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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Trp73

Z-value: 0.84

Motif logo

Transcription factors associated with Trp73

Gene Symbol Gene ID Gene Info
ENSMUSG00000029026.18 Trp73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Trp73mm39_v1_chr4_-_154181562_1541816300.483.0e-03Click!

Activity profile of Trp73 motif

Sorted Z-values of Trp73 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp73

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr11_+_32246489 6.12 ENSMUST00000093207.4
hemoglobin alpha, adult chain 2
chr11_+_32233511 4.68 ENSMUST00000093209.4
hemoglobin alpha, adult chain 1
chr4_-_87724533 2.95 ENSMUST00000126353.8
ENSMUST00000149357.8
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
chr5_+_137286535 2.68 ENSMUST00000024099.11
ENSMUST00000196208.5
ENSMUST00000085934.4
acetylcholinesterase
chr11_-_69838971 1.91 ENSMUST00000179298.3
ENSMUST00000018710.13
ENSMUST00000135437.3
ENSMUST00000141837.9
ENSMUST00000142500.8
solute carrier family 2 (facilitated glucose transporter), member 4
chr17_+_29309942 1.89 ENSMUST00000119901.9
cyclin-dependent kinase inhibitor 1A (P21)
chr7_-_141023199 1.78 ENSMUST00000106005.9
p53 induced death domain protein 1
chr3_-_129763801 1.76 ENSMUST00000029624.15
mitochondrial calcium uniporter dominant negative beta subunit
chr8_+_27575611 1.72 ENSMUST00000178514.8
ENSMUST00000033876.14
adhesion G protein-coupled receptor A2
chr16_-_16942970 1.70 ENSMUST00000093336.8
ENSMUST00000231681.2
RIKEN cDNA 2610318N02 gene
chr3_-_129763638 1.70 ENSMUST00000146340.2
ENSMUST00000153506.8
mitochondrial calcium uniporter dominant negative beta subunit
chr6_-_29212295 1.63 ENSMUST00000078155.12
inosine monophosphate dehydrogenase 1
chr4_-_87724512 1.62 ENSMUST00000148059.2
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
chr6_-_29212239 1.60 ENSMUST00000160878.8
inosine monophosphate dehydrogenase 1
chr11_+_97917746 1.51 ENSMUST00000017548.7
ribosomal protein L19
chr2_+_150751475 1.50 ENSMUST00000028948.5
GINS complex subunit 1 (Psf1 homolog)
chr11_+_69804714 1.20 ENSMUST00000072581.9
ENSMUST00000116358.8
G protein pathway suppressor 2
chr11_-_103235475 1.18 ENSMUST00000041385.14
Rho GTPase activating protein 27
chr13_-_55169100 1.06 ENSMUST00000148221.8
ENSMUST00000052949.13
hexokinase 3
chr2_-_91854844 1.01 ENSMUST00000028663.5
cAMP responsive element binding protein 3-like 1
chr15_-_98505508 1.00 ENSMUST00000096224.6
adenylate cyclase 6
chr3_+_159545309 1.00 ENSMUST00000068952.10
ENSMUST00000198878.2
wntless WNT ligand secretion mediator
chr13_-_55169000 0.99 ENSMUST00000153665.8
hexokinase 3
chr6_-_83031358 0.92 ENSMUST00000113962.8
ENSMUST00000089645.13
ENSMUST00000113963.8
HtrA serine peptidase 2
chr7_-_97387145 0.92 ENSMUST00000084986.8
aquaporin 11
chr7_-_115637970 0.79 ENSMUST00000166877.8
SRY (sex determining region Y)-box 6
chr5_+_135698881 0.76 ENSMUST00000153500.8
P450 (cytochrome) oxidoreductase
chr9_-_58065800 0.75 ENSMUST00000168864.4
immunoglobulin superfamily containing leucine-rich repeat
chr5_+_64960705 0.74 ENSMUST00000165536.8
Kruppel-like factor 3 (basic)
chr11_-_76359222 0.73 ENSMUST00000065028.14
active BCR-related gene
chr10_+_110581293 0.65 ENSMUST00000174857.8
ENSMUST00000073781.12
ENSMUST00000173471.8
ENSMUST00000173634.2
E2F transcription factor 7
chrX_-_10083157 0.65 ENSMUST00000072393.9
ENSMUST00000044598.13
ENSMUST00000073392.11
ENSMUST00000115533.8
ENSMUST00000115532.2
retinitis pigmentosa GTPase regulator
chr9_-_44624496 0.63 ENSMUST00000144251.8
ENSMUST00000156918.8
pleckstrin homology like domain, family B, member 1
chr19_+_53317844 0.56 ENSMUST00000111737.3
ENSMUST00000025998.15
ENSMUST00000237837.2
MAX interactor 1, dimerization protein
chr17_-_46513499 0.55 ENSMUST00000024749.9
polymerase (DNA directed), eta (RAD 30 related)
chr7_+_127344942 0.51 ENSMUST00000189562.7
ENSMUST00000186116.7
F-box and leucine-rich repeat protein 19
chr4_+_108857803 0.51 ENSMUST00000065977.11
ENSMUST00000102736.9
nardilysin, N-arginine dibasic convertase, NRD convertase 1
chr11_+_60030891 0.47 ENSMUST00000171108.8
ENSMUST00000090806.5
retinoic acid induced 1
chr19_-_47126719 0.46 ENSMUST00000140512.8
ENSMUST00000035822.2
calcium homeostasis modulator family member 2
chr4_+_108857967 0.46 ENSMUST00000106644.9
nardilysin, N-arginine dibasic convertase, NRD convertase 1
chr15_+_98953044 0.45 ENSMUST00000230021.2
ENSMUST00000047104.15
ENSMUST00000024249.5
peripherin
chr14_-_24295988 0.40 ENSMUST00000073687.13
ENSMUST00000090398.11
discs large MAGUK scaffold protein 5
chr6_+_41095752 0.39 ENSMUST00000103269.3
T cell receptor beta, variable 12-2
chr5_-_103777145 0.36 ENSMUST00000031263.2
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr18_-_32170012 0.35 ENSMUST00000134663.2
myosin VIIB
chr4_+_32238712 0.33 ENSMUST00000108180.9
BTB and CNC homology, basic leucine zipper transcription factor 2
chr2_-_180562718 0.33 ENSMUST00000037299.15
ENSMUST00000108876.9
YTH N6-methyladenosine RNA binding protein 1
chr14_+_53607470 0.28 ENSMUST00000103652.5
T cell receptor alpha variable 14N-3
chr4_-_49383576 0.28 ENSMUST00000107698.8
acyl-coenzyme A amino acid N-acyltransferase 2
chr19_+_46292759 0.28 ENSMUST00000237330.2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr4_+_100926170 0.26 ENSMUST00000106955.2
ENSMUST00000038463.15
ribonucleoprotein, PTB-binding 2
chr12_-_84923252 0.25 ENSMUST00000163189.8
ENSMUST00000110254.9
ENSMUST00000002073.13
latent transforming growth factor beta binding protein 2
chr11_+_75546989 0.25 ENSMUST00000136935.2
myosin IC
chr7_-_4517367 0.24 ENSMUST00000166161.8
troponin T1, skeletal, slow
chr9_-_32454157 0.24 ENSMUST00000183767.2
Friend leukemia integration 1
chr4_+_127137577 0.23 ENSMUST00000142029.2
small integral membrane protein 12
chr17_+_28910714 0.22 ENSMUST00000233250.2
mitogen-activated protein kinase 14
chr3_+_28752050 0.21 ENSMUST00000029240.14
solute carrier family 2 (facilitated glucose transporter), member 2
chr14_+_33807935 0.20 ENSMUST00000022519.15
annexin A8
chr19_+_46293210 0.20 ENSMUST00000236591.2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr7_+_140462343 0.19 ENSMUST00000163610.9
ENSMUST00000164681.8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr1_+_75483721 0.19 ENSMUST00000037330.5
inhibin alpha
chr7_+_140461860 0.18 ENSMUST00000026560.14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr14_-_52341426 0.18 ENSMUST00000227536.2
ENSMUST00000227195.2
ENSMUST00000228815.2
ENSMUST00000228198.2
ENSMUST00000227458.2
ENSMUST00000228232.2
ENSMUST00000227242.2
ENSMUST00000228748.2
heterogeneous nuclear ribonucleoprotein C
chr6_-_97408367 0.18 ENSMUST00000124050.3
FERM domain containing 4B
chr2_-_75808508 0.17 ENSMUST00000099995.5
tetratricopeptide repeat domain 30A2
chr19_-_11261177 0.17 ENSMUST00000186937.7
ENSMUST00000067673.13
membrane-spanning 4-domains, subfamily A, member 5
chr12_+_3415107 0.16 ENSMUST00000220210.2
kinesin family member 3C
chr15_-_7427815 0.14 ENSMUST00000096494.5
EGF-like, fibronectin type III and laminin G domains
chr16_-_56748424 0.14 ENSMUST00000210579.2
leukemia NUP98 fusion partner 1
chr4_-_63414188 0.14 ENSMUST00000063650.10
ENSMUST00000102867.8
ENSMUST00000107393.8
ENSMUST00000084510.8
ENSMUST00000095038.8
ENSMUST00000119294.8
ENSMUST00000095037.2
ENSMUST00000063672.10
whirlin
chr13_+_58955675 0.13 ENSMUST00000224402.2
neurotrophic tyrosine kinase, receptor, type 2
chr2_+_119067832 0.12 ENSMUST00000028783.14
serine protease inhibitor, Kunitz type 1
chr7_+_30487322 0.12 ENSMUST00000189673.7
ENSMUST00000190990.7
ENSMUST00000189962.7
ENSMUST00000187493.7
ENSMUST00000098559.3
keratinocyte differentiation associated protein
chr1_+_55127110 0.12 ENSMUST00000075242.7
heat shock protein 1 (chaperonin 10)
chr15_-_7427759 0.12 ENSMUST00000058593.10
EGF-like, fibronectin type III and laminin G domains
chr19_+_46293160 0.11 ENSMUST00000073116.13
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr11_-_102120917 0.11 ENSMUST00000008999.12
histone deacetylase 5
chr12_+_3415143 0.11 ENSMUST00000020999.7
kinesin family member 3C
chr11_+_46295547 0.11 ENSMUST00000063166.6
family with sequence similarity 71, member B
chr6_-_97464761 0.10 ENSMUST00000032146.14
FERM domain containing 4B
chr17_+_28451674 0.10 ENSMUST00000002320.16
ENSMUST00000232879.2
ENSMUST00000166744.8
peroxisome proliferator activator receptor delta
chr15_-_76259126 0.08 ENSMUST00000071119.8
testis-specific serine kinase 5
chr11_+_98632953 0.08 ENSMUST00000153043.8
thyroid hormone receptor alpha
chr2_+_119068012 0.08 ENSMUST00000110817.3
serine protease inhibitor, Kunitz type 1
chr10_-_105677184 0.07 ENSMUST00000046638.10
methyltransferase like 25
chr11_-_102120953 0.06 ENSMUST00000107150.8
ENSMUST00000156337.2
ENSMUST00000107151.9
ENSMUST00000107152.9
histone deacetylase 5
chr11_+_69914746 0.06 ENSMUST00000124568.10
discs large MAGUK scaffold protein 4
chr7_-_4517608 0.04 ENSMUST00000166959.8
troponin T1, skeletal, slow
chr16_+_11802445 0.03 ENSMUST00000170672.9
ENSMUST00000023138.8
shisa family member 9
chr13_+_58956077 0.02 ENSMUST00000109838.10
neurotrophic tyrosine kinase, receptor, type 2
chr17_+_34159633 0.00 ENSMUST00000025170.11
WD repeat domain 46

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0045212 acetylcholine metabolic process(GO:0008291) neurotransmitter receptor biosynthetic process(GO:0045212) acetate ester metabolic process(GO:1900619)
0.5 3.2 GO:0006177 GMP biosynthetic process(GO:0006177)
0.3 1.0 GO:1904117 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.3 1.0 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.3 3.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.3 0.9 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.2 1.7 GO:0090210 regulation of establishment of blood-brain barrier(GO:0090210)
0.2 0.9 GO:0048388 endosomal lumen acidification(GO:0048388)
0.2 4.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 0.7 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.2 3.7 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.2 1.0 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.2 0.8 GO:0090345 nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346)
0.2 11.6 GO:0048821 erythrocyte development(GO:0048821)
0.1 1.5 GO:1902969 mitotic DNA replication(GO:1902969)
0.1 0.6 GO:0002266 follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268)
0.1 0.4 GO:0045186 zonula adherens assembly(GO:0045186)
0.1 2.0 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.1 0.7 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.1 0.4 GO:1904970 brush border assembly(GO:1904970)
0.1 0.5 GO:0006290 pyrimidine dimer repair(GO:0006290) cellular response to UV-C(GO:0071494)
0.1 1.9 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.1 0.2 GO:0090367 negative regulation of mRNA modification(GO:0090367)
0.0 0.3 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 0.2 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.6 GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 1.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.2 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.2 GO:2001184 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) stress-induced premature senescence(GO:0090400) positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.0 0.1 GO:0099538 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.0 1.2 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.8 GO:0042073 intraciliary transport(GO:0042073)
0.0 0.5 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.2 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 0.1 GO:0006776 vitamin A metabolic process(GO:0006776)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 10.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.6 1.9 GO:0070557 PCNA-p21 complex(GO:0070557)
0.5 1.5 GO:0000811 GINS complex(GO:0000811)
0.5 3.5 GO:1990246 uniplex complex(GO:1990246)
0.1 2.7 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.6 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.1 1.9 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 0.2 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.1 4.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.4 GO:0044299 C-fiber(GO:0044299)
0.1 0.9 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.2 GO:0045160 myosin I complex(GO:0045160)
0.0 1.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.6 GO:0045180 basal cortex(GO:0045180)
0.0 0.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:1990696 stereocilia ankle link complex(GO:0002142) USH2 complex(GO:1990696)
0.0 0.3 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.3 GO:0005861 troponin complex(GO:0005861)
0.0 0.7 GO:0032391 photoreceptor connecting cilium(GO:0032391)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 10.8 GO:0031720 haptoglobin binding(GO:0031720)
0.9 2.7 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.6 1.9 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.5 3.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.4 2.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.4 1.5 GO:1990932 5.8S rRNA binding(GO:1990932)
0.3 2.0 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 3.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 0.8 GO:0016708 nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726)
0.1 1.0 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 1.5 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 1.0 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 0.9 GO:0015250 water channel activity(GO:0015250)
0.1 1.0 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.3 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0016501 prostacyclin receptor activity(GO:0016501)
0.0 0.2 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.2 GO:0034711 inhibin binding(GO:0034711)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.1 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.0 0.1 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.0 0.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.9 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.0 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 2.7 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.6 ST GAQ PATHWAY G alpha q Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 2.1 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 2.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 1.9 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 1.0 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 2.0 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.6 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 1.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors