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GSE58827: Dynamics of the Mouse Liver

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Results for Aire

Z-value: 0.72

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Transcription factors associated with Aire

Gene Symbol Gene ID Gene Info
Aire
ENSMUSG00000000731.16 autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Airemm39_v1_chr10_-_77879414_77879445-0.183.1e-01Click!

Activity profile of Aire motif

Sorted Z-values of Aire motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_39275518 4.05 ENSMUST00000003137.15
Cyp2c29
cytochrome P450, family 2, subfamily c, polypeptide 29
chr6_+_42222841 3.51 ENSMUST00000031897.8
Gstk1
glutathione S-transferase kappa 1
chr10_-_95678786 2.89 ENSMUST00000211096.2
Gm33543
predicted gene, 33543
chr10_-_95678748 2.81 ENSMUST00000210336.2
Gm33543
predicted gene, 33543
chr5_+_8010445 2.67 ENSMUST00000115421.3
Steap4
STEAP family member 4
chr1_+_88128323 2.33 ENSMUST00000049289.9
Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
chr12_+_84098888 1.95 ENSMUST00000120927.8
ENSMUST00000021653.8
Acot3
acyl-CoA thioesterase 3
chr5_+_130398261 1.76 ENSMUST00000086029.10
Caln1
calneuron 1
chrM_+_11735 1.74 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr5_+_31079177 1.67 ENSMUST00000031053.15
ENSMUST00000202752.2
Khk
ketohexokinase
chr5_+_137979763 1.61 ENSMUST00000035390.7
Azgp1
alpha-2-glycoprotein 1, zinc
chr7_-_127494750 1.53 ENSMUST00000033074.8
Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr7_-_126275529 1.47 ENSMUST00000106372.11
ENSMUST00000155419.3
ENSMUST00000106373.9
Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chr15_+_10358611 1.46 ENSMUST00000110541.8
ENSMUST00000110542.8
Agxt2
alanine-glyoxylate aminotransferase 2
chrM_+_7758 1.45 ENSMUST00000082407.1
mt-Atp8
mitochondrially encoded ATP synthase 8
chr16_+_22877000 1.41 ENSMUST00000039492.14
ENSMUST00000023589.15
ENSMUST00000089902.8
Kng1
kininogen 1
chr15_+_10358643 1.40 ENSMUST00000022858.8
Agxt2
alanine-glyoxylate aminotransferase 2
chr5_-_121798541 1.28 ENSMUST00000031412.12
ENSMUST00000111770.2
Acad10
acyl-Coenzyme A dehydrogenase family, member 10
chr15_+_10981833 1.24 ENSMUST00000070877.7
Amacr
alpha-methylacyl-CoA racemase
chr11_-_69586884 1.21 ENSMUST00000180587.8
Tnfsfm13
tumor necrosis factor (ligand) superfamily, membrane-bound member 13
chr16_-_18904240 1.19 ENSMUST00000103746.3
Iglv1
immunoglobulin lambda variable 1
chr10_-_106959444 1.18 ENSMUST00000165067.9
Acss3
acyl-CoA synthetase short-chain family member 3
chrM_+_7006 1.18 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr9_-_108140925 1.17 ENSMUST00000171412.7
ENSMUST00000195429.6
ENSMUST00000080435.9
Dag1
dystroglycan 1
chr16_-_22847808 1.10 ENSMUST00000115349.9
Kng2
kininogen 2
chr16_-_22847829 1.09 ENSMUST00000100046.9
Kng2
kininogen 2
chr15_-_89263790 1.07 ENSMUST00000238996.2
Odf3b
outer dense fiber of sperm tails 3B
chrM_+_9459 1.07 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chrM_+_7779 1.02 ENSMUST00000082408.1
mt-Atp6
mitochondrially encoded ATP synthase 6
chr14_+_3575406 1.01 ENSMUST00000124353.2
Ube2e2
ubiquitin-conjugating enzyme E2E 2
chr17_+_56935118 1.00 ENSMUST00000112979.4
Catsperd
cation channel sperm associated auxiliary subunit delta
chrM_+_14138 0.97 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr5_-_105491795 0.93 ENSMUST00000171587.2
Gbp11
guanylate binding protein 11
chrM_-_14061 0.92 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr12_+_37292029 0.90 ENSMUST00000160390.2
Agmo
alkylglycerol monooxygenase
chrM_+_8603 0.85 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr16_-_19079594 0.85 ENSMUST00000103752.3
ENSMUST00000197518.2
Iglv2
immunoglobulin lambda variable 2
chr17_-_74257164 0.83 ENSMUST00000024866.6
Xdh
xanthine dehydrogenase
chr3_+_57332735 0.82 ENSMUST00000029377.8
Tm4sf4
transmembrane 4 superfamily member 4
chr1_-_128287347 0.79 ENSMUST00000190495.2
ENSMUST00000027601.11
Mcm6
minichromosome maintenance complex component 6
chr7_-_126522014 0.77 ENSMUST00000134134.3
ENSMUST00000119781.8
ENSMUST00000121612.4
Tmem219
transmembrane protein 219
chr13_+_64309675 0.71 ENSMUST00000021929.10
Habp4
hyaluronic acid binding protein 4
chr10_-_127587576 0.71 ENSMUST00000079692.6
Gpr182
G protein-coupled receptor 182
chr1_-_90771674 0.61 ENSMUST00000097653.11
ENSMUST00000188587.7
ENSMUST00000056925.16
ENSMUST00000187753.2
Col6a3
collagen, type VI, alpha 3
chr7_-_19398930 0.57 ENSMUST00000055242.11
Clptm1
cleft lip and palate associated transmembrane protein 1
chr17_-_59320257 0.57 ENSMUST00000174122.2
ENSMUST00000025065.12
Nudt12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr7_-_45136235 0.55 ENSMUST00000210701.2
Gm45808
predicted gene 45808
chr3_-_89319088 0.55 ENSMUST00000107429.10
ENSMUST00000129308.9
ENSMUST00000107426.8
ENSMUST00000050398.11
ENSMUST00000162701.2
Flad1
flavin adenine dinucleotide synthetase 1
chr17_-_35827676 0.54 ENSMUST00000160885.2
ENSMUST00000159009.2
ENSMUST00000161012.8
Tcf19
transcription factor 19
chr14_+_76714350 0.48 ENSMUST00000140251.9
Tsc22d1
TSC22 domain family, member 1
chr17_+_31652029 0.48 ENSMUST00000136384.9
Pde9a
phosphodiesterase 9A
chr9_+_45924120 0.44 ENSMUST00000120463.9
ENSMUST00000120247.8
Sik3
SIK family kinase 3
chr11_+_97206542 0.43 ENSMUST00000019026.10
ENSMUST00000132168.2
Mrpl45
mitochondrial ribosomal protein L45
chr9_+_108883907 0.43 ENSMUST00000154184.5
Shisa5
shisa family member 5
chr11_+_48977495 0.42 ENSMUST00000152914.2
Ifi47
interferon gamma inducible protein 47
chr1_-_45542442 0.39 ENSMUST00000086430.5
Col5a2
collagen, type V, alpha 2
chr5_-_100521343 0.38 ENSMUST00000182433.8
Sec31a
Sec31 homolog A (S. cerevisiae)
chr9_+_45924105 0.37 ENSMUST00000126865.8
Sik3
SIK family kinase 3
chr11_-_66943389 0.36 ENSMUST00000116363.2
Adprm
ADP-ribose/CDP-alcohol diphosphatase, manganese dependent
chr1_-_65225617 0.31 ENSMUST00000186222.7
ENSMUST00000169032.8
ENSMUST00000191459.2
ENSMUST00000188876.7
Idh1
isocitrate dehydrogenase 1 (NADP+), soluble
chr7_+_45546365 0.31 ENSMUST00000069772.16
ENSMUST00000210503.2
ENSMUST00000209350.2
Tmem143
transmembrane protein 143
chr17_+_35455532 0.31 ENSMUST00000068261.9
Atp6v1g2
ATPase, H+ transporting, lysosomal V1 subunit G2
chr5_-_50216249 0.29 ENSMUST00000030971.7
Adgra3
adhesion G protein-coupled receptor A3
chr1_-_65225572 0.29 ENSMUST00000188109.7
Idh1
isocitrate dehydrogenase 1 (NADP+), soluble
chr5_+_115034997 0.29 ENSMUST00000031542.13
ENSMUST00000146072.8
ENSMUST00000150361.2
Oasl2
2'-5' oligoadenylate synthetase-like 2
chr17_-_56343531 0.28 ENSMUST00000233803.2
Sh3gl1
SH3-domain GRB2-like 1
chr11_+_17161912 0.25 ENSMUST00000046955.7
Wdr92
WD repeat domain 92
chr15_-_76809607 0.25 ENSMUST00000229865.2
ENSMUST00000229055.2
Zfp647
zinc finger protein 647
chr12_+_36207113 0.23 ENSMUST00000041640.5
Ankmy2
ankyrin repeat and MYND domain containing 2
chr6_-_3399451 0.22 ENSMUST00000120087.6
Samd9l
sterile alpha motif domain containing 9-like
chr6_+_91678630 0.22 ENSMUST00000205828.2
Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr6_-_91492860 0.22 ENSMUST00000206476.2
ENSMUST00000032182.5
Xpc
xeroderma pigmentosum, complementation group C
chr1_-_90771638 0.21 ENSMUST00000130846.9
Col6a3
collagen, type VI, alpha 3
chr7_+_28869770 0.20 ENSMUST00000033886.8
ENSMUST00000209019.2
ENSMUST00000208330.2
Ggn
gametogenetin
chr11_+_66943453 0.19 ENSMUST00000108690.10
ENSMUST00000092996.5
Sco1
SCO1 cytochrome c oxidase assembly protein
chr2_+_89804937 0.18 ENSMUST00000214630.2
ENSMUST00000111512.10
ENSMUST00000144710.3
ENSMUST00000216678.2
Olfr1260
olfactory receptor 1260
chr18_+_37858753 0.18 ENSMUST00000066149.9
Pcdhga8
protocadherin gamma subfamily A, 8
chr8_+_112370088 0.17 ENSMUST00000077791.8
ENSMUST00000211926.2
Zfp1
zinc finger protein 1
chr3_+_89986831 0.17 ENSMUST00000029549.16
Tpm3
tropomyosin 3, gamma
chr11_+_105866030 0.15 ENSMUST00000001964.8
Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr1_+_44159106 0.15 ENSMUST00000114709.3
ENSMUST00000129068.2
Bivm
basic, immunoglobulin-like variable motif containing
chr8_+_112370033 0.15 ENSMUST00000212072.2
Zfp1
zinc finger protein 1
chr7_+_30681287 0.13 ENSMUST00000128384.3
Fam187b
family with sequence similarity 187, member B
chr13_+_49658249 0.12 ENSMUST00000051504.8
Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr6_+_41039255 0.12 ENSMUST00000103266.3
Trbv5
T cell receptor beta, variable 5
chr9_-_19163273 0.11 ENSMUST00000214019.2
ENSMUST00000214267.2
Olfr843
olfactory receptor 843
chr10_+_3822667 0.11 ENSMUST00000136671.8
ENSMUST00000042438.13
Plekhg1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr3_+_92339886 0.11 ENSMUST00000067102.3
Sprr2k
small proline-rich protein 2K
chrY_-_79161056 0.10 ENSMUST00000179922.2
Gm20917
predicted gene, 20917
chr11_-_49077864 0.10 ENSMUST00000153999.3
ENSMUST00000066531.13
Btnl9
butyrophilin-like 9
chr11_-_115518774 0.09 ENSMUST00000154623.2
ENSMUST00000106503.10
ENSMUST00000141614.3
Slc25a19
solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
chr2_-_93841152 0.09 ENSMUST00000111240.8
Alkbh3
alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase
chr8_+_65399831 0.09 ENSMUST00000026595.13
ENSMUST00000209852.2
ENSMUST00000079896.9
Tmem192
transmembrane protein 192
chr3_+_82933383 0.09 ENSMUST00000029630.15
ENSMUST00000166581.4
Fga
fibrinogen alpha chain
chr2_-_93841062 0.09 ENSMUST00000040005.13
ENSMUST00000126378.8
Alkbh3
alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase
chr16_+_36695479 0.08 ENSMUST00000023534.7
ENSMUST00000114812.9
ENSMUST00000134616.8
Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1
chrX_-_91059789 0.08 ENSMUST00000099471.3
ENSMUST00000072269.2
Mageb1
MAGE family member B1
chr9_-_110818679 0.08 ENSMUST00000084922.6
ENSMUST00000199891.2
Rtp3
receptor transporter protein 3
chr16_-_91415873 0.07 ENSMUST00000143058.2
ENSMUST00000049244.10
ENSMUST00000169982.2
ENSMUST00000133731.2
Dnajc28
DnaJ heat shock protein family (Hsp40) member C28
chr14_-_50919102 0.07 ENSMUST00000078075.5
Olfr747
olfactory receptor 747
chr4_-_118667141 0.07 ENSMUST00000084313.5
ENSMUST00000219094.2
Olfr1335
olfactory receptor 1335
chr2_-_112089627 0.07 ENSMUST00000043970.2
Nutm1
NUT midline carcinoma, family member 1
chr11_-_96002784 0.06 ENSMUST00000097162.6
ENSMUST00000068686.13
Calcoco2
calcium binding and coiled-coil domain 2
chr10_-_130116088 0.06 ENSMUST00000061571.5
Neurod4
neurogenic differentiation 4
chr2_+_83554741 0.06 ENSMUST00000028499.11
Itgav
integrin alpha V
chr2_+_128433125 0.06 ENSMUST00000155430.8
Spdye4c
speedy/RINGO cell cycle regulator family, member E4C
chr3_-_92734546 0.05 ENSMUST00000072363.5
Kprp
keratinocyte expressed, proline-rich
chr1_-_85247864 0.05 ENSMUST00000159582.8
ENSMUST00000161267.8
C130026I21Rik
RIKEN cDNA C130026I21 gene
chr1_+_189460461 0.05 ENSMUST00000097442.9
Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr16_-_36695166 0.05 ENSMUST00000075946.12
Eaf2
ELL associated factor 2
chr10_+_80441855 0.04 ENSMUST00000178231.2
Gm49322
predicted gene, 49322
chr3_-_95125190 0.04 ENSMUST00000136139.8
Gabpb2
GA repeat binding protein, beta 2
chr8_+_47439916 0.04 ENSMUST00000039840.15
Enpp6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr15_-_98063441 0.04 ENSMUST00000123922.2
Asb8
ankyrin repeat and SOCS box-containing 8
chr17_+_87943401 0.03 ENSMUST00000235125.2
ENSMUST00000053577.9
ENSMUST00000234009.2
Epcam
epithelial cell adhesion molecule
chr15_-_75793312 0.03 ENSMUST00000053918.9
Pycrl
pyrroline-5-carboxylate reductase-like
chrX_-_6907858 0.02 ENSMUST00000115752.8
Ccnb3
cyclin B3
chr6_+_11907808 0.02 ENSMUST00000155037.4
Phf14
PHD finger protein 14
chr1_+_173877941 0.02 ENSMUST00000062665.4
Olfr432
olfactory receptor 432
chr8_-_110688716 0.02 ENSMUST00000001722.14
ENSMUST00000051430.7
Marveld3
MARVEL (membrane-associating) domain containing 3
chr9_-_39920878 0.02 ENSMUST00000216463.3
Olfr980
olfactory receptor 980
chr1_+_21419819 0.01 ENSMUST00000088407.4
Khdc1a
KH domain containing 1A
chr13_-_105429514 0.01 ENSMUST00000224011.2
Rnf180
ring finger protein 180
chr14_+_53531798 0.01 ENSMUST00000103626.3
Trav9n-4
T cell receptor alpha variable 9N-4
chr5_-_105198913 0.01 ENSMUST00000112718.5
Gbp8
guanylate-binding protein 8
chr7_-_84059170 0.01 ENSMUST00000208995.2
Arnt2
aryl hydrocarbon receptor nuclear translocator 2
chr3_+_107008867 0.01 ENSMUST00000038695.6
Kcna2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr11_+_62349238 0.00 ENSMUST00000014389.6
Pigl
phosphatidylinositol glycan anchor biosynthesis, class L

Network of associatons between targets according to the STRING database.

First level regulatory network of Aire

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0042853 glycine biosynthetic process, by transamination of glyoxylate(GO:0019265) L-alanine catabolic process(GO:0042853)
0.7 2.0 GO:0032789 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.4 1.7 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.4 1.2 GO:0021682 nerve maturation(GO:0021682)
0.4 1.5 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187)
0.3 2.7 GO:0097461 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.2 2.3 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.2 0.5 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.2 0.8 GO:0009115 xanthine catabolic process(GO:0009115)
0.2 0.6 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 1.0 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 4.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 1.0 GO:0033762 response to glucagon(GO:0033762)
0.1 0.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 1.2 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.1 0.6 GO:0006742 NADP catabolic process(GO:0006742)
0.1 1.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 2.5 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.2 GO:0015734 beta-alanine transport(GO:0001762) taurine transport(GO:0015734)
0.1 0.2 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.9 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 0.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 1.4 GO:0051923 sulfation(GO:0051923)
0.1 3.7 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 1.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.1 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.0 2.9 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 3.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.9 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.2 GO:0035553 oxidative single-stranded DNA demethylation(GO:0035552) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 1.0 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.1 GO:0030974 thiamine pyrophosphate transport(GO:0030974)
0.0 0.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:2000536 negative regulation of entry of bacterium into host cell(GO:2000536)
0.0 1.1 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.7 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.8 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0 0.5 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.6 GO:2000398 regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398)
0.0 0.2 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.4 GO:0005588 collagen type V trimer(GO:0005588)
0.1 1.2 GO:0016011 dystroglycan complex(GO:0016011)
0.1 1.0 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 1.0 GO:0036128 CatSper complex(GO:0036128)
0.1 1.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.2 GO:0071942 XPC complex(GO:0071942)
0.1 3.7 GO:0070469 respiratory chain(GO:0070469)
0.0 0.8 GO:0042555 MCM complex(GO:0042555)
0.0 1.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 7.9 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.2 GO:0033648 host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.0 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.1 GO:0034686 integrin alphav-beta3 complex(GO:0034683) integrin alphav-beta8 complex(GO:0034686)
0.0 3.7 GO:0072562 blood microparticle(GO:0072562)
0.0 0.3 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.1 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.6 1.7 GO:0004454 ketohexokinase activity(GO:0004454)
0.5 1.5 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.5 2.9 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.4 1.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.3 2.7 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.3 0.9 GO:0050479 glyceryl-ether monooxygenase activity(GO:0050479)
0.2 1.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.2 1.0 GO:0042296 ISG15 transferase activity(GO:0042296)
0.2 0.8 GO:0043546 xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726) molybdenum ion binding(GO:0030151) molybdopterin cofactor binding(GO:0043546)
0.2 3.5 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.2 0.6 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 1.2 GO:0043237 laminin-1 binding(GO:0043237)
0.1 1.0 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 3.7 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.0 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 2.3 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.6 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.7 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 0.2 GO:0001761 beta-alanine transmembrane transporter activity(GO:0001761) taurine transmembrane transporter activity(GO:0005368) taurine:sodium symporter activity(GO:0005369)
0.1 2.0 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.2 GO:0051747 cytosine C-5 DNA demethylase activity(GO:0051747)
0.1 1.3 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 1.2 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 0.4 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240) bradykinin receptor binding(GO:0031711)
0.0 2.8 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.8 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 1.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.1 GO:0015234 thiamine transmembrane transporter activity(GO:0015234)
0.0 0.1 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 1.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.2 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.5 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 1.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 0.8 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects