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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Sox7

Z-value: 1.02

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Transcription factors associated with Sox7

Gene Symbol Gene ID Gene Info
Sox7
ENSMUSG00000063060.7 Sox7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox7mm39_v1_chr14_+_64181115_64181136-0.231.7e-01Click!

Activity profile of Sox7 motif

Sorted Z-values of Sox7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox7

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_-_14180496 9.25 ENSMUST00000063509.11
Sult2a8
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
chr7_-_14180576 7.78 ENSMUST00000125941.3
Sult2a8
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
chr3_+_146302832 3.24 ENSMUST00000029837.14
ENSMUST00000147409.2
ENSMUST00000121133.2
Uox
urate oxidase
chr1_-_136888118 2.56 ENSMUST00000192357.6
ENSMUST00000027649.14
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr2_+_15060051 2.11 ENSMUST00000069870.11
ENSMUST00000239125.2
ENSMUST00000193836.3
Arl5b
ADP-ribosylation factor-like 5B
chr3_-_146302343 1.74 ENSMUST00000029836.9
Dnase2b
deoxyribonuclease II beta
chr12_-_75782502 1.69 ENSMUST00000021450.6
Sgpp1
sphingosine-1-phosphate phosphatase 1
chr18_+_12874390 1.54 ENSMUST00000121018.8
ENSMUST00000119108.8
ENSMUST00000186263.2
ENSMUST00000191078.7
Cabyr
calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)
chr5_-_108022900 1.40 ENSMUST00000138111.8
ENSMUST00000112642.8
Evi5
ecotropic viral integration site 5
chr1_-_119576347 1.22 ENSMUST00000027632.14
ENSMUST00000187194.2
Epb41l5
erythrocyte membrane protein band 4.1 like 5
chr1_+_107289659 1.11 ENSMUST00000027566.3
Serpinb11
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
chr19_-_32085532 1.10 ENSMUST00000236030.2
ENSMUST00000237104.2
ENSMUST00000236208.2
ENSMUST00000235273.2
Asah2
N-acylsphingosine amidohydrolase 2
chr14_+_64890008 1.10 ENSMUST00000224503.2
Kif13b
kinesin family member 13B
chr11_-_46280336 1.09 ENSMUST00000020664.13
Itk
IL2 inducible T cell kinase
chr18_+_12874368 0.93 ENSMUST00000235000.2
ENSMUST00000115857.9
Cabyr
calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)
chr8_+_107662352 0.87 ENSMUST00000212524.2
ENSMUST00000047425.5
Sntb2
syntrophin, basic 2
chr11_-_46280298 0.83 ENSMUST00000109237.9
Itk
IL2 inducible T cell kinase
chr14_+_64889973 0.80 ENSMUST00000100473.5
Kif13b
kinesin family member 13B
chr19_-_21418215 0.79 ENSMUST00000237823.2
Gda
guanine deaminase
chr11_-_46280281 0.69 ENSMUST00000101306.4
Itk
IL2 inducible T cell kinase
chr14_+_53245069 0.69 ENSMUST00000178650.3
Trav6d-7
T cell receptor alpha variable 6D-7
chr15_-_13173736 0.69 ENSMUST00000036439.6
Cdh6
cadherin 6
chr12_-_75782406 0.68 ENSMUST00000220285.2
Sgpp1
sphingosine-1-phosphate phosphatase 1
chr6_+_48661477 0.65 ENSMUST00000118802.8
Gimap4
GTPase, IMAP family member 4
chr2_-_120144622 0.58 ENSMUST00000054651.8
Pla2g4f
phospholipase A2, group IVF
chr14_+_66378382 0.56 ENSMUST00000022620.11
Chrna2
cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)
chr2_-_6134926 0.55 ENSMUST00000126551.2
ENSMUST00000054254.12
ENSMUST00000114942.9
Proser2
proline and serine rich 2
chr3_+_58913234 0.54 ENSMUST00000040846.15
Med12l
mediator complex subunit 12-like
chr6_+_48661503 0.45 ENSMUST00000067506.14
ENSMUST00000119575.8
ENSMUST00000121957.8
ENSMUST00000090070.6
Gimap4
GTPase, IMAP family member 4
chr2_+_38401655 0.42 ENSMUST00000054234.10
ENSMUST00000112902.8
Nek6
NIMA (never in mitosis gene a)-related expressed kinase 6
chr3_-_19319123 0.40 ENSMUST00000121951.2
Pde7a
phosphodiesterase 7A
chr7_+_45164005 0.34 ENSMUST00000210532.2
ENSMUST00000085331.14
ENSMUST00000210299.2
Tulp2
tubby-like protein 2
chr3_-_30194559 0.32 ENSMUST00000108271.10
Mecom
MDS1 and EVI1 complex locus
chr6_-_123395075 0.30 ENSMUST00000172199.3
Vmn2r20
vomeronasal 2, receptor 20
chr6_+_67532481 0.29 ENSMUST00000103302.3
Igkv2-137
immunoglobulin kappa chain variable 2-137
chr7_+_99671306 0.26 ENSMUST00000144808.2
Chrdl2
chordin-like 2
chr16_+_8455538 0.26 ENSMUST00000023396.10
ENSMUST00000230828.2
Pmm2
phosphomannomutase 2
chrX_-_59193003 0.24 ENSMUST00000033478.5
ENSMUST00000101531.10
Mcf2
mcf.2 transforming sequence
chr7_-_10488291 0.19 ENSMUST00000226874.2
ENSMUST00000227003.2
ENSMUST00000228561.2
ENSMUST00000228248.2
ENSMUST00000228526.2
ENSMUST00000228098.2
ENSMUST00000227940.2
ENSMUST00000228374.2
ENSMUST00000227702.2
Vmn1r71
vomeronasal 1 receptor 71
chrX_+_102465616 0.19 ENSMUST00000182089.2
Gm26992
predicted gene, 26992
chr7_+_45164042 0.18 ENSMUST00000210868.2
Tulp2
tubby-like protein 2
chr9_+_38684364 0.17 ENSMUST00000217114.3
ENSMUST00000213958.3
Olfr921
olfactory receptor 921
chr11_+_49033101 0.16 ENSMUST00000203377.4
ENSMUST00000214195.3
Olfr1395
olfactory receptor 1395
chr7_-_48293559 0.16 ENSMUST00000094383.3
Mrgprb3
MAS-related GPR, member B3
chr6_-_99243455 0.11 ENSMUST00000113326.9
Foxp1
forkhead box P1
chr11_-_46057224 0.09 ENSMUST00000020679.3
Nipal4
NIPA-like domain containing 4
chr2_+_87854404 0.06 ENSMUST00000217006.2
Olfr1161
olfactory receptor 1161
chr12_-_114793177 0.05 ENSMUST00000103511.2
ENSMUST00000195735.2
Ighv1-31
immunoglobulin heavy variable 1-31
chr6_-_57938488 0.05 ENSMUST00000228097.2
Vmn1r24
vomeronasal 1 receptor 24
chr11_+_73489420 0.05 ENSMUST00000214228.2
Olfr384
olfactory receptor 384
chr10_-_79449826 0.04 ENSMUST00000059699.9
ENSMUST00000178228.3
C2cd4c
C2 calcium-dependent domain containing 4C
chr12_-_31684588 0.03 ENSMUST00000020979.9
ENSMUST00000177962.9
Bcap29
B cell receptor associated protein 29
chr9_-_111100859 0.02 ENSMUST00000035079.10
Mlh1
mutL homolog 1
chr6_-_123510365 0.02 ENSMUST00000163607.2
Vmn2r21
vomeronasal 2, receptor 21
chr10_-_107747995 0.01 ENSMUST00000165341.5
Otogl
otogelin-like
chr16_-_58583539 0.00 ENSMUST00000214139.2
Olfr172
olfactory receptor 172

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.4 GO:0006668 sphinganine-1-phosphate metabolic process(GO:0006668)
0.2 1.2 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.2 2.6 GO:0061113 pancreas morphogenesis(GO:0061113)
0.2 0.8 GO:0046098 guanine metabolic process(GO:0046098)
0.1 3.2 GO:0046415 urate metabolic process(GO:0046415)
0.1 2.6 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 1.7 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.1 0.3 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.1 2.5 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.5 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.6 GO:0071236 cellular response to antibiotic(GO:0071236)
0.0 0.3 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 1.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.6 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.1 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.9 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 3.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.8 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.3 1.7 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.2 3.2 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 1.1 GO:0017040 ceramidase activity(GO:0017040)
0.1 0.3 GO:0004615 phosphomannomutase activity(GO:0004615)
0.1 0.6 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 1.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.6 GO:0042166 acetylcholine-gated cation channel activity(GO:0022848) acetylcholine binding(GO:0042166)
0.0 2.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 2.6 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.8 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.9 PID ARF6 PATHWAY Arf6 signaling events
0.0 2.6 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 1.4 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 2.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 2.6 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.8 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.6 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.6 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 1.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis