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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Zscan4c

Z-value: 0.75

Motif logo

Transcription factors associated with Zscan4c

Gene Symbol Gene ID Gene Info
ENSMUSG00000054272.7 Zscan4c

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zscan4cmm39_v1_chr7_+_10739672_107396720.086.6e-01Click!

Activity profile of Zscan4c motif

Sorted Z-values of Zscan4c motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Zscan4c

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr17_-_28779678 2.81 ENSMUST00000114785.3
ENSMUST00000025062.5
colipase, pancreatic
chr4_-_46991842 2.22 ENSMUST00000107749.4
gamma-aminobutyric acid (GABA) B receptor, 2
chr2_+_102489558 2.18 ENSMUST00000111213.8
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr4_+_137589548 2.17 ENSMUST00000102518.10
endothelin converting enzyme 1
chr2_+_102488985 2.06 ENSMUST00000080210.10
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr10_+_87694117 2.01 ENSMUST00000122386.8
insulin-like growth factor 1
chr5_+_65127412 1.39 ENSMUST00000031080.15
family with sequence similarity 114, member A1
chr9_-_44710480 1.37 ENSMUST00000214833.2
ENSMUST00000213972.2
ENSMUST00000214431.2
ENSMUST00000213363.2
ENSMUST00000114705.9
ENSMUST00000002100.8
transmembrane protein 25
chr2_+_57128309 1.32 ENSMUST00000112618.9
ENSMUST00000028167.3
glycerol phosphate dehydrogenase 2, mitochondrial
chr2_-_165997551 1.31 ENSMUST00000109249.9
ENSMUST00000146497.9
sulfatase 2
chr6_+_91661074 1.22 ENSMUST00000205480.2
ENSMUST00000206545.2
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr9_+_37466989 1.20 ENSMUST00000213126.2
sialic acid acetylesterase
chr16_-_38533597 1.11 ENSMUST00000023487.5
Rho GTPase activating protein 31
chr6_+_124470053 1.08 ENSMUST00000049124.10
complement component 1, r subcomponent-like
chr15_+_44482545 0.98 ENSMUST00000227691.2
estrogen receptor-binding fragment-associated gene 9
chr7_-_30754792 0.97 ENSMUST00000206328.2
FXYD domain-containing ion transport regulator 1
chr15_+_44482667 0.96 ENSMUST00000228648.2
ENSMUST00000226165.2
estrogen receptor-binding fragment-associated gene 9
chr2_-_165997179 0.94 ENSMUST00000088086.4
sulfatase 2
chr1_+_182591425 0.93 ENSMUST00000155229.7
ENSMUST00000153348.8
sushi domain containing 4
chr19_-_47452557 0.87 ENSMUST00000111800.4
SH3 and PX domains 2A
chr2_+_30254239 0.86 ENSMUST00000077977.14
ENSMUST00000140075.9
ENSMUST00000142801.8
ENSMUST00000100214.10
mitoguardin 2
chr2_+_169474916 0.85 ENSMUST00000109159.3
teashirt zinc finger family member 2
chr5_-_96309600 0.84 ENSMUST00000129646.8
ENSMUST00000113005.9
ENSMUST00000154500.2
ENSMUST00000141383.8
CCR4-NOT transcription complex, subunit 6-like
chr13_-_9815350 0.82 ENSMUST00000110636.9
ENSMUST00000152725.8
zinc finger, MYND domain containing 11
chr6_+_91661034 0.76 ENSMUST00000032185.9
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr6_+_48570817 0.74 ENSMUST00000154010.8
ENSMUST00000009420.15
ENSMUST00000163452.7
ENSMUST00000118229.2
ENSMUST00000135151.3
replication initiator 1
chr1_+_87983189 0.74 ENSMUST00000173325.2
UDP glycosyltransferase 1 family, polypeptide A10
chr1_+_87983099 0.74 ENSMUST00000138182.8
ENSMUST00000113142.10
UDP glycosyltransferase 1 family, polypeptide A10
chr15_+_44482944 0.72 ENSMUST00000022964.9
estrogen receptor-binding fragment-associated gene 9
chr2_+_169475436 0.68 ENSMUST00000109157.2
teashirt zinc finger family member 2
chr13_-_9814901 0.67 ENSMUST00000223421.2
ENSMUST00000128658.8
zinc finger, MYND domain containing 11
chr13_-_9815173 0.67 ENSMUST00000062658.15
ENSMUST00000222358.2
zinc finger, MYND domain containing 11
chr12_+_52551092 0.66 ENSMUST00000217820.2
Rho GTPase activating protein 5
chr15_-_37458768 0.65 ENSMUST00000116445.9
neurocalcin delta
chr18_+_64473091 0.58 ENSMUST00000175965.10
one cut domain, family member 2
chr17_-_63188139 0.56 ENSMUST00000078839.5
ENSMUST00000076840.12
ephrin A5
chr16_+_44914397 0.56 ENSMUST00000061050.6
coiled-coil domain containing 80
chr5_+_102629365 0.52 ENSMUST00000112854.8
Rho GTPase activating protein 24
chr19_-_21449916 0.50 ENSMUST00000087600.10
guanine deaminase
chr13_+_58955675 0.50 ENSMUST00000224402.2
neurotrophic tyrosine kinase, receptor, type 2
chr13_-_9814979 0.50 ENSMUST00000110634.8
zinc finger, MYND domain containing 11
chr16_-_94091101 0.49 ENSMUST00000227141.2
holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
chr9_-_50639367 0.48 ENSMUST00000117646.8
DIX domain containing 1
chr12_+_52550775 0.48 ENSMUST00000219443.2
Rho GTPase activating protein 5
chr19_-_43879031 0.48 ENSMUST00000212048.2
dynamin binding protein
chr14_+_65596070 0.47 ENSMUST00000066994.7
zinc finger protein 395
chr2_+_179684288 0.45 ENSMUST00000041126.9
SS18, nBAF chromatin remodeling complex subunit like 1
chr13_-_9815276 0.44 ENSMUST00000130151.8
zinc finger, MYND domain containing 11
chr5_-_134776101 0.44 ENSMUST00000015138.13
elastin
chr10_+_18345706 0.40 ENSMUST00000162891.8
ENSMUST00000100054.4
NHS-like 1
chr3_-_51184895 0.40 ENSMUST00000108051.8
ENSMUST00000108053.9
E74-like factor 2
chr4_+_118384426 0.39 ENSMUST00000030261.6
RIKEN cDNA 2610528J11 gene
chr7_+_112278520 0.37 ENSMUST00000084705.13
ENSMUST00000239442.2
ENSMUST00000239404.2
ENSMUST00000059768.18
TEA domain family member 1
chr19_+_8641369 0.37 ENSMUST00000035444.10
ENSMUST00000163785.2
cholinergic receptor, muscarinic 1, CNS
chr2_+_68691778 0.35 ENSMUST00000028426.9
ceramide synthase 6
chr1_+_182591771 0.34 ENSMUST00000193660.6
sushi domain containing 4
chr2_-_35995283 0.32 ENSMUST00000112960.8
ENSMUST00000112967.12
ENSMUST00000112963.8
LIM homeobox protein 6
chr17_+_75772475 0.31 ENSMUST00000095204.6
RAS, guanyl releasing protein 3
chr19_-_38807600 0.29 ENSMUST00000025963.8
NOC3 like DNA replication regulator
chr9_+_43978369 0.29 ENSMUST00000177054.8
ubiquitin specific peptidase 2
chr15_-_77037756 0.27 ENSMUST00000227314.2
ENSMUST00000227930.2
ENSMUST00000227533.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr15_-_77037972 0.27 ENSMUST00000111581.4
ENSMUST00000166610.8
RNA binding protein, fox-1 homolog (C. elegans) 2
chr5_-_44956932 0.26 ENSMUST00000199261.2
ENSMUST00000199534.5
LIM domain binding 2
chr9_-_50650663 0.26 ENSMUST00000117093.2
ENSMUST00000121634.8
DIX domain containing 1
chr18_-_40352372 0.25 ENSMUST00000025364.6
Yip1 domain family, member 5
chr7_+_141276575 0.25 ENSMUST00000185406.8
mucin 2
chr3_-_51184730 0.24 ENSMUST00000195432.2
ENSMUST00000091144.11
ENSMUST00000156983.3
E74-like factor 2
chr15_-_77037926 0.22 ENSMUST00000228087.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr19_-_57227742 0.22 ENSMUST00000111559.8
actin-binding LIM protein 1
chr5_-_44956981 0.21 ENSMUST00000070748.10
LIM domain binding 2
chr5_-_44957016 0.19 ENSMUST00000199256.5
LIM domain binding 2
chr19_+_28941292 0.19 ENSMUST00000045674.4
phospholipid phosphatase 6
chr16_-_9812410 0.18 ENSMUST00000115835.8
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
chr9_+_21279802 0.16 ENSMUST00000214474.2
interleukin enhancer binding factor 3
chr18_+_37108994 0.16 ENSMUST00000193984.2
predicted gene, 37388
chr2_-_115895528 0.15 ENSMUST00000028639.13
ENSMUST00000102538.11
Meis homeobox 2
chr2_-_35994819 0.13 ENSMUST00000148852.4
LIM homeobox protein 6
chr13_+_58955506 0.13 ENSMUST00000079828.7
neurotrophic tyrosine kinase, receptor, type 2
chr16_-_78373510 0.12 ENSMUST00000231973.2
ENSMUST00000232528.2
ENSMUST00000114220.9
DNA segment, Chr 16, ERATO Doi 472, expressed
chr5_-_129030367 0.12 ENSMUST00000111346.6
ENSMUST00000200470.5
RIMS binding protein 2
chr2_+_68691902 0.12 ENSMUST00000176018.2
ceramide synthase 6
chr16_-_78373537 0.11 ENSMUST00000232052.2
ENSMUST00000114219.8
ENSMUST00000114218.2
DNA segment, Chr 16, ERATO Doi 472, expressed
chr10_+_127478844 0.10 ENSMUST00000092074.12
ENSMUST00000120279.2
signal transducer and activator of transcription 6
chr8_-_49008881 0.09 ENSMUST00000110345.8
teneurin transmembrane protein 3
chr9_+_89791943 0.08 ENSMUST00000189545.2
ENSMUST00000034909.11
ENSMUST00000034912.6
RAS protein-specific guanine nucleotide-releasing factor 1
chr7_-_98010478 0.07 ENSMUST00000094161.11
ENSMUST00000164726.8
ENSMUST00000206414.2
ENSMUST00000167405.3
tsukushi, small leucine rich proteoglycan
chr9_-_87613301 0.07 ENSMUST00000034991.8
T-box18
chr11_-_113641980 0.07 ENSMUST00000153453.2
CDC42 effector protein (Rho GTPase binding) 4
chrX_-_160942713 0.06 ENSMUST00000087085.10
NHS actin remodeling regulator
chr9_+_36744016 0.06 ENSMUST00000214772.2
fasciculation and elongation protein zeta 1 (zygin I)
chr10_-_108535970 0.05 ENSMUST00000218023.2
predicted gene 5136
chr7_+_144450260 0.05 ENSMUST00000033389.7
ENSMUST00000207229.2
fibroblast growth factor 15
chr6_-_122317156 0.05 ENSMUST00000159384.8
polyhomeotic 1
chr9_-_31824758 0.04 ENSMUST00000116615.5
BarH-like homeobox 2
chr18_-_79152504 0.04 ENSMUST00000025430.11
SET binding protein 1
chr15_-_85462271 0.03 ENSMUST00000229191.2
wingless-type MMTV integration site family, member 7B
chr7_-_98010534 0.02 ENSMUST00000165257.8
tsukushi, small leucine rich proteoglycan
chr8_+_63404395 0.02 ENSMUST00000119068.8
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr5_-_129030111 0.02 ENSMUST00000196085.5
RIMS binding protein 2
chr10_+_81128795 0.02 ENSMUST00000163075.8
ENSMUST00000105327.10
ENSMUST00000045469.15
phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
chr7_+_139827152 0.02 ENSMUST00000164583.8
ENSMUST00000093984.3
scavenger receptor family member expressed on T cells 2
chr15_-_98705791 0.01 ENSMUST00000075444.8
dendrin
chr14_+_53257873 0.00 ENSMUST00000196756.2
T cell receptor alpha variable 7D-6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0034959 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.7 2.0 GO:0001762 beta-alanine transport(GO:0001762) taurine transport(GO:0015734)
0.6 4.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.4 2.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 1.3 GO:0030450 regulation of complement activation, classical pathway(GO:0030450)
0.3 2.0 GO:1904073 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.1 1.3 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.1 0.5 GO:0046098 guanine metabolic process(GO:0046098)
0.1 1.5 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.5 GO:0071110 protein biotinylation(GO:0009305) response to biotin(GO:0070781) histone biotinylation(GO:0071110)
0.1 0.6 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.1 1.0 GO:1903278 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) positive regulation of inorganic anion transmembrane transport(GO:1903797)
0.1 0.4 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 0.8 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 0.9 GO:0072675 osteoclast fusion(GO:0072675)
0.1 0.5 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 3.1 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.1 0.8 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 2.8 GO:0032094 response to food(GO:0032094)
0.1 0.7 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 0.5 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 2.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.4 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.6 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.1 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.0 0.1 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.0 0.9 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.2 GO:0033058 directional locomotion(GO:0033058)
0.0 0.7 GO:2001273 regulation of glucose import in response to insulin stimulus(GO:2001273)
0.0 0.1 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.0 0.4 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
0.0 1.1 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.0 0.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.3 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.0 GO:0072054 renal outer medulla development(GO:0072054)
0.0 0.0 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0 0.3 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.3 1.3 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 2.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 2.0 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 0.4 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 0.4 GO:0071953 elastic fiber(GO:0071953)
0.1 4.2 GO:0030673 axolemma(GO:0030673)
0.0 0.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.4 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.5 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.1 GO:0070722 Tle3-Aes complex(GO:0070722)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 0.4 GO:0071565 nBAF complex(GO:0071565)
0.0 1.0 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.6 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.7 2.0 GO:0005369 beta-alanine transmembrane transporter activity(GO:0001761) taurine transmembrane transporter activity(GO:0005368) taurine:sodium symporter activity(GO:0005369)
0.4 1.3 GO:0016901 glycerol-3-phosphate dehydrogenase activity(GO:0004368) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.4 2.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.3 2.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 0.6 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 0.5 GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity(GO:0004077) biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity(GO:0004078) biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity(GO:0004079) biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity(GO:0004080) biotin-protein ligase activity(GO:0018271)
0.1 0.6 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.1 0.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.9 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 2.0 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 2.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.7 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 1.1 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.6 GO:0001968 fibronectin binding(GO:0001968)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 1.0 GO:0017080 sodium channel regulator activity(GO:0017080)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 PID IGF1 PATHWAY IGF1 pathway
0.0 2.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.6 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.6 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.6 PID SHP2 PATHWAY SHP2 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.0 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 2.8 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 4.2 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis