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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Smad4

Z-value: 1.18

Motif logo

Transcription factors associated with Smad4

Gene Symbol Gene ID Gene Info
ENSMUSG00000024515.14 Smad4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad4mm39_v1_chr18_-_73836810_738368770.019.3e-01Click!

Activity profile of Smad4 motif

Sorted Z-values of Smad4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad4

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chrX_+_135171002 4.30 ENSMUST00000178632.8
ENSMUST00000053540.11
brain expressed X-linked 3
chrX_+_135171049 3.71 ENSMUST00000113112.2
brain expressed X-linked 3
chr9_-_45847344 3.28 ENSMUST00000034590.4
transgelin
chr7_+_44865177 2.88 ENSMUST00000033060.14
ENSMUST00000210447.2
ENSMUST00000211744.2
ENSMUST00000107801.10
TEA domain family member 2
chr19_+_4282487 2.44 ENSMUST00000235306.2
polymerase (DNA-directed), delta 4
chrX_-_7537580 2.29 ENSMUST00000033486.6
proteolipid protein 2
chr17_-_28705082 2.09 ENSMUST00000079413.11
FK506 binding protein 5
chr7_+_25386418 1.97 ENSMUST00000002678.10
transforming growth factor, beta 1
chr17_-_28705055 1.84 ENSMUST00000233870.2
FK506 binding protein 5
chr11_-_106050724 1.84 ENSMUST00000064545.11
LIM domain containing 2
chr11_-_106050927 1.81 ENSMUST00000045923.10
LIM domain containing 2
chr2_+_120307390 1.77 ENSMUST00000110716.9
ENSMUST00000028748.14
ENSMUST00000090028.13
ENSMUST00000110719.4
calpain 3
chr19_+_4281953 1.63 ENSMUST00000025773.5
polymerase (DNA-directed), delta 4
chr14_+_76652369 1.62 ENSMUST00000110888.8
TSC22 domain family, member 1
chr15_+_81820954 1.59 ENSMUST00000038757.8
ENSMUST00000230633.2
cold shock domain containing C2, RNA binding
chr4_-_119047202 1.56 ENSMUST00000239029.2
ENSMUST00000138395.9
ENSMUST00000156746.3
erythroblast membrane-associated protein
chr17_-_32622525 1.37 ENSMUST00000135618.8
ENSMUST00000063824.14
RAS protein activator like 3
chr4_-_117035922 1.32 ENSMUST00000153953.2
ENSMUST00000106436.8
kinesin family member 2C
chr19_+_5790918 1.26 ENSMUST00000081496.6
latent transforming growth factor beta binding protein 3
chr2_+_29759495 1.25 ENSMUST00000047521.7
ENSMUST00000134152.2
cerebral endothelial cell adhesion molecule
chr4_-_133981387 1.23 ENSMUST00000060050.6
glycine/arginine rich protein 1
chr19_+_4282040 1.17 ENSMUST00000237518.2
polymerase (DNA-directed), delta 4
chr6_-_68681962 1.16 ENSMUST00000103330.2
immunoglobulin kappa variable 10-94
chr18_-_33597060 1.14 ENSMUST00000168890.2
neuronal regeneration related protein
chr15_-_103275190 1.09 ENSMUST00000023128.8
integrin alpha 5 (fibronectin receptor alpha)
chr4_+_130640436 1.07 ENSMUST00000151698.8
lysosomal-associated protein transmembrane 5
chr7_+_44866095 1.06 ENSMUST00000209437.2
TEA domain family member 2
chr4_-_119047167 1.05 ENSMUST00000030396.15
erythroblast membrane-associated protein
chr7_+_101070897 1.05 ENSMUST00000163751.10
ENSMUST00000211368.2
ENSMUST00000166652.2
phosphodiesterase 2A, cGMP-stimulated
chr18_-_33596468 1.02 ENSMUST00000171533.9
neuronal regeneration related protein
chr11_+_69737437 0.98 ENSMUST00000152566.8
ENSMUST00000108633.9
phospholipid scramblase 3
chr10_-_37014859 0.97 ENSMUST00000092584.6
myristoylated alanine rich protein kinase C substrate
chr5_+_31070739 0.96 ENSMUST00000031055.8
elastin microfibril interfacer 1
chr7_+_18817767 0.96 ENSMUST00000032568.14
ENSMUST00000122999.8
ENSMUST00000108473.10
ENSMUST00000108474.2
ENSMUST00000238982.2
dystrophia myotonica-protein kinase
chr7_-_131918926 0.95 ENSMUST00000080215.6
carbohydrate sulfotransferase 15
chr14_-_55950545 0.94 ENSMUST00000002389.9
ENSMUST00000226907.2
transglutaminase 1, K polypeptide
chr6_+_125122172 0.94 ENSMUST00000119527.8
ENSMUST00000117675.8
intermediate filament family orphan 1
chr5_+_31454787 0.93 ENSMUST00000201166.4
ENSMUST00000072228.9
glucokinase regulatory protein
chr4_+_130640611 0.93 ENSMUST00000156225.8
ENSMUST00000156742.8
lysosomal-associated protein transmembrane 5
chr11_+_69737491 0.92 ENSMUST00000019605.4
phospholipid scramblase 3
chr14_-_25903524 0.91 ENSMUST00000052286.16
placenta specific 9a
chrX_+_55824797 0.89 ENSMUST00000114773.10
four and a half LIM domains 1
chr15_+_78312764 0.88 ENSMUST00000162517.8
ENSMUST00000166142.10
ENSMUST00000089414.11
potassium channel tetramerisation domain containing 17
chr11_-_69304501 0.87 ENSMUST00000094077.5
KDM1 lysine (K)-specific demethylase 6B
chr3_-_102871440 0.87 ENSMUST00000058899.13
nuclear receptor subfamily 1, group H, member 5
chr15_-_103161237 0.85 ENSMUST00000154510.8
nuclear factor, erythroid derived 2
chr18_-_33596890 0.84 ENSMUST00000237066.2
neuronal regeneration related protein
chr1_+_87397980 0.82 ENSMUST00000027476.6
secondary ossification center associated regulator of chondrocyte maturation
chr15_-_98505508 0.80 ENSMUST00000096224.6
adenylate cyclase 6
chr3_-_116762617 0.78 ENSMUST00000143611.2
ENSMUST00000040097.14
palmdelphin
chr14_-_58063585 0.76 ENSMUST00000022536.3
spindle and kinetochore associated complex subunit 3
chr9_-_58065800 0.75 ENSMUST00000168864.4
immunoglobulin superfamily containing leucine-rich repeat
chr17_-_32622497 0.75 ENSMUST00000137458.2
RAS protein activator like 3
chr7_-_30062197 0.74 ENSMUST00000046351.7
leucine rich repeat and fibronectin type III domain containing 3
chr17_-_35381945 0.73 ENSMUST00000174805.2
proline-rich coiled-coil 2A
chr6_-_69800923 0.73 ENSMUST00000103368.3
immunoglobulin kappa chain variable 5-43
chr1_+_171509565 0.71 ENSMUST00000015499.14
ENSMUST00000068584.7
CD48 antigen
chr14_-_30890544 0.69 ENSMUST00000036618.14
stabilin 1
chr15_-_103231921 0.69 ENSMUST00000229551.2
zinc finger protein 385A
chr15_+_38940307 0.68 ENSMUST00000067072.5
collagen triple helix repeat containing 1
chr11_+_115331365 0.66 ENSMUST00000093914.5
tripartite motif-containing 80
chr4_-_156339769 0.66 ENSMUST00000217934.2
sterile alpha motif domain containing 11
chr4_-_119047146 0.66 ENSMUST00000124626.9
erythroblast membrane-associated protein
chr15_+_78312851 0.64 ENSMUST00000159771.8
potassium channel tetramerisation domain containing 17
chr4_-_119047180 0.63 ENSMUST00000150864.3
ENSMUST00000141227.9
erythroblast membrane-associated protein
chr2_+_152578164 0.63 ENSMUST00000038368.9
ENSMUST00000109824.2
inhibitor of DNA binding 1, HLH protein
chr12_-_103304573 0.62 ENSMUST00000149431.2
ankyrin repeat and SOCS box-containing 2
chr18_-_33596792 0.60 ENSMUST00000051087.16
neuronal regeneration related protein
chr3_-_116762476 0.58 ENSMUST00000119557.8
palmdelphin
chr11_+_60590498 0.57 ENSMUST00000052346.10
LLGL1 scribble cell polarity complex component
chr12_-_36206780 0.56 ENSMUST00000223382.2
ENSMUST00000020856.6
basic leucine zipper and W2 domains 2
chr11_+_4110346 0.56 ENSMUST00000002198.4
splicing factor 3a, subunit 1
chr12_-_114286421 0.56 ENSMUST00000103483.3
immunoglobulin heavy variable V3-8
chr11_+_60590584 0.56 ENSMUST00000108719.4
LLGL1 scribble cell polarity complex component
chr6_+_121320008 0.55 ENSMUST00000166457.8
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr14_-_54791816 0.55 ENSMUST00000022784.9
HAUS augmin-like complex, subunit 4
chr9_-_110576124 0.55 ENSMUST00000199862.5
ENSMUST00000198865.5
parathyroid hormone 1 receptor
chr8_-_49008305 0.52 ENSMUST00000110346.9
ENSMUST00000211976.2
teneurin transmembrane protein 3
chr8_+_110432132 0.51 ENSMUST00000212964.2
ENSMUST00000034163.9
zinc finger protein 821
chr7_-_26880574 0.51 ENSMUST00000071986.13
ENSMUST00000121848.2
melanoma inhibitory activity
chr17_-_71158703 0.51 ENSMUST00000166395.9
TGFB-induced factor homeobox 1
chr6_+_68414401 0.50 ENSMUST00000103324.3
immunoglobulin kappa chain variable 15-103
chr4_+_140428777 0.48 ENSMUST00000138808.8
ENSMUST00000038893.6
regulator of chromosome condensation 2
chr11_-_102209767 0.48 ENSMUST00000174302.8
ENSMUST00000178839.8
ENSMUST00000006754.14
upstream binding transcription factor, RNA polymerase I
chr4_-_148584906 0.48 ENSMUST00000030840.4
angiopoietin-like 7
chr4_+_128582519 0.47 ENSMUST00000106080.8
polyhomeotic 2
chr9_-_14292453 0.47 ENSMUST00000167549.2
endonuclease domain containing 1
chr6_+_108637577 0.46 ENSMUST00000032194.11
basic helix-loop-helix family, member e40
chr2_+_3115250 0.44 ENSMUST00000072955.12
family with sequence similarity 171, member A1
chr8_+_79754980 0.43 ENSMUST00000087927.11
ENSMUST00000098614.9
zinc finger protein 827
chr13_-_22227114 0.42 ENSMUST00000091741.6
H2A clustered histone 11
chr13_-_22016364 0.40 ENSMUST00000102979.2
H4 clustered histone 18
chr15_+_38940351 0.39 ENSMUST00000226433.2
ENSMUST00000132192.3
collagen triple helix repeat containing 1
chrX_+_98179725 0.39 ENSMUST00000052839.7
ephrin B1
chr4_-_133972890 0.39 ENSMUST00000030644.8
zinc finger protein 593
chr1_-_153061758 0.38 ENSMUST00000185356.7
laminin, gamma 2
chr11_-_3454766 0.38 ENSMUST00000044507.12
inositol polyphosphate 5-phosphatase J
chr3_+_89344006 0.38 ENSMUST00000038942.10
ENSMUST00000130858.8
ENSMUST00000146630.8
ENSMUST00000145753.2
pre B cell leukemia transcription factor interacting protein 1
chr7_+_127084283 0.37 ENSMUST00000048896.8
fibrosin
chr17_+_34816826 0.37 ENSMUST00000015596.10
ENSMUST00000174496.9
ENSMUST00000173992.8
advanced glycosylation end product-specific receptor
chr17_+_34372046 0.36 ENSMUST00000114232.4
histocompatibility 2, class II, locus Mb1
chr17_+_75485791 0.36 ENSMUST00000135447.8
ENSMUST00000112516.8
latent transforming growth factor beta binding protein 1
chrX_+_158491589 0.35 ENSMUST00000080394.13
SH3-domain kinase binding protein 1
chrX_+_149371219 0.34 ENSMUST00000153221.8
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr15_-_38300937 0.32 ENSMUST00000227920.2
ENSMUST00000074043.7
ENSMUST00000228416.2
Kruppel-like factor 10
chr19_-_40260060 0.32 ENSMUST00000068439.13
PDZ and LIM domain 1 (elfin)
chr6_+_108637816 0.32 ENSMUST00000163617.2
basic helix-loop-helix family, member e40
chr17_+_46957151 0.31 ENSMUST00000002844.14
ENSMUST00000113429.8
ENSMUST00000113430.2
mitochondrial ribosomal protein L2
chr8_+_96551974 0.31 ENSMUST00000074053.6
Sin3-associated polypeptide 18B
chr2_-_163592127 0.30 ENSMUST00000017841.4
adenosine deaminase
chr7_+_19197192 0.30 ENSMUST00000137613.9
exocyst complex component 3-like 2
chr9_-_49710190 0.30 ENSMUST00000114476.8
ENSMUST00000193547.6
neural cell adhesion molecule 1
chr8_+_55407872 0.30 ENSMUST00000033915.9
glycoprotein m6a
chr3_+_96128427 0.29 ENSMUST00000090781.8
H2B clustered histone 21
chr11_-_101062111 0.29 ENSMUST00000164474.8
ENSMUST00000043397.14
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr7_+_55417967 0.28 ENSMUST00000060416.15
ENSMUST00000094360.13
ENSMUST00000165045.9
ENSMUST00000173835.2
sialic acid binding Ig-like lectin H
chr19_-_40260286 0.28 ENSMUST00000182432.2
PDZ and LIM domain 1 (elfin)
chr18_+_60659257 0.28 ENSMUST00000223984.2
ENSMUST00000025505.7
ENSMUST00000223590.2
dynactin 4
chrX_-_149371067 0.27 ENSMUST00000140207.8
ENSMUST00000112719.2
ENSMUST00000112727.10
ENSMUST00000112721.10
ENSMUST00000026303.16
apurinic/apyrimidinic endonuclease 2
chr8_+_110432210 0.27 ENSMUST00000212192.2
zinc finger protein 821
chr9_-_36678868 0.27 ENSMUST00000217599.2
ENSMUST00000120381.9
STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
chr10_+_90412827 0.27 ENSMUST00000182550.8
ENSMUST00000099364.12
ankyrin repeat and sterile alpha motif domain containing 1B
chr17_-_25300112 0.26 ENSMUST00000024984.7
transmembrane protein 204
chr12_-_36206750 0.25 ENSMUST00000221388.2
basic leucine zipper and W2 domains 2
chr17_+_75485906 0.25 ENSMUST00000112514.2
latent transforming growth factor beta binding protein 1
chr17_+_34482183 0.25 ENSMUST00000040828.7
ENSMUST00000237342.2
ENSMUST00000237866.2
histocompatibility 2, class II antigen A, beta 1
chr14_-_54651442 0.24 ENSMUST00000227334.2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr12_-_36206626 0.24 ENSMUST00000220828.2
basic leucine zipper and W2 domains 2
chr9_+_21336300 0.24 ENSMUST00000172482.8
ENSMUST00000174050.8
dynamin 2
chr18_-_52662917 0.23 ENSMUST00000171470.8
lysyl oxidase
chr16_+_34605282 0.23 ENSMUST00000023538.9
myosin, light polypeptide kinase
chr13_+_22227359 0.23 ENSMUST00000110452.2
H2B clustered histone 11
chr11_+_97554192 0.22 ENSMUST00000044730.12
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
chr11_-_3881995 0.21 ENSMUST00000020710.11
ENSMUST00000109989.10
ENSMUST00000109991.8
ENSMUST00000109993.9
transcobalamin 2
chr9_-_49710058 0.21 ENSMUST00000192584.2
ENSMUST00000166811.9
neural cell adhesion molecule 1
chr4_+_132738787 0.21 ENSMUST00000105915.8
ENSMUST00000105916.8
AT hook, DNA binding motif, containing 1
chr19_-_5345423 0.21 ENSMUST00000235182.2
ENSMUST00000025774.11
splicing factor 3b, subunit 2
chr18_-_52662728 0.20 ENSMUST00000025409.9
lysyl oxidase
chr6_+_17749169 0.19 ENSMUST00000053148.14
ENSMUST00000115417.4
suppression of tumorigenicity 7
chr6_-_138399896 0.19 ENSMUST00000161450.8
ENSMUST00000163024.8
ENSMUST00000162185.8
LIM domain only 3
chr3_-_135397298 0.18 ENSMUST00000029812.14
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
chr7_-_12770556 0.18 ENSMUST00000123541.2
ubiquitin-conjugating enzyme E2M
chr13_-_98773862 0.17 ENSMUST00000050389.5
transmembrane protein 174
chr13_+_21995906 0.16 ENSMUST00000104941.4
H4 clustered histone 17
chr19_-_23425757 0.16 ENSMUST00000036069.8
MAM domain containing 2
chr9_+_53678801 0.16 ENSMUST00000048670.10
solute carrier family 35, member F2
chr14_+_65187485 0.16 ENSMUST00000043914.8
ENSMUST00000239450.2
integrator complex subunit 9
chr5_+_20112704 0.15 ENSMUST00000115267.7
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr19_+_46316617 0.15 ENSMUST00000026256.9
ENSMUST00000177667.2
F-box and leucine-rich repeat protein 15
chr7_+_116980173 0.15 ENSMUST00000032892.7
xylosyltransferase 1
chr7_+_140796537 0.15 ENSMUST00000141804.2
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr15_+_82230155 0.14 ENSMUST00000023086.15
single-pass membrane protein with aspartate rich tail 1
chr17_-_26420300 0.14 ENSMUST00000025019.9
Rho GDP dissociation inhibitor (GDI) gamma
chr11_-_3881960 0.13 ENSMUST00000109990.8
transcobalamin 2
chr18_+_68066328 0.13 ENSMUST00000063775.5
low density lipoprotein receptor class A domain containing 4
chr19_-_7779943 0.13 ENSMUST00000120522.8
solute carrier family 22 (organic cation transporter), member 26
chr18_+_87774402 0.13 ENSMUST00000091776.7
predicted gene 5096
chr10_-_119075910 0.12 ENSMUST00000020315.13
cullin associated and neddylation disassociated 1
chr1_+_171197660 0.12 ENSMUST00000111286.9
nectin cell adhesion molecule 4
chr5_+_92831468 0.12 ENSMUST00000168878.8
shroom family member 3
chr12_+_36207113 0.12 ENSMUST00000041640.5
ankyrin repeat and MYND domain containing 2
chr8_-_34614187 0.11 ENSMUST00000033910.9
leptin receptor overlapping transcript-like 1
chr11_-_3881789 0.11 ENSMUST00000109992.8
ENSMUST00000109988.2
transcobalamin 2
chr12_-_11200306 0.11 ENSMUST00000055673.2
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr13_-_115226666 0.11 ENSMUST00000109226.5
pelota mRNA surveillance and ribosome rescue factor
chr1_+_187730032 0.11 ENSMUST00000110938.2
estrogen-related receptor gamma
chr9_-_20809888 0.10 ENSMUST00000004206.10
eukaryotic translation initiation factor 3, subunit G
chr11_+_11414256 0.10 ENSMUST00000020410.11
spermatogenesis associated 48
chr7_+_101010447 0.09 ENSMUST00000137384.8
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr17_-_26420332 0.09 ENSMUST00000121959.3
Rho GDP dissociation inhibitor (GDI) gamma
chr15_+_6599001 0.09 ENSMUST00000227175.2
FYN binding protein
chr5_-_24650164 0.09 ENSMUST00000115043.8
ENSMUST00000115041.2
ENSMUST00000030800.13
Fas-activated serine/threonine kinase
chr15_-_39807081 0.08 ENSMUST00000022916.13
low density lipoprotein-related protein 12
chr14_+_58063668 0.08 ENSMUST00000022538.5
mitochondrial ribosomal protein L57
chr18_+_69478790 0.08 ENSMUST00000202116.4
ENSMUST00000114982.8
ENSMUST00000078486.13
ENSMUST00000202772.4
ENSMUST00000201288.4
transcription factor 4
chr17_-_90395771 0.07 ENSMUST00000197268.5
ENSMUST00000173917.8
neurexin I
chr13_+_111391544 0.07 ENSMUST00000054716.4
actin, beta-like 2
chr1_+_187730018 0.07 ENSMUST00000027906.13
estrogen-related receptor gamma
chr3_+_68479578 0.07 ENSMUST00000170788.9
schwannomin interacting protein 1
chr5_+_20112500 0.07 ENSMUST00000101558.10
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr9_+_57847387 0.06 ENSMUST00000043059.9
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr5_+_75735576 0.06 ENSMUST00000144270.8
ENSMUST00000005815.7
KIT proto-oncogene receptor tyrosine kinase
chr11_-_118233326 0.06 ENSMUST00000103024.4
CEP295 N-terminal like
chr17_-_30107544 0.06 ENSMUST00000171691.9
MAM domain containing glycosylphosphatidylinositol anchor 1
chr19_-_10716335 0.06 ENSMUST00000025571.9
ENSMUST00000238167.2
CD5 antigen
chr10_+_33780993 0.05 ENSMUST00000169670.8
radial spoke head 4 homolog A (Chlamydomonas)
chr19_-_5711650 0.05 ENSMUST00000236006.2
signal-induced proliferation associated gene 1
chr3_+_102641822 0.05 ENSMUST00000029451.12
tetraspanin 2
chr19_-_7780025 0.04 ENSMUST00000065634.8
solute carrier family 22 (organic cation transporter), member 26
chr1_-_74130488 0.04 ENSMUST00000187584.7
tensin 1
chr1_+_53100796 0.03 ENSMUST00000027269.7
ENSMUST00000191197.2
myostatin
chr14_+_70314727 0.03 ENSMUST00000225200.2
early growth response 3
chr2_+_96148418 0.03 ENSMUST00000135431.8
ENSMUST00000162807.9
leucine rich repeat containing 4C
chr4_+_42950367 0.02 ENSMUST00000084662.12
DnaJ heat shock protein family (Hsp40) member B5
chr4_-_94940425 0.02 ENSMUST00000107094.2
jun proto-oncogene
chr12_+_36431449 0.02 ENSMUST00000221452.2
ENSMUST00000062041.6
ENSMUST00000220519.2
ENSMUST00000221895.2
CDP-L-ribitol pyrophosphorylase A
chr18_+_69479211 0.02 ENSMUST00000201235.4
transcription factor 4
chr2_-_173117936 0.02 ENSMUST00000139306.2
prostate transmembrane protein, androgen induced 1
chr10_-_90918515 0.02 ENSMUST00000159110.8
apoptotic peptidase activating factor 1
chrX_+_40490353 0.02 ENSMUST00000165288.2
glutamate receptor, ionotropic, AMPA3 (alpha 3)

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0051834 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.4 1.8 GO:1990091 sodium-dependent self proteolysis(GO:1990091)
0.4 1.3 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.4 2.1 GO:0051142 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.3 0.8 GO:1904117 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.2 1.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 1.0 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.2 1.0 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.2 0.6 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.2 0.7 GO:1902164 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.2 0.5 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.2 3.9 GO:0048368 lateral mesoderm development(GO:0048368)
0.1 5.2 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.1 0.9 GO:0009750 response to fructose(GO:0009750)
0.1 0.5 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 3.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.4 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.1 1.0 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.1 0.6 GO:0009992 cellular water homeostasis(GO:0009992)
0.1 0.9 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 0.3 GO:0070256 germinal center B cell differentiation(GO:0002314) adenosine catabolic process(GO:0006154) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) purine deoxyribonucleoside metabolic process(GO:0046122) negative regulation of mucus secretion(GO:0070256)
0.1 0.3 GO:0043686 co-translational protein modification(GO:0043686)
0.1 0.2 GO:0002343 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
0.1 0.2 GO:1903406 regulation of sodium:potassium-exchanging ATPase activity(GO:1903406)
0.1 1.1 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 0.5 GO:0015889 cobalamin transport(GO:0015889)
0.1 0.2 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.1 0.8 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1 0.2 GO:1904631 negative regulation of interleukin-12 biosynthetic process(GO:0045083) response to diterpene(GO:1904629) cellular response to diterpene(GO:1904630) response to glucoside(GO:1904631) cellular response to glucoside(GO:1904632)
0.1 1.1 GO:0090177 establishment of planar polarity involved in neural tube closure(GO:0090177)
0.1 8.0 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 1.1 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.0 0.3 GO:0033133 positive regulation of glucokinase activity(GO:0033133)
0.0 0.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 1.5 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.0 0.5 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.5 GO:0097264 self proteolysis(GO:0097264)
0.0 1.0 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.5 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.1 GO:1905065 positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.0 0.3 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.9 GO:0031424 keratinization(GO:0031424)
0.0 0.0 GO:0035026 leading edge cell differentiation(GO:0035026)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.4 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 2.7 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015)
0.0 0.6 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 0.4 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.3 GO:0051601 exocyst localization(GO:0051601)
0.0 0.4 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 1.0 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.9 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 1.9 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.4 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.5 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.4 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.0 GO:0014732 skeletal muscle atrophy(GO:0014732)
0.0 0.1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.2 GO:0015747 urate transport(GO:0015747)
0.0 0.1 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.0 0.1 GO:0042631 cellular response to water deprivation(GO:0042631)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.0 3.9 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.3 1.0 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.2 0.6 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.2 1.0 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.4 GO:0005607 laminin-2 complex(GO:0005607)
0.1 0.3 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 2.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.6 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 1.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.5 GO:0070652 HAUS complex(GO:0070652)
0.1 0.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.8 GO:0008305 integrin complex(GO:0008305)
0.0 0.8 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.3 GO:0061574 ASAP complex(GO:0061574)
0.0 1.0 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.5 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.5 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)
0.0 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.3 GO:0000145 exocyst(GO:0000145)
0.0 0.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.4 GO:0030315 T-tubule(GO:0030315)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0036004 GAF domain binding(GO:0036004)
0.3 2.0 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.3 1.0 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.3 8.0 GO:0005123 death receptor binding(GO:0005123)
0.2 3.9 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 0.7 GO:0032093 SAM domain binding(GO:0032093)
0.2 3.9 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 5.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.9 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 1.3 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.4 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 0.9 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 0.4 GO:0050785 advanced glycation end-product receptor activity(GO:0050785)
0.1 1.8 GO:0031432 titin binding(GO:0031432)
0.1 0.8 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 0.9 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.5 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.1 0.6 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 0.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.8 GO:0043426 MRF binding(GO:0043426)
0.1 0.3 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.1 2.3 GO:0019956 chemokine binding(GO:0019956)
0.1 1.9 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.7 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 1.9 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.2 GO:0018169 ribosomal S6-glutamic acid ligase activity(GO:0018169)
0.1 0.4 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.1 0.2 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.5 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.1 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.3 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.3 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.6 GO:0070628 proteasome binding(GO:0070628)
0.0 0.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 0.3 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 1.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.6 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.5 GO:0070410 co-SMAD binding(GO:0070410)
0.0 2.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.2 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 4.2 GO:0051015 actin filament binding(GO:0051015)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.2 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.1 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.8 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.5 PID AURORA B PATHWAY Aurora B signaling
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 3.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.6 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 2.4 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 2.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 3.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.0 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 0.8 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.8 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.9 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.5 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.6 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.9 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.7 REACTOME KINESINS Genes involved in Kinesins
0.0 0.8 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.4 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.4 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane