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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Trp53

Z-value: 2.05

Motif logo

Transcription factors associated with Trp53

Gene Symbol Gene ID Gene Info
ENSMUSG00000059552.14 Trp53

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Trp53mm39_v1_chr11_+_69471185_694712080.931.8e-16Click!

Activity profile of Trp53 motif

Sorted Z-values of Trp53 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp53

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr3_+_90576285 22.08 ENSMUST00000069927.10
S100 calcium binding protein A8 (calgranulin A)
chr7_-_24459736 14.58 ENSMUST00000063956.7
CD177 antigen
chr17_-_34109513 14.12 ENSMUST00000173386.2
ENSMUST00000114361.9
ENSMUST00000173492.9
kinesin family member C1
chr8_+_95703728 12.21 ENSMUST00000179619.9
adhesion G protein-coupled receptor G1
chr17_-_35285146 10.23 ENSMUST00000174190.2
ENSMUST00000097337.8
megakaryocyte and platelet inhibitory receptor G6b
chr4_+_114914880 10.06 ENSMUST00000161601.8
T cell acute lymphocytic leukemia 1
chr17_+_28426752 8.53 ENSMUST00000002327.6
ENSMUST00000233560.2
ENSMUST00000233958.2
ENSMUST00000233170.2
differentially expressed in FDCP 6
chr9_-_21874802 8.00 ENSMUST00000006397.7
erythropoietin receptor
chr17_+_36132567 7.98 ENSMUST00000003635.7
immediate early response 3
chr11_-_102815910 7.64 ENSMUST00000021311.10
kinesin family member 18B
chr6_-_136918885 7.31 ENSMUST00000111891.4
Rho, GDP dissociation inhibitor (GDI) beta
chr17_+_27136065 7.18 ENSMUST00000078961.6
kinesin family member C5B
chr5_-_30278552 6.99 ENSMUST00000198095.2
ENSMUST00000196872.2
ENSMUST00000026846.11
thymidylate synthase
chr2_-_69036489 6.99 ENSMUST00000127243.8
ENSMUST00000149643.2
ENSMUST00000167875.9
ENSMUST00000005365.15
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr6_-_136918495 6.99 ENSMUST00000111892.8
Rho, GDP dissociation inhibitor (GDI) beta
chr11_-_102360664 6.88 ENSMUST00000103086.4
integrin alpha 2b
chr6_-_136918844 6.45 ENSMUST00000204934.2
Rho, GDP dissociation inhibitor (GDI) beta
chr6_-_136918671 6.43 ENSMUST00000032344.12
Rho, GDP dissociation inhibitor (GDI) beta
chr8_+_95703506 6.30 ENSMUST00000212581.2
adhesion G protein-coupled receptor G1
chr12_-_78953703 6.13 ENSMUST00000021544.8
pleckstrin 2
chr4_+_114914607 5.98 ENSMUST00000136946.8
T cell acute lymphocytic leukemia 1
chr10_+_75399920 5.88 ENSMUST00000141062.8
ENSMUST00000152657.8
gamma-glutamyltransferase 1
chr8_-_22675773 5.59 ENSMUST00000046916.9
cytoskeleton associated protein 2
chr2_-_69036472 5.52 ENSMUST00000112320.8
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr8_-_106578613 5.30 ENSMUST00000040776.6
centromere protein T
chr6_-_128868068 4.98 ENSMUST00000178918.2
ENSMUST00000160290.8
cDNA sequence BC035044
chr8_-_89362745 4.93 ENSMUST00000034087.9
sorting nexin 20
chr6_-_116437985 4.76 ENSMUST00000164547.8
ENSMUST00000170186.2
arachidonate 5-lipoxygenase
chr15_+_85744147 4.66 ENSMUST00000231074.2
G two S phase expressed protein 1
chr6_-_116438116 4.53 ENSMUST00000026795.13
arachidonate 5-lipoxygenase
chr1_-_88133472 4.53 ENSMUST00000119972.4
DnaJ heat shock protein family (Hsp40) member B3
chr4_-_133981387 4.46 ENSMUST00000060050.6
glycine/arginine rich protein 1
chr15_+_85743887 4.44 ENSMUST00000170629.3
G two S phase expressed protein 1
chr3_-_132655804 4.40 ENSMUST00000117164.8
ENSMUST00000093971.5
ENSMUST00000042729.16
nephronectin
chr17_+_28426831 4.33 ENSMUST00000233264.2
differentially expressed in FDCP 6
chr5_+_35156389 4.16 ENSMUST00000114281.8
ENSMUST00000114280.8
regulator of G-protein signaling 12
chr12_-_91351177 4.15 ENSMUST00000141429.8
centrosomal protein 128
chr8_+_70735477 4.04 ENSMUST00000087467.12
ENSMUST00000140212.8
ENSMUST00000110124.9
homer scaffolding protein 3
chr15_+_79784365 4.01 ENSMUST00000230135.2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chr15_-_102259158 4.00 ENSMUST00000231061.2
ENSMUST00000041208.9
achalasia, adrenocortical insufficiency, alacrimia
chrX_+_73298388 3.84 ENSMUST00000119197.8
ENSMUST00000088313.5
emerin
chr11_+_58839716 3.81 ENSMUST00000078267.5
H2B.U histone 2
chrX_+_73298342 3.81 ENSMUST00000096424.11
emerin
chr7_+_24584197 3.80 ENSMUST00000156372.8
ENSMUST00000124035.2
ribosomal protein S19
chr1_+_172327569 3.68 ENSMUST00000111230.8
transgelin 2
chr18_-_35781422 3.47 ENSMUST00000237462.2
marginal zone B and B1 cell-specific protein 1
chr17_+_29309942 3.44 ENSMUST00000119901.9
cyclin-dependent kinase inhibitor 1A (P21)
chrX_+_73298285 3.27 ENSMUST00000002029.13
emerin
chr3_-_90297187 3.26 ENSMUST00000029541.12
solute carrier family 27 (fatty acid transporter), member 3
chr14_-_56181993 3.20 ENSMUST00000022834.7
ENSMUST00000226280.2
chymase 1, mast cell
chr13_+_94954202 2.99 ENSMUST00000220825.2
tubulin cofactor A
chr7_+_24583994 2.82 ENSMUST00000108428.8
ribosomal protein S19
chr7_+_24584076 2.79 ENSMUST00000153451.9
ENSMUST00000108429.8
ribosomal protein S19
chr9_-_114811807 2.79 ENSMUST00000053150.8
ribosomal protein S27, retrogene
chr11_-_79037213 2.72 ENSMUST00000018478.11
ENSMUST00000108264.8
kinase suppressor of ras 1
chr7_-_141023199 2.61 ENSMUST00000106005.9
p53 induced death domain protein 1
chr6_+_71684846 2.46 ENSMUST00000212792.2
receptor accessory protein 1
chr5_+_35146727 2.45 ENSMUST00000114284.8
regulator of G-protein signaling 12
chr1_+_75377616 2.44 ENSMUST00000122266.3
SPEG complex locus
chr7_+_89780785 2.37 ENSMUST00000208684.2
phosphatidylinositol binding clathrin assembly protein
chr11_-_115968373 2.35 ENSMUST00000174822.8
unc-13 homolog D
chr10_+_110581293 2.34 ENSMUST00000174857.8
ENSMUST00000073781.12
ENSMUST00000173471.8
ENSMUST00000173634.2
E2F transcription factor 7
chr5_+_35156454 2.31 ENSMUST00000114283.8
regulator of G-protein signaling 12
chr1_+_82817794 2.21 ENSMUST00000186043.2
ArfGAP with FG repeats 1
chr5_+_144127102 2.19 ENSMUST00000060747.8
basic helix-loop-helix family, member a15
chr5_+_35146880 2.08 ENSMUST00000114285.8
regulator of G-protein signaling 12
chr6_-_38814159 2.04 ENSMUST00000160962.8
homeodomain interacting protein kinase 2
chr13_-_98951890 2.02 ENSMUST00000040340.16
ENSMUST00000179563.8
ENSMUST00000109403.2
FCH domain only 2
chr11_-_3477916 1.96 ENSMUST00000020718.10
smoothelin
chr2_+_128942900 1.94 ENSMUST00000103205.11
polymerase (RNA) I polypeptide B
chr13_-_22227114 1.92 ENSMUST00000091741.6
H2A clustered histone 11
chr9_-_110886576 1.89 ENSMUST00000199839.5
chemokine (C-C motif) receptor-like 2
chr6_-_29212295 1.82 ENSMUST00000078155.12
inosine monophosphate dehydrogenase 1
chr14_-_73563212 1.82 ENSMUST00000022701.7
RB transcriptional corepressor 1
chr11_+_118367651 1.81 ENSMUST00000135383.9
endo-beta-N-acetylglucosaminidase
chrX_-_141089165 1.73 ENSMUST00000134825.3
potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene
chr11_-_116058961 1.71 ENSMUST00000139020.2
ENSMUST00000103031.8
ENSMUST00000124828.8
Fas (TNFRSF6) binding factor 1
chr2_+_128942919 1.70 ENSMUST00000028874.8
polymerase (RNA) I polypeptide B
chr13_+_22227359 1.68 ENSMUST00000110452.2
H2B clustered histone 11
chr1_+_133278248 1.68 ENSMUST00000094556.3
renin 1 structural
chr6_+_41098273 1.63 ENSMUST00000103270.4
T cell receptor beta, variable 13-2
chr9_+_5298669 1.62 ENSMUST00000238505.2
caspase 1
chr1_+_51328265 1.59 ENSMUST00000051572.8
caveolae associated 2
chr4_-_135300934 1.58 ENSMUST00000105855.2
grainyhead like transcription factor 3
chr6_+_71684872 1.51 ENSMUST00000212631.2
receptor accessory protein 1
chr9_-_56151334 1.48 ENSMUST00000188142.7
pseudopodium-enriched atypical kinase 1
chr4_-_129534853 1.47 ENSMUST00000046425.16
ENSMUST00000133803.8
taxilin alpha
chr1_-_38704028 1.43 ENSMUST00000039827.14
AF4/FMR2 family, member 3
chr13_-_23755374 1.42 ENSMUST00000102969.6
H2A clustered histone 8
chr6_+_127423779 1.38 ENSMUST00000112191.8
poly (ADP-ribose) polymerase family, member 11
chr3_-_19319155 1.38 ENSMUST00000091314.11
phosphodiesterase 7A
chr4_-_129534403 1.37 ENSMUST00000084264.12
taxilin alpha
chr6_-_124698805 1.35 ENSMUST00000173315.8
protein tyrosine phosphatase, non-receptor type 6
chr4_-_129534752 1.34 ENSMUST00000132217.8
ENSMUST00000130017.2
ENSMUST00000154105.8
taxilin alpha
chr16_+_20536415 1.28 ENSMUST00000021405.8
polymerase (RNA) II (DNA directed) polypeptide H
chr14_-_8536869 1.26 ENSMUST00000238865.2
ENSMUST00000159275.4
predicted gene 11100
chr7_+_75105282 1.26 ENSMUST00000207750.2
ENSMUST00000166315.7
A kinase (PRKA) anchor protein 13
chr8_-_112580910 1.25 ENSMUST00000034432.7
craniofacial development protein 1
chr2_+_29780073 1.21 ENSMUST00000028128.13
outer dense fiber of sperm tails 2
chr16_+_20536545 1.17 ENSMUST00000231656.2
polymerase (RNA) II (DNA directed) polypeptide H
chr5_+_114845821 1.17 ENSMUST00000094441.11
trichoplein, keratin filament binding
chr6_+_67586695 1.14 ENSMUST00000103303.3
immunoglobulin kappa variable 1-135
chr2_-_163239865 1.13 ENSMUST00000017961.11
ENSMUST00000109425.3
junctophilin 2
chr13_-_98152768 1.08 ENSMUST00000238746.2
Rho guanine nucleotide exchange factor (GEF) 28
chr1_-_192812509 1.06 ENSMUST00000085555.7
UTP25 small subunit processome component
chr1_-_79836344 1.02 ENSMUST00000027467.11
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr2_+_85838122 1.01 ENSMUST00000062166.2
olfactory receptor 1032
chr13_+_22220000 1.00 ENSMUST00000110455.4
H2B clustered histone 12
chr13_-_74956640 0.99 ENSMUST00000231578.2
calpastatin
chr9_-_106324642 0.98 ENSMUST00000185334.7
ENSMUST00000187001.2
ENSMUST00000171678.9
ENSMUST00000190798.7
ENSMUST00000048685.13
ENSMUST00000171925.8
abhydrolase domain containing 14A
chr11_+_6366259 0.96 ENSMUST00000213200.2
peptidylprolyl isomerase A
chr14_-_70412804 0.95 ENSMUST00000143393.2
PDZ and LIM domain 2
chr13_-_22219738 0.95 ENSMUST00000091742.6
H2A clustered histone 12
chr8_+_18896267 0.93 ENSMUST00000149565.8
ENSMUST00000033847.5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr4_-_111755892 0.92 ENSMUST00000102720.8
solute carrier family 5 (sodium/glucose cotransporter), member 9
chr14_-_49303826 0.92 ENSMUST00000161504.8
exocyst complex component 5
chr15_-_102154874 0.89 ENSMUST00000063339.14
retinoic acid receptor, gamma
chr17_-_22152003 0.87 ENSMUST00000074295.8
zinc finger protein 942
chr5_-_6926523 0.85 ENSMUST00000164784.2
zinc finger protein 804B
chr19_+_46316617 0.85 ENSMUST00000026256.9
ENSMUST00000177667.2
F-box and leucine-rich repeat protein 15
chr19_-_47126719 0.83 ENSMUST00000140512.8
ENSMUST00000035822.2
calcium homeostasis modulator family member 2
chr11_+_55360502 0.76 ENSMUST00000018727.4
GTPase activating protein (SH3 domain) binding protein 1
chr7_+_24099037 0.74 ENSMUST00000002280.11
smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr3_+_116653113 0.74 ENSMUST00000040260.11
ferric-chelate reductase 1
chr10_+_94386714 0.73 ENSMUST00000148910.3
ENSMUST00000117460.8
transmembrane and coiled coil domains 3
chr1_-_181985663 0.73 ENSMUST00000169123.4
vomeronasal 1 receptor 1
chr13_-_55718899 0.70 ENSMUST00000225240.3
ENSMUST00000021957.8
family with sequence similarity 193, member B
chr4_-_9643636 0.70 ENSMUST00000108333.8
ENSMUST00000108334.8
ENSMUST00000108335.8
ENSMUST00000152526.8
ENSMUST00000103004.10
aspartate-beta-hydroxylase
chr1_+_171386752 0.70 ENSMUST00000004829.13
CD244 molecule A
chr2_-_91795910 0.67 ENSMUST00000239257.2
diacylglycerol kinase zeta
chr7_-_64522741 0.66 ENSMUST00000094331.5
NSE3 homolog, SMC5-SMC6 complex component
chr18_+_47245204 0.62 ENSMUST00000234633.2
heat shock protein 1 (chaperonin 10), related sequence 1
chr9_-_106035308 0.62 ENSMUST00000159809.2
ENSMUST00000162562.2
ENSMUST00000036382.13
glycerate kinase
chr2_-_155434487 0.61 ENSMUST00000155347.2
ENSMUST00000130881.8
ENSMUST00000079691.13
glutathione synthetase
chr9_-_19968858 0.59 ENSMUST00000216538.2
ENSMUST00000212098.3
olfactory receptor 867
chr15_-_77854988 0.58 ENSMUST00000100484.6
eukaryotic translation initiation factor 3, subunit D
chr16_+_38279289 0.58 ENSMUST00000099816.3
ENSMUST00000232409.2
CD80 antigen
chr15_-_77854711 0.58 ENSMUST00000230419.2
eukaryotic translation initiation factor 3, subunit D
chr3_+_59832635 0.58 ENSMUST00000049476.3
AADACL2 family member 1
chr9_-_106035332 0.54 ENSMUST00000112543.9
glycerate kinase
chr13_+_21938258 0.54 ENSMUST00000091709.3
H2B clustered histone 15
chr7_-_28661648 0.53 ENSMUST00000127210.8
actinin alpha 4
chr13_+_23758555 0.52 ENSMUST00000090776.7
H2A clustered histone 7
chr12_-_114330574 0.50 ENSMUST00000103485.3
immunoglobulin heavy variable V12-3
chr10_+_56253418 0.49 ENSMUST00000068581.9
ENSMUST00000217789.2
gap junction protein, alpha 1
chr1_+_161796854 0.48 ENSMUST00000160881.2
ENSMUST00000159648.2
phosphatidylinositol glycan anchor biosynthesis, class C
chr7_+_103586589 0.47 ENSMUST00000098189.4
olfactory receptor 632
chr15_+_100052260 0.46 ENSMUST00000023768.14
disco interacting protein 2 homolog B
chr9_-_58065800 0.46 ENSMUST00000168864.4
immunoglobulin superfamily containing leucine-rich repeat
chr1_+_161796748 0.45 ENSMUST00000111594.3
ENSMUST00000028021.7
ENSMUST00000193784.2
ENSMUST00000161826.2
phosphatidylinositol glycan anchor biosynthesis, class C
predicted gene, 38304
chr10_+_78410803 0.45 ENSMUST00000218763.2
ENSMUST00000220430.2
ENSMUST00000218885.2
ENSMUST00000218215.2
ENSMUST00000218271.2
ilvB (bacterial acetolactate synthase)-like
chr3_-_92528480 0.43 ENSMUST00000170676.3
late cornified envelope 6A
chr16_+_20470402 0.43 ENSMUST00000007212.9
ENSMUST00000232629.2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr10_-_129962924 0.39 ENSMUST00000074161.2
olfactory receptor 824
chr11_-_32217547 0.38 ENSMUST00000109389.9
ENSMUST00000129010.2
ENSMUST00000020530.12
nitrogen permease regulator-like 3
chr11_+_81948649 0.35 ENSMUST00000000342.3
chemokine (C-C motif) ligand 11
chr5_+_136086045 0.34 ENSMUST00000111137.8
ENSMUST00000156530.8
ENSMUST00000006303.11
uroplakin 3B-like
chr1_-_160958998 0.33 ENSMUST00000111611.8
kelch-like 20
chr2_+_29779227 0.32 ENSMUST00000123335.8
outer dense fiber of sperm tails 2
chr1_+_40364752 0.32 ENSMUST00000193388.2
interleukin 1 receptor-like 2
chr7_+_24099346 0.31 ENSMUST00000108434.2
smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr9_+_65253374 0.31 ENSMUST00000048184.4
ENSMUST00000214433.2
programmed cell death 7
chr14_-_9015639 0.30 ENSMUST00000112656.4
synaptoporin
chr12_-_26465253 0.30 ENSMUST00000020971.14
ring finger protein 144A
chr5_-_135494775 0.29 ENSMUST00000212301.2
huntingtin interacting protein 1
chr7_-_28661751 0.27 ENSMUST00000068045.14
ENSMUST00000217157.2
actinin alpha 4
chr6_+_90246088 0.27 ENSMUST00000058039.3
vomeronasal 1 receptor 54
chr9_+_45049687 0.26 ENSMUST00000060125.7
sodium channel, type IV, beta
chr6_+_68414401 0.26 ENSMUST00000103324.3
immunoglobulin kappa chain variable 15-103
chr7_-_3828640 0.26 ENSMUST00000189095.7
ENSMUST00000094911.5
ENSMUST00000153846.8
ENSMUST00000108619.8
ENSMUST00000108620.8
predicted gene 15448
chr9_-_121621544 0.25 ENSMUST00000035110.11
hedgehog acyltransferase-like
chr5_+_138019523 0.24 ENSMUST00000171498.3
ENSMUST00000085886.3
sperm motility kinase 3A
chr16_+_16962464 0.23 ENSMUST00000231726.2
YdjC homolog (bacterial)
chr15_-_73114855 0.23 ENSMUST00000227686.2
PTK2 protein tyrosine kinase 2
chr2_+_72115981 0.23 ENSMUST00000090824.12
ENSMUST00000135469.8
mitogen-activated protein kinase kinase kinase 20
chr4_-_14796052 0.22 ENSMUST00000108276.2
ENSMUST00000023917.8
leucine rich repeat containing 69
chr1_+_55276336 0.21 ENSMUST00000061334.10
methionine-tRNA synthetase 2 (mitochondrial)
chr2_+_37029334 0.21 ENSMUST00000214905.2
ENSMUST00000217298.2
ENSMUST00000104995.3
olfactory receptor 364, pseudogene 1
chr19_-_45580258 0.19 ENSMUST00000160003.8
ENSMUST00000162879.8
F-box and WD-40 domain protein 4
chr9_+_38630317 0.19 ENSMUST00000129598.2
von Willebrand factor A domain containing 5A
chr4_+_155875629 0.18 ENSMUST00000105593.2
ankyrin repeat domain 65
chr3_+_20043315 0.15 ENSMUST00000173779.2
ceruloplasmin
chr6_+_68547717 0.15 ENSMUST00000196839.5
ENSMUST00000103327.3
immunoglobulin kappa variable 12-98
chr4_+_148642879 0.15 ENSMUST00000017408.14
ENSMUST00000076022.7
exosome component 10
chr11_+_88095222 0.14 ENSMUST00000118784.8
ENSMUST00000139170.8
ENSMUST00000107915.10
ENSMUST00000144070.3
mitochondrial ribosomal protein S23
chr19_-_5399368 0.14 ENSMUST00000238111.2
cystatin E/M
chr5_+_36361360 0.14 ENSMUST00000052224.6
prosaposin-like 1
chr14_+_73475335 0.13 ENSMUST00000044405.8
lysophosphatidic acid receptor 6
chr10_+_21469039 0.12 ENSMUST00000057341.6
RIKEN cDNA 1700020N01 gene
chr12_-_26465130 0.12 ENSMUST00000222082.2
ENSMUST00000062149.6
ring finger protein 144A
chr5_-_138270995 0.12 ENSMUST00000161665.2
ENSMUST00000100530.8
ENSMUST00000161279.8
ENSMUST00000161647.8
galactose-3-O-sulfotransferase 4
chr7_-_18301211 0.12 ENSMUST00000094794.5
pregnancy-specific glycoprotein 27
chr19_-_10581622 0.11 ENSMUST00000037678.7
triokinase, FMN cyclase
chr11_-_59078565 0.10 ENSMUST00000170895.3
guanylate kinase 1
chr2_+_37080286 0.10 ENSMUST00000218602.2
olfactory receptor 365
chr3_-_116474909 0.09 ENSMUST00000140672.3
predicted gene 43191
chr9_+_121946321 0.09 ENSMUST00000119215.9
ENSMUST00000146832.8
ENSMUST00000118886.9
ENSMUST00000120173.9
ENSMUST00000139181.2
SNF related kinase
chr14_-_104081119 0.08 ENSMUST00000227824.2
ENSMUST00000172237.2
endothelin receptor type B
chr4_+_102287244 0.07 ENSMUST00000172616.2
phosphodiesterase 4B, cAMP specific
chr11_+_66802807 0.07 ENSMUST00000123434.3
phosphoinositide-interacting regulator of transient receptor potential channels

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 22.1 GO:0070488 neutrophil aggregation(GO:0070488)
5.3 16.0 GO:0060217 hemangioblast cell differentiation(GO:0060217)
3.5 14.1 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
3.0 27.2 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
2.4 9.4 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
2.2 11.0 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
1.5 9.3 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
1.4 7.0 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
1.0 4.2 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.9 3.6 GO:0017126 nucleologenesis(GO:0017126)
0.9 8.0 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.9 4.4 GO:0097195 pilomotor reflex(GO:0097195) positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.8 3.2 GO:0042222 interleukin-1 biosynthetic process(GO:0042222)
0.7 18.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.7 5.9 GO:0031179 peptide modification(GO:0031179) leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.7 3.5 GO:0002378 immunoglobulin biosynthetic process(GO:0002378) negative regulation of glucose import in response to insulin stimulus(GO:2001274)
0.6 3.0 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.5 8.0 GO:0061032 visceral serous pericardium development(GO:0061032)
0.5 10.1 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.4 1.6 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.4 2.4 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.3 1.0 GO:0044704 mating plug formation(GO:0042628) single-organism reproductive behavior(GO:0044704) post-mating behavior(GO:0045297) seminal vesicle development(GO:0061107)
0.3 6.1 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.3 5.3 GO:0034501 protein localization to kinetochore(GO:0034501)
0.3 2.3 GO:0002432 granuloma formation(GO:0002432)
0.3 1.2 GO:0002191 formation of cytoplasmic translation initiation complex(GO:0001732) cap-dependent translational initiation(GO:0002191)
0.3 1.7 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.3 1.8 GO:0006177 GMP biosynthetic process(GO:0006177)
0.2 0.7 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.2 2.0 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.2 0.8 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.2 4.0 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.2 0.9 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.2 1.4 GO:0033277 abortive mitotic cell cycle(GO:0033277)
0.2 3.5 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.2 0.5 GO:0003347 atrial ventricular junction remodeling(GO:0003294) epicardial cell to mesenchymal cell transition(GO:0003347) regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.2 12.4 GO:0007019 microtubule depolymerization(GO:0007019)
0.2 1.3 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.2 4.0 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 1.7 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.1 1.1 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.1 1.2 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.1 0.2 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.1 1.6 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.1 1.8 GO:0006517 protein deglycosylation(GO:0006517)
0.1 2.2 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.1 1.3 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 2.2 GO:0001675 acrosome assembly(GO:0001675)
0.1 11.8 GO:0007052 mitotic spindle organization(GO:0007052)
0.1 2.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 6.9 GO:0070527 platelet aggregation(GO:0070527)
0.1 0.9 GO:1904659 glucose transmembrane transport(GO:1904659)
0.1 1.1 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.1 1.0 GO:0007343 egg activation(GO:0007343)
0.0 1.0 GO:0034389 lipid particle organization(GO:0034389)
0.0 1.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 1.3 GO:0097320 membrane tubulation(GO:0097320)
0.0 6.1 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.7 GO:0072711 cellular response to hydroxyurea(GO:0072711)
0.0 0.2 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 5.3 GO:0051028 mRNA transport(GO:0051028)
0.0 0.6 GO:0046641 positive regulation of alpha-beta T cell proliferation(GO:0046641)
0.0 0.7 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 2.1 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 1.0 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 1.1 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 1.4 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.0 0.3 GO:0002551 mast cell chemotaxis(GO:0002551)
0.0 3.0 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.0 0.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.1 GO:0009153 purine deoxyribonucleotide biosynthetic process(GO:0009153)
0.0 0.1 GO:0007494 midgut development(GO:0007494)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0 2.3 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 0.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.0 GO:2001201 regulation of transforming growth factor-beta secretion(GO:2001201)
0.0 1.0 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.3 GO:0099623 regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) regulation of cardiac muscle cell membrane repolarization(GO:0099623)
0.0 0.6 GO:0046686 response to cadmium ion(GO:0046686)
0.0 1.5 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.9 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.4 GO:2000785 regulation of autophagosome assembly(GO:2000785)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 16.0 GO:0033193 Lsd1/2 complex(GO:0033193)
2.1 12.5 GO:0031262 Ndc80 complex(GO:0031262)
1.7 18.5 GO:0097451 glial limiting end-foot(GO:0097451)
1.1 3.4 GO:0070557 PCNA-p21 complex(GO:0070557)
1.1 11.6 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.7 14.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.7 7.6 GO:0000235 astral microtubule(GO:0000235)
0.5 9.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.5 2.0 GO:0098833 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.5 4.4 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.4 5.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 6.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.4 1.6 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.4 1.8 GO:0035189 Rb-E2F complex(GO:0035189)
0.3 2.4 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.2 2.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 3.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.2 11.0 GO:0097440 apical dendrite(GO:0097440)
0.2 3.5 GO:0097539 ciliary transition fiber(GO:0097539)
0.2 14.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 4.0 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 6.9 GO:0008305 integrin complex(GO:0008305)
0.1 8.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 1.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 1.1 GO:0030314 junctional membrane complex(GO:0030314)
0.1 7.1 GO:0005871 kinesin complex(GO:0005871)
0.1 17.3 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 0.4 GO:1990130 Iml1 complex(GO:1990130)
0.1 1.0 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 0.7 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.3 GO:0098890 extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of postsynaptic membrane(GO:0098890)
0.1 12.9 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.9 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 3.2 GO:0031901 early endosome membrane(GO:0031901)
0.1 5.4 GO:0005643 nuclear pore(GO:0005643)
0.0 0.8 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 0.9 GO:0000145 exocyst(GO:0000145)
0.0 4.1 GO:0000922 spindle pole(GO:0000922)
0.0 0.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 3.0 GO:0045178 basal part of cell(GO:0045178)
0.0 2.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 2.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 7.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 1.6 GO:0005901 caveola(GO:0005901)
0.0 1.6 GO:0016605 PML body(GO:0016605)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.3 GO:0000776 kinetochore(GO:0000776)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 27.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
2.8 22.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
1.9 9.3 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
1.4 6.9 GO:0070051 fibrinogen binding(GO:0070051)
1.1 3.4 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.6 3.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.6 4.0 GO:0031849 olfactory receptor binding(GO:0031849)
0.5 7.0 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.5 5.9 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.5 6.1 GO:0001054 RNA polymerase I activity(GO:0001054)
0.4 12.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.4 1.2 GO:0098808 mRNA cap binding(GO:0098808)
0.4 3.3 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.3 0.3 GO:0019961 interferon binding(GO:0019961)
0.3 1.8 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 18.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 9.4 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.2 4.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.2 16.0 GO:0070888 E-box binding(GO:0070888)
0.2 1.8 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.2 12.7 GO:0048487 beta-tubulin binding(GO:0048487)
0.2 7.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2 4.0 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.2 14.7 GO:0003777 microtubule motor activity(GO:0003777)
0.2 2.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 2.0 GO:0046790 virion binding(GO:0046790)
0.2 9.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 4.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.0 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 1.0 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 1.6 GO:0050700 CARD domain binding(GO:0050700)
0.1 1.7 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1 0.3 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.1 1.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.7 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 0.3 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.1 0.9 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.1 0.9 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 3.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 8.3 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 1.7 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.9 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 1.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.9 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.7 GO:0001727 lipid kinase activity(GO:0001727) diacylglycerol kinase activity(GO:0004143)
0.0 0.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 4.2 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.3 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.4 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.1 GO:0034012 glycerone kinase activity(GO:0004371) FAD-AMP lyase (cyclizing) activity(GO:0034012) triokinase activity(GO:0050354)
0.0 0.9 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.1 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.6 GO:0016594 glycine binding(GO:0016594)
0.0 3.7 GO:0005178 integrin binding(GO:0005178)
0.0 1.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 2.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 5.3 GO:0042393 histone binding(GO:0042393)
0.0 1.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 3.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.7 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 21.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 40.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.3 3.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 6.9 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.1 9.4 PID EPO PATHWAY EPO signaling pathway
0.1 11.2 PID E2F PATHWAY E2F transcription factor network
0.1 4.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 1.5 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 2.7 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 1.1 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.5 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.9 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.3 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 2.0 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.2 PID IGF1 PATHWAY IGF1 pathway
0.0 0.6 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.9 PID INSULIN PATHWAY Insulin Pathway
0.0 0.5 PID NCADHERIN PATHWAY N-cadherin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 14.1 REACTOME KINESINS Genes involved in Kinesins
0.3 7.1 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.3 7.0 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 1.0 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.2 6.1 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.2 1.8 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.2 17.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 10.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 3.0 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 4.0 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 6.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 3.4 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 27.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.8 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 3.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.6 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.4 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.6 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 9.0 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.5 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.9 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 2.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.8 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.9 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.1 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex