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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Tfap2e

Z-value: 0.48

Motif logo

Transcription factors associated with Tfap2e

Gene Symbol Gene ID Gene Info
ENSMUSG00000042477.8 Tfap2e

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tfap2emm39_v1_chr4_-_126630028_1266300390.202.4e-01Click!

Activity profile of Tfap2e motif

Sorted Z-values of Tfap2e motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2e

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr9_-_46146558 4.34 ENSMUST00000121916.8
ENSMUST00000034586.9
apolipoprotein C-III
chr9_-_46146928 3.69 ENSMUST00000118649.8
apolipoprotein C-III
chr2_+_102488985 1.71 ENSMUST00000080210.10
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr4_+_118217179 1.52 ENSMUST00000006562.6
hydroxypyruvate isomerase (putative)
chr5_-_34345014 1.30 ENSMUST00000042701.13
ENSMUST00000119171.2
Max dimerization protein 4
chr4_-_57143437 0.91 ENSMUST00000095076.10
ENSMUST00000030142.4
erythrocyte membrane protein band 4.1 like 4b
chr16_-_46317135 0.91 ENSMUST00000149901.2
ENSMUST00000096052.9
nectin cell adhesion molecule 3
chr14_+_57124028 0.89 ENSMUST00000223669.2
zinc finger, MYM-type 2
chr17_+_64170967 0.87 ENSMUST00000232945.2
fer (fms/fps related) protein kinase
chr6_+_108190163 0.86 ENSMUST00000203615.3
inositol 1,4,5-trisphosphate receptor 1
chr6_+_54016543 0.83 ENSMUST00000046856.14
chimerin 2
chr6_+_108190050 0.78 ENSMUST00000032192.9
inositol 1,4,5-trisphosphate receptor 1
chr11_-_51647204 0.77 ENSMUST00000109092.8
ENSMUST00000064297.5
Sec24 related gene family, member A (S. cerevisiae)
chr2_+_133394079 0.77 ENSMUST00000028836.7
bone morphogenetic protein 2
chr11_-_51647290 0.65 ENSMUST00000109097.9
Sec24 related gene family, member A (S. cerevisiae)
chr9_+_100525637 0.62 ENSMUST00000041418.13
stromal antigen 1
chr9_+_100525807 0.61 ENSMUST00000133388.2
stromal antigen 1
chr17_-_64170786 0.59 ENSMUST00000050753.4
RIKEN cDNA A930002H24 gene
chr8_+_108020132 0.55 ENSMUST00000151114.8
ENSMUST00000125721.8
ENSMUST00000075922.11
nuclear factor of activated T cells 5
chr9_+_100525501 0.54 ENSMUST00000146312.8
ENSMUST00000129269.8
stromal antigen 1
chr11_-_109613040 0.52 ENSMUST00000020938.8
FAM20A, golgi associated secretory pathway pseudokinase
chr8_+_108020092 0.49 ENSMUST00000169453.8
nuclear factor of activated T cells 5
chr9_+_109760856 0.48 ENSMUST00000169851.8
microtubule-associated protein 4
chr6_+_56691875 0.47 ENSMUST00000031805.11
ENSMUST00000177249.3
AVL9 cell migration associated
chr9_+_109760931 0.46 ENSMUST00000165876.8
microtubule-associated protein 4
chr7_-_116042674 0.42 ENSMUST00000170430.3
ENSMUST00000206219.2
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
chr2_+_83642910 0.40 ENSMUST00000051454.4
family with sequence similarity 171, member B
chrX_+_12937714 0.39 ENSMUST00000169594.9
ENSMUST00000089302.11
ubiquitin specific peptidase 9, X chromosome
chr11_+_95304903 0.37 ENSMUST00000107724.9
ENSMUST00000150884.8
ENSMUST00000107722.8
ENSMUST00000127713.2
speckle-type BTB/POZ protein
chr13_-_111626562 0.37 ENSMUST00000091236.11
ENSMUST00000047627.14
GC-rich promoter binding protein 1
chrX_+_7588505 0.37 ENSMUST00000207675.2
ENSMUST00000116633.9
ENSMUST00000208996.2
ENSMUST00000144148.4
ENSMUST00000125991.9
ENSMUST00000148624.8
WD repeat domain 45
chr2_+_109721189 0.35 ENSMUST00000028583.8
lin-7 homolog C (C. elegans)
chr8_+_41692755 0.34 ENSMUST00000210862.2
ENSMUST00000045218.9
ENSMUST00000211247.2
pericentriolar material 1
chr13_+_38009981 0.32 ENSMUST00000110238.10
ras responsive element binding protein 1
chr8_+_80366247 0.32 ENSMUST00000173078.8
ENSMUST00000173286.8
OTU domain containing 4
chrX_+_7589166 0.31 ENSMUST00000115687.8
WD repeat domain 45
chrX_+_72760318 0.30 ENSMUST00000114461.3
ATP-binding cassette, sub-family D (ALD), member 1
chr14_+_73380577 0.29 ENSMUST00000165567.8
ENSMUST00000022702.13
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr15_-_38299934 0.29 ENSMUST00000228772.2
Kruppel-like factor 10
chr6_-_39702381 0.29 ENSMUST00000002487.15
Braf transforming gene
chr3_-_54962899 0.28 ENSMUST00000199144.5
cyclin A1
chr7_-_30298287 0.28 ENSMUST00000108150.2
zinc finger and BTB domain containing 32
chr13_+_38010203 0.28 ENSMUST00000128570.9
ras responsive element binding protein 1
chr3_-_88362606 0.27 ENSMUST00000125526.8
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr16_-_35589726 0.27 ENSMUST00000023554.9
solute carrier family 49 member 4
chr9_+_108394351 0.26 ENSMUST00000192932.6
ENSMUST00000193348.2
ENSMUST00000194385.2
glutamine-rich 1
chr5_-_149559792 0.26 ENSMUST00000202361.4
ENSMUST00000202089.4
ENSMUST00000200825.2
ENSMUST00000201559.4
heat shock 105kDa/110kDa protein 1
chr7_+_80707328 0.25 ENSMUST00000107348.2
alpha-kinase 3
chr3_-_54962922 0.25 ENSMUST00000197238.5
cyclin A1
chr14_+_73380539 0.24 ENSMUST00000169513.8
ENSMUST00000165727.8
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr9_+_108394005 0.23 ENSMUST00000195563.6
glutamine-rich 1
chrX_+_72760183 0.23 ENSMUST00000002084.14
ATP-binding cassette, sub-family D (ALD), member 1
chr5_-_149559737 0.22 ENSMUST00000200805.4
heat shock 105kDa/110kDa protein 1
chr9_+_108394761 0.21 ENSMUST00000192819.2
glutamine-rich 1
chrX_-_103024847 0.21 ENSMUST00000121153.8
ENSMUST00000070705.6
ring finger protein, LIM domain interacting
chr1_-_177624017 0.19 ENSMUST00000016105.9
adenylosuccinate synthetase, non muscle
chr13_+_38009951 0.19 ENSMUST00000138043.8
ras responsive element binding protein 1
chr7_+_101916992 0.19 ENSMUST00000033289.6
ENSMUST00000209255.2
stromal interaction molecule 1
chr14_-_14371476 0.19 ENSMUST00000225653.2
ENSMUST00000112689.9
ENSMUST00000036682.9
PX domain containing serine/threonine kinase
chr2_-_38177359 0.19 ENSMUST00000102787.10
DENN/MADD domain containing 1A
chr4_+_148123554 0.18 ENSMUST00000141283.8
methylenetetrahydrofolate reductase
chr6_-_39702127 0.18 ENSMUST00000101497.4
Braf transforming gene
chr3_-_94693740 0.17 ENSMUST00000153263.9
ENSMUST00000107272.7
ENSMUST00000155485.4
cingulin
chr12_+_111540920 0.17 ENSMUST00000075281.8
ENSMUST00000084953.13
MAP/microtubule affinity regulating kinase 3
chr6_-_136638926 0.17 ENSMUST00000032336.7
phospholipase B domain containing 1
chr12_-_45120895 0.16 ENSMUST00000120531.8
ENSMUST00000143376.8
syntaxin binding protein 6 (amisyn)
chr15_+_80862074 0.16 ENSMUST00000229727.2
small G protein signaling modulator 3
chr9_+_21077010 0.15 ENSMUST00000039413.15
phosphodiesterase 4A, cAMP specific
chr2_-_150746574 0.15 ENSMUST00000056149.15
abhydrolase domain containing 12
chr3_+_103187162 0.15 ENSMUST00000106860.6
tripartite motif-containing 33
chr3_-_113423774 0.15 ENSMUST00000092154.10
ENSMUST00000106536.8
ENSMUST00000106535.2
RNA-binding region (RNP1, RRM) containing 3
chr2_-_173117936 0.15 ENSMUST00000139306.2
prostate transmembrane protein, androgen induced 1
chr9_+_25163735 0.15 ENSMUST00000115272.9
ENSMUST00000165594.4
septin 7
chr8_+_94879235 0.14 ENSMUST00000034211.10
ENSMUST00000211930.2
ENSMUST00000211915.2
metallothionein 3
chr3_+_89680867 0.13 ENSMUST00000038356.13
ubiquitin-conjugating enzyme E2Q family member 1
chr2_+_27055245 0.13 ENSMUST00000000910.7
dopamine beta hydroxylase
chr1_+_180553569 0.12 ENSMUST00000027780.6
acyl-Coenzyme A binding domain containing 3
chr5_-_149559636 0.12 ENSMUST00000201452.4
heat shock 105kDa/110kDa protein 1
chr11_-_102109748 0.10 ENSMUST00000131254.2
histone deacetylase 5
chr9_-_13245834 0.10 ENSMUST00000110582.4
Jrk-like
chr5_-_149559667 0.10 ENSMUST00000074846.14
heat shock 105kDa/110kDa protein 1
chr6_+_136804828 0.09 ENSMUST00000204086.2
cDNA sequence BC049715
chr10_+_85763545 0.09 ENSMUST00000170396.3
achaete-scute family bHLH transcription factor 4
chr17_+_37356854 0.09 ENSMUST00000025338.16
gamma-aminobutyric acid (GABA) B receptor, 1
chr1_+_74811045 0.09 ENSMUST00000006716.8
wingless-type MMTV integration site family, member 6
chr9_+_108394269 0.08 ENSMUST00000195513.6
ENSMUST00000193258.6
ENSMUST00000112155.9
ENSMUST00000006851.15
glutamine-rich 1
chr4_-_127247864 0.07 ENSMUST00000106090.8
ENSMUST00000060419.2
gap junction protein, beta 4
chr11_+_49916136 0.07 ENSMUST00000054684.14
ENSMUST00000238748.2
ENSMUST00000102776.5
ring finger protein 130
chr11_-_100139728 0.06 ENSMUST00000007280.9
keratin 16
chr9_-_119812042 0.06 ENSMUST00000214058.2
cysteine-serine-rich nuclear protein 1
chr16_+_93629009 0.06 ENSMUST00000044068.10
ENSMUST00000202261.5
ENSMUST00000201097.3
microrchidia 3
chr6_-_137626207 0.05 ENSMUST00000134630.6
ENSMUST00000058210.13
ENSMUST00000111878.8
epidermal growth factor receptor pathway substrate 8
chr12_-_114186874 0.04 ENSMUST00000103477.4
ENSMUST00000192499.3
immunoglobulin heavy variable 7-4
chr11_+_98277276 0.03 ENSMUST00000041301.8
phenylethanolamine-N-methyltransferase
chr5_-_146521629 0.03 ENSMUST00000200112.2
ENSMUST00000197431.2
ENSMUST00000197825.2
G-protein coupled receptor 12
chr2_+_31204314 0.03 ENSMUST00000113532.9
hemicentin 2
chr15_+_89383799 0.03 ENSMUST00000109309.9
SH3 and multiple ankyrin repeat domains 3
chr12_+_4967376 0.03 ENSMUST00000045664.7
ATPase family, AAA domain containing 2B
chr3_+_60408678 0.02 ENSMUST00000191747.6
ENSMUST00000194069.6
muscleblind like splicing factor 1
chr7_-_19363280 0.02 ENSMUST00000094762.10
ENSMUST00000049912.15
ENSMUST00000098754.5
avian reticuloendotheliosis viral (v-rel) oncogene related B
chr11_-_97635484 0.02 ENSMUST00000018691.9
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr7_-_19362328 0.01 ENSMUST00000141586.2
ENSMUST00000153309.8
avian reticuloendotheliosis viral (v-rel) oncogene related B
chr7_-_103832599 0.01 ENSMUST00000216612.3
olfactory receptor 648
chr6_-_136804728 0.01 ENSMUST00000146348.4
WW domain binding protein 11
chr4_+_42158092 0.01 ENSMUST00000098122.3
predicted gene 13306
chr7_-_44174065 0.00 ENSMUST00000165208.4
myosin binding protein C, fast-type

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 8.0 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)
0.2 1.7 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2 0.8 GO:0003130 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134)
0.2 1.6 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 0.4 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.1 0.9 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.5 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.1 0.8 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 0.9 GO:0038109 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Fc-epsilon receptor signaling pathway(GO:0038095) Kit signaling pathway(GO:0038109)
0.1 1.4 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 0.4 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.1 0.9 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.1 0.7 GO:1903753 negative regulation of p38MAPK cascade(GO:1903753)
0.1 0.4 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 0.3 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 0.5 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 0.2 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
0.0 0.3 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.7 GO:0070166 enamel mineralization(GO:0070166)
0.0 0.1 GO:0097212 lysosomal membrane organization(GO:0097212)
0.0 0.9 GO:1902414 protein localization to cell junction(GO:1902414)
0.0 0.1 GO:0046333 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.0 0.2 GO:0070829 heterochromatin maintenance(GO:0070829)
0.0 0.7 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 1.0 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.1 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0070459 prolactin secretion(GO:0070459)
0.0 0.2 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.2 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.2 GO:0009048 dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.0 0.0 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.1 GO:0051546 keratinocyte migration(GO:0051546)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 8.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.4 1.6 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 0.3 GO:0097123 cyclin A1-CDK2 complex(GO:0097123)
0.1 1.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.1 GO:0060205 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
0.0 0.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 1.8 GO:0030673 axolemma(GO:0030673)
0.0 0.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:0000242 pericentriolar material(GO:0000242)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 8.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.3 1.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.3 1.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.8 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 0.2 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.2 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.5 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.3 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.9 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.5 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.1 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.5 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0097157 pre-mRNA intronic binding(GO:0097157)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.8 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.0 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.3 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.5 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.5 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 1.7 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.1 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling