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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Tbx3

Z-value: 0.81

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Transcription factors associated with Tbx3

Gene Symbol Gene ID Gene Info
Tbx3
ENSMUSG00000018604.19 Tbx3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx3mm39_v1_chr5_+_119808890_1198089270.307.6e-02Click!

Activity profile of Tbx3 motif

Sorted Z-values of Tbx3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_+_107166653 1.41 ENSMUST00000120990.2
Olfml1
olfactomedin-like 1
chr7_+_107166925 1.24 ENSMUST00000239087.2
Olfml1
olfactomedin-like 1
chr17_-_59320257 1.17 ENSMUST00000174122.2
ENSMUST00000025065.12
Nudt12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr19_+_7471398 0.98 ENSMUST00000170373.9
ENSMUST00000236308.2
ENSMUST00000235557.2
Atl3
atlastin GTPase 3
chr4_+_135487016 0.94 ENSMUST00000105854.2
Myom3
myomesin family, member 3
chr7_-_4525793 0.91 ENSMUST00000140424.8
Tnni3
troponin I, cardiac 3
chr3_+_60380243 0.78 ENSMUST00000195724.6
Mbnl1
muscleblind like splicing factor 1
chr7_-_4525426 0.64 ENSMUST00000209148.2
ENSMUST00000098859.10
Tnni3
troponin I, cardiac 3
chr10_+_75242745 0.59 ENSMUST00000039925.8
Upb1
ureidopropionase, beta
chr7_+_43885573 0.54 ENSMUST00000223070.2
ENSMUST00000205530.2
Gm36864
predicted gene, 36864
chr1_+_175747895 0.46 ENSMUST00000201297.2
ENSMUST00000194391.2
Gm38100
predicted gene, 38100
chr16_+_17437367 0.44 ENSMUST00000231887.2
Smpd4
sphingomyelin phosphodiesterase 4
chr5_-_107074110 0.41 ENSMUST00000117588.8
Hfm1
HFM1, ATP-dependent DNA helicase homolog
chr12_-_84408576 0.41 ENSMUST00000021659.2
ENSMUST00000065536.9
Fam161b
family with sequence similarity 161, member B
chr19_+_5754395 0.39 ENSMUST00000052448.4
Kcnk7
potassium channel, subfamily K, member 7
chr7_-_43885552 0.38 ENSMUST00000236952.2
1700028J19Rik
RIKEN cDNA 1700028J19 gene
chr2_+_173561208 0.38 ENSMUST00000073081.6
1700010B08Rik
RIKEN cDNA 1700010B08 gene
chr7_-_139941566 0.38 ENSMUST00000215023.2
ENSMUST00000216027.2
ENSMUST00000210932.3
ENSMUST00000211031.3
Olfr60
olfactory receptor 60
chr3_-_122828592 0.36 ENSMUST00000029761.14
Myoz2
myozenin 2
chr10_-_18619439 0.35 ENSMUST00000019999.7
Arfgef3
ARFGEF family member 3
chr7_-_119744509 0.32 ENSMUST00000208874.2
ENSMUST00000033207.6
Zp2
zona pellucida glycoprotein 2
chr16_-_13548833 0.30 ENSMUST00000023364.7
Pla2g10
phospholipase A2, group X
chr6_-_97037366 0.28 ENSMUST00000089295.6
Tafa4
TAFA chemokine like family member 4
chrX_-_133377225 0.28 ENSMUST00000009740.9
Taf7l
TATA-box binding protein associated factor 7 like
chr9_+_37808020 0.27 ENSMUST00000086062.4
ENSMUST00000213688.2
Olfr145
olfactory receptor 145
chr16_-_13548307 0.27 ENSMUST00000115807.9
Pla2g10
phospholipase A2, group X
chr4_-_128512401 0.27 ENSMUST00000074829.4
Tlr12
toll-like receptor 12
chr4_-_145041710 0.26 ENSMUST00000030339.13
Tnfrsf8
tumor necrosis factor receptor superfamily, member 8
chr10_-_18619658 0.25 ENSMUST00000215836.2
Arfgef3
ARFGEF family member 3
chr3_-_89153135 0.25 ENSMUST00000041022.15
Trim46
tripartite motif-containing 46
chr13_-_59853995 0.25 ENSMUST00000066510.8
ENSMUST00000224469.2
Spata31d1a
spermatogenesis associated 31 subfamily D, member 1A
chr7_-_43885522 0.24 ENSMUST00000206686.2
ENSMUST00000037220.5
1700028J19Rik
RIKEN cDNA 1700028J19 gene
chr2_+_154393691 0.23 ENSMUST00000104928.2
Actl10
actin-like 10
chr11_+_58549642 0.21 ENSMUST00000214392.2
Olfr322
olfactory receptor 322
chr8_-_96033213 0.21 ENSMUST00000119870.9
ENSMUST00000093268.5
Cngb1
cyclic nucleotide gated channel beta 1
chr3_+_89153704 0.21 ENSMUST00000168900.3
Krtcap2
keratinocyte associated protein 2
chr7_-_118042772 0.21 ENSMUST00000081574.8
Syt17
synaptotagmin XVII
chr11_+_73241609 0.20 ENSMUST00000120137.3
Olfr20
olfactory receptor 20
chr7_+_140284078 0.19 ENSMUST00000080681.4
Olfr541
olfactory receptor 541
chr3_-_51184895 0.18 ENSMUST00000108051.8
ENSMUST00000108053.9
Elf2
E74-like factor 2
chr19_-_10434837 0.16 ENSMUST00000171400.4
Lrrc10b
leucine rich repeat containing 10B
chr8_+_70107131 0.15 ENSMUST00000204285.3
Zfp964
zinc finger protein 964
chr1_+_191307748 0.15 ENSMUST00000045450.7
Ints7
integrator complex subunit 7
chr2_-_90101376 0.14 ENSMUST00000216383.2
Olfr1271
olfactory receptor 1271
chr13_+_33668761 0.14 ENSMUST00000081927.4
Serpinb9g
serine (or cysteine) peptidase inhibitor, clade B, member 9g
chr3_+_89153258 0.12 ENSMUST00000040888.12
Krtcap2
keratinocyte associated protein 2
chr1_-_31261678 0.12 ENSMUST00000187892.8
ENSMUST00000233331.2
4931428L18Rik
RIKEN cDNA 4931428L18 gene
chr15_-_97806142 0.11 ENSMUST00000023119.15
Vdr
vitamin D (1,25-dihydroxyvitamin D3) receptor
chr2_-_88108746 0.11 ENSMUST00000216887.2
Olfr1173
olfactory receptor 1173
chr14_+_67982630 0.10 ENSMUST00000223929.2
ENSMUST00000111095.4
Gnrh1
gonadotropin releasing hormone 1
chr13_-_23372145 0.09 ENSMUST00000228239.2
ENSMUST00000227950.2
ENSMUST00000226651.2
ENSMUST00000227679.2
ENSMUST00000228854.2
Vmn1r220
vomeronasal 1 receptor 220
chr13_+_22574543 0.08 ENSMUST00000226157.2
ENSMUST00000227326.2
ENSMUST00000228726.2
Vmn1r200
vomeronasal 1 receptor 200
chr3_+_60380463 0.01 ENSMUST00000195077.6
ENSMUST00000193647.6
ENSMUST00000195001.2
ENSMUST00000192807.6
Mbnl1
muscleblind like splicing factor 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.2 1.2 GO:0006742 NADP catabolic process(GO:0006742)
0.2 0.6 GO:0051977 lysophospholipid transport(GO:0051977)
0.1 0.6 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.3 GO:0060468 prevention of polyspermy(GO:0060468)
0.0 0.1 GO:0010980 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) bile acid signaling pathway(GO:0038183)
0.0 0.4 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.3 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.6 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.0 0.2 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.3 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.0 1.0 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.1 GO:0034472 snRNA 3'-end processing(GO:0034472)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 0.2 GO:1990769 proximal neuron projection(GO:1990769)
0.0 1.0 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.9 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:0001651 dense fibrillar component(GO:0001651)
0.0 0.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0030172 troponin C binding(GO:0030172)
0.2 1.2 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.3 GO:0032190 acrosin binding(GO:0032190)
0.1 0.4 GO:0051373 FATZ binding(GO:0051373)
0.1 0.8 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.1 GO:1902121 lithocholic acid binding(GO:1902121)
0.0 0.3 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.6 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.3 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:0043855 cyclic nucleotide-gated ion channel activity(GO:0043855)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.6 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction