaminase activity(GO:0047316) L-glutamine:pyruvate aminotransferase activity(GO:0047945)
0.1 2.1 GO:0015250 water channel activity(GO:0015250)
0.1 3.8 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.5 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.6 GO:0001179 RNA polymerase I transcription factor binding(GO:0001179)
0.1 0.7 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 0.2 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.1 0.2 GO:0018169 ribosomal S6-glutamic acid ligase activity(GO:0018169)
0.0 0.6 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.5 GO:0019864 IgG binding(GO:0019864)
0.0 0.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.9 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.5 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.9 GO:0009975 cyclase activity(GO:0009975)
0.0 0.5 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.2 GO:0050699 WW domain binding(GO:0050699)
0.0 1.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 1.4 GO:0005550 pheromone binding(GO:0005550)
0.0 0.7 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.3 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.2 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.7 GO:0004601 peroxidase activity(GO:0004601)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.7 PID AURORA A PATHWAY Aurora A signaling
0.0 1.1 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.7 PID TCPTP PATHWAY Signaling events mediated by TCPTP

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 0.5 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.5 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 0.9 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.3 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.6 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling