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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Tbx2

Z-value: 2.38

Motif logo

Transcription factors associated with Tbx2

Gene Symbol Gene ID Gene Info
ENSMUSG00000000093.7 Tbx2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx2mm39_v1_chr11_+_85723377_85723377-0.616.8e-05Click!

Activity profile of Tbx2 motif

Sorted Z-values of Tbx2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_+_130754413 25.88 ENSMUST00000027675.14
ENSMUST00000133792.8
polymeric immunoglobulin receptor
chr17_-_34218301 16.35 ENSMUST00000235463.2
histocompatibility 2, K1, K region
chr19_+_20470056 15.75 ENSMUST00000225337.3
aldehyde dehydrogenase family 1, subfamily A1
chr15_+_6474808 14.97 ENSMUST00000022749.17
ENSMUST00000239466.2
complement component 9
chr6_-_141801897 14.03 ENSMUST00000165990.8
solute carrier organic anion transporter family, member 1a4
chr19_+_20470114 12.39 ENSMUST00000225313.2
aldehyde dehydrogenase family 1, subfamily A1
chr6_-_141801918 11.07 ENSMUST00000163678.2
solute carrier organic anion transporter family, member 1a4
chr9_-_43151179 8.43 ENSMUST00000034512.7
out at first homolog
chr16_+_22926162 7.38 ENSMUST00000023599.13
ENSMUST00000168891.8
eukaryotic translation initiation factor 4A2
chr19_+_37686240 7.35 ENSMUST00000025946.7
cytochrome P450, family 26, subfamily a, polypeptide 1
chr1_-_51955126 7.21 ENSMUST00000046390.14
myosin IB
chr14_-_30665232 6.78 ENSMUST00000006704.17
ENSMUST00000163118.2
inter-alpha trypsin inhibitor, heavy chain 1
chr3_-_107851021 5.88 ENSMUST00000106684.8
ENSMUST00000106685.9
glutathione S-transferase, mu 6
chr6_-_21851827 5.82 ENSMUST00000202353.2
ENSMUST00000134635.2
ENSMUST00000123116.8
ENSMUST00000120965.8
ENSMUST00000143531.2
tetraspanin 12
chr6_+_116241146 5.45 ENSMUST00000112900.9
ENSMUST00000036503.14
ENSMUST00000223495.2
zinc finger, AN1-type domain 4
chr5_-_151113619 4.48 ENSMUST00000062015.15
ENSMUST00000110483.9
StAR-related lipid transfer (START) domain containing 13
chr3_-_115508680 4.45 ENSMUST00000055676.4
sphingosine-1-phosphate receptor 1
chr1_+_88066086 4.43 ENSMUST00000014263.6
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr8_-_106660470 4.10 ENSMUST00000034368.8
chymotrypsin-like
chr4_+_84802592 4.04 ENSMUST00000102819.10
centlein, centrosomal protein
chr5_-_5564873 3.92 ENSMUST00000060947.14
claudin 12
chr5_-_5564730 3.89 ENSMUST00000115445.8
ENSMUST00000179804.8
ENSMUST00000125110.2
ENSMUST00000115446.8
claudin 12
chr7_-_45136235 3.68 ENSMUST00000210701.2
predicted gene 45808
chr4_+_84802513 3.66 ENSMUST00000047023.13
centlein, centrosomal protein
chr4_-_49549489 3.66 ENSMUST00000029987.10
aldolase B, fructose-bisphosphate
chr15_-_81244940 3.59 ENSMUST00000023040.9
solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17
chr1_+_131898325 3.59 ENSMUST00000027695.8
solute carrier family 45, member 3
chrX_+_100427331 3.48 ENSMUST00000119190.2
gap junction protein, beta 1
chr19_-_42190589 3.14 ENSMUST00000018966.8
secreted frizzled-related sequence protein 5
chr4_+_41465134 3.09 ENSMUST00000030154.7
nudix (nucleoside diphosphate linked moiety X)-type motif 2
chr6_-_94677118 2.92 ENSMUST00000101126.3
ENSMUST00000032105.11
leucine-rich repeats and immunoglobulin-like domains 1
chr3_+_59939175 2.76 ENSMUST00000029325.5
arylacetamide deacetylase
chr3_+_90421742 2.62 ENSMUST00000048138.8
S100 calcium binding protein A13
chr5_+_120651158 2.62 ENSMUST00000111889.2
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr14_-_55880708 2.62 ENSMUST00000120041.8
ENSMUST00000121937.8
ENSMUST00000133707.2
ENSMUST00000002391.15
ENSMUST00000121791.8
transmembrane 9 superfamily member 1
chr14_+_11307729 2.49 ENSMUST00000160956.2
ENSMUST00000160340.8
ENSMUST00000162278.8
fragile histidine triad gene
chr12_-_75782502 2.44 ENSMUST00000021450.6
sphingosine-1-phosphate phosphatase 1
chr15_-_96917804 2.42 ENSMUST00000231039.2
solute carrier family 38, member 4
chr3_+_52175757 2.41 ENSMUST00000053764.7
forkhead box O1
chr18_+_36414122 2.41 ENSMUST00000051301.6
purine rich element binding protein A
chr10_+_106306122 2.35 ENSMUST00000029404.17
ENSMUST00000217854.2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr2_+_160722562 2.31 ENSMUST00000109456.9
lipin 3
chr3_+_85878376 2.31 ENSMUST00000238443.2
SH3 domain protein D19
chr7_+_19197192 2.26 ENSMUST00000137613.9
exocyst complex component 3-like 2
chr13_+_81034214 2.22 ENSMUST00000161441.2
arrestin domain containing 3
chr9_-_20657643 2.17 ENSMUST00000215999.2
olfactomedin 2
chr13_+_112600604 2.13 ENSMUST00000183663.8
ENSMUST00000184311.8
ENSMUST00000183886.8
interleukin 6 signal transducer
chr9_+_48406706 2.11 ENSMUST00000048824.9
predicted gene 5617
chr4_+_116078787 2.07 ENSMUST00000147292.8
phosphoinositide-3-kinase regulatory subunit 3
chr4_+_116078874 2.02 ENSMUST00000106490.3
phosphoinositide-3-kinase regulatory subunit 3
chr9_-_63509699 2.00 ENSMUST00000171243.2
ENSMUST00000163982.8
ENSMUST00000163624.8
IQ motif containing H
chr7_+_27307422 1.99 ENSMUST00000142365.8
thymoma viral proto-oncogene 2
chr2_+_52747855 1.98 ENSMUST00000155586.9
ENSMUST00000090952.11
ENSMUST00000127122.9
ENSMUST00000049483.14
ENSMUST00000050719.13
formin-like 2
chr6_+_22288220 1.96 ENSMUST00000128245.8
ENSMUST00000031681.10
ENSMUST00000148639.2
wingless-type MMTV integration site family, member 16
chr4_-_140393185 1.96 ENSMUST00000069623.12
Rho guanine nucleotide exchange factor (GEF) 10-like
chr7_-_28001624 1.92 ENSMUST00000108315.4
delta like canonical Notch ligand 3
chr16_-_38533597 1.88 ENSMUST00000023487.5
Rho GTPase activating protein 31
chr1_+_132243849 1.86 ENSMUST00000072177.14
ENSMUST00000082125.6
NUAK family, SNF1-like kinase, 2
chrX_-_138683102 1.84 ENSMUST00000101217.4
ripply transcriptional repressor 1
chr7_+_105053775 1.81 ENSMUST00000033187.6
ENSMUST00000210344.2
cyclic nucleotide gated channel alpha 4
chr15_-_95426108 1.80 ENSMUST00000075275.3
NEL-like 2
chr7_+_27770655 1.79 ENSMUST00000138392.8
ENSMUST00000076648.8
Fc fragment of IgG binding protein
chr7_+_4240697 1.73 ENSMUST00000117550.2
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
chr1_-_105284383 1.70 ENSMUST00000058688.7
ring finger protein 152
chr17_+_46991972 1.63 ENSMUST00000002845.8
male enhanced antigen 1
chr9_-_63509747 1.53 ENSMUST00000080527.12
ENSMUST00000042322.11
IQ motif containing H
chr9_-_48406564 1.49 ENSMUST00000213276.2
ENSMUST00000170000.4
RNA binding motif protein 7
chr1_+_87254729 1.48 ENSMUST00000172794.8
ENSMUST00000164992.9
ENSMUST00000173173.8
GRB10 interacting GYF protein 2
chr7_-_30262512 1.46 ENSMUST00000207747.2
ENSMUST00000207797.2
presenilin enhancer gamma secretase subunit
chr19_+_8817883 1.44 ENSMUST00000086058.13
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr1_-_80439165 1.35 ENSMUST00000211023.2
predicted gene 45261
chr4_+_116078830 1.30 ENSMUST00000030464.14
phosphoinositide-3-kinase regulatory subunit 3
chr6_+_50087826 1.29 ENSMUST00000167628.2
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr1_-_105284407 1.29 ENSMUST00000172299.2
ring finger protein 152
chr7_+_27307173 1.29 ENSMUST00000136962.8
thymoma viral proto-oncogene 2
chr5_+_96357337 1.28 ENSMUST00000117766.8
mitochondrial ribosomal protein L1
chr11_-_23720953 1.28 ENSMUST00000102864.5
reticuloendotheliosis oncogene
chr7_+_133239414 1.27 ENSMUST00000128901.9
erythroid differentiation regulatory factor 1
chr1_-_87017633 1.23 ENSMUST00000027455.13
ENSMUST00000188310.2
alkaline phosphatase, placental-like 2
chr10_+_97528915 1.23 ENSMUST00000060703.6
coiled-coil glutamate-rich protein 1
chr1_+_163942833 1.22 ENSMUST00000162746.2
selectin, platelet
chr15_-_76004395 1.22 ENSMUST00000239552.1
epiplakin 1
chr1_+_92838479 1.22 ENSMUST00000027487.15
arginyl aminopeptidase (aminopeptidase B)-like 1
chr5_-_3852857 1.21 ENSMUST00000043551.11
ankyrin repeat and IBR domain containing 1
chr1_+_10108433 1.21 ENSMUST00000071087.12
ENSMUST00000117415.8
centrosome and spindle pole associated protein 1
chr11_+_98441998 1.20 ENSMUST00000107513.3
zona pellucida binding protein 2
chr1_-_171910324 1.14 ENSMUST00000003550.11
nicastrin
chr1_+_171910073 1.11 ENSMUST00000135192.8
coatomer protein complex subunit alpha
chr5_-_87634665 1.10 ENSMUST00000201519.2
predicted gene 43638
chr9_-_22042930 1.08 ENSMUST00000213815.2
acid phosphatase 5, tartrate resistant
chr15_-_67048595 1.06 ENSMUST00000229213.2
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr10_+_98750268 1.05 ENSMUST00000219557.2
ATPase, Ca++ transporting, plasma membrane 1
chr7_+_79460475 1.02 ENSMUST00000107394.3
mesoderm posterior 2
chr4_-_119031050 1.00 ENSMUST00000052715.10
ENSMUST00000179290.8
ENSMUST00000154226.2
zinc finger protein 691
chr1_-_156936197 0.94 ENSMUST00000187546.7
ENSMUST00000118207.8
ENSMUST00000027884.13
ENSMUST00000121911.8
testis expressed 35
chr7_-_30826184 0.93 ENSMUST00000211945.2
sodium channel, voltage-gated, type I, beta
chr11_-_23845207 0.93 ENSMUST00000102863.3
ENSMUST00000020513.10
poly(A) polymerase gamma
chr14_+_52131067 0.93 ENSMUST00000047726.12
solute carrier family 39 (zinc transporter), member 2
chr2_-_103627937 0.91 ENSMUST00000028607.13
cell cycle associated protein 1
chr4_+_156214969 0.86 ENSMUST00000209248.2
ring finger 223
chr9_-_22043083 0.86 ENSMUST00000069330.14
ENSMUST00000217643.2
acid phosphatase 5, tartrate resistant
chr17_+_71859026 0.85 ENSMUST00000124001.8
ENSMUST00000167641.8
ENSMUST00000064420.12
speedy/RINGO cell cycle regulator family, member A
chr13_+_33268095 0.85 ENSMUST00000016951.8
serine (or cysteine) peptidase inhibitor, clade B, member 1b
chr1_+_152830720 0.84 ENSMUST00000043313.15
ENSMUST00000186621.2
nicotinamide nucleotide adenylyltransferase 2
chr1_+_171910343 0.83 ENSMUST00000027833.12
coatomer protein complex subunit alpha
chr4_+_94502719 0.83 ENSMUST00000107104.3
ENSMUST00000030311.11
intraflagellar transport 74
chr2_+_172821620 0.82 ENSMUST00000109125.8
ENSMUST00000109126.5
ENSMUST00000050442.15
SPO11 initiator of meiotic double stranded breaks
chr14_+_50683002 0.82 ENSMUST00000214792.2
olfactory receptor 740
chr1_+_87254719 0.81 ENSMUST00000027475.15
GRB10 interacting GYF protein 2
chr19_+_28941292 0.78 ENSMUST00000045674.4
phospholipid phosphatase 6
chr6_+_42263609 0.77 ENSMUST00000238845.2
ENSMUST00000031894.13
chloride channel, voltage-sensitive 1
chr11_+_98441923 0.76 ENSMUST00000081033.13
ENSMUST00000107511.8
ENSMUST00000107509.8
ENSMUST00000017339.12
zona pellucida binding protein 2
chr6_+_42263644 0.74 ENSMUST00000163936.8
chloride channel, voltage-sensitive 1
chr10_+_90412114 0.70 ENSMUST00000182427.8
ENSMUST00000182053.8
ENSMUST00000182113.8
ankyrin repeat and sterile alpha motif domain containing 1B
chr19_+_21249636 0.69 ENSMUST00000237651.2
zinc finger, AN1-type domain 5
chr1_-_172156828 0.68 ENSMUST00000194204.2
potassium inwardly-rectifying channel, subfamily J, member 9
chr3_-_145355725 0.66 ENSMUST00000029846.5
cellular communication network factor 1
chr3_+_96011810 0.64 ENSMUST00000132980.8
ENSMUST00000138206.8
ENSMUST00000090785.9
ENSMUST00000035519.12
OTU domain containing 7B
chr15_-_89294434 0.61 ENSMUST00000109314.9
synaptonemal complex central element protein 3
chr15_-_67048673 0.61 ENSMUST00000229028.2
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr1_-_172156884 0.61 ENSMUST00000062387.8
potassium inwardly-rectifying channel, subfamily J, member 9
chr14_+_53574579 0.59 ENSMUST00000179580.3
T cell receptor alpha variable 13N-3
chr16_-_36648586 0.58 ENSMUST00000023537.6
ENSMUST00000114829.9
ELL associated factor 2
chr5_+_52521133 0.58 ENSMUST00000101208.6
superoxide dismutase 3, extracellular
chr6_-_28261881 0.57 ENSMUST00000115320.8
ENSMUST00000123098.8
ENSMUST00000115321.9
ENSMUST00000155494.2
zinc finger protein 800
chr1_+_132119169 0.55 ENSMUST00000188169.7
ENSMUST00000112357.9
ENSMUST00000188175.2
LEM domain containing 1
predicted gene, 29695
chr1_-_161615927 0.54 ENSMUST00000193648.2
Fas ligand (TNF superfamily, member 6)
chr12_-_87742525 0.52 ENSMUST00000164517.3
eukaryotic translation initiation factor 1A domain containing 19
chr7_+_45135784 0.52 ENSMUST00000107758.10
tubby-like protein 2
chr19_-_28941264 0.52 ENSMUST00000161813.2
spermatogenesis associated 6 like
chr17_-_16051295 0.52 ENSMUST00000231985.2
repulsive guidance molecule family member B
chr1_+_93301596 0.50 ENSMUST00000058682.11
ENSMUST00000186641.7
anoctamin 7
chr1_+_131526977 0.50 ENSMUST00000027690.7
arginine vasopressin receptor 1B
chr2_-_164670452 0.48 ENSMUST00000017911.4
spermatogenesis associated 25
chr19_+_4053290 0.48 ENSMUST00000025806.5
double C2, gamma
chr4_+_125384481 0.47 ENSMUST00000030676.8
glutamate receptor, ionotropic, kainate 3
chr10_-_62723103 0.47 ENSMUST00000218438.2
tet methylcytosine dioxygenase 1
chrX_+_159865500 0.45 ENSMUST00000238603.2
Scm polycomb group protein like 2
chr11_-_83959175 0.45 ENSMUST00000100705.11
dual specificity phosphatase 14
chr4_+_53440389 0.44 ENSMUST00000107646.9
ENSMUST00000102911.10
solute carrier family 44, member 1
chr4_+_148085179 0.44 ENSMUST00000103230.5
natriuretic peptide type A
chr2_+_130038463 0.44 ENSMUST00000166774.3
transmembrane channel-like gene family 2
chrX_+_99773784 0.43 ENSMUST00000113744.2
glycerophosphodiester phosphodiesterase domain containing 2
chr9_+_63509925 0.43 ENSMUST00000041551.9
alpha- and gamma-adaptin binding protein
chr15_+_79113341 0.41 ENSMUST00000163571.8
protein interacting with C kinase 1
chr3_-_108062172 0.39 ENSMUST00000062028.8
G protein-coupled receptor 61
chr4_+_127062924 0.39 ENSMUST00000046659.14
DLG associated protein 3
chrX_-_133375735 0.34 ENSMUST00000113223.3
TATA-box binding protein associated factor 7 like
chr1_-_190711151 0.33 ENSMUST00000047409.9
vasohibin 2
chr2_-_60503998 0.32 ENSMUST00000059888.15
ENSMUST00000154764.2
integrin beta 6
chr4_-_58785722 0.31 ENSMUST00000059608.5
olfactory receptor 267
chr11_-_87783073 0.31 ENSMUST00000213672.2
ENSMUST00000213928.2
olfactory receptor 462
chr9_-_85631361 0.29 ENSMUST00000039213.15
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chrX_-_47123719 0.28 ENSMUST00000039026.8
apelin
chr14_+_68321302 0.28 ENSMUST00000022639.8
neurofilament, light polypeptide
chr7_-_141783708 0.26 ENSMUST00000097942.3
keratin associated protein 5-5
chr7_-_121306476 0.26 ENSMUST00000046929.7
ubiquitin specific peptidase 31
chrX_+_151789457 0.24 ENSMUST00000095755.4
ubiquitin specific protease 51
chr2_-_91013362 0.22 ENSMUST00000066420.12
MAP-kinase activating death domain
chr2_+_68691902 0.21 ENSMUST00000176018.2
ceramide synthase 6
chr7_-_108529375 0.19 ENSMUST00000055745.5
NLR family, pyrin domain containing 10
chr6_-_24956296 0.18 ENSMUST00000127247.4
transmembrane protein 229A
chr9_-_40915895 0.17 ENSMUST00000180384.3
cytotoxic and regulatory T cell molecule
chrX_+_99773523 0.16 ENSMUST00000019503.14
glycerophosphodiester phosphodiesterase domain containing 2
chr1_-_161616031 0.15 ENSMUST00000000834.4
Fas ligand (TNF superfamily, member 6)
chr18_+_65158873 0.15 ENSMUST00000226058.2
neural precursor cell expressed, developmentally down-regulated gene 4-like
chr6_-_141954471 0.14 ENSMUST00000111832.3
predicted gene 6614
chr8_-_26505605 0.13 ENSMUST00000016138.11
farnesyltransferase, CAAX box, alpha
chr1_+_171156568 0.12 ENSMUST00000111300.8
death effector domain-containing
chr9_+_110948492 0.11 ENSMUST00000217341.3
leucine rich repeat (in FLII) interacting protein 2
chr12_-_52074846 0.11 ENSMUST00000040161.5
G protein-coupled receptor 33
chr16_-_32688640 0.10 ENSMUST00000089684.10
ENSMUST00000040986.15
ENSMUST00000115105.9
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
chr10_-_23968192 0.10 ENSMUST00000092654.4
trace amine-associated receptor 8B
chr7_-_79443536 0.09 ENSMUST00000032760.6
mesoderm posterior 1
chr15_-_99864936 0.08 ENSMUST00000100209.6
family with sequence similarity 186, member A
chr2_-_120946877 0.08 ENSMUST00000110675.3
transglutaminase 7
chr2_+_151923449 0.07 ENSMUST00000064061.4
scratch family zinc finger 2
chrX_+_41591410 0.07 ENSMUST00000005839.11
SH2 domain containing 1A
chr11_-_69791774 0.07 ENSMUST00000102580.10
RIKEN cDNA 2810408A11 gene
chr10_+_26105605 0.05 ENSMUST00000218301.2
ENSMUST00000164660.8
ENSMUST00000060716.6
sterile alpha motif domain containing 3
chr16_-_88609108 0.05 ENSMUST00000232664.2
predicted gene, 20741
chr4_+_119397710 0.04 ENSMUST00000160219.2
forkhead box J3
chr7_+_26456567 0.03 ENSMUST00000077855.8
cytochrome P450, family 2, subfamily b, polypeptide 19
chr9_-_40915858 0.02 ENSMUST00000188848.8
ENSMUST00000034519.13
cytotoxic and regulatory T cell molecule

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.6 25.9 GO:0002414 immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells(GO:0002414)
3.3 16.4 GO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
3.1 28.1 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
1.5 4.5 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
1.1 7.4 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
1.0 3.1 GO:2000040 regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
1.0 2.9 GO:0032474 otolith morphogenesis(GO:0032474)
0.9 3.6 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.9 4.5 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.9 15.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.7 2.2 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.7 2.1 GO:0070104 negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.6 7.1 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.6 3.7 GO:0006116 NADH oxidation(GO:0006116)
0.5 25.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.5 3.3 GO:0071484 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.4 7.7 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.4 2.4 GO:0006668 sphinganine-1-phosphate metabolic process(GO:0006668)
0.4 2.0 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.4 1.9 GO:0007386 compartment pattern specification(GO:0007386)
0.4 4.4 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.3 0.9 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.3 2.6 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.3 2.5 GO:0015961 diadenosine polyphosphate catabolic process(GO:0015961)
0.3 0.8 GO:1990918 meiotic DNA double-strand break formation(GO:0042138) double-strand break repair involved in meiotic recombination(GO:1990918)
0.2 1.9 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.2 1.3 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.2 2.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.2 2.8 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.2 0.7 GO:0048388 endosomal lumen acidification(GO:0048388)
0.2 0.5 GO:0061589 calcium activated phosphatidylserine scrambling(GO:0061589)
0.2 2.4 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.2 1.5 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 6.8 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 2.6 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.1 1.3 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.1 0.8 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 5.6 GO:0010842 retina layer formation(GO:0010842)
0.1 1.1 GO:0008078 mesodermal cell migration(GO:0008078)
0.1 1.0 GO:1990034 calcium ion export from cell(GO:1990034)
0.1 7.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 2.3 GO:0051601 exocyst localization(GO:0051601)
0.1 2.2 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 0.5 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.1 2.6 GO:0007220 Notch receptor processing(GO:0007220)
0.1 0.8 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 1.8 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 0.4 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.1 0.6 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.1 5.5 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 0.3 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 0.3 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.1 2.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 2.0 GO:0001675 acrosome assembly(GO:0001675)
0.1 2.1 GO:0030157 pancreatic juice secretion(GO:0030157)
0.1 1.2 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.1 2.0 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 0.4 GO:0015871 choline transport(GO:0015871)
0.1 0.4 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.5 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.1 0.4 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 0.7 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 1.4 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.2 GO:0002355 detection of tumor cell(GO:0002355)
0.1 7.2 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.1 0.6 GO:0090527 actin filament reorganization(GO:0090527)
0.0 2.3 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.6 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 3.0 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.4 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 1.8 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 2.3 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.3 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 0.5 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.5 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 1.2 GO:0043171 peptide catabolic process(GO:0043171)
0.0 1.7 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 1.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0018343 protein farnesylation(GO:0018343)
0.0 1.3 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.0 0.6 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.2 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
0.0 0.1 GO:0035660 MyD88-dependent toll-like receptor 4 signaling pathway(GO:0035660)
0.0 0.9 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.9 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.9 GO:0007140 male meiosis(GO:0007140)
0.0 0.7 GO:0003016 respiratory system process(GO:0003016)
0.0 0.6 GO:0046688 response to copper ion(GO:0046688)
0.0 0.1 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 1.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 15.0 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
1.2 16.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.7 3.7 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.7 2.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.6 25.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.3 1.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 1.8 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 7.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 2.6 GO:0070765 gamma-secretase complex(GO:0070765)
0.2 0.6 GO:0032783 ELL-EAF complex(GO:0032783)
0.2 1.3 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.2 3.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.2 5.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 2.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 3.5 GO:0005922 connexon complex(GO:0005922)
0.1 1.9 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 2.6 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.4 GO:0098842 postsynaptic early endosome(GO:0098842)
0.1 2.3 GO:1990635 proximal dendrite(GO:1990635)
0.1 3.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 1.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 2.0 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.1 2.3 GO:0000145 exocyst(GO:0000145)
0.1 7.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 1.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.3 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 0.3 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.1 0.6 GO:0000801 central element(GO:0000801)
0.0 2.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.4 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 4.5 GO:0005811 lipid particle(GO:0005811)
0.0 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 5.4 GO:0005814 centriole(GO:0005814)
0.0 0.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.3 GO:0010369 chromocenter(GO:0010369)
0.0 25.7 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.0 0.4 GO:0001741 XY body(GO:0001741)
0.0 2.5 GO:0001650 fibrillar center(GO:0001650)
0.0 3.0 GO:0072562 blood microparticle(GO:0072562)
0.0 0.9 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 28.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
2.2 25.9 GO:0019763 immunoglobulin receptor activity(GO:0019763)
1.2 7.4 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
1.1 25.1 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
1.1 16.4 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.9 3.6 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.7 3.6 GO:0051185 coenzyme transporter activity(GO:0051185)
0.7 2.1 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.7 2.6 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.6 2.5 GO:0047710 bis(5'-adenosyl)-triphosphatase activity(GO:0047710)
0.6 2.4 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.6 2.4 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.6 2.2 GO:0031699 beta-3 adrenergic receptor binding(GO:0031699)
0.5 5.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.4 9.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 0.9 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.3 1.2 GO:0042806 fucose binding(GO:0042806)
0.3 1.8 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223)
0.3 7.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.3 4.5 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.3 2.6 GO:0050786 RAGE receptor binding(GO:0050786)
0.2 3.5 GO:0005243 gap junction channel activity(GO:0005243)
0.2 0.8 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.2 1.7 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.2 0.9 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.2 1.3 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.2 3.1 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.2 1.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 3.7 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 1.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.8 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1 2.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 4.6 GO:0070064 proline-rich region binding(GO:0070064)
0.1 4.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.9 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 5.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 2.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.6 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 7.4 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.4 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 1.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.5 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 2.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 0.5 GO:0005000 vasopressin receptor activity(GO:0005000)
0.1 0.6 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 5.5 GO:0005080 protein kinase C binding(GO:0005080)
0.1 1.9 GO:0005112 Notch binding(GO:0005112)
0.1 1.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 7.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.4 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 2.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 1.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.7 GO:0005123 death receptor binding(GO:0005123)
0.0 0.5 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 1.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 2.7 GO:0000149 SNARE binding(GO:0000149)
0.0 0.8 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 5.9 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.0 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0043274 phospholipase binding(GO:0043274)
0.0 3.0 GO:0031267 small GTPase binding(GO:0031267)
0.0 1.5 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 2.2 GO:0030674 protein binding, bridging(GO:0030674)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 27.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 6.9 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.2 3.3 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 2.6 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 8.3 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 2.1 PID IL27 PATHWAY IL27-mediated signaling events
0.1 1.9 PID ARF 3PATHWAY Arf1 pathway
0.1 2.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 3.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.3 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.9 PID NOTCH PATHWAY Notch signaling pathway
0.0 5.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.0 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.3 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 2.0 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.7 PID FOXO PATHWAY FoxO family signaling
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 28.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.5 15.0 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.2 5.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.2 3.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.2 7.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.2 7.4 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.2 1.9 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.2 3.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 2.6 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 5.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 2.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 2.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 3.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.7 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.4 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 2.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 2.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.9 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 2.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 6.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 2.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.2 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.4 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.3 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 3.9 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.3 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.4 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression