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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Trp63

Z-value: 0.58

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Transcription factors associated with Trp63

Gene Symbol Gene ID Gene Info
Trp63
ENSMUSG00000022510.15 Trp63

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Trp63mm39_v1_chr16_+_25620652_256206780.019.6e-01Click!

Activity profile of Trp63 motif

Sorted Z-values of Trp63 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp63

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_-_69838971 1.79 ENSMUST00000179298.3
ENSMUST00000018710.13
ENSMUST00000135437.3
ENSMUST00000141837.9
ENSMUST00000142500.8
Slc2a4
solute carrier family 2 (facilitated glucose transporter), member 4
chr7_-_141023199 1.73 ENSMUST00000106005.9
Pidd1
p53 induced death domain protein 1
chr7_-_115637970 1.68 ENSMUST00000166877.8
Sox6
SRY (sex determining region Y)-box 6
chr2_-_13496624 1.62 ENSMUST00000091436.7
Cubn
cubilin (intrinsic factor-cobalamin receptor)
chr2_-_170269748 1.47 ENSMUST00000013667.3
ENSMUST00000109152.9
ENSMUST00000068137.11
Bcas1
breast carcinoma amplified sequence 1
chr17_+_47983587 1.35 ENSMUST00000152724.2
Usp49
ubiquitin specific peptidase 49
chr19_+_53128901 1.24 ENSMUST00000235754.2
ENSMUST00000237301.2
ENSMUST00000238130.2
Add3
adducin 3 (gamma)
chr1_+_180762587 1.21 ENSMUST00000037361.9
Lefty1
left right determination factor 1
chr9_+_108437485 1.11 ENSMUST00000081111.14
ENSMUST00000193421.2
Impdh2
inosine monophosphate dehydrogenase 2
chr13_-_55169100 1.05 ENSMUST00000148221.8
ENSMUST00000052949.13
Hk3
hexokinase 3
chr13_-_55169000 0.96 ENSMUST00000153665.8
Hk3
hexokinase 3
chr10_-_90918566 0.95 ENSMUST00000162618.8
ENSMUST00000020157.13
ENSMUST00000160788.2
Apaf1
apoptotic peptidase activating factor 1
chr19_+_53128861 0.73 ENSMUST00000111741.10
Add3
adducin 3 (gamma)
chr6_+_34686543 0.72 ENSMUST00000031775.13
Cald1
caldesmon 1
chrX_+_158038778 0.66 ENSMUST00000126686.8
ENSMUST00000033671.13
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr18_-_21433186 0.58 ENSMUST00000049260.7
Garem1
GRB2 associated regulator of MAPK1 subtype 1
chr1_-_160134873 0.56 ENSMUST00000193185.6
Rabgap1l
RAB GTPase activating protein 1-like
chr7_-_125760164 0.50 ENSMUST00000164741.2
Xpo6
exportin 6
chr19_-_5925239 0.50 ENSMUST00000155227.2
Frmd8
FERM domain containing 8
chr6_+_4505493 0.46 ENSMUST00000031668.10
Col1a2
collagen, type I, alpha 2
chr4_-_133746138 0.46 ENSMUST00000051674.3
Lin28a
lin-28 homolog A (C. elegans)
chr8_+_85412928 0.43 ENSMUST00000177531.8
Trmt1
tRNA methyltransferase 1
chr18_-_21433167 0.40 ENSMUST00000234115.2
Garem1
GRB2 associated regulator of MAPK1 subtype 1
chr19_-_40365318 0.34 ENSMUST00000239304.2
Sorbs1
sorbin and SH3 domain containing 1
chr19_+_11382092 0.34 ENSMUST00000153546.8
Ms4a4c
membrane-spanning 4-domains, subfamily A, member 4C
chr8_-_86159398 0.31 ENSMUST00000047749.7
4921524J17Rik
RIKEN cDNA 4921524J17 gene
chr19_-_5925296 0.31 ENSMUST00000025728.13
Frmd8
FERM domain containing 8
chr8_+_27575611 0.31 ENSMUST00000178514.8
ENSMUST00000033876.14
Adgra2
adhesion G protein-coupled receptor A2
chr2_-_91795910 0.29 ENSMUST00000239257.2
Dgkz
diacylglycerol kinase zeta
chr5_-_5315968 0.29 ENSMUST00000115451.8
ENSMUST00000115452.8
ENSMUST00000131392.8
Cdk14
cyclin-dependent kinase 14
chr9_+_21498591 0.27 ENSMUST00000216160.2
Carm1
coactivator-associated arginine methyltransferase 1
chr7_+_24584197 0.24 ENSMUST00000156372.8
ENSMUST00000124035.2
Rps19
ribosomal protein S19
chr17_+_29309942 0.23 ENSMUST00000119901.9
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr14_-_31299275 0.22 ENSMUST00000112027.9
Colq
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr17_-_84495364 0.19 ENSMUST00000060366.7
Zfp36l2
zinc finger protein 36, C3H type-like 2
chr6_+_11907808 0.18 ENSMUST00000155037.4
Phf14
PHD finger protein 14
chr12_-_114646685 0.17 ENSMUST00000194350.6
ENSMUST00000103504.3
Ighv1-18
immunoglobulin heavy variable V1-18
chr7_-_113853894 0.17 ENSMUST00000033012.9
Copb1
coatomer protein complex, subunit beta 1
chr4_-_140537957 0.14 ENSMUST00000026377.9
Padi3
peptidyl arginine deiminase, type III
chr14_+_64331130 0.14 ENSMUST00000224112.2
ENSMUST00000165710.2
ENSMUST00000170709.2
Prss51
protease, serine 51
chr7_-_65020655 0.11 ENSMUST00000032729.8
Tjp1
tight junction protein 1
chr2_+_119803230 0.11 ENSMUST00000229024.2
Mapkbp1
mitogen-activated protein kinase binding protein 1
chr11_+_98754434 0.10 ENSMUST00000142414.8
ENSMUST00000037480.9
Wipf2
WAS/WASL interacting protein family, member 2
chr7_+_24583994 0.09 ENSMUST00000108428.8
Rps19
ribosomal protein S19
chr6_+_34686373 0.07 ENSMUST00000115021.8
Cald1
caldesmon 1
chrX_+_135723531 0.05 ENSMUST00000113085.2
Plp1
proteolipid protein (myelin) 1
chr14_-_55114989 0.05 ENSMUST00000168622.2
ENSMUST00000177403.2
Ppp1r3e
protein phosphatase 1, regulatory subunit 3E
chr4_-_63414188 0.04 ENSMUST00000063650.10
ENSMUST00000102867.8
ENSMUST00000107393.8
ENSMUST00000084510.8
ENSMUST00000095038.8
ENSMUST00000119294.8
ENSMUST00000095037.2
ENSMUST00000063672.10
Whrn
whirlin
chr7_+_101732323 0.03 ENSMUST00000124189.3
Trpc2
transient receptor potential cation channel, subfamily C, member 2
chr7_+_24584076 0.02 ENSMUST00000153451.9
ENSMUST00000108429.8
Rps19
ribosomal protein S19
chr2_-_104324035 0.01 ENSMUST00000111124.8
Hipk3
homeodomain interacting protein kinase 3
chr4_-_95965747 0.01 ENSMUST00000097973.3
Cyp2j13
cytochrome P450, family 2, subfamily j, polypeptide 13

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.3 1.6 GO:0015889 cobalamin transport(GO:0015889)
0.2 1.2 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.2 1.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.2 1.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.4 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.1 2.0 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.1 2.0 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.1 0.4 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.1 0.3 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.1 1.0 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.1 0.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 1.8 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.0 0.3 GO:0090210 regulation of establishment of blood-brain barrier(GO:0090210)
0.0 0.2 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.0 0.2 GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.5 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.1 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.2 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.0 0.3 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 1.0 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256) negative regulation of defense response to bacterium(GO:1900425)
0.0 0.6 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.3 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0043202 lysosomal lumen(GO:0043202)
0.2 1.0 GO:0043293 apoptosome(GO:0043293)
0.2 0.5 GO:0005584 collagen type I trimer(GO:0005584)
0.1 1.8 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 0.8 GO:0030478 actin cap(GO:0030478)
0.1 0.2 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.3 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.3 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 1.1 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.3 1.2 GO:0038100 nodal binding(GO:0038100)
0.3 2.0 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 1.6 GO:0030492 hemoglobin binding(GO:0030492)
0.2 1.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.4 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 1.0 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.3 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 1.0 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.0 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.3 GO:0001727 lipid kinase activity(GO:0001727) diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 1.4 GO:0004843 cysteine-type endopeptidase activity(GO:0004197) thiol-dependent ubiquitin-specific protease activity(GO:0004843)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.0 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.5 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.5 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 2.0 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.5 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.8 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol